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The article highlights the findings of a recent survey on patient care in Minnesota hospitals, revealing persistent delays in discharges from emergency departments and inpatient care, resulting in significant financial losses and hindering patients from receiving timely and necessary care.

A study conducted by researchers at the Catholic University of Korea suggests that glycated albumin (GA) may be a useful parameter for monitoring glucose levels in pediatric patients with acute leukemia. The study found that GA levels were positively correlated with glycated hemoglobin (HbA1c) levels in both acute leukemia patients and patients with type 2 diabetes mellitus (T2DM). This indicates that GA could serve as a complementary tool to HbA1c in monitoring glucose levels in pediatric patients with acute leukemia, similar to its use in patients with T2DM. The study highlights the potential value of GA in glycemic monitoring for this specific patient population. [Extracted from the article]

A recent study conducted at Aydin Adnan Menderes University Faculty of Medicine in Turkey examined the use of handheld ultrasound devices (HHUSD) for assessing the thyroid gland in children. The study found that there was a strong correlation between the measurements taken by the pediatric endocrinologist using the HHUSD and the measurements taken by the radiologists using advanced high-range ultrasound devices (AHUSD), which are considered the gold-standard method. The HHUSD was found to be effective in assessing normal thyroid tissue and detecting thyroid pathologies in pediatric patients, but for more comprehensive evaluations and classification of thyroid nodules, AHUSD systems and the expertise of radiologists are necessary. [Extracted from the article]

A recent study conducted by Ankara University Faculty of Medicine in Turkey examined the prevalence of endocrine and metabolic comorbidities in pediatric patients with craniopharyngiomas (CPG). The study found that CPG patients often experience hormone abnormalities, including deficiencies in thyroid-stimulating hormone, adrenocorticotropic hormone, antidiuretic hormone, growth hormone, and gonadotropin. The research also revealed challenges in managing CPG, with hesitancy among physicians regarding the use of recombinant growth hormone treatment. The study suggests that early interventions, such as dietary restrictions and increased exercise, should be implemented to prevent obesity in these patients. [Extracted from the article]

A recent study conducted at Jehangir Hospital in Maharashtra, India aimed to establish age and gender-specific reference data for muscle function parameters in the Indian population using Jumping Mechanography. The study included 2056 healthy individuals aged 5 to 60 years, and the results showed that maximum power and force increased with age in the 5-20 year age group, but declined with age in the 21-60 year age group. Females consistently had lower maximum power values than males across all age groups, and in older age groups, females also had lower maximum force values. The study provides ethnicity-specific reference values for muscle function, which can be used for clinical assessment and identifying individuals at risk of poor muscle function. [Extracted from the article]

A recent study conducted in Maharashtra, India, examined the bone health of adolescent girls and young women living in slum areas compared to those in non-slum areas. The study found that slum-dwelling participants had lower bone density and geometry, as well as shorter stature and lower dietary intake of calcium and protein. These differences in bone health were attributed to factors such as residential location, dietary habits, and physical activity levels. The study suggests that interventions are needed to address the poor bone health observed in these individuals. [Extracted from the article]

A recent study conducted at the University of California Los Angeles (UCLA) Medical Center explored the use of selpercatinib, a tyrosine kinase inhibitor, in the treatment of pediatric papillary thyroid cancer (PTC). The researchers found that administering selpercatinib prior to radioactive iodine therapy (RAI) resulted in a reduction in tumor burden and potentially enhanced the effectiveness of RAI. The study focused on a 10-year-old Hispanic girl with metastatic PTC, and the treatment approach was well-tolerated with minimal side effects. This research suggests that selpercatinib could be a promising intervention for RET-fusion positive PTC in pediatric patients. [Extracted from the article]

A recent study conducted at Stanford University in California examined the patient-reported outcomes (PROs) associated with a virtual clinic model for diabetes care. The study included 234 adults with diabetes who received virtual care and support for continuous glucose monitoring (CGM) over a 6-month period. The results showed that participants experienced improvements in depression, diabetes distress, hypoglycemic fears, satisfaction with glucose monitoring, and confidence for managing hypoglycemia. The study suggests that virtual diabetes care, including support for CGM use, can lead to improved PROs and quality of life for adults with diabetes. [Extracted from the article]

A report from Amsterdam University Medical Centers discusses the challenges of diagnosing and treating pediatric thyrotoxicosis, a condition characterized by an overactive thyroid gland. The report highlights cases of different etiologies of thyrotoxicosis in children, such as thyroid hormone resistance, autonomous functioning thyroid nodules, and subacute thyroiditis. It also addresses therapeutic challenges, including recurrent immunological flare-ups and non-compliance with anti-thyroid drug treatment. The research emphasizes the need for a comprehensive approach to pediatric thyrotoxicosis beyond the guidelines provided by the European Thyroid Association. [Extracted from the article]

Researchers at Aristotle University of Thessaloniki conducted a study on the association between certain genetic polymorphisms and the age at which girls of Greek descent experience their first menstruation (menarche). The study involved 248 girls and found that there was no significant association between the genetic polymorphisms (rs7759938, rs314280, and rs314276) and the age at menarche. The study also found that the age at menarche in the girls correlated significantly with that of their mothers. The researchers suggest that further studies with larger sample sizes are needed to confirm these results. [Extracted from the article]

New research conducted at the University of Western Australia has found that continuous glucose monitoring (CGM) can detect early dysglycemia in very young children at risk of developing type 1 diabetes (T1D). The study, which involved children from birth to age 10, found that children with persistent multiple islet autoimmunity (PM Ab+) had higher levels of glucose variability and spent more time with elevated glucose levels compared to age-matched controls. The research suggests that CGM is feasible and well-tolerated in young children at risk of T1D, providing valuable insights into the early detection and monitoring of the disease. [Extracted from the article]

A study conducted at West China Second University Hospital aimed to analyze the growth pattern and incidence of growth deceleration in girls with central precocious puberty (CPP) and early female puberty (EFP) who were treated with GnRHa. The study found that growth velocity trajectories showed gradual decreases until 18 months of treatment, followed by recovery until the 24th month, particularly in girls with CPP. The incidence of growth deceleration was lower in the CPP group compared to the EFP group in the second year of treatment. Bone age was identified as an independent predictor of growth deceleration. The study concluded that caution should be exercised when using GnRHa for EFP treatment and that bone age can be used to predict the occurrence of growth deceleration during GnRHa treatment. [Extracted from the article]

A report from Radboud University Medical Center in the Netherlands discusses the findings of a study on differentiated thyroid carcinoma (DTC) in children with PTEN hamartoma tumor syndrome (PHTS). The study aimed to determine the effectiveness of thyroid ultrasound surveillance in detecting thyroid abnormalities in children with PHTS. The results showed that initiating ultrasound surveillance from age 12 led to the detection of DTC in two patients before the age of 18. The study supports the recommendation to start thyroid ultrasound surveillance in children with PHTS from age 12, preferably within an expertise center. [Extracted from the article]

A recent study conducted by researchers at the University of Health Sciences examined the impact of puberty on body esteem and quality of life in girls aged 9-11 years. The study found that girls with precocious puberty had lower quality of life compared to their healthy peers. Additionally, the untreated group experienced lower health and activity-related quality of life scores, suggesting that girls with precocious puberty may be significantly affected by the physical changes associated with the condition. The study highlights the importance of addressing the psychosocial well-being of girls with precocious puberty. [Extracted from the article]

A recent study conducted at Xinhua Hospital in China examined the clinical outcomes of patients with mut-type methylmalonic acidemia, a genetic disorder, identified through expanded newborn screening (NBS). The study compared 168 patients diagnosed through NBS with 210 patients diagnosed after disease onset without NBS. The results showed that NBS-detected patients had better outcomes, including younger age at diagnosis, better responsiveness to vitamin B12 therapy, and improved long-term prognosis. The study concluded that NBS can prevent major disease-related events and improve the overall survival of infants with mut-type methylmalonic acidemia. [Extracted from the article]

A report from the Hospital Italiano de Buenos Aires in Argentina discusses the impact of the COVID-19 pandemic on cases of precocious puberty. The research suggests that the lockdown measures implemented by governments may have contributed to an increase in the number of consultations related to early or accelerated central precocious puberty (CPP), particularly in girls. The study concludes that changes in habits and the environment during the lockdown may have played a significant role in triggering the early onset of puberty. This research has been peer-reviewed and provides valuable insights into the effects of the pandemic on pediatric endocrinology. [Extracted from the article]

A new report discusses research on pediatric endocrinology and metabolism, specifically focusing on ovarian hyperthecosis (OHT) in adolescent females. The report presents two case reports and a review of the literature on this rare condition, which causes severe hyperandrogenism in young girls. The management approach for OHT in this age group involves gonadotropin suppression and hormone replacement. It is important to consider OHT as a potential cause of severe hyperandrogenism in pre-menopausal women, after ruling out other conditions such as adrenal and ovarian tumors. [Extracted from the article]

A recent study conducted in Moradabad, India, has reported an unusual case of a thyroid abscess in an adolescent girl with normal thyroid gland structure. The girl presented with symptoms of fever, sore throat, and neck swelling, and imaging revealed an abscess in the left lobe of the thyroid gland. The patient also had low TSH and elevated T3 and T4 levels, indicating transient hyperthyroidism. The case was successfully managed with parental antibiotics without the need for incision and drainage. The researchers emphasize the importance of monitoring children with thyroid abscesses for the development of permanent hypothyroidism and prompt diagnosis and appropriate antibiotic therapy. [Extracted from the article]

A recent study conducted by researchers at the Medical University of Silesia in Katowice, Poland, explores the causes of central precocious puberty (CPP), a rare disease with an unclear etiology. While the cause of CPP is mostly idiopathic, the study suggests that congenital and acquired structural changes in the central nervous system may also play a role. The research emphasizes the importance of timely diagnosis and treatment to prevent complications associated with untreated CPP. The study aims to provide a comprehensive understanding of the neurological aspects of CPP. [Extracted from the article]

A study conducted at Tianjin Medical University Cancer Institute and Hospital aimed to investigate the clinical features and prognosis of differentiated thyroid carcinoma (DTC) in children and adolescents. The study involved 198 patients who underwent surgery for DTC between 1998 and 2018. The results showed that low-risk DTC patients had a favorable prognosis even without radioactive iodine (RAI) treatment, while intermediate- and high-risk DTC patients had higher rates of persistent disease, local recurrence, and distant metastasis despite RAI and levothyroxine treatment. This research provides valuable insights into the management of thyroid cancer in pediatric patients. [Extracted from the article]

A research study from the Department of Pediatric Endocrinology and Diabetes discusses the manifestations and understanding of hypothyroidism in children. The study focuses on Van Wyk-Grumbach syndrome (VWGS), a condition characterized by hypothyroidism and incomplete isosexual precocious puberty. The researchers describe two cases of severe autoimmune thyroiditis and VWGS in a boy and a girl, highlighting the clinical, biochemical, and radiological characteristics. Thyroxine replacement therapy was found to reverse the VWGS phenotype and hypothyroidism in both patients. The study provides valuable insights into the diagnosis and treatment of hypothyroidism in children. [Extracted from the article]

A study conducted by the Division of Pediatric Endocrinology in Pittsburgh, Pennsylvania, explored the use of the arginine + LevoDopa/Carbidopa stimulation test (ALD-ST) for copeptin in children with polyuria-polydipsia syndrome (PPS). The researchers found that ALD-ST induced a robust peak copeptin in healthy short children and children with primary polydipsia. Nausea/vomiting, a side effect of ALD-ST, amplified the copeptin response. The study concluded that ALD-ST may be a suitable initial screening test for children with PPS. [Extracted from the article]

A recent report from Qazvin University of Medical Sciences in Iran discusses a case of pseudohypoaldosteronism type 1 (PHA1B) in a newborn boy. PHA1B is a genetic disorder that affects the sodium channels in the kidneys and can lead to electrolyte imbalances. The researchers identified a novel homozygous mutation in the SCNN1A gene, which is responsible for encoding the alpha subunit of the epithelial sodium channel. This case highlights the importance of considering PHA1B in neonates with hyponatremia and hyperkalemia. Further research is needed to understand the link between genotype and phenotype in these patients. [Extracted from the article]

A recent report from the Division of Pediatric Endocrinology at Stanford University highlights the challenges faced by the pediatric endocrinology workforce in the United States. The study examines the current state of the workforce and projects its future capacity and geographic distribution through 2040. The report identifies factors such as aging, part-time appointments, and an unbalanced distribution of providers as contributing to the workforce's struggles. Additionally, limited exposure, financial concerns, and lifestyle perceptions may impact trainees. The study emphasizes the need for deliberate actions to address these challenges and ensure the continued provision of care for children. [Extracted from the article]

A study conducted by researchers at the University of North Carolina Chapel Hill examines the future supply of pediatric subspecialists in the United States from 2020 to 2040. The study focuses on 14 pediatric subspecialties certified by the American Board of Pediatrics and addresses concerns about the adequacy and distribution of these specialists across the country. The research utilizes a workforce projection model that takes into account factors such as geographic moves and changes in training and workforce dynamics. The model's projections can provide valuable insights for decision-making and are available on a public, interactive website. [Extracted from the article]

A study conducted in Orlando, Florida, focused on improving the transition of care from pediatric to adult endocrinology for adolescents with diabetes. Adolescence can be a challenging time for individuals with chronic medical conditions like diabetes mellitus. The study aimed to create a transition of care program for youth with diabetes by implementing a formalized health care transition process. After implementing the program, 90% of the patients indicated they were ready to transition to adult care. The study provides a practical tool for pediatric diabetes providers interested in implementing a similar program. [Extracted from the article]

A recent study conducted by researchers at Dicle University aimed to determine the factors associated with final height in patients with central precocious puberty (CPP) who received gonadotropin-releasing hormone analogs (GnRHa) treatment. The study found that 94% of the patients who received GnRHa treatment reached their target height, with 35.8% exceeding it. The researchers also found that GnRHa treatment did not have a negative effect on body mass index (BMI). Factors such as height-SDS and predicted adult height (PAH) on admission were associated with a greater final height. [Extracted from the article]

A recent study conducted by researchers at Indiana University School of Medicine explores the topic of precocious puberty. The study highlights the extensive differential diagnosis of peripheral precocious puberty (PPP), which includes both congenital and acquired causes. The research emphasizes the importance of hormonal, imaging, and genetic studies in diagnosing PPP, and notes that effective treatments are available for most cases. The study concludes by stating that ongoing research will further enhance our understanding of the pathophysiology of PPP and improve treatment options. [Extracted from the article]

A recent study conducted in Ho Chi Minh City, Vietnam explored the relationship between bisphenol A (BPA) and phthalates with precocious puberty (PP) in Vietnamese children. The study involved 250 children, with 124 diagnosed with PP and 126 serving as controls. The researchers assessed the levels of urinary BPA, diethylhexylphthalate (DEHP), and dibutylphthalate (DBP) in all participants and found that BPA was detected in 11.3% of PP cases but not in the control group. Positive urinary results for DBP were observed in 8.1% of PP cases and 2.4% in the control group. The study concluded that the PP group had a higher prevalence of positive urinary BPA and DBP levels compared to the control group. [Extracted from the article]

A recent study conducted at Ankara Bilkent City Hospital focused on pediatric endocrinology and metabolism, specifically on a condition called benign transient hyperphosphatasemia (BTH). The researchers aimed to evaluate the characteristics of infants and children with BTH. The study found that out of 249 children with elevated levels of alkaline phosphatase (ALP), 38.1% had BTH. The average age at diagnosis was 2.4 years, and the ALP levels were significantly higher than the normal range. The study concluded that BTH should be considered when high ALP levels are detected in children without bone or liver disease symptoms. [Extracted from the article]

A report from Servico de Pediatria in Porto, Portugal discusses the challenges of diagnosing and treating Cushing's disease (CD) in pediatric patients. CD is primarily caused by pituitary adenomas that secrete adrenocorticotropic hormone, leading to growth retardation and weight gain. The report highlights three cases of pediatric CD and the different treatment approaches used, including transsphenoidal pituitary surgery (TSS), medical therapy, pituitary radiotherapy, and bilateral adrenalectomy. The researchers emphasize the importance of multidisciplinary care and continuous surveillance in managing pediatric CD. [Extracted from the article]

A study conducted by the Chungnam National University College of Medicine in South Korea explored the relationship between urinary sodium excretion and bone mineral density (BMD) in a pediatric population. The study included 2,018 participants aged 10-18 years and found that higher sodium intake was associated with lower BMD in Korean children and adolescents. The results suggest a negative association between urine sodium excretion and BMD, highlighting the importance of public health interventions targeting sodium intake. Further longitudinal studies are recommended to understand the long-term effects of sodium on bone health in younger populations. [Extracted from the article]

A report from Aalborg University Hospital in Denmark discusses the findings on Turner Syndrome, a genetic condition that affects females. The report highlights the need for multidisciplinary care throughout a person's life due to the impact of Turner Syndrome on multiple organs. The research includes new advances in diagnostics, genetics, estrogen treatment, fertility, co-morbidities, and neurocognition and neuropsychology. The guidelines were developed through collaboration with various medical societies and advocacy groups. The research has been peer-reviewed and published in the European Journal of Endocrinology. [Extracted from the article]

A recent study conducted at Jehangir Hospital in Pune, India, compared the efficacy and safety of once-weekly somatrogon with once-daily somatropin in Asian children with pediatric growth hormone deficiency (pGHD). The study found that once-weekly somatrogon was non-inferior to once-daily somatropin in terms of efficacy and safety. The subgroup analysis showed that Asian children treated with somatrogon had higher height velocity and similar height standard deviation score and insulin-like growth factor 1 score compared to those treated with somatropin. The study was financially supported by Pfizer and has been peer-reviewed. [Extracted from the article]

A study conducted by the Isfahan University of Medical Sciences in Iran aimed to examine the relationship between maternal and cord blood thyroid hormones, urine iodine concentration, and fetal growth. The study involved 188 mother-newborn pairs, and various measurements were taken, including levels of thyrotropin in maternal serum and cord blood serum samples, as well as urinary iodine concentration levels in mothers. The results showed a positive correlation between maternal TSH levels in the first trimester of pregnancy and the birth length of newborns, but no significant association between maternal urine iodine concentration levels and birth anthropometric parameters. [Extracted from the article]

A recent report from Hospital Universitari i Politecnic La Fe in Valencia, Spain, discusses the use of [18F]fluorocholine PET/CT in the detection of primary hyperparathyroidism (PPH) in pediatric patients. PPH is most commonly caused by a parathyroid adenoma in children, and it can have more severe effects compared to adults. The traditional imaging tests for PPH are cervical ultrasound and Tc-sestamibi SPECT/CT, but [18F]fluorocholine PET/CT has shown higher sensitivity in adults. This case report highlights the successful use of [18F]fluorocholine PET/CT in identifying a hyperfunctioning parathyroid adenoma in an adolescent female, leading to successful surgery and normalization of PTH levels. The researchers suggest considering [18F]fluorocholine PET/CT when conventional imaging tests yield negative results or discrepancies. [Extracted from the article]

A recent study conducted by researchers at Christian-Albrechts University in Kiel, Germany, focused on the development of reliable reference intervals for estradiol (E2) in pediatric endocrinology. The study used an ultra-performance liquid chromatographic tandem mass spectrometry (UPLC-MS/MS) method to establish reference intervals for both sexes and compare them with existing literature. The results showed that E2 levels peaked during mini-puberty in both sexes and were higher in girls during puberty. However, boys also showed high E2 levels during puberty, indicating the need for a better understanding of the role of E2 in boys. The study highlights the importance of laboratory-specific reference intervals for accurate diagnosis and treatment. [Extracted from the article]

A recent study conducted by the University of Messina in Italy examined the relationship between atrophic autoimmune thyroiditis (AAT) and growth impairment in children. AAT is a rare form of autoimmune thyroiditis that occurs without thyroid enlargement, making it difficult to diagnose. The study found that prolonged severe hypothyroidism can cause pituitary hyperplasia (PH) in children, leading to growth failure. However, with timely diagnosis and treatment, significant improvement in height growth was observed in 88% of patients. The researchers concluded that hypothyroidism should always be considered as a potential cause of growth impairment in children, even in the absence of clear clinical signs of thyroid dysfunction. [Extracted from the article]

A new report on rickets has been published by investigators from University Hospital in Pisa, Italy. Rickets is a condition that occurs due to impaired mineralization of growing bone, resulting from alterations in calcium and phosphate homeostasis. The report discusses the various forms of rickets, including nutritional rickets caused by a deficiency of vitamin D, dietary calcium, or phosphate, as well as hereditary forms caused by mutations in genes responsible for vitamin D metabolism or function. The aim of the report is to provide practical guidance to specialists and healthcare professionals on the diagnosis, treatment, and management of patients with rickets. [Extracted from the article]

A recent report discusses research findings on pediatric endocrinology and metabolism, specifically focusing on the risk of premature ovarian insufficiency in childhood cancer survivors. The report highlights a case of a 14-year-old girl who had a positive pregnancy test despite having premature ovarian insufficiency. The researchers determined that the false-positive result was due to low levels of hCG produced by the pituitary gland as a result of high LH concentrations. The report suggests that performing an LH/hCG suppression test can help confirm the pituitary origin of hCG overproduction. [Extracted from the article]

A recent study conducted in Lisbon, Portugal examined the growth patterns of pediatric patients who underwent kidney transplantation. The study found that even after transplantation, up to 50% of patients did not achieve their expected final height. The researchers reviewed the medical records of 149 patients over a 25-year period and assessed factors such as height-for-age, body mass index, and glomerular filtration rate. While there was some catch-up growth observed after transplantation, the results were still below optimal levels. The study highlights the need for further research and interventions to improve growth outcomes in pediatric kidney transplant recipients. [Extracted from the article]

A new report discusses research findings on pediatric endocrinology and metabolism conducted at Inha University Hospital in Incheon, South Korea. The researchers used next-generation sequencing (NGS) to investigate the genetic causes of suspected genetic short stature in 37 patients. They identified 15 pathogenic/likely pathogenic variants in 13 genes, with a diagnostic rate of 40.5%. The study concludes that genetic evaluation using NGS can be helpful in patients with suspected genetic short stature, but further research is needed to develop patient selection algorithms and panels containing growth-related genes. [Extracted from the article]

A recent report from CHA University in South Korea discusses the case of a 16-month-old boy with familial male-limited precocious puberty (FMPP), a rare form of gonadotropin-independent precocious puberty caused by an activating mutation of the LHCGR gene. The patient exhibited signs of precocious puberty, including pubic hair and increased growth velocity. Genetic testing confirmed the presence of a pathogenic variant of LHCGR, and treatment with bicalutamide and anastrozole successfully suppressed pubertal progression. This is the first genetically confirmed case of FMPP in Korea. The full report can be accessed for free online. [Extracted from the article]

Researchers from the University of Ulsan College of Medicine in Seoul, South Korea have published a study on prenatal diagnosis of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. The study included 27 pregnant women who had previously borne a child with CAH, and prenatal genetic testing was performed using molecular genetic analysis. Out of the 39 prenatal genetic tests conducted, 11 fetuses were diagnosed with CAH. All affected patients were treated with hydrocortisone and 9a-fludrocortisone early after birth to prevent adrenal crisis. The study demonstrates the diagnostic efficacy and clinical benefits of prenatal genetic testing for families at risk of CAH. [Extracted from the article]

A recent report from researchers in Rochester, Minnesota highlights the potential risks of exclusively consuming almond milk in infants and toddlers. The case study involved a fourteen-month-old girl who developed hypercalcemia and hypophosphatemia after consuming almond milk for two months. The researchers emphasize that while plant-based milk alternatives can be a viable option for those with cow milk allergies or lactose intolerance, caregivers should be aware of the differences in mineral content and consider other sources of nutrition for infants and toddlers. The study concludes that sole reliance on almond milk is not recommended for this population. [Extracted from the article]

A recent study conducted at the University of Pittsburgh focused on an unusual case of MCT8 deficiency, also known as Allan-Herndon-Dudley syndrome. This X-linked condition is caused by genetic variants in the SLC16A2 gene, resulting in impaired transport of thyroid hormones. While males typically experience severe neurodevelopmental impairment, females are usually asymptomatic or have mild hormone abnormalities. The study presented the case of a 17-year-old girl who was diagnosed with MCT8 deficiency during evaluation for primary ovarian insufficiency. The researchers found that nonrandom X inactivation and a translocation disrupting the SLC16A2 gene were contributing factors in this case. The study highlights the potential clinical and phenotypic manifestations of MCT8 deficiency in women with specific genetic aberrations and emphasizes the impact of X chromosome integrity on ovarian function. [Extracted from the article]

A recent study conducted by researchers at Aydin Adnan Menderes University aimed to gather data on thyroid volume and iodine status in school-age children living in Aydin province, Turkey. The study included 1,553 participants aged 6-17, and found that the median urinary iodine concentration (UIC) was optimal according to WHO criteria. The study also revealed that thyroid volume was smaller in the participants compared to the WHO standards, and that there was a positive correlation between thyroid volume and age, height, weight, body mass index (BMI), and body surface area (BSA). The researchers concluded that the study provides normative data on thyroid volume and iodine status in a population with sufficient iodine, and showed a low prevalence of goiter. [Extracted from the article]

A recent report from the Aga Khan University in Nairobi, Kenya discusses the findings of a study on central precocious puberty (CPP) in Sudan. The study aimed to gather baseline data on this condition and identify any unique features specific to Sudan, as well as explore the challenges faced in managing CPP and how cultural and traditional practices may affect care. The study found that most children with CPP in Sudan presented late, and organic causes were more common in girls compared to boys. The researchers recommend establishing a unified protocol for managing these cases and promoting collaboration between governmental and non-governmental organizations and health services. [Extracted from the article]

A recent study conducted by Ankara University Faculty of Medicine focused on pediatric endocrinology and metabolism, specifically on Primary Coenzyme Q10 Deficiency-7 (OMIM 616276). The study presented two cases of patients diagnosed with this deficiency, along with a review of previously published cases. The clinical manifestations of the disease include hypotonia, seizures, respiratory distress, and cardiomyopathy. The research concluded that Primary Coenzyme Q10 Deficiency-7 should be considered in the differential diagnosis of infants with neurological and dysmorphic manifestations. [Extracted from the article]

A recent study conducted at Karolinska University Hospital in Stockholm, Sweden, has examined the current and novel treatment strategies for children with Congenital Adrenal Hyperplasia (CAH). The standard treatment for CAH in children is hydrocortisone, but improved strategies for timing and dosage have led to better outcomes for patients. Neonatal screening has also been found to be beneficial in diagnosing and treating CAH earlier, preventing adrenal crisis, and improving growth and development. The study highlights the need for further research on the long-term effects of new therapies and their impact on bone health, gonadal functions, and cognitive development. The use of glucocorticoids and mineralocorticoids remains the basis of treatment for CAH, but additional therapies may be beneficial in reducing androgen load during certain life stages. [Extracted from the article]