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Objective: To study the correlation between serum C-reactive protein (CRP), melatonin (MT), insulin-like growth factor-1 (IGF-1) and oxidative stress indexes and cognitive function in patients with first-episode untreated schizophrenia (SP). Methods: 140 patients with first-episode untreated SP who were treated in Xuzhou Oriental Hospital Affiliated to Xuzhou Medical University from January 2021 to June 2023 were selected as observation group, the patients were divided into high score group (≥70 points) with 57 cases and low score group (<70 points) with 83 cases according to the positive and negative symptom scale (PANSS) score. Another 140 volunteers who received physical examination in our hospital during the same period were selected as control group. Serum oxidative stress indexes, CRP, MT and IGF-1 levels were detected, and patients' cognitive dysfunction was evaluated by MATRICS cognitive assessment system (MCCB) score. The correlation between serum CRP, MT, IGF-1 and PANSS score, serum oxidative stress index, MCCB score and total score was analyzed. Results: Serum CRP in observation group was higher than that in control group, and MT and IGF-1 were lower than those in control group (P<0.05). The serum CRP in high score group was higher than that in low score group, and the MT and IGF-1 were lower than those in low score group (P<0.05). Serum SOD and GSH-Px in high score group were lower than those in low score group, while NO was higher than that in low score group (P<0.05). The MCCB scores and total scores in high score group were lower than those in low score group, and the PANSS score was higher than that in low score group (P<0.05). Pearson correlation showed that, serum CRP was positively correlated with PANSS score and NO, and negatively correlated with SOD, GSH-Px and MCCB scores and total scores (P<0.05). Serum MT and IGF-1 were negatively correlated with PANSS score and NO, and positively correlated with SOD, GSH-Px and MCCB scores and total score (P<0.05). Conclusion: The level of serum CRP in patients with first-episode untreated SP increase, and the levels of MT and IGF-1 decrease, there is a significant correlation between the three and oxidative stress indicators and cognitive function. [ABSTRACT FROM AUTHOR]

目的: 研究CRP血常规联合检验在儿科中的应用价值。方法: 选取2022年5月1日至2024年04月30日内接 受临床治疗的90例儿科患儿作为实验观察对象, 以抽签法分组, 抽中短签的45例患儿选入联合检验组, 采用CRP血常 规联合检验, 抽中长签的45例患儿选入单项检验组, 采用血常规检验, 比较联合检验组与单项检验组的诊断指标。结 果: 联合检验组患儿的CRP、白细胞计数、中性粒子细胞计数均高于单项检验组, 组间差有统计学意义 (P < 0.05) 。 联合检验组与单项检验组患儿的疾病检出率分别为93.33%、73.33%, 联合检验组患儿的疾病检出率更高, 组间差有 统计学意义 (P < 0.05)。联合检验组与单项检验组患儿的敏感度分别为93.33%、75.56%, 特异性分别为82.22%、 73.33%, 准确性分别为93.33%、77.78%, 联合检验组患儿的敏感度、特异性及准确性更高, 组间差有统计学意义 (P < 0.05) 。联合检验组与单项检验组患儿的的显效人数分别为22例、17例, 有效人数分别为20例、16例, 无效人数分别为 3例、12例, 总有效率分别为93.33%、73.33%；联合检验组患儿的预后效果强于单项检验组, 组间差有统计学意义 (P < 0.05)。结论: CRP血常规联合检验在儿科中的应用价值更大, 有助于强化患儿预后效果, 值得临床广泛运用。 [ABSTRACT FROM AUTHOR]

Objective: To investigate the relationship between serum levels of procalcitonin（PCT), C-reactive protein（CRP),glycogen phosphorylase isoenzyme BB（GPBB) and high mobility group protein B1（HMGB1) and myocardial injury indexes and prognosis in children with sepsis. Methods: 271 children with sepsis myocardial injury（myocardial injury group) who were admitted to No. 926 Hospital of Joint Logistics Support Force of PLA from March 2019 to March 2022 and 227 children with sepsis infectious diseases and without myocardial injury（control group) who were admitted during the same period were selected. The levels of serum PCT, CRP, GPBB, HMGB1 and myocardial injury indexes were detected in both groups. Pearson correlation coefficient was used to analyze the correlation between serum PCT, CRP, GPBB, HMGB1 and myocardial injury indexes. According to the prognosis of children with myocardial injury at 28d, the children in the myocardial injury group were divided into the death group and the survival group, and the risk factors of death in children with myocardial injury of sepsis were analyzed by multivariate Logistic regression. Results: The levels of serum PCT, myoglobin（Mb), CRP, GPBB, cardiac troponin I（cTnI), HMGB1, and creatine kinase isoenzyme（CK-MB) in the myocardial injury group were higher than those in the control group（P＜0.05). The levels of serum PCT, CRP, GPBB and HMGB1 were positively correlated with MB, CK-MB and cTnI（P＜0.05). The proportion of septic shock, APACHE II score, SOFA score, urea nitrogen, serum creatinine and the levels of serum PCT, CRP, GPBB and HMGB1 in the death group were higher than those in the survival group（P＜0.05). The prealbumin was lower than that of survival group（P＜0.05). Multivariate Logistic regression analysis showed that high APACHE Ⅱ score, presence of septic shock, high PCT, high CRP, high GPBB, high HMGB1 and high cTnI were risk factors for prognosis of children with sepsis（P＜0.05). Conclusion: The levels of serum PCT, CRP, GPBB and HMGB1 in children with sepsis myocardial injury increased, which are related to poor prognosis and myocardial injury indexes. [ABSTRACT FROM AUTHOR]

Objective: To analyze the pathogenic bacteria of postoperative incision infection in patients with acute appendicitis (AA) and to investigate the predictive value of the combined detection of neutrophil-to-lymphocyte ratio (NLR), procalcitonin (PCT) and C-reactive protein (CRP). Methods: 379 patients with AA who received laparoscopic or open surgery in Affiliated Hospital of Qingdao University from January 2020 to September 2022 were selected, and they were divided into infected group and non-infected group according to whether postoperative incision infection occurred. Clinical data of patients with AA were collected and NLR, PCT and CRP levels were detected. The distribution of pathogenic bacteria of postoperative incision infection in patients with AA was analyzed. The influencing factors of postoperative incision infection in patients with AA were analyzed by univariate and multivariate Logistic regression. The predictive value of NLR, PCT and CRP in postoperative incision infection in patients with AA was analyzed by receiver operating characteristic (ROC) curve. Results: The incidence of postoperative incision infection in 379 patients with AA was 12.40% (47/379), and 75 strains of pathogenic bacteria were detected in the incision secretions of postoperative incision infection in 47 patients with AA, with Gram-positive bacteria and Gram-negative bacteria accounting for 42.67% (32/75) and 57.33% (43/75), respectively. The levels of NLR, PCT and CRP in the infected group were higher than those in the non-infected group (P＜0.05). Multivariate Logistic regression analysis showed that age ≥60 years old, disease course ≥24 h, appendectomy purulent or gangrene and perforation, open surgery, indwelling drainage tube and increased serum NLR, PCT and CRP were independent risk factors for postoperative incision infection in patients with AA, and preventive use of antibacterial drugs was independent protective factor(P＜0.05). ROC curve analysis showed that the combined prediction of NLR, PCT and CRP for postoperative incision infection in patients with AA was larger than that of NLR, PCT and CRP alone. Conclusion: The pathogenic bacteria of postoperative incision infection in patients with AA are mainly Gram-negative bacteria. The increase of preoperative NLR, PCT and CRP levels are closely related to postoperative incision infection in patients with AA, and the combined value of the three is high in predicting postoperative incision infection in patients with AA. [ABSTRACT FROM AUTHOR]

Objective To determine the differences in the expression of serum complement （C） and IL-25 in systemic lupus erythematosus （SLE） involved with single or multi-organ systems， and analyze the correlation between serum C3， C4， CH50， IL-25， C-reactive protein （CRP） and anti-dsDNA antibody. Methods A total of 151 SLE patients were included in this study. According to the organ involvement status， all patients were divided into the SLE alone （n = 58）， SLE complicated with single organ injury （n = 67， 51 cases of lupus nephritis， 13 cases of blood system injury and 3 cases of other organ injury）， and SLE complicated with multi-organ injury groups （n = 26， 25 cases of lupus nephritis complicated with other organ injury and 1 blood system complicated with brain injury）. The levels of serum C3， C4， CH50， IL-25 and CRP， and positive rate of anti-dsDNA antibody were detected among three groups. The correlation among these indexes was analyzed. Results There was no significant difference in the C4， CH50， IL-25 and CRP levels among three groups. There were significant differences in the C3 level and positive rate of anti-dsDNA antibody among three groups （all P < 0.05）. In the multi-organ injury group， C3 level was significantly lower， whereas positive rate of anti-dsDNA antibody was significantly higher compared with those in the remaining two groups （all P < 0.017）. Spearman rank correlation test indicated that C3 level was positively correlated with C4 （rs = 0.73， P < 0.001） and CH50 levels （rs = 0.81， P < 0.01）， whereas negatively correlated with IL-25 level （rs = -0.14， P < 0.001）. Conclusions In SLE patients with multi-organ involvement， serum C3 level is significantly decreased， whereas positive rate of anti-dsDNA antibody is significantly increased. Detection of serum complement levels is of clinical significance for the prediction of multi-organ injury in SLE patients.

Objective: To investigate the predictive value of serum amyloid A (SAA), C-reactive protein (CRP), platelet distribution width (PDW) and neutrophil/lymphocyte ratio (NLR) for the timing of neonatal necrotizing enterocolitis (NEC) surgery.Methods: 70 children with NEC who were admitted to Foshan Maternal and Child Health Hospital from January 2019 to January 2022were selected, and they were divided into surgery group with 35 cases and non-surgery group with 35 cases according to treatment methods. Clinical data of children with NEC were collected, and the levels of serum SAA, CRP, peripheral blood PDW and NLR in the two groups were detected. Univariate and multivariate Logistic regression were used to analyze the influencing factors of neonatal NEC surgery. The predictive value of serum SAA, CRP, peripheral blood PDW and NLR on the timing of neonatal NEC surgery was analyzed by receiver operating characteristic (ROC) curve. Results: The gestational age ≥37 weeks and the proportion of weight ＞2500 g at diagnosis in the surgery group were lower than those in the non-surgery group, the proportion of weight 1500～2500 g at diagnosis, poor mental response, abdominal distension, weak bowel sound and the levels of serum SAA, CRP, peripheral blood PDW and NLR were higher than those in the non-surgery group (all P＜0.05). Multivariate Logistic regression analysis showed that weight＞2500 g at diagnosis was an independent protective factor for neonatal NEC surgery, poor mental response, abdominal distension, weak bowel sound and increased levels of serum SAA, CRP, PDW and NLR were independent risk factors for neonatal NEC surgery (all P＜0.05). ROC curve analysis showed that the area under the curve (AUC) of the combination of serum SAA, CRP, peripheral blood PDW and NLR in predicting the timing of neonatal NEC surgery was greater than that of each indicator alone. Conclusion: The increase levels of serum SAA, CRP, peripheral blood PDW and NLR are closely related to neonatal NEC surgery, and the combined value of these four indicators in predicting the timing of neonatal NEC surgery is higher [ABSTRACT FROM AUTHOR]

Objective To establish the conversion equation from DAS28CRP to DAS28ESR and derive the corresponding thresholds of DAS28CRP using DAS28ESR as the standard. Methods Patients who received simultaneous measurement of DAS28ESR and DAS28CRP at Department of Rheumatology of Sun Yat-sen Memorial Hospital were recruited and randomly assigned into the training set （70%） and validation set （30%）. The Bisquare-weighted robust regression was applied to establish the conversion equation from DAS28CRP to DAS28ESR. The Wilcoxon signed-rank test was used to compare the difference between the converted values and actual values of DAS28ESR and the kappa values were used to assess the agreement in disease activity classification. Results A total of 955 patients were enrolled in the study. The conversion equation was： DAS28ESR1 = 1.06 × DAS28CRP + 0.4275. According to the conversion equation, the corresponding thresholds for DAS28CRP were 2.05, 2.61 and 4.40, respectively. After conversion, there was no statistical difference between the converted values and actual values of DAS28ESR （P > 0.05）. The kappa values were increased from 0.54 to 0.78. Conclusions The conversion equation from DAS28CRP to DAS28ESR is successfully established, which facilitates the comparison of findings among different studies. The derived DAS28CRP thresholds contribute to improving the agreement with DAS28ESR in assessing the disease activity.

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Copyright of China Tropical Medicine is the property of China Tropical Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To analyze the correlation between gingival crevicular fluid C-reactive protein (CRP), interleukin-17 (IL-17), receptor activator of NF-KB ligand (RANKL) and periodontal clinical indicators in patients with peri-implantitis (PI) and to explore the evaluation value of combined detection for prognosis after treatment. 80 patients with PI who were admitted to our hospital from January 2018 to January 2022 were selected as the inflammation group. Another 80 healthy implant patients in the same period were selected as the healthy group. The levels of gingival crevicular fluid CRP, IL-17 and RANKL and periodontal clinical indicators were measured and compared between the two groups. Pearson correlation was used to analyze the correlation between gingival crevicular fluid CRP, IL-17, RANKL and periodontal clinical indicators. In addition, all patients with PI were divided into good prognosis group with 27 cases and poor prognosis group with 53 cases according to the difference between acute physiology and chronic health status score II (APACHE II). The levels of gingival crevicular fluid CRP, IL-17 and RANKL were compared between the two groups. Through the receiver operating characteristic (ROC) curve, the efficacy of the above three indicators combined to predict the poor prognosis of patients with PI after treatment was analyzed. The levels of gingival crevicular fluid CRP, IL-17 and RANKL in inflammatory group were higher than those in healthy group (all P＜0.05). The scores of modified gingival index (mGI), modified gingival sulcus bleeding index (mSBI) and probing depth (PD) in the inflammatory group were higher than those in the healthy group (all P＜0.05). Pearson correlation analysis showed that the levels of gingival crevicular fluid CRP, IL-17 and RANKL were positively correlated with mGI, mSBI scores and PD (all P＜0.05). The levels of gingival crevicular fluid CRP, IL-17 and RANKL in the poor prognosis group were higher than those in the good prognosis group (all P＜0.05). The ROC curve analysis showed that the area under the curve (0.95CI) of gingival crevicular fluid CRP, IL-17 and RANKL combined to predict the poor prognosis of patients with PI after treatment was 0.851 (0.752 ~ 0.944), which was better than the above three indicators alone. The gingival crevicular fluid CRP, IL-17 and RANKL are closely related to mGI, mSBI scores and PD in patients with PI. The detection of these three indicators is helpful to evaluate the patient's condition and prognosis after treatment. [ABSTRACT FROM AUTHOR]

Objective: To investigate the expression of serum N-terminal B-type natriuretic peptide (NT-proBNP), amyloid A (SAA）, C-reactive protein (CRP) and cystatin C (Cysc) in children with Kawasaki disease (KD) and its prediction efficiency of combined detection on the risk of coronary artery damage (CAL). Methods: 98 children with KD who were treated in our hospital from January 2019 to December 2021 were included. According to the results of echocardiography, they were divided into CAL group (n=31) and non-CAL group (n=67）. The levels difference of NT-proBNP, SAA, CRP and Cysc in the two groups were compared. The data of patients were collected, and the influencing factors of CAL were analyzed by Logistic multivariate analysis. The receiver operating characteristic (ROC) curve was drawn to analyze the predictive efficacy of the combined detection of serum NT-proBNP, SAA, CRP and Cysc on the risk of CAL. Results: The levels of serum NT-proBNP, SAA, CRP and Cysc in CAL group were higher than those in non-CAL group (P<0.05). Univariate analysis showed that CAL in children with KD was related to age, fever time before treatment, whether it was typical KD, platelet count (PLT) and leukocyte count (WBC) (P<0.05）. Multivariate Logistic regression analysis showed that the high levels of serum NT-proBNP, SAA, CRP, Cysc and WBC, age < 3 years, fever time before treatment > 6 days and atypical KD were the risk factors of children with KD complicated with CAL (P<0.05). The areas under the curve of serum NT-proBNP, SAA, CRP and Cysc to predict the CAL occurrence were 0.761, 0.759, 0.753 and 0.746 respectively. The area under the curve of four joint tests to predict the CAL occurrence was 0.906, which has a higher predictive value. Conclusion: Serum NT-proBNP, SAA, CRP, Cysc, WBC, age, fever time be fore treatment and atypical KD are the influencing factors of CAL in children with KD. Combined detection of serum NT-proBNP, SAA, CRP and Cysc has a good prediction efficiency on the risk of CAL occurrence. [ABSTRACT FROM AUTHOR]

Objective: To investigate the differential role of procalcitonin (PCT), interleukin-6 (IL-6), C-reactive protein (CRP) and neutrophil/lymphocyte ratio (NLR) in Gram-positive bacteria (G+bacteria) and Gram-negative bacteria (G-bacteria) in patients with bacterial bloodstream infection (BSI) in intensive care unit (ICU) and its predictive value for the risk of death. Methods: 99 patients with bacterial BSI who were treated in our hospital from February 2019 to December 2021 were selected, and they were divided into G-bacteria infection group and G+bacteria infection group according to the identification results of bacterial Gram staining culture. The levels of PCT, IL-6, CRP and NLR in the two groups were detected and compared, and the differential value of the above indexes for G+bacteria and G-bacteria infection was analyzed according to the receiver operating characteristic (ROC) curve. The difference of levels of PCT, IL-6, CRP and NLR of different pathogen types of G+bacteria and G-bacteria were compared. In addition, all patients were divided into death group and survival group according to the 28 d prognosis difference. The levels of PCT, IL-6, CRP and NLR in the two groups were compared. The predictive value of the above indexes for the death of patients with bacterial BSI in ICU was analyzed by ROC curve. Results: (1) Among 99 patients with bacterial BSI, the pathogen type were G-bacteria with 70 cases (70.71%), and G+bacteria with 29 cases (29.29%). (2) The levels of PCT and NLR in G-bacteria infection group were higher than those in G+bacteria infection group (P＜0.05), but there was no significant difference in the levels of IL-6 and CRP between the two groups (P>0.05). The ROC-AUC (0.95CI) of combined detection of levels of PCT and NLR to identify G+bacteria and G-bacteria was 0.855 (0.770～0.912), the identification efficiency was good. (3) The levels of PCT, IL-6 and CRP of Klebsiella pneumoniae were higher than those of Escherichia coli, Acinetobac ter baumannii, Pseudomonas aeruginosa and other G-bacteria, while the level of NLR was lower than that of Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa and other G-bacteria (P<0.05). The levels of PCT, IL-6, CRP and NLR in Streptococcus were higher than those in coagulase negative staphylococcus, Staphylococcus aureus and Enterococcus (P<0.05). (4) The levels of PCT, IL-6 and NLR in the death group were higher than those in the survival group (P<0.05), but there was no significant difference in the level of CRP between the two groups(P>0.05). The ROC-AUC (0.95CI) of combined detection of the levels of PCT, IL-6 and NLR to predict the death of patients with bacterial BSI in ICU was 0.871 (0.787～0.937), the prediction efficiency was good. Conclusion: The combined detection of PCT and NLR has a certain value in identifying G-bacteria and G+bacteria in patients with bacterial BSI in ICU, while the combined detection of PCT, IL-6 and NLR has a certain predictive value for the risk of death. [ABSTRACT FROM AUTHOR]

To observe the relationship between red blood cell distribution width (RDW) combined with serum C-reactive protein (CRP), procalcitonin (PCT), soluble bone marrow cell like transcription factor-1 (sTLT-1) and cerebral infarction volume, neurological impairment and prognosis in patients with acute cerebral infarction (ACI). 100 patients with ACI who were treated in our hospital from April 2019 to October 2021 were selected as the research object. 100 patients were divided into mild to moderate injury group (61 cases, NIHSS ≤ 8 scores) and severe injury group (39 cases, NIHSS > 8 scores) according to the National Institutes of Health Stroke Scale (NIHSS), small focal infarction group (41 cases, infarct volume < 5 cm³ ), medium focal infarction group (35 cases, 5 cm³ ≤ infarct volume ≤ 15 cm³ ) and large focal infarction group (24 cases, infarct volume > 15 cm3 ) according to different volume of cerebral infarction. poor prognosis group (31 cases, mRS ≥ 3 scores) and good prognosis group (69 cases, mRS < 3 scores) according to the modified Rankin Scale (mRS) at discharge. The RDW and the serum CRP, PCT and sTLT-1 levels with different cerebral infarction volume, different NIHSS score and different prognosis in patients with ACI were compared. The influencing factors of poor prognosis in patients with ACI were analyzed by univariate and multivariate Logistic regression. RDW, serum CRP, PCT and stlt-1 increased in turn of patients in small focal infarction group, medium focal infarction group and large focal infarction group, and the difference between the groups was statistically significant ( P<0.05). The RDW and serum CRP, PCT, sTLT-1 levels in severe injury group were higher than those in mild to moderate injury group (P<0.05). The RDW and serum CRP, PCT, sTLT-1 levels in the poor prognosis group were higher than those in the good prognosis group ( P<0.05). There were significant differences in classification of cerebral infarction, smoking history, gender, NIHSS score at admission, age, infarct volume and drinking history between the good prognosis group and the poor prognosis group ( P<0.05). Multivariate Logistic regression analysis showed that higher NIHSS score at admission, larger cerebral infarction volume, complete anterior circulation cerebral infarction, higher RDW, higher CRP, higher PCT and higher sTT-1 were the risk factors for poor prognosis of patients with ACI ( P<0.05). RDW and the serum CRP, PCT, sTLT-1 levels can effectively reflect the cerebral infarction volume and the degree of neurological impairment in patients with ACI, and the prognosis of patients with ACI is affected by NIHSS score, cerebral infarction volume, cerebral infarction classification, RDW, CRP, PCT, sTLT-1 and other factors. [ABSTRACT FROM AUTHOR]

To observe the effects of Xingpi Yanger granule combined with Bifidobacterium triple viable powder on immune function, myocardial enzyme indexes, serum interleukin-6(IL-6) and C-reactive protein(CRP) in children with rotavirus diarrhea. Methods: 92 children with rotavirus diarrhea who were received in our hospital from January 2018 to January 2021 were selected. Ac-cording to the random number table method, the children were divided into control group and study group, with 46 cases in each group. The children in the control group were treated with Bifidobacterium triple viable powder, and the children in the study group were treated with Xingpi Yanger granule combined with Bifidobacterium triple viable powder, all patients were treated for 3 days. The curative effects of the two groups were observed and the adverse reactions were recorded. The changes of immune function [immunoglobulin (Ig) m, IgG and IgA], myocardial enzyme indexes [phosphocreatine kinase (CK), lactate dehydrogenase (LDH), creatine kinase isoenzyme (CK-MB)]and serum IL-6 and CRP were observed and compared between the two groups. Results: The total clinical effective rate in the study group was 91.30% (42/46), which was higher than 71.74% (33/46) in the control group (P<0.05). The levels of serum IgM, IgG and IgA in the two groups were higher than those before treatment, and the improvement degree of the study group was better than that of the control group (P<0.05). The levels of serum LDH, CK and CK-MB in the two groups were lower than those before treatment, and the improvement degree of the study group was better than that of the control group (P<0.05). The levels of serum IL-6 and CRP in the two groups were lower than those before treatment, and the improvement degree of the study group was better than that of the control group(P<0.05). There were no significant adverse reactions in both groups. Conclusion: Xingpi Yanger granule combined with Bifidobacterium triple viable powder in the treatment of children with rotavirus diarrhea can improve immunity, reduce myocardial injury and reduce the levels of serum IL-6 and CRP, which is safe and effective. [ABSTRACT FROM AUTHOR]

Objective: The whole blood CRP levels, HbA1c and serum vitamin B12 levels of pregnant women with GDM in different pregnancy periods were detected, and their correlations were analyzed. Methods: Taking pregnant women as research subjects, they were divided into control group and study group according to the OGTT test results. The control group was healthy pregnant women and the study group was GDM pregnant women. The whole blood CRP levels, HbA1c and serum vitamin B12 of pregnant women in the second and third trimesters of the two groups were tested. Results: The whole blood CRP and HbA1c levels of GDM in the second and third trimesters of the study group were significantly higher than those of the control group (P<0.05). Compared with the second trimester, there was no significant change in the whole blood CRP level of the two groups in the third trimester (P>0.05), the whole blood HbA1c level of pregnant women in the control group did not change significantly (P>0.05), while the whole blood HbA1c level of the study group was significantly increased in the third trimester (P<0.05). Compared with the control group, the serum vitamin B12 levels of the study group during the second and third trimesters were significantly reduced (P<0.05); compared with the second trimester, the serum vitamin B12 levels of pregnant women in the control group did not change significantly (P>0.05), while serum vitamin B12 level in the third trimester of the study group was significantly reduced (P＜0.05). The CRP levels in the second and third trimesters of the study group were significantly positively correlated with HbA1c, and significantly negatively correlated with vitamin B12 (P<0.05). There was no correlation between CRP levels and HbA1c and vitamin B12 levels in normal pregnant women during the second and third trimesters (P>0.05). Conclusion: The whole blood CRP, HbA1c and serum vitamin B12 of GDM pregnant women were abnormal in the second and third trimesters, and the CRP level was significantly positively correlated with HbA1c, and significantly negatively correlated with the vitamin B12 level. [ABSTRACT FROM AUTHOR]

Objective To explore the influence of Zeste homologous complex 2（EZH2）gene expression on endothelial cell inflammation induced by oxidized low-density lipoprotein（ox-LDL）. Methods Human umbilical vein endothelial cells（HUVEC）were cultured and induced by ox-LDL at different concentrations（0，25，50，100 µg/mL）for 12 and 24 h. The level of interleukin 6（IL-6）in the supernatant was detected by ELISA. The results showed that at the same time，the level of IL-6 in the supernatant of HUVEC treated with 25，50，and100 µ mol/L ox-LDL was significantly higher than that of HUVEC treated with 0 µ mol/L ox-LDL，and the level of IL-6 in the supernatant increased significantly after treatment with 100 µg/mL ox-LDL. Because the level of IL-6 in the supernatant increased after 24 h treatment with 0 µ g/mL ox-LDL，100 µ g/mL ox-LDL for 12 h was chosen as the follow-up experimental condition. HUVEC were randomly divided into two parts：the first part was divided into the experimental group A（EZH2 adenovirus + 100 µg/mL ox-LDL），positive control group A（control adenovirus + 100 µg/mL ox-LDL），negative control group A（100 µg/mL ox-LDL），and blank group A（untreated）. The other part was divided into the experimental group B（EZH2 specific inhibitor GSK126+ 100 µ g/mL ox-LDL），positive control group B（1% DMSO+100 µg/mL ox-LDL），negative control group B（100 µg/mL ox-LDL）and blank group B（untreated）for 12 h. Western blotting was applied to detect the expression of EZH2 protein， ELISA was applied to detect the level of IL-6 in the supernatant，and PCR was applied to detect and the expression levels of EZH2 and IL-6，TNF-α，e-NOS，IL-8 and CRP mRNA. Results Compared with the blank group A，the expression levels of EZH2 mRNA and protein in the experimental group A increased，while there were no significant changes in the expression levels of EZH2 mRNA and protein in the positive control group A and negative control group A（all P>0. 05）. Compared with the blank group A，the level of IL-6 in the supernatant and the expression of TNF- α，e-NOS，IL-8 and IL6 mRNA increased in the experimental group A，positive control group A and negative control group A（all P<0. 05）. Compared with the blank group B，the expression levels of EZH2 mRNA and protein in the experimental group B decreased， while there were no significant changes in the expression of EZH2 mRNA and protein in positive control group and negative control group（all P>0. 05）. Compared with the blank group B，the level of IL-6 in the supernatant and the expression levels of TNF- α，e-NOS，IL-8 mRNA in the experimental group B，positive control group B and negative control group B decreased significantly，with more significant decrease in the positive control B group and negative control B group（all P< 0. 05）. There was no significant difference in the expression of CRP mRNA among the groups（all P>0. 05）. Conclusion The overexpression of EZH2 in HUVEC may promote the ox-LDL-induced endothelial inflammation by targeting the expression of inflammatory factors TNF-α，e-NOS，IL-8，and IL-6，while inhibiting the expression of EZH2 has the opposite effect. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of noninvasive positive pressure ventilation on the treatment effect and prognosis of severe community-acquired pneumonia. Methods: Taking 80 patients with SCAP admitted to our hospital from July 2018 to February 2020 as the research object, they were divided into non-invasive group and routine group by random number method, 40 cases each. Both groups of patients received conventional treatment after admission, and the non-invasive group received NIPPV treatment based on conventional treatment. The patient's body temperature, respiration, blood pressure, heart rate, PaCO2, PaO2/FIO2, endotracheal intubation rate, fatality rate, and ICU hospitalization days were recorded before and after treatment. The serum PCT, CRP and suPAR levels on the first, third and seventh days of the patients' admission were tested. Results: 1 h and 24 h after treatment, the patients in the noninvasive group had significant improvement in respiration, heart rate, PaCO2, PaO2/FIO2 and PH (P<0.05), It shows that NIPPV can significantly improve the gas exchange in the lungs of patients, slow down the respiratory rate, increase oxygen and index, and reduce the partial pressure of carbon dioxide. On the first day, there was no significant difference in the levels of PCT, CRP and suPAR between the two groups (P>0.05). Compared with the first day, the PCT, CRP and suPAR levels on the third and seventh days of the two groups of patients were significantly reduced (P<0.05). Compared with the conventional group, the PCT on the third and seventh days of the noninvasive group, CRP and suPAR levels were significantly reduced (P<0.05). Compared with the conventional group, there was no statistically significant difference in the intubation rate, ICU hospital stay, and mortality in the noninvasive group (P>0.05), but they all decreased to a certain extent. Conclusion: NIPPV can significantly improve the expiratory condition of SCAP patients, reduce serum PCT, CRP and suPAR levels, have a certain effect on reducing the rate of tracheal intubation, shortening the length of hospital stay in ICU and reducing the mortality of patients. [ABSTRACT FROM AUTHOR]

Objective: To investigate levels of inflammatory markers and matrix metalloproteinase-9 (MMP-9) in serum and cerebrospinal fluid of children with central nervous system infection and its clinical significance. Methods: 198 children with meningitis admitted to our hospital from August 2017 to June 2018 were divided into infection group. They were divided into purulent meningitis (PM=107) and viral meningitis (VM=91) according to different causes. 58 healthy children were selected as control group (Normal Control, NC=58) during the same period. The levels of procalcitonin (PCT) in serum and cerebrospinal fluid (CF) were detected by double antibody sandwich immunofluorescence assay; the levels of C -reactive protein (CRP) in serum and cerebrospinal fluid were detected by immunofluorescence analyzer; the levels of Tumor necrosis factor-alpha (TNF-alpha) and MMP-9 in serum and cerebrospinal fluid were detected by enzyme-linked immunosorbent assay (ELISA) before and after treatment in three groups of children; the serum White was analyzed by electrochemiluminescence automatic immunoanalyzer. Protein and cerebrospinal fluid albumin content, and calculate albumin index. Results: Compared with the control group, the levels of CRP, PCT, TNF-琢and MMP-9 in serum and cerebrospinal fluid of the patients in the Huanao group and the diseased brain group were significantly higher (P<0.05), and the levels of CRP, PCT, TNF-琢and MMP-9 in the serum and cerebrospinal fluid of the patients in the Huanao group were significantly higher than those in the diseased brain group (P<0.05). Compared with the control group, PCT levels in serum and cerebrospinal fluid of children in the Huanao group decreased before treatment, 72 hours after treatment and 1 week after treatment (P<0.05). There was no significant difference in PCT levels in serum and cerebrospinal fluid between the two groups before and after treatment (P>0.05). CRP, PCT, TNF-alpha and MMP-9 levels in the cerebrospinal fluid of children in the Huanao group and the sick cerebrospinal group were similar to those of children with albumin index positive correlation. Conclusion: The levels of inflammatory markers and MMP-9 in serum and cerebrospinal fluid can be used to differentiate suppurative meningitis from viral meningiti. [ABSTRACT FROM AUTHOR]

Copyright of Practical Pharmacy & Clinical Remedies is the property of Editorial Department of Practical Pharmacy & Clinical Remedies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Laboratory Medicine is the property of Journal of Modern Laboratory Medicine Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Laboratory Medicine is the property of Journal of Modern Laboratory Medicine Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To analyze of the clinical values of serum amyloidA (SAA), serum sedimentation (ESR) and c-reactive protein (CRP) in sera from COVID-19 patients. Methods: 51 patients with COVID-19 diagnosed in our hospital from January 2020 to February 2020 were involved as the experimental group. Among them, 21 severe patients, 30 mild patients, and 30 non-infected patients were treated as the control group. The levels of SAA, ESR and CRP were detected sera from COVID-19 patients. Results: The levels of SAA, ESR and CRP in the experimental group were higher than those in the control group (P<0.05).The levels of SAA, ESR and CRP in the severe group were higher than that in the mild group (P<0.05). According to the ROC curve, the AUC of SAA, ESR and CRP in the prediction of COVID-19 was lower than that in the combined detection of the three. Conclusion: The serum levels of SAA, ESR and CRP of COVID-19 will increase. The Combined detection of SAA, ESR and CRP can improve the accuracy of diagnosis of COVID-19. It provides the basis for clinical prediction and treatment to evaluate the disease and predict the development of the disease. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical effect of Tongqiaohuoxue decoction combined with brain protein hydrolysate on the ability of daily life and serum Hcy, CRP and FA levels of senile patients with dementia. Methods: 79 cases of senile patients with dementia who were treated in our hospital from January 2014 to December 2016 were selected and randomly divided into two groups.The control group was treated with intravenous infusion of brain protein hydrolysate, 60 mg each time, 2 times a day. The observation group was combined with Tongqiaohuoxue decoction treatment. The mental state of patients was evaluated by mini mental state examination(MMSE) before and after treatment. The clinical effective rate, daily living ability and serum Hcy, CRP and FA levels of the two groups were compared before and after treatment. The incidence of adverse reactions in the two groups was compared between the two groups. Results: After treatment, the effective rate of observation group was 92.31%(36/39), which was significantly higher than that of the control group [72.50%(29/40)](P<0.05); the BI score of daily living ability, score, mental state MMSE score and serum FA level of both groups were significantly increased(P<0.05), which were significantly higher in the observation group than those of the control group(P<0.05); while the levels of serum Hcy and CRP of both groups were significantly decreased(P<0.05), which were significantly lower in the observation group(P<0.05). There was no significant difference in the adverse reactions between the two groups(P>0.05).Conclusions: Tongqiaohuoxue decoction combined with brain protein hydrolysate had more significant clinical effect on the senile dementia patients with high safety, it could improve the ability of daily life, mental state and serum Hcy, CRP, FA levels. [ABSTRACT FROM AUTHOR]

Objective: To study the clinical value of combined detection of serum calcitonin (PCT), c-reactive protein (CRP) and interleukin-6 (il-6) for the diagnosis of bacterial bloodstream infection (BSI). Methods: From August 2015 to October 2015, 216 cases of patients with suspected bacterial BSI were selected for this study, blood culture were performed after admission, according to the result of blood culture, the patients were divided into the positive group (102 cases) and the negative group (114 cases). The bacterial BSI positive rate, gram-positive bacteria infection and gram-negative bacteria infection rate were calculated. The serum PCT and CRP, IL-6 levels were compared between the two groups of patients. The ROC curve and the sensitivity, specific, positive predictive value, negative predictive value were drawn and compared. Results: The positive detection rate of all suspected BSI patients was 47.22%, among which there was no difference in the infection rate of gram-positive bacteria (P>0.05). The serum PCT, CRP and il-6 levels of positive groups were significantly higher than those of the negative group (P<0.05). The AUC of il-6 was significantly larger than PCT and CRP(P<6).05). The sensitivity, specificity, positive predictive value, negative predictive value and Jordan index of PCT, CRP and il-6 were significantly higher than those of the single test (P<0.05). Conclusion: Serum PCT, CRP and IL-6 had some diagnostic value for the diagnosis of BSI, the combined detection can obviously improve the diagnostic value for BSI. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of dexmedetomidine on delirium and serum levels of C reactive protein (CRP), Matrix metalloproteinases (MMPs), N end forebrain natriuretic peptide (NT-proBNP) and neutrophil elastase (NE) in patients with acute aortic dissection. Methods: 84 patients with acute aortic dissection who were treated in our hospital from January 2014 to January 2017 were selected, they were divided into the control group (n=42) and the study group (n=42). The control group was given morphine anal­gesia immediately after admission, while the study group was given dexmedetomidine analgesia. The levels of CRP, MMP-9, MMP-2, NT-proBNP and NE,the incidence of delirium, and the duration of weaning and ICU stay time between the two groups were observed and compared before and after treatment of 24 h. Results: There was no significant difference in CRP, MMP-9, MMP-2, NT-proBNP and NE levels between the two groups before treatment (P>0.05). The levels of CRP, MMP-9, MMP-2, NT-proBNP and NE in the study group were lower than those in the control group after treatment of 24 h, and the difference was statistically significant (P<0.05). The in­cidence of postoperative delirium in the study group was 7.14%(3/42), which was lower than 26.19% (11/42) of the control group (P<0.05). The duration of weaning and ICU stay in the study group were lower than those in the control group, the difference was statistically significant (P<0.05). Conclusion: Dexmedetomidine not only has analgesic and sedative effects, it also has a significant inhibitory effect on inflammatory response in patients with acute aortic dissection, and reduce the incidence of delirium, the prognosis quality of the pa­tients is guaranteed. [ABSTRACT FROM AUTHOR]

Objective: To study the effects of abibin on the serum CRP, PCT, LD, NSE levels and brain protective effect on the children with fast pathway anesthesia. Metiiods: 61 cases of chidren underwent anesthesia surgery from April 2016 to April 2017 were selected and randomly divided into the observation group and the control group. The observation group was given Ai Benin line fast pathway anesthesia, while the control group were treated with the conventional drugs fast pathway anesthesia. Then the serum levels of CRP and PCT of two groups were compared before and after treatment, the serum levels of LD, NSE, cerebral arteriovenous blood glucose difference (Ca-j), lactic acid (AVDL) at T0 (1 days before operation), Tj (after 1 days), T2 (after 2 days), T3 (after 3 days), T4 (after 4 days), and the difference of cerebral oxygen uptake rate (O2Ext), arterial venous oxygen concentration (Ca-jvO2) and arterial oxygen concentration (CaO2) in the two groups were observed and compared. Results: After treatment, the levels of CRP and PCT in the observation group were lower than those in the control group (P <0.05). The level of LD in the observation group was significantly lower than that in the control group (P <0.05), and the levels of Ca-j and AVDL in the observation group were significantly lower than those in the control group (P <0.05), while the levels of O2Ext, Ca-jvO2 and CaO2 were significantly higher than those in the control group (P <0. 05). Conclusion: Abeton fast pathway anesthesia can significantly decrease the serum CRP, PCT, LD and NSE levels of children, and effectively improve the brain tissue metabolism. [ABSTRACT FROM AUTHOR]

Objective: To explore the significance of detecting serum CRP, myocardial enzymes, liver function index in pediatric patients with rotavirus infectious diarrhea. Methods: 110 pediatric patients with rotavirus infectious diarrhea and 85 age-matched patients with bacterial infectious diarrhea who were both treated in our hospital from January, 2014 to May, 2016 were enrolled in the present study. Another 20 healthy patients who had physical examination in our hospital were considered as control group.The differences of serum CRP, IL-6, hs-cTnT, CK, CL-MB, AST, ALT level and the incidence of parenteral injury were compared. Results: The incidence rate of lower respiratory tract infectivity, rash, myocardial damage and hepatic injury in RV group were significantly lower than the bacterial infectious group (P＜0.05), the level of serum CRP, IL-6 in RV group and bacterial infectious group were significantly higher than the control group,and those of RV group were significantly lower than bacterial infectious group (P ＜0.05); the level of hs-cTnT, CK, CL-MB, AST, ALT in RV group were significantly higher than bacterial infectious group and control group (P＜0.05),and those indexes of bacterial infectious group were no significantly differences compared with healthy control (P ＞ 0.05). Conclusion: The combined detection of serum CRP, myocardial enzyme and liver function indexes were of certain significance in the early distinguishing diagnosis of bacterial infectious diarrhea from rotavirus infectious diarrhea. [ABSTRACT FROM AUTHOR]

Objective: To study Clinical Effect of Anterolateral Approach ofor the Patients with Hip Arthroplasty and the effect on the serum CRP,IL-6, D-Dimer in levels. Methods:102 Patients with Hip Arthroplasty who received therapy from February 2013 to January 2015 in our hospital, Patients were asked to be divided into observation group and control group. Among them, the control group of 54 cases, through the conventional approach to hip arthroplasty; 48 cases of observation group.Serum CRP, IL-6 and D-dimer levels were compared between the two groups before and after surgery, and the efficacy of the two groups was compared by follow-up. Results: After treatment, the total effective rate of the observation group was significantly higher than that of the control group (P＜0.05), Serum CRP, IL-6 and D-dimers increased in both groups at 12 h after surgery and decreased gradually at 7 and 14 days. The levels of serum CRP, IL-6 and D-dimer in the observation group were significantly lower than those in the control group at 12 h, 7 d and 14d(P＜0.05). Conclusion: The clinical effect of the anterolateral approach on hip arthroplasty is more significant than that of conventional approach, and can effectively reduce the levels of serum CRP, IL-6 and D-dimer, and is more favorable for postoperative recovery. [ABSTRACT FROM AUTHOR]

Objective: To explore the early diagnostic value of serum procalcitonin(PCT),C-reactive protein (CRP) and endotoxin in patients with sepsis caused by bacterial bloodstream infection. Methods: Retrospectively analyzed 123 cases of patients diagnosed with sepsis induced by bacterial bloodstream infection in our hospital from May 2010 to May 2015. detected their serum PC'T. C'RP and endotoxin levels, and analyzed the evaluation value of these three indexes for sepsis induced by bacterial bloodstream infection by receiver-operating characteristic curve (ROC). Results: Blood sample culture results showed that 123 cases of bacterial bloodstream infections caused by sepsis patients in the presence of infection of G-bacteria were 35 cases. G-bacteria infection of 88 cases: The levels of three index in the G+bacteria group were significantly lower than that in the G-bacteria group (P<0.05): The serum PCT. C'RP and endotoxin levels was positive correlated with each other among G+bacteria group. G-bacteria group and all bacteria group; ROC curves showed that the cutoff value of serum PCT. C'RP and endotoxin for diagnosis of patients with sepsis induced by G+bacteria bloodstream infection were 1.58 p.g/L, 95.25 mg/L and 16.71ng/L. and their sensitivity and specificity were (65.92%. 88.37%). (67.39%. 84.38%) and (56.34%.78.93%) respectively: and the cutoff value for diagnosis of patients with sepsis induced by G- bacteria bloodstream infection were 2.45 p.g/L. 79.45 mg/L and 15.54 ng/L. their sensitivity and specificity were (78.73%. 97.13%). (68.89%. 92.38%) and (65.39%, 95.33%)respectively. Conclusion: Detecting the serum PC'T.C'RP and endotoxin levels is helpful to identify patients with sepsis induced by G+ or G-bacteria bloodstream infection, with high sensitivity and specificity, which can be used in the early diagnosis of sepsis induced by bacterial bloodstream infection. [ABSTRACT FROM AUTHOR]

Objective: To explore the relationship between serum inflammatory factors and sequential organ failure assessment (SOFA) in patients with sepsis, which help to evaluate the severity of the disease, scientific judgment prognosis. Methods: From January 2014 to December 2015,142 cases for treatment of sepsis in our hospital were included as the research objects. Within 24h after admission,patients were detected serum inflammatory factors, such as IL-6, PCT, CRP, so as SOFA. According to the patients in the hospital treatment group survival outcomes in 28 d, respectively, the death group (87 cases) and survival group (55 cases), and according to the patients whether with MODS was divided into MODS group (76 cases) and non MODS group (66 cases). Compare the differences of IL-6, PCT, CRP and SOFA scores between different groups, and compare the serum levels of, PCT and in patients with different SOFA scores, and analyze the correlation Results: In comparison with IL-6, PCT and SOFA scores, the death group was higher than the survival group, the MODS group was higher than the non MODS group, the difference was statistically significant (P<0.05). The higher the SOFA score, serum IL-6, PCT level was higher, the difference was statistically significant (P<0.05); the SOFA score increased, the mortality rate was significantly increased, SOFA>10, the fatality rate was 78.3%, the difference was statistically significant (P<0.05); Spearman correlation analysis showed that SOFA score was positively correlated with serum IL-6 levels (r=0.261, P=0.012), was positively correlated with serum PCT level(r=0.453, P=0.000), there is no correlation between SOFA and CRP levels (r=0.112, P=0.323). Conclusion: Serum IL-6, PCT levels have a correlation with SOFA, and can be used as biological indicators in judging the severity of patients with sepsis and prognosis in routine monitoring. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of mesalazine on serum levels of CRP, IL-10 and TNF-α in of patients with ulcerative colitis. Methods: 120 patients with ulcerative colitis were randomly divided into the experimental group and the control group, with 60 cases in each group. The patients in the control group were treated with sulfasalazine enteric-coated tablets, while the patients in the experimental group were treated with mesalazine enteric-coated tablets. Then serum levels of C- reactive protein (CRP), tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10), and clinical efficiency and safety in the two groups were observed and compared before and after the treatment. Results: Compared with before treatment, the serum levels of CRP and TNF-α decreased, while the levels ofIL-10 increased in the two groups after treatment, and the differences were statistically significant (P<0.05); Compared with the control group, the serum levels of CRP and TNF-α were lower, and the IL-10 was higher in experimental group, and the differences were statistically significant (P<0.05); Compared with the control group, the clinical effective rate in the experimental group were higher, while the incidence of adverse reactions was lower, and the differences were statistically significant (P<0.05). Conclusion: Mesalazine can reduce the serum levels of IL-10, CRP and TNF-α in patients with ulcerative colitis, which is effective and safety for clinical treatment. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical effect of shexpangbaoxin capsules combined with salvia miltiorrhiza polyphenols on the treatment of coronary heart disease and angina pectoris. Methods: 94 cases with angina pectoris and coronary heart disease who were admitted in our hospital from May 2014 to May 2016 were selected and according to the different treatment methods, the patients were divided into the study group and the control group with 47 cases in each group. The patients in the control group were treated with salvia miltiorrhiza. and the patients in the study group were treated with shexiangbaoxin capsules on the basis of the control group. Then the cardiac function indexes and serum levels of homocysteine (Hey) and C reactive protein (CRP) in the two groups were observed and compared before and after the treatment. Results: Compared with before treatment, the Pro-BNP, LVEDD and E/A in the two groups decreased after the treatment, while the LVEF increased, and the differences were statistically significant (P<0.05); Compared with the control group, the Pro-BNP, LVEDD and E/A in the study group were lower after the treatment, while the LVEF was higher, and the differences were statistically significant (P<0.05). Compared with before treatment, the serum levels of Hey and CRP in the two groups increased after the treatment, and the differences were statistically significant (P<0.05): Compared with the control group, the serum levels of Hey and CRP in the study group were higher after the treatment, and the differences were statistically significant (P<0.05). The clinical total effective rate of the study group was significantly higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: Shexiangbaoxin capsules combined with salvia miltiorrhiza polyphenols in the treatment of coronary heart disease angina pectoris has significant clinical efficacy, which can improve the heart function and promote coronary flow*, and it is worthy of clinical application. [ABSTRACT FROM AUTHOR]

Objective: To explore the clinical value of CRP combined with tumor marker detection in early diagnosis of gastric cancer. Methods: 103 patients treated and diagnosed as early gastric cancer in our hospital from March. 2014 to June. 2016 were enrolled in gastric cancer group, including early gastric cancer 30 cases, middle and advanced gastric cancer 73 cases: other 61 patients with benign gastric disease was enrolled in benign gastric disease group; another 20 health people was control group. The level of serum CRP. tumor markers were compared among three groups, and its relevance to clinical pathology of gastric cancer patients was also discussed. Results: The level and positive rate of serum CRP. CA72-4. CEA. CA19-9 of gastric cancer group and benign gastric disease group were significantly higher than control group, and those of gastric cancer group were obviously higher than benign gastric disease group (p< 0.05): gastric cancer patients with lower tumor differentiation, metastasis. III, IV stages presented higher serum CRP. CA72-4. CEA. CA19-9 level (p< 0.05): the sensitivity and specificity of combined detection of serum CRP and CA72-4. CEA. CA19-9was 92.23% and 90.85%. respectively, which were significantly higher than single detection (p< 0.05). Conclusion: The level of serum CRP. CA72-4. CEA. CA19-9was closely related to clinical pathology, combined detection of serum CRP and CA72-4. CEA. CA19-9 could effective improve the sensitivity, which will benefit the early diagnosis of gastric cancer. [ABSTRACT FROM AUTHOR]

Objective: To observe the clinical effect of ulinastatin on acute pancreatitis and the serum levels of inflammatory factors in patients. Methods: 178 cases with acute pancreatitis who were treated in our hospital were selected and according to the different treatment methods, the patients were divided into the observation group and the control group, with 89 cases in each group. The patients in the observation group were treated with UTI and octreotide, while the patients in the control group were treated with octreotide. Then the changes of APACHEⅡ score and serum inflammatory factors of patients were observed and compared before and after treatment. Results: At admission, the levels of serum CRP, IL-1, IL-6, TNF-α and APACHEⅡ score were without statistical differences (P> 0.05). After treatment, the CRP, IL-1, IL-6, TNF-α and APACHEⅡ score in the two groups significantly decreased (P<0.05). The CRP, IL-1, IL-6, TNF-α and APACHEⅡ scores in the observation group were significantly lower than those of the control group (P <0.05). The total clinical efficiency rate of the observation group was 86.52%, which was significantly higher than 71.91 in the control group, and the complications in the observation group was 12.36%, which was significantly lower than 24.72%in the control group, and the differences were statistically significant (P<0.05). Conclusion: Ulinastatin can significantly improve the clinical efficacy of acute pancreatitis, and promote the rehabilitation of patients, and its mechanism may be related to inhibition of inflammatory cytokine expressions. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the efficacy of Maxingshigan decoction combined with azithromycin in treatment of mycoplasma pneumonia in children and its effect on serum inflammatory factors. METHODS: 80 children with mycoplasma pneumonia admitted into pediatric department of Wuhu Hospital of Traditional Chinese Medicine from 2017 to 2018 were selected and divided into control group and observation group via random number table, with 40 cases in each group. The control group was treated with azithromycin, while the observation group was given Maxingshigan decoction combined with azithromycin. Differences in improvements of clinical symptoms, C-reactive protein ( CRP) , lactic dehydrogenase ( LDH) levels, clinical efficacy, incidences of adverse drug reactions and recurrence rale between two groups were compared. RESULTS: The disappearance time of expectoration, disappearance time of rale and recovery time of temperature of observation group were significantly shorter than those of the control group; after treatment, the CRP and LDH levels of both groups had been significantly decreased, and those of the observation group were significantly lower than the control group; the total effective rate of observation group was 95. 00% (38/40) , which was significantly higher than that of the control group ( 77. 50%, 31/40) , with statistically significant difference (P<0. 05). The incidences of adverse drug reactions of observation group and control group were respectively 2. 50% ( 1/40) and 5. 00% (2/40) , the difference had no statistical significance (P>0.05) ; after 6-month follow-up, the recurrence rate of observation group was 5.00% (2/40), which was significantly lower than that of the control group ( 20.00%, 8/40) , with statistically significant difference (P< 0.05). CONCLUSIONS: Maxingshigan decoction combined with azithromycin in treatment of mycoplasma pneumonia in children can effectively relief physical inflammatory reaction, improve pulmonary function, with remarkable effects and low recurrence rate. [ABSTRACT FROM AUTHOR]

Objective: To explore the early diagnostic value of serum procalcitonin(PCT),C reactive protein(CRP)and endotoxin in patients with sepsis induced by gram positive(G+)and gram negative(G-)bacteria bloodstream infection. Methods: Retrospectively analyzed 123 cases of patients diagnosed with sepsis induced by bacterial bloodstream infection in our hospital from May 2010 to May2015, detected their serum PCT, CRP and endotoxin levels, and analyzed the evaluation value of these three indexes for sepsis induced by bacterial bloodstream infection by receiver-operating characteristic curve(ROC). Results: Bacterial etiology training results showed that 35 patients infected with G+ bacteria and 88 patients infected with G- bacteria;The serum PCT, CRP and endotoxin levels in Ggroup were significant higher than G+group(P<0.05); The serum PCT,CRP and endotoxin levels was positive correlated with each other among G+ group, G- group and all bacteria group; ROC curves showed that the cutoff value of serum PCT, CRP and endotoxin for diagnosis of patients with sepsis induced by G+ bacteria bloodstream infection were 1.58 μg/L, 95.25 mg/L and 16.71 ng/L, and their sensitivity and specificity were(65.92%, 88.37%),(67.39%, 84.38%) and(56.34%,78.93%) respectively; and the cutoff value for diagnosis of patients with sepsis induced by G- bacteria bloodstream infection were 2.45 μg/L, 79.45 mg/L and 15.54 ng/L, their sensitivity and specificity were(78.73%,97.13%),(68.89%, 92.38%) and(65.39%,95.33%) respectively. Conclusion: Detecting the serum PCT, CRP and endotoxin levels is helpful to identify patients with sepsis induced by G+ or G- bacteria bloodstream infection, with high sensitivity and specificity, which can be used in the early diagnosis of sepsis induced by bacterial bloodstream infection. [ABSTRACT FROM AUTHOR]

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Objective: To investigate the clinical efficacy of ginkgo dipyidamolum combined with rosuvastatin of atorvastatin on unstable angina pectoiis patients and its effect on the serum level of IL-6. C-reactive protein. Methods: 100 patients with unstable angina were selected and randomly divided into experimental group and control group with 50 cases in each group. All patients were given the crown expansion, antiplatelet, anticoagulant therapy, and the patients in the control group received rosuvastatin simvastatin, while the patients in experimental group were given intravenous drip of ginkgo dipyidamolum on the basis of the control group. All the patients were treated for 4 consecutive weeks. After the end of treatment, the serum level of IL-6 and CRP. and the angina attack frequency and duration and incidence of adverse reactions as well as the clinical efficacy of patients were detected and compared. Results: Compared with before treatment, the serum IL-6 and CRP level, the angina attack frequency and duration were decreased in both groups (P<0.05); Compared with the control group, the serum level of IL-6 and CRP. and the angina attack frequency were lower (P<0.05) and the duration was shorter in the experimental group (P<0.05). the incidence of adverse reactions was low (P<0.05),and the clinical treatment of the total efficiency was higher in the experimental gr oup with statistical significance compared with control group (P<0.05). Conclusions: Ginkgo dipyidamolum combined with rosuvastatin of atorvastatin can reduce the serum level of IL-6 and CRP in the patients with unstable angina pectoris patients, and has good clinical efficacy. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical efficacy and safety of rt-PA intravenous thrombolysis on the treatment of acute middle cerebral artery infarction. Methods: 70 cases with acute middle cerebral artery infarction from our hospital were collected and randomly divided into the experiment group and control group, with 35 cases in each group. The patients in the control group were treated with regular methods, while the patients in the experiment group were treated with alteplase intravenous thrombolysis. Then the serum levels of BNP, CRP and NSE, and the clinical efficacy and the incidence of complications between the two groups were observed and compared before and after treatment. Results: Compared with before treatment, the serum levels of BNP, CRP and NSE in the two groups decreased after treatment, and the differences were statistically significant (P<0.05); Compared with the control group after treatment, the serum levels of BNP, CRP and NSE in the experiment group were lower, and the differences were statistically significant (P<0.05); The clinical efficacy rate in the experiment group was 85.71%which was higher than 65.71%in the control group, and the difference was statistically significant (P<0.05); There was no statistically significant about the incidence of adverse reactions between the two groups (P>0. 05); Conclusion: rt-PA intravenous thrombolysis has good clinical efficacy in the treatment of acute middle cerebralartery infarction, which can reduce the serum levels of BNP, CRP and NSE. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical effects and mechanisms of nifedipine combined with magnesiumsulfate on elderly pregnant with hypertension. Methods: A total of 54 elderly pregnant with hypertension of pregnancy fromour hospital were collected and randomly divided into the group A and groupB with 27 cases in each group. Patients in the group A were treated by 5%glucose injection 100 mL and 25%magnesium sulphate injection 20 mL intravenous drip, 30 min infusion; 5%glucose injection500ml added 40 mL 25% magnesium sulfate injection 1~2 g/h, intravenous drip; patients in the group B were treated on the basis of group A with nifedipine release tablets 30 mg oral, 1 time/day, 2 groups of patients were treated for 7 days. After treatment, the blood pressure, CRP, IL-6, TNF-α and proteinuria levels were compared between the two groups. Results: Compared with before treatment, the systolic blood pressure, diastolic blood pressure, CRP, IL-6, TNF-αand proteinuria levels of both groups were significantly decreased after treatment (P<0.05); compared with group A, the systolic blood pressure, diastolic blood pressure, CRP, IL-6, TNF-αand proteinuria levels of group B were obviously lower (P<0.05). Conclusions: Nifedipine combined with magnesium sulfate had better clinical efficacy in the treatment of elderly pregnant women with pregnancy hypertension, which might be relate to the reduce of CRP, IL-6 and TNF-αlevels. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of serum HCY, CRP and fibrinogen levels by ozagrel sodium combined with ligustrazine injection on acute cerebral infarction patients. Methods: 68 patients with acute cerebral infarction from our hospital were collected and randomly divided into experiment group and control group, with 34 cases in each group. The patients in the control group were treated with ozagrel sodium, while the patients m the experiment group were treated with ligustrazine injection. Then the serum levels of homocysteine (HCY), C-reactive protein (CRP), fibrinogen (FIB) and internal carotid artery atherosclerosis of the two groups before and after treatment, and the clinical total effective rate were observed and compared. Results: Compared with before treatment, two groups of patients with serum HCY, CRP and FIB levels decreased, and internal carotid artery atherosclerosis was better (P < 0.05); And compared with the control group, the serum HCY, CRP and FIB levels of the expemnent group were lower, while the internal carotid artery atherosclerosis was lighter (P<0.05); Compared with the control group, the clinical total effective rate of the experiment group was higher (P<0.05). Conclusion: Sodium ozagrel combine hgustrazine injection could effectively reduce the degree of internal carotid artery atherosclerosis and the serum levels of HCY, CRP and fibrinogen in the treatment of acute cerebral infarction. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical effect of laparoscopic surgery in treatment of acute appendicitis and its impact on serumprocalcitonin (PCT) and C reactive protein (CRP) levels. Methods: A total of 80 patients with acute appendicitis who were treated in our hospital from September 2014 to September 2015, they were divided into control group (n=40) and observation group (n=40) according to the randomnumber table method, the observation group was underwent laparoscopic surgery, and the control group was underwent open surgery, then compared the effect, the complication, serum PCT and CRP during perioperative period in two groups. Results: The intraoperative bleeding volume, the first postoperative anus exhaust time and length of stay in observation group were significantly less than control group(P<0.05). The total postoperative complication rate in observation group was significantly lower than control group (P<0.05); The serum PCT and CRP levels in two groups 1d day after surgery were significantly increased than before surgery (P<0.05), 3 d day after surgery in observation group had no different than before surgery (P>0.05), while the control group were still higher than before surgery(P<0.05); 5 d day after surgery in observation group were lower than before surgery(P<0.05), while the control group had no different than before surgery(P>0.05). Compared to open surgery, the laparoscopic surgery has obvious effect in in treatment of acute appendicitis, which can control the serum PCT and CRP levels better, and is help for the early recovery of patients. [ABSTRACT FROM AUTHOR]

Objective: To explore the predictive value of serum β-HCG, hsCRP and C’RP levels on intrauterine infection of pregnant women with premature rupture of membranes. Methods: 61 patients with fetal membrane who were treated in our hospital front August 2013 to August 2015 were selected as the study group and another 55 cases who had taken the cesarean section at the same tune in our hospital were chosen to be the control group. Then the serum levels of β-HCG, hsCRP and C’RP in the two groups were detected and compared, and the sensitivity and specificity of β-HCG, hsCRJP and C'RP on the diagnosis of intrauterine infection were analyzed. Results: The intrauterine infection rate in the study group was higher than that of the control group, and the difference was statistically significant (P<0.05). The serum levels of β-HC'G. hsCRP and CRP in the study group were significantly higher than those of the control group, and the difference was statistically significant (P<0.05). The serum levels of β-HCG, hsCRP and CRP of patients with severe intrauterine infection were significantly higher than those of the moderate intrauterine infection and the slight intrauterine infection, and the difference was statistically significant (P<0.05): The serum levels of β-HCG. hsCRP and CRP in patients with moderate intrauterine infection were higher than those of the slight intrauterine infection, and the difference was statistically significant (P<0.05): The sensitivity and specificity of the combination detection of serum β-HCG. hsCRP and CRP levels were significantly higher than that of the single index detection (P<0.05). Conclusion: The combination detection of serum levels of β-HCG. hsCRP and CRP has high sensitivity and specificity on the prediction of the intrauterine infection of pregnant women with premature rupture of membranes. [ABSTRACT FROM AUTHOR]

Objective: To investigate the evaluation value of serum levels of C reactive protein (CRP) and procalcitonin (PCT)in the early diagnosis and prognosis of sepsis patients. Methods: A total of 100 patients with severe systemic infection were divided into sepsis group (n=67) and non-sepsis group (n=33) by whether the systemic infection occurred, and the sepsis group was divided into survival group (n=42) and death group (n=25) by prognosis; 30 healthy people were chosen as control group. After 24 hours in the intensive care unit 8 mL of venous blood of the patients was collected, in which, the level of CRP was detected by immunoturbidimetry and the level of PCT,by ]immunochromatographic method.A nalyzed the value of serum levels of CRP and PCT in early diagnosis and prognosis of the sepsis patients. Results: The difference of CRP and PCT levels between two groups were statistically significant (P<0.05), in which, the CRP and PCT levels of sepsis group and non-sepsis group were higher than those of control group,and the CRP and PCT levels of sepsis group were higher than those of non-sepsis group, the differences were statistically significant (P<0.05). The CRP and PCT levels of the patients in sepsis survival group gradually reduced along with the prolonged hospitalization time, the differences were statistically significant (P<0.05); the CRP and PCT levels of death group at 3rd day increased compared with the 1st day, and gradually decreased at the 7th and 9th day, the differences were not statistically significant (P>0.05). The CRP and PCT levels of the patients in death group were higher than those in sepsis survival group. Conclusion: The combination detection of CRP and PCT have better early diagnostic value for patients with sepsis, and the expression levels of CRP and PCT may reflect the prognosis of patients with sepsis. [ABSTRACT FROM AUTHOR]

Objective: To study the influence of retroperitoneal laparoscopic operation on traumatic stress response. Methods: 69 patients with renal surgery were selected from the department of urology in our hospital in January 2011 to December 2013, and divided into retroperitoneal laparoscopic renal surgery group(39 cases) and open renal surgery group(30 cases). The content of ACTH, COR and CRP in two groups was detected and comparatively analyzed before operation and 1 h, 24 h and 72 h, 120 h after operation. Results: The level of ACTH and COR was statistically significant between two groups(Fgroup)=107.286, P=0.000; Fgroup=9.092, P=0.004); the level of ACTH and COR was statistically significant at all the time points(Ftime=221.454, P=0.000; Ftime=94.257, P=0.000), and the level of ACTH and COR of the two groups was significantly higher after 1 h of operation, and significantly decreased after 24 h, 72 h and 120 h,and the level of ACTH and COR was returned to the preoperative level after 72 h in laparoscopic group and after 120 h in open renal surgery group. The change of ACTH and COR in different time points was smaller in laparoscopic group than that of the open renal surgery group(Ftime*group=36.446, P=0.000; Ftime*group=7.271, P=0.000). The difference of CRP between the two groups was statistically significant(Fgroup=41.526, P=0.000); and CRP were statistically significant at all the time points(Ftime=405.201, P=0.000), after 1h,24 h and 72 h of operation, the level of CRP continued to increase in two groups, and the level of CRP was decreased after 120 h of operation, but the increase of COR in different time points was smaller in laparoscopic group than that of the open renal surgery group(F time*group=14.111, P=0.000). Conclusions: The effect of retroperitoneal laparoscopic renal surgery on stress response is less than that of open renal operation, and it can maintain the stability of the nervous system and endocrine system, and is more conducive to the recovery of the body. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of Shenfu injection on the serum NT-proBNP, H-FABP and CRP levels of elderly patients with chronic heart failure. Methods: 70 patients with chronic heart failure were selected and randomly divided into the control group and experimental group, 35 cases in each group. The control group was treated by conventional symptomatic treatment and the experimental group was treated on the base of the control group with Shen Fu injection. The changes of serum CRP, H-FABP and NT-proBNP levels before and after treatment and clinical efficacy were compared between two groups. Results: Compared with before treatment, the serum NT-proBNP, H-FABP and CRP levels of both groups were significantly lower after treatment (P<0.05). Compared with the control group, the serum NT-proBNP, H-FABP and CRP levels of the experimental group were obviously lower than those of the control group after treatment (P<0.05). The clinical total effective rate was higher in the experimental group tha that of the control group, but no significant difference was found between two groups (P>0.05). Conclusions: Shenfu injection could significantly decrease the serum H-FABP, NT-proBNP and CRP levels of elderly patients with chronic heart failure and significantly enhance the clinical efficacy. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of Xingnaojing Injection on the serum TNF-α, CRP levels and immune function of elderly patients with mycoplasma pneumoniae. Methods: 80 elderly patients with mycoplasma pneumoniae from our hospital were selected and randomly divided into the control group and the experimental group. The control group was treated with Azithromycin and the experimental group was treated with Xingnaojing Injection. The serum TNF-α, CRP, CD3+, CD4+ and CD8+ levels in the two groups were tested and compared before and after treatment. The disappearance time of cough, headache, fever and other symptoms and X-ray examination of the lung shadow were compared. Results: Compared with before treatment, the TNF-αand CRP levels in the two groups were lower (P<0.05), the CD3+, CD4+ levels were higher (P<0.05), the CD8+level were lower (P<0.05), and the experimental group improved more obviously than the control group (P<0.05). Compared with the control group after treatment, the disappearance time of symptoms and signs such as cough, headache, chest X-ray were shorter in the experimental group than that of the control group(P<0.05). Conclusion: Xingnaojing injection could significantly reduce the serum levels of TNF-α, CRP levels in senile mycoplasma pneumonia patients, regulate the cell immunity, improve the immune function and relieve the symptoms and signs. [ABSTRACT FROM AUTHOR]

Objective To observe the changes of inflammatory factors and clinical parameters on septic patients with hemoperfusion，and to discuss the application of hemoperfusion on sepsis. Methods 43 patients with sepsis were divided into treatment group and control group randomly. In the treatment group，the patients received conventional treatment and hemoperfusion together， which performed every 24 hours，continuously for 3 times when they arrived in ICU in the first hour. The concentrations of TNF-α，IL-6，IL-10 and PAF were dynamically detected before hemoperfusion， after 24 hours， 48 hours and 72 hours in treatment group. The concentrations of TNF-α，IL-6，IL-10 and PAF were compared between the two groups after 72 hours. So did the clinical parameters as WBC count，CRP，PCT and blood lactate acid. Results The concentrations of TNF-α，IL-6， IL-10 and PAF were increased significantly in the early stage of sepsis，and were decreased obviously after hemoperfusion（P < 0.01）. After 72 hours treatment， the concentrations of TNF-α，IL-6 and PAF were decreased rapidly， so did the level of CRP，PCT and blood lactate acid. There were significant differences between the two groups （P < 0.05）. Conclusion　Hemoperfusion could remove the inflammatory factor of septic patients and improve the clinical symptoms of them. [ABSTRACT FROM AUTHOR]

Objective: To investigate the level and clinical significance of procalcitonin(PCT) and C-reactive protein(CRP) in plasma of rats with acute intestinal obstruction. Methods: 83 Wistar rats were randomly divided into control group(n=13), sham operation group(n=35) and acute intestinal obstruction group(n=35). The rats in control group were sacrificed, the rats in the sham group were only taken the open surgery, and the rats in the intestinal obstruction group were taken the open surgery and the ligation of the terminal ileum. The serum levels of CRP and PCT were detected at different time points, and the pathological changes of ileum in rats with acute intestinal obstruction were observed. Results: The level of PCT and CRP in sham operation group was gradually increased at 8h and 24 h and decreased gradually at 48 h, 72 h and 96 h, and the level of PCT was higher than that of control group at different time points, but the level of CRP at 96 h was returned to control. The level of PCT and CRP in intestinal obstruction group at different time points were significantly higher than those of the control group, and it was gradually increased to the peak at the end of the experiment,and the level of PCT and CRP in intestinal obstruction group at 48 h, 72 h and 96 h were significantly higher than those in sham operation group with statistical significance(P<0.05). Histopathological examination showed that the structure of the intestinal wall in the control group was normal, and mild pathological changes were detected in the sham operation group, and the ileum tissues of the intestinal obstruction group were obviously damaged, with the villi necrosis, severe edema and inflammatory cell infiltration. Conclusions: The levels of PCT and CRP can reflect the state of intestinal obstruction and the extent of intestinal mucosal damage. [ABSTRACT FROM AUTHOR]

Objective To explore the clinical significance of white blood cell （WBC），C-reactive protein （CRP），Erythrocyte sedimentation rate （ESR），serum amyloid A （SAA），procalcitonin （PCT） and neutrophil granulocyte percentage （GR%） in patients with knee infection. Methods A retrospective study was conducted from March 2012 to January 2015. One hundred and eighty-five patients were collected in the study. They were divided into knee infection group （A，37 patients） and non-infection group （B，148 patients） according to the results of postoperative blood culture. The values of WBC， CRP， ESR， SAA，PCT and GR% were compared and analyzed between the two groups. Results The values of the 6 indicators in group A were higher than those in group B before operation，with statistically significant differences （ < 0.05） . The values of WBC， CRP，ESR and SAA in group A were higher than those in group B on post-operation day 1 （ < 0.05） . However，PCT and GR% were no statistically significance between groups A and B （ > 0.05） . The values of 6 indicators on post-operation days 3 and 7 were no statistically significance between the two groups （ > 0.05） . Conclusion WBC， CRP， ESR， SAA， PCT and GR% showed good reference values for early diagnosis and prevention of infection，which can be used as the screen testing indexes in the early knee infection. [ABSTRACT FROM AUTHOR]