40 results on '"Sun, Yuanyuan"'
Search Results
2. Morphological and Molecular Characterization of the Unarmored Dinoflagellate Gymnodinium trapeziforme (Dinophyceae) from Jiaozhou Bay, China.
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Gao, Menghan, Hu, Zhangxi, Luo, Zhaohe, Deng, Yunyan, Shang, Lixia, Sun, Yuanyuan, and Tang, Yingzhong
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GYMNODINIUM ,BIOGEOGRAPHY ,DINOFLAGELLATES ,TERRITORIAL waters ,MOLECULAR phylogeny - Abstract
The genus Gymnodinium contains more than 230 extant species, approximately 30% of which have not been reported since their original description. Approximately eight Gymnodinium species have been reported or described in the coastal waters of China. This work reports the presence of Gymnodinium trapeziforme from Jiaozhou Bay, China, in 2020, and its morphological and phylogenetic characterization by using light and scanning electron microscopy and systematic analysis based on partial LSU rDNA sequences. We observed the typical diagnostic features of G. trapeziforme, including a small size, biconical to ovoid shape, and a sulcal extension intruded to the epicone and connected to the horseshoe-shaped apical structure complex (ASC). Additionally, we firstly observed that the ASC consisted of three parallel series of vesicles, with the central one possessing knobs, and having more than 10 amphiesmal vesicles within the ASC. The nucleus was cucurbit-shaped, and the amphiesmal vesicles covering the cell surface, which would be peeled off for the cells in stress. While our molecular phylogeny inferred with the maximum likelihood (ML) and Bayesian inference (BI) confirmed the conspecificity of our isolate with the holotype G. trapeziforme (accession No. EF192414), we found a difference of 14 bases in the D1–D6 domains of the LSU rDNA sequences between the two entities, which indicates a detectable speciation of the two populations. Our work provides a detailed morphological and molecular characterization of G. trapeziforme that was isolated from the coastal water of China, which also broadens the geographical distribution of this species. [ABSTRACT FROM AUTHOR]
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- 2023
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3. Do politically connected, economically powerful firms comply with labor laws in China?
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Chen, Ying and Sun, Yuanyuan
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LABOR laws ,CONTRACT labor ,LABOR contracts ,CONTRACTS ,FREE enterprise ,PRIVATE sector ,STOCK ownership ,RESOURCE dependence theory - Abstract
Purpose: This study investigates, from a resource dependence perspective, the effects of domestic private firms' political connections and economic power on their labor law compliance in China. Design/methodology/approach: This study used data from a large-scale nationwide survey on Chinese domestic private firms, the Chinese Private Enterprise Survey collected from 2004 to 2012, to examine factors of interest that affect firms' compliance to labor laws. Hypotheses were tested using OLS regression models with robust standard errors. Findings: The results indicate that domestic private firms' institutional political connections specified by the presence of a union or a Chinese Communist Party committee is positively related to firms' labor law compliance, and firm owners' formal political connections indicated by their membership in the People's Congress or the Chinese People's Political Consultative Conference have a somewhat negative effect. The post-hoc analysis shows that firm owners' political representation at the county and city levels is negatively related with labor law compliance, while the political representation at the national level is positively related to labor law compliance. Moreover, the economic power of a domestic private firm is related positively to its labor law compliance. Finally, although the authors did not find evidence that the 2008 Labor Contract Law increased labor contract coverage, it did increase pension coverage after 2008. Research limitations/implications: The present study reveals a more refined relationship between domestic private firm owners' political connections and the degree of labor law compliance. It also demonstrates that the economic power of domestic private firms has a positive effect on their labor law compliance. This implies the importance of the contribution of domestic private firms to economic and social development in China, warranting continued support of the development of the private sector in China. Originality/value: This study adds to the sparse literature on the determinants of domestic private firms' labor law compliance in China. It also sheds light on whether political connections and the rising economic power of Chinese domestic private firms influence their compliance with labor laws. [ABSTRACT FROM AUTHOR]
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- 2022
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4. Adherence to the dietary approaches to stop hypertension diet and non‐alcoholic fatty liver disease.
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Sun, Yuanyuan, Chen, Shuohua, Zhao, Xinyu, Wang, Yanhong, Lan, Yanqi, Jiang, Xiaozhong, Gao, Xiang, Wu, Shouling, and Wang, Li
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DASH diet , *NON-alcoholic fatty liver disease , *SOFT drinks , *HIGH density lipoproteins , *BABY foods , *LOGISTIC regression analysis , *DIET - Abstract
Background and Aims: The evidence of the relationship between dietary approaches to stop hypertension (DASH) and non‐alcoholic fatty liver disease (NAFLD) is limited. Thus, we conducted a cohort‐based case‐control study to examine whether adherence to the DASH diet was associated with lower NAFLD risk in China. Methods: We included 11 888 participants (2529 incident NAFLD and 9359 non‐NAFLD) from the Kailuan cohort with no history of hepatitis B/C infection and alcohol drinking. DASH score was calculated based on the energy‐adjusted consumption of vegetables, fruits, dairy, beans, grains, meats, fat, sodium and beverage, collected by a validated food frequency questionnaire. We used Logistic regression analysis to determine the NAFLD's risk according to the DASH score. Results: Higher DASH score was associated with lower risk of NAFLD. Compared with the lowest quintile of DASH score, the highest DASH quintile had a lower risk of occurring NAFLD, with odds ratio (OR) of 0.82 (95% confidence interval [CI]: 0.70‐0.96) in the multivariate model. Stratified analysis showed that the inverse association was only observed in women (OR = 0.67, 95% CI: 0.48‐0.94), and participants with overweight/obesity (OR = 0.79, 95% CI: 0.66‐0.94), fasting blood glucose <6.1 mmol/L (OR = 0.80, 95%: 0.67‐0.96), low density lipoprotein ≥3.4 mmol/L (OR = 0.71, 95% CI: 0.53‐0.96), high density lipoprotein ≥1.0 mmol/L (OR = 0.81, 95% CI: 0.69‐0.96), ALT < 40 U/L (OR = 0.79, 95% CI:0.67‐0.93) and C‐reactive protein ≥2.0 mg/L (OR = 0.56, 95% CI: 0.40‐0.78). Conclusions: Adherence to the DASH diet was inversely associated with a lower risk of NAFLD in the Chinese population. DASH diet should be highly recommended, especially for women and people with overweight/obesity and a high CRP level. [ABSTRACT FROM AUTHOR]
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- 2022
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5. Multi-harmonic sources identification and evaluation method based on cloud-edge-end collaboration.
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Yin, Shulin, Sun, Yuanyuan, Xu, Qingshen, Sun, Kaiqi, Li, Yahui, Ding, Lei, and Liu, Yang
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POWER distribution networks , *EVALUATION methodology , *EDGE computing , *GYROTRONS , *ELECTRIC power distribution grids , *ENERGY storage , *ELECTRONIC equipment - Abstract
• The framework combines a cloud-edge-end structure to break the information barriers of multi-source measured data. • The method executes different strategies according to voltage levels based on interaction of edge computing is proposed. • Harmonic source identification and evaluation are achieved through the multi-level interaction of edge computing. • TVE, CMHSE and HHSE method for cloud-edge-end collaborative computing strategy are developed into the system. With the increase of power electronic devices such as distributed renewable energies, energy storage, and flexible loads, the disturbance sources are rapidly raised and distributed in multiple voltage levels in the distributed network. The harmonics they produce are random and uncertain, and the massive amounts of data propose high demands on server computing capability, which restrict harmonic sources evaluation and significantly influence the judgments of the power quality in the distribution network. In order to improve the power quality and the harmonic source evaluation function of the distribution network, in this paper, a framework for multi-harmonic source identification and evaluation based on cloud-edge-end collaboration is proposed. Firstly, based on the analysis of the functional requirements harmonic sources evaluation in multiple voltage levels, a novel framework of cloud-edge-end collaboration is proposed. Secondly, the cloud-edge-end collaborative harmonic sources evaluation method which executes different service strategies according to voltage levels and grid operation based on the multi-level interaction of edge computing is proposed. Further, the working principle of the proposed novel framework with multiple evaluation methods including the dominant harmonic source identification, concentrated multiple harmonic sources evaluation (CMHSE) and hierarchical harmonic sources evaluation (HHSE) is described in detail in order to show the completed work processes of the proposed framework. Finally, the performance of the proposed method is verified based on the real data measured from different realistic urban power grids in China. The proposed method can effectively evaluate harmonic contributions in distribution systems and in turn provide a basis for harmonic mitigation measures. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Time trends and other sources of variation in Helicobacter pylori infection in mainland China: A systematic review and meta‐analysis.
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Li, Mengmeng, Sun, Yuanyuan, Yang, Jun, Martel, Catherine, Charvat, Hadrien, Clifford, Gary M, Vaccarella, Salvatore, and Wang, Li
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HELICOBACTER pylori infections , *META-analysis , *HELICOBACTER pylori , *STOMACH cancer - Abstract
Background: Helicobacter pylori (H pylori) is a carcinogen that causes a huge burden of gastric cancer in China. We aimed to evaluate the temporal trends and other sources of variation of H pylori infection in adults from mainland China. Materials and methods: For this systematic review and meta‐analysis, we searched PubMed, Embase, China National Knowledge Infrastructure, and Wanfang databases for articles published from January 1983 to June 2020. We included studies reporting H pylori prevalence in adults and then applied random effect meta‐analyses to obtain pooled prevalence estimates for all studies and subgroups. Sources of heterogeneity were investigated by moderator analysis, and time trends were assessed through random effect meta‐regression. Results: Of the 2121 studies identified, 98 were eligible for inclusion. The pooled estimate of 670 572 participants from 26 provinces during 1983‐2018 was 49.6% (95% CI: 46.9%, 52.4%). H pylori prevalence varied considerably, ranging from 20.6% to 81.8%. Periods, urban/rural status, detection method, and study design explained 18.8%, 24.0%, 17.8%, and 30.4% of the heterogeneity, respectively. Overall, H pylori prevalence declined by −0.9% (95% CI: −1.1%, −0.6%) annually. Consistent declines in prevalence were observed by sex, age, and study characteristics. Conclusions: Helicobacter pylori prevalence is slowly decreasing over time in mainland China, but the low declining speed is not enough to have a major impact on gastric cancer incidence for many years. The time trends and the large heterogeneity should be taken into account when conducting regional comparisons, disease burden estimations, and customized strategy making. [ABSTRACT FROM AUTHOR]
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- 2020
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7. Morphology, ultrastructure, and molecular phylogeny of the unarmoured dinoflagellate Kirithra sigma sp. nov. (Ceratoperidiniaceae, Dinophyceae).
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Hu, Zhangxi, Li, Zhun, Deng, Yunyan, Iwataki, Mitsunori, Luo, Zhaohe, Wang, Jinxiu, Sun, Yuanyuan, Zhao, Zengxia, Gu, Haifeng, Shin, Hyeon Ho, and Tang, Ying Zhong
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RIBOSOMAL RNA ,PIGMENT analysis ,TRANSMISSION electron microscopy ,MORPHOLOGY ,CELL membranes ,MOLECULAR phylogeny ,DINOFLAGELLATES - Abstract
A Gymnodinium-like dinoflagellate, Kirithra sigma sp. nov., was isolated from Jiaozhou Bay, China, and the southern coast of Korea, and examined by light, scanning, and transmission electron microscopy. Pigment composition and nuclear-encoded partial large subunit ribosomal RNA (LSU rRNA) gene were determined. Cells were oval-shaped (26.4‒36.4 μm long and 17.7‒27.2 μm wide), with a conical epicone and hemispherical hypocone. Its cingulum and sulcus were deep and wide. The cingulum encircled the cell completely, its ends slightly overlapping and displaced one to two cingular widths; the sulcus and sulcal extension formed a sigmoid curve. The anterior sulcal extension contacted the apical structure complex (ASC). The ASC formed a complete circle, consisting of three parallel series of vesicles, and the amphiesmal vesicles within ASC were arranged with one central vesicle (sometimes two) encircled by approximately three rows of polygonal amphiesmal vesicles. Polygonal amphiesmal vesicles of different sizes covered the whole cell surface. The subspherical nucleus was located in the hypocone. Pigment analysis showed that peridinin was the main accessory pigment. The present species is morphologically similar to Kirithra asteri but differs in numbers and rows of amphiesmal vesicles within the ASC, absence of ventral pore, and a sigmoid curve formed by the sulcus and sulcal extension. The partial LSU rRNA gene sequence (c. 1400 bases) of K. sigma differed by c. 5.3% from that of K. asteri. Molecular phylogeny revealed that K. sigma formed an independent sister clade to K. asteri, indicating they are congeneric but different species. [ABSTRACT FROM AUTHOR]
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- 2020
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8. Clinical characteristics of preterm ovarian hyperstimulation syndrome: seven cases from China and 14 cases from the literature.
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Sun, Yuanyuan, Chen, Cuie, Di, Tianwei, Zhu, Yanke, Zhu, Ronghe, Chen, Shujun, and Qian, Yan
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OVARIAN hyperstimulation syndrome , *THIGH , *OVARIAN cysts - Abstract
Preterm ovarian hyperstimulation syndrome (POHS) is a rare condition with only a few reported cases. The objective of this study is to investigate the clinical characteristics of 21 POHS cases (seven from China and 14 from the literature). Suspected patients (n = 7) were referred for further confirmation and data on demographics, family history, clinical manifestations (edema developed in the vulva, the hypogastric site and the upper leg), serum and sonographic assessments (ovarian cyst/cysts, gonadotropins, and estradiol levels), the natural course of patients were documented. We did not observe substantial differences in clinical manifestations among POHS patients from China relative to that from the literature. Preterm female newborns developed edema in the vulva, the hypogastric site and the upper leg at 30–39+6 weeks of post-conception age (PCA) as the major clinical manifestations. The characteristic also included high gonadotropins and estradiol, and ovarian cysts. This condition can self-resolve. Clinical manifestations of POHS patients from China are similar to those from the literature. The pathognomonic signs of POHS include vulvar, hypogastric, and upper leg edema developed at 30–39+6 PCA along with high gonadotropins and E2 values and the presence of ovarian cysts in preterm female newborns and the syndrome can self-resolve. [ABSTRACT FROM AUTHOR]
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- 2019
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9. Development and application of a novel method for regional assessment of groundwater contamination risk in the Songhua River Basin.
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Nixdorf, Erik, Sun, Yuanyuan, Lin, Mao, and Kolditz, Olaf
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GROUNDWATER pollution risk assessment , *GROUNDWATER pollution , *MODELS of watersheds , *PREVENTION - Abstract
The main objective of this study is to quantify the groundwater contamination risk of Songhua River Basin by applying a novel approach of integrating public datasets, web services and numerical modelling techniques. To our knowledge, this study is the first to establish groundwater risk maps for the entire Songhua River Basin, one of the largest and most contamination-endangered river basins in China. Index-based groundwater risk maps were created with GIS tools at a spatial resolution of 30 arc sec by combining the results of groundwater vulnerability and hazard assessment. Groundwater vulnerability was evaluated using the DRASTIC index method based on public datasets at the highest available resolution in combination with numerical groundwater modelling. As a novel approach to overcome data scarcity at large scales, a web mapping service based data query was applied to obtain an inventory for potential hazardous sites within the basin. The groundwater risk assessment demonstrated that < 1% of Songhua River Basin is at high or very high contamination risk. These areas were mainly located in the vast plain areas with hotspots particularly in the Changchun metropolitan area. Moreover, groundwater levels and pollution point sources were found to play a significantly larger impact in assessing these areas than originally assumed by the index scheme. Moderate contamination risk was assigned to 27% of the aquifers, predominantly associated with less densely populated agricultural areas. However, the majority of aquifer area in the sparsely populated mountain ranges displayed low groundwater contamination risk. Sensitivity analysis demonstrated that this novel method is valid for regional assessments of groundwater contamination risk. Despite limitations in resolution and input data consistency, the obtained groundwater contamination risk maps will be beneficial for regional and local decision-making processes with regard to groundwater protection measures, particularly if other data availability is limited. [ABSTRACT FROM AUTHOR]
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- 2017
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10. Comprehensive evaluation of shallow groundwater quality in Central and Southern Jiangsu Province, China.
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Yin, Xin, Jiang, Beilei, Feng, Zhixiang, Yao, Bingkui, Shi, Xiaoqing, Sun, Yuanyuan, and Wu, Jichun
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GROUNDWATER quality ,GROUNDWATER ,PUBLIC health ,SUSTAINABLE development ,GROUNDWATER pollution ,POLLUTANTS - Abstract
Evaluation of the shallow groundwater quality in Central and Southern Jiangsu Province (CSJ) in China is important not only to public health but also to sustainable development and utilization of groundwater resources. In this work, 968 groundwater samples were collected by field surveys during 2006 to 2010 to investigate spatial distribution and extent of pollution. The single factor pollution standard index method, considering the values of both the natural groundwater background and the standard of safe drinking water, was used to assess the groundwater quality in the study area. Results showed that the shallow groundwater was severely polluted with Grade V and VI (i.e., severe and extremely severe pollution) groundwater covered about 1/3 and 1/4 of the study area, respectively. The main groundwater contaminants that cause the severe and extremely severe pollutions were manganese, iron, arsenic, and nitrogen. Findings from this work showed that natural hydrogeochemical processes were the main causes of the iron and manganese pollution, however, human activities (e.g., industrial, agricultural, and domestic pollutions) mainly contributed to the nitrogen pollution in the study area. [ABSTRACT FROM AUTHOR]
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- 2017
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11. Effects of circular-agriculture economic measures on environmental conservation and socioeconomic development.
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Sun, Yuanyuan and Li, Chunling
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ENVIRONMENTAL protection , *WATER consumption , *WATER supply , *SCIENTIFIC development , *ECONOMIC development - Abstract
Analyzing the effect of circular-agriculture (CA) measures could be helpful to promote its scientific development. Previous research has focused on technological measures and their effects on the agricultural sector. However, economic measures can also promote the development of CA, and due to their correlation with socio-economic sectors, CA measures can impose effects on non-agricultural sectors and on the whole socioeconomic system. In this research, a computable general equilibrium (CGE) model was established to comprehensively reveal the effects of CA measures. In this model, measure simulation and environmental blocks were extended. The production tax was adopted as the economic measure for adjusting the development of CA. Both environmental and socioeconomic effects have been explored. Hebei Province in China was adopted as the study case. Three kinds of production tax adjustment scenarios were considered: a promotion-measure scenario (decreasing the production tax for CA sectors), an inhibition-measure scenario (increasing the production tax for traditional-agriculture sectors), and a hybrid-measure scenario (implementing the promotion- and inhibition-measures simultaneously). The results showed that all three scenarios could promote the development of CA. The inhibition and hybrid measures had positive effects on GDP, and all the scenarios could decrease the intensities of CO2, COD and NH3–N emissions and water resource consumption. In addition, higher measure intensity could bring more significant effects. • Economic measures can promote the development of circular agriculture (CA). • CA economic measure can improve the cleanliness of economic development. • Higher measure intensity can bring more significant effects. [ABSTRACT FROM AUTHOR]
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- 2022
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12. Molecular Identification and Epidemiological Features of Human Adenoviruses Associated with Acute Respiratory Infections in Hospitalized Children in Southern China, 2012-2013.
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Chen, Yi, Liu, Fanghua, Wang, Changbing, Zhao, Mingqi, Deng, Li, Zhong, Jiayu, Zhang, Yingying, Ye, Jun, Jing, Shuping, Cheng, Zetao, Guan, Yongxin, Ma, Yi, Sun, Yuanyuan, Zhu, Bing, and Zhang, Qiwei
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RESPIRATORY infections in children ,EPIDEMIOLOGY ,HUMAN adenoviruses ,HOSPITAL care of children ,POLYMERASE chain reaction - Abstract
Background: Acute respiratory infections (ARI) are the major worldwide health problem associated with high morbidity and mortality rates. Human adenovirus (HAdV) is one of the most common pathogens associated with viral ARI, and thus calls for specific diagnosis and better understanding of the epidemiology and clinical characteristics. Methods: Total 4,130 children with ARI requiring hospitalization from 2012 to 2013 were retrospectively studied. Throat swab specimens were collected from each patient. Fluorescence Quantitative PCR was performed to detect adenovirus as well as other common ARI-related pathogens. The seven HAdV hypervariable regions (HVRs) of the hexon gene from fifty-seven HAdVs-positive samples collected in the seasonal peaks were sequenced. Phylogenetic analysis of HVRs was also conducted to confirm the molecular types and genetic variation. In addition, epidemiological features and co-infection with other human respiratory pathogens were investigated and analyzed. Results: Of 4,130 hospitalized pediatric patients tested, the positive rates of respiratory syncytial virus (RSV), Mycoplasma pneumoniae (MP), and HAdV were 13.7%, 13.2%, and 12.0%, respectively. The HAdV positive patients accounted for 7.9%, 17.2%, 17.5% and 10.7% in age groups <1, 1–3, 3–6 and 6–14 years, respectively. Eighty-four HAdV positive children were co-infected with other respiratory pathogens (84/495, 17.0%). The most common co-infection pathogens with HAdV were MP (57.1%) and Human Bocavirus (HBoV) (16.7%). The majority of HAdV infected patients were totally recovered (96.9%, 480/495); However, four (0.8%) patients, who were previously healthy and at the age of 2 years or younger died of pneumonia. Seasonal peaks of HAdV infection occurred in the summer season of 2012 and 2013; the predominant HAdV type was HAdV-3 (70%), followed by HAdV-7 (28%). These epidemiological features were different from those in Northern China. The HAdV-55 was identified and reported for the first time in Guangzhou metropolitan area. Phylogenetic analysis indicated that all the HVR sequences of the hexon gene of HAdV-3 and -7 strains have high similarity within their individual types, and these strains were also similar to those circulating in China currently, indicating the conservation of hexon genes of both HAdV-3 and HAdV-7. Conclusions: Knowledge of the epidemiological features and molecular types of HAdV, a major pathogen of pediatric ARI, as well as other co-infected respiratory pathogens circulating in Guangzhou, southern China, is vital to predict and prevent future disease outbreaks in children. This study will certainly facilitate HAdV vaccine development and treatment of HAdV infections in children. [ABSTRACT FROM AUTHOR]
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- 2016
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13. Effects of virtual water strategy on water conservation and socioeconomic development in water-scare regions.
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Sun, Yuanyuan, Li, Chunling, and Sheng, Yiyao
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COMPUTABLE general equilibrium models , *WATER conservation , *ECONOMIC systems , *WATER supply , *WATER use , *ECONOMIC development - Abstract
Strategies based on virtual water have become a controversial measure to alleviate pressure on the water resource in regions with scarce water. Advocates of this approach highlight its potentially low cost and high efficiency, whereas opponents criticize its over-simplification and neglect of important factors other than water. Detailed analysis of the strategy's effects on water use and socioeconomic development is essential to fully understand the strengths and weaknesses of the strategy, and to support its reasonable and scientific implementation. In the present study, we defined three virtual water strategy scenarios (i.e., reduce agricultural production, increase agricultural imports, and reduce production and increase imports simultaneously) and developed a computable general equilibrium model to simulate the effects of the scenarios. We chose China's Bohai Bay area, a rapidly developing region with scarce water, for a case study. We found that the virtual water strategy was a double-edged sword: it improved water conservation (water use decreased by 3.6%, 6.9%, and 3.2% under the three scenarios, respectively), but had negative effects on economic development, employment, and economic welfare. The scenario that only increased agricultural imports had the greatest negative impact on socioeconomic development, whereas the scenario that simultaneously decreased production and increased imports most effectively balanced the economic development and water conservation requirements. • The virtual water strategy (VWS) exerts negative effects on economic systems. • VWS produces tradeoffs between water conservation and economic development. • The dual-policy strategy could achieve a better tradeoff. [ABSTRACT FROM AUTHOR]
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- 2022
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14. Persistent organic pollutants contaminate Chinese water resources: overview of the current status, challenges and European strategies.
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Nixdorf, Erik, Chen, Cui, Sun, Yuanyuan, and Kolditz, Olaf
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PERSISTENT pollutants ,POLYCYCLIC aromatic hydrocarbons ,PESTICIDES ,WASTE products ,WATER pollution ,WATER supply ,SUSTAINABILITY - Abstract
The article examines the persistent organic pollutants (POPs) that contaminated water resources in China, based on the European Union (EU)-China Environmental Sustainability Programme. These POPs include polyaromatic hydrocarbons and haloginated hydrocarbons with subcategories of pesticides, industrial chemicals and unintentional by-products. Also discussed are the water body assessment in China and the EU, remediation experience in European countries and the Sustain H
2 O Project.- Published
- 2015
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15. Trend analysis and influencing factors of healthy aging in middle-aged population in China: a longitudinal study based on the China Health and Retirement Longitudinal Study.
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Wang, Ping, Lei, Lubi, Cui, Jingjing, Li, Jingkuo, Zhang, Lihua, and Sun, Yuanyuan
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STATISTICAL models , *SELF-evaluation , *SATISFACTION , *INCOME , *HEALTH status indicators , *SEX distribution , *AGE distribution , *LONGITUDINAL method , *ODDS ratio , *METROPOLITAN areas , *CONFIDENCE intervals , *ACTIVE aging , *SOCIALIZATION , *EDUCATIONAL attainment , *MIDDLE age - Abstract
This study aimed to assess the trends of healthy aging and investigate its determinants in the middle-aged population. This was a longitudinal study. The sample comprised 3043 participants aged 45–59 years from the China Longitudinal Study of Health and Retirement 2011–2018. We plotted the prevalence across four waves and used ordered logistic models to investigate the determinants of cumulative times of healthy aging. We enrolled 3043 middle-aged people in our study. The prevalence of healthy aging is 28.2% at baseline but subsequently decreased to 19.72% at wave 4. Active socializing consistently ranked the lowest among the five dimensions. Participants with older age (odds ratio [OR] = 0.95, 95% confidence interval [CI] = 0.94–0.97), low monthly income (OR = 0.82, 95% CI: 0.69–0.97) or lived in urban (OR = 0.81, 95% CI: 0.70–0.94) were less likely to have per time increase in healthy aging. Participants with more than primary school degree (OR = 1.79, 95% CI: 1.31–2.46), high life satisfaction (OR = 2.38, 95% CI: 1.86–3.06), and good self-report health (OR = 1.97, 95% CI: 1.66–2.34) were more likely to have healthy aging. The number of middle-aged individuals in China who achieved healthy aging is declining and eventually less than one in five, which was far from ideal. Particular attention should be paid to older, women, urban dwellers, individuals with low income, low life satisfaction or poor self-report health. It is urgent to develop public health policies to improve the health and well-being of the middle-aged population. [ABSTRACT FROM AUTHOR]
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- 2024
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16. Optimizing carbon tax rates and revenue recycling schemes: Model development, and a case study for the Bohai Bay area, China.
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Sun, Yuanyuan, Mao, Xianqiang, Yin, Xinan, Liu, Gengyuan, Zhang, Jun, and Zhao, Yanwei
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CARBON taxes , *INTERNAL revenue , *TAX rates , *COMPUTABLE general equilibrium models , *ENVIRONMENTAL impact charges , *CARBON pricing , *CARBON emissions - Abstract
Carbon taxation has long been proposed to mitigate carbon emissions. Carbon tax rate determination and tax revenue recycling are two key steps to achieve a double dividend under carbon taxation. However, few research has sought to optimize the allocation proportion of tax revenue to various categories of taxpayers (households, enterprises, sectors, etc.), or to optimize the two steps synchronously based on nonlinear optimization methods. In this study, a computable general equilibrium model was established to explore the influence of carbon tax rate and tax revenue recycling shares on the economy and on carbon emissions. Meanwhile, a nonlinear optimization model was proposed, for optimizing both steps of carbon taxation synchronously, as well as for promoting GDP and CO 2 emission reduction. The Bohai Bay area, a typical area with enormous carbon emissions in China, was adopted as the study case for this research. The results showed that the optimized taxation scheme could lead to lower carbon emissions and greater economic growth, i.e., a strong double dividend was obtained. The optimized taxation scheme could lead to both cleaner air and cleaner energy and industrial structures while still promoting economic growth. • CGE model is used for effect analysis under different taxation schemes. • Carbon tax rate and revenue recycling are optimized synchronously. • Lower CO 2 emissions can be achieved without economic decline. [ABSTRACT FROM AUTHOR]
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- 2021
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17. Indirect effects of carbon taxes on water conservation: A water footprint analysis for China.
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Sun, Yuanyuan, Zhi, Yuan, and Zhao, Yanwei
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CARBON taxes , *WATER conservation , *COMPUTABLE general equilibrium models , *WATER analysis , *COMPARATIVE economics , *WATER shortages - Abstract
Water scarcity is a severe problem for regional environmental protection and socioeconomic development, and water footprints are effective tools for evaluating the magnitude of the water scarcity. However, water is closely intertwined with energy. Carbon taxes are an essential policy tool for managing energy use, and could therefore indirectly change the water footprint. Previous research on water footprints has revealed the historical characteristics of water footprints, but has not predicted how these characteristics would change under a carbon tax. Identifying the indirect impacts of carbon taxes on water footprints could therefore offer important information to support more effective energy and water policies. In the present study, we explored the impacts of carbon taxes on water footprints. We established a computable general equilibrium model to predict the effects of carbon taxes on the socioeconomic system, and adopted an input-output model to account for changes in the water footprint. We then used China as a case study. We found that a carbon tax could reduce the total water footprint, even though the water footprint for primary industries increased. In addition, the tax could decrease the virtual water content, and the reduction of virtual water content is the greatest for the secondary industries. • The impacts of carbon taxes on water footprints are predicted. • CGE model is used for the economic system analysis under energy tax. • A carbon tax could reduce the total water footprint. [ABSTRACT FROM AUTHOR]
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- 2021
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18. Cenozoic moisture fluctuations on the northeastern Tibetan Plateau and association with global climatic conditions.
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Sun, Yuanyuan, Liu, Jun, Liang, Yu, Ji, Junliang, Liu, Weiguo, Aitchison, Jonathan C., Sun, Jimin, Lu, Jingfang, Song, Bowen, Xu, Yadong, Zhang, Kexin, and Liu, Zhonghui
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CARBON isotopes , *OXYGEN isotopes , *MOISTURE , *GLOBAL cooling , *CLIMATE change , *CENOZOIC Era , *PLATEAUS , *STABLE isotopes - Abstract
• δ18O carb and δ13C alk records from a >5,000 m-thick sequence in the Qaidam Basin. • Regional moisture fluctuations over the Cenozoic inferred. • Linkage of moisture changes to global climate depends on the chosen chronology. The Cenozoic history of aridification in the Asian interior is thought to be intimately linked to uplift of the Tibetan Plateau and long-term global cooling. How fluctuating climatic conditions influenced regional moisture levels during the Cenozoic remains largely unknown. To infer moisture changes, we present oxygen isotope values of carbonates (δ18O carb) and carbon isotope values of long-chain n -alkanes (δ13C alk) from a continuous geological section in the Qaidam Basin, northwestern China. The section spans most of the Cenozoic Era, from ~52 to 5 million years ago (Ma), based on conventional chronology, whereas recently a drastically revised chronology has placed its basal age at ~26 Ma. The association of moisture changes with global climate largely depends on the chosen chronology. With the revised chronology, our records are inconsistent with existing moisture records from the Asian interior and do not show clear association with global climatic conditions. However, with the conventional chronology, our δ18O carb record shows a long-term aridification trend over the Cenozoic, whereas the δ13C alk suggests reduced moisture levels during the Oligocene. Both records consistently show enhanced aridity, notably during the Oligocene, ~20–17 Ma and after ~13 Ma, which largely corresponded to relatively cool global periods. Our records thus suggest that global climatic conditions during the Cenozoic exerted more influence on the moisture levels in the Asian interior than previously thought, if the conventional chronology is correct. Our study also highlights the importance of constructing a reliable chronology in order to make an association of Cenozoic terrestrial records with global climate. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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19. A bottom-up approach to evaluate the harmonics and power of home appliances in residential areas.
- Author
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Sun, Yuanyuan, Xie, Xiangmin, Wang, Qingyan, Zhang, Linghan, Li, Yahui, and Jin, Zongshuai
- Subjects
- *
HOUSEHOLD appliances , *RESIDENTIAL areas , *MARKOV chain Monte Carlo , *MONTE Carlo method , *HARMONIC generation - Abstract
• Harmonic couplings of home appliances between supply voltages and currents are strong. • Harmonics of home appliance are affected by supply voltage fluctuation and distortion. • Various behavioral factors are considered to improve the appliance random usage model. • Bottom-up approach can consider the appliance diversity and upgrading replacement. With expansion of the urban population, the power consumed by Chinese residential load is increasing rapidly. At the same time, power-electronic devices are widely adopted in home appliances, injecting a great amount of harmonics into the power system, which makes the harmonic problem in residential areas more serious than ever before. In this paper, a bottom-up approach is proposed to evaluate the harmonics of residential energy use. Firstly, a harmonic coupled model is proposed to calculate the harmonics generated by individual nonlinear home appliance. The model directly exhibits the couplings between different order harmonic voltages and currents. Secondly, based on the Markov chain Monte Carlo method, a random usage model is established to determine the usage pattern of home appliances. Various behavioral factors that affect the domestic use of energy in China are considered, and corresponding correction factors are proposed to improve the model accuracy. Thirdly, based on the proposed electrical and random usage models, a bottom-up approach is used to evaluate the harmonics and power of large-scale residential loads. Simulation results are compared with field measurements to verify the accuracy and validity of the proposed method. Furthermore, the proposed methodologies are applied to predict the harmonic generation and power consumption of some rapidly developing harmonic sources such as electric vehicles. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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20. Smart 6S roadmap for deciphering the migration and risk of heavy metals in soil and groundwater systems at brownfield sites nationwide in China.
- Author
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Qiu, Hao, Lou, Ziyang, Gu, Xueyuan, Sun, Yuanyuan, Wang, Jun, Zhang, Wei, and Cao, Xinde
- Subjects
- *
HEAVY metals , *GROUNDWATER , *BROWNFIELDS , *SOILS - Abstract
[Display omitted] [ABSTRACT FROM AUTHOR]
- Published
- 2022
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21. Unravelling chilling-stress resistance mechanisms in endangered Mangrove plant Lumnitzera littorea (Jack) Voigt.
- Author
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Xia, Xinhui, Hao, Lulu, Sun, Yifei, Lv, Yiqing, Wang, Yihong, Wu, Haiyu, Jiang, Zongjin, Li, Xinru, Yan, Yuhan, Chen, Xiaojian, Li, Binghou, Li, Hao, Li, Minhui, Sun, Yuanyuan, Ren, Wenxu, Xue, Yalin, You, Qing, Zhu, Lei, Liao, Qiuchang, and Xie, Shiyun
- Subjects
- *
MANGROVE plants , *ENDANGERED plants , *GENETIC regulation , *RNA regulation , *GENE expression , *ENDANGERED species - Abstract
Lumnitzera littorea (Jack) Voigt is one of the most endangered mangrove species in China. Previous studies have showed the impact of chilling stress on L. littorea and the repsonses at physiological and biochemical levels, but few attentions have been paid at molecular level. In this study, we conducted genome-wide investigation of transcriptional and post-transcriptional dynamics in L. littorea in response to chilling stress (8 °C day/5 °C night). In the seedlings of L. littorea , chilling sensing and signal transducing, photosystem II regeneration and peroxidase-mediated reactive oxygen species (ROS) scavenging were substantially enhanced to combat the adverse impact induced by chilling exposure. We further revealed that alternative polyadenylation (APA) events participated in chilling stress-responsive processes, including energy metabolism and steroid biosynthesis. Furthermore, APA-mediated miRNA regulations downregulated the expression of the genes involved in fatty acid biosynthesis and elongation, and protein phosphorylation, reflecting the important role of post-transcriptional regulation in modulating chilling tolerance in L. littorea. Our findings present a molecular view to the adaptive characteristics of L. littorea and shed light on the conservation genomic approaches of endangered mangrove species. • Chilling stress caused damage to cell membrane and photosynthesis of L. littorea. • L. littorea coped with cold stress at transcriptional and post-transcriptional level. • Photosystem II regeneration and ROS scavenging were enhanced against oxidative damage. • APA acts a fine-tuning role in regulating stress-responsive gene expression. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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22. Essential metal mixtures exposure and NAFLD: A cohort-based case-control study in northern Chinese male adults.
- Author
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Zhang, Di, Wu, Shouling, Lan, Yanqi, Chen, Shuohua, Wang, Yanhong, Sun, Yuanyuan, Lu, Ying, Liao, Wei, and Wang, Li
- Subjects
- *
NON-alcoholic fatty liver disease , *DISEASE risk factors , *IRON , *COPPER , *METALS , *CASE-control method - Abstract
Epidemiologic evidence on metal mixtures and non-alcoholic fatty liver disease (NAFLD) is limited. We aimed to assess the relationship between multiple metal co-exposure and NAFLD among male adults in Northern China. We conducted a cohort-based case-control study with 648 NAFLD and 648 non-NAFLD males. Seven metal concentrations (calcium, copper, iron, magnesium, manganese, selenium, and zinc) were determined in the blood. We used logistic regression and restricted cubic splines (RCS) to estimate the associations between the single metal and NAFLD. The impact of metal mixtures was quantified by the environmental risk score (ERS) in the adaptive elastic-net regression, and the association with NAFLD was estimated by logistic regression. Age-adjusted RCS showed linear relationships between blood calcium, selenium, and NAFLD. Blood copper, iron, magnesium, and manganese were non-linearly associated with NAFLD. Single metal analysis observed significant relationships between calcium, copper, manganese, and NAFLD, with the adjusted odds ratio (95% confidence interval) for quartile 1 vs. quartile 4 of 1.99 (1.30, 3.05), 2.36 (1.52, 3.64), and 1.77 (1.22, 2.55), respectively. However, metal mixtures analysis revealed one squared term (copper [β = −0.146]) and five metal-metal interactions (calcium × copper [β = 0.200], copper × magnesium [β = 0.188], copper × selenium [β = 0.188], iron × magnesium [β = 0.143], magnesium × selenium [β = −0.297]) except the three main effects. Higher ERS indicated a higher risk for NAFLD when exposed to metal mixtures, with an adjusted odds ratio = 6.50 (95% confidence interval: 4.36–9.69) for quartile 4 vs. quartile 1. Mediation analysis suggested that 11.66% of the effect of ERS on NAFLD was suppressed by fasting blood glucose. Our results show that exposure to metal mixtures is associated with a higher risk for NAFLD than the single metal. Interactions between metals suggest the importance of balancing the various metals for health benefits. Prospective cohorts and mechanism studies need to confirm the findings. [Display omitted] •Lower blood Ca, Cu, and Mn may be potential risk factors for NAFLD in non-occupational exposed males. •Exposure to metal mixtures is associated with a significantly higher risk for NAFLD than a single metal. •Interactions between metals suggest the importance of balancing the various metals for NAFLD prevention. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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23. Spatiotemporal analysis of PM2.5 and pancreatic cancer mortality in China.
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Wang, Yanhong, Li, Mengmeng, Wan, Xia, Sun, Yuanyuan, Cheng, Kailiang, Zhao, Xinyu, Zheng, Yuan, Yang, Gonghuan, and Wang, Li
- Subjects
- *
CANCER-related mortality , *SPATIOTEMPORAL processes , *PARTICULATE matter , *PANCREATIC cancer , *AIR pollution , *HEALTH , *PUBLIC health - Abstract
Background Previous studies have reported that the development of pancreatic cancer (PC) may be associated with environment pollution. But the relationship between ambient air pollution and PC remains unclear. Objectives This study aimed to examine the association between PC mortality and exposure of fine particular matter. Methods We used PC mortality data from 103 continuous points in national Disease Surveillance Point system from 1991 to 2009 in China. The annual concentrations of PM 2.5 at 0.1° × 0.1° spatial resolution for each points were estimated based on the context of the Global Burden of Disease Study 2015. A spatial age-period-cohort model was used to examine the relative risks of PC mortality associated with PM exposure, after adjusting gender, urban/rural status, spatial variation as well as age, period and cohort effect. Results The relative risks of PC mortality related to 10 μg/m 3 increase of PM 2.5 were 1.16 (95% confidence interval (CI): 1.13, 1.20) for all the population, 1.08 (1.05,1.13) for those aged 40–64 years, 1.21 (1.17,1.25) for those aged 65–84 years, 1.14 (1.10,1.18) for the male, 1.19 (1.14,1.24) for the female, 1.23 (1.16,1.30) for the urban population and 1.29 (1.22, 1.37) for the rural population. Conclusions Ambient PM 2.5 may raise the risk of mortality from PC, especially in older population. Pollution control policy should be further strengthened to reduce the health damages. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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24. Blood manganese and nonalcoholic fatty liver disease: A cohort-based case-control study.
- Author
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Zhang, Di, Wu, Shouling, Lan, Yanqi, Chen, Shuohua, Wang, Yanhong, Sun, Yuanyuan, Liao, Wei, and Wang, Li
- Subjects
- *
NON-alcoholic fatty liver disease , *MANGANESE , *CASE-control method , *TRACE elements - Abstract
As both a toxic and essential trace element in humans, limited research focuses on the association between blood manganese (Mn) and nonalcoholic fatty liver disease (NAFLD). We aimed to assess blood Mn concentration and its relationship with NAFLD among adults in Northern China. We conducted a cohort-based case-control study among 1816 patients with NAFLD (970 males and 846 females) and 1111 healthy controls (598 males and 513 females). We used the restricted cubic splines method to investigate the potential non-linear relationship and logistic regression models to analyze the association between blood Mn and NAFLD. The median (p 25 , p 75) of blood Mn concentration in males was 10.08 (8.42,11.98) μg/L, higher than that in females [9.79 (8.01,12.04)] μg/L, P = 0.011. Compared with the tertile 1 group of Mn in males, the odds ratio (95 % confidence interval) of NAFLD for tertile 2 and tertile 3 group was 0.82 (0.61,1.10) and 0.64 (0.47,0.87), respectively. The reverse correlation was consistent in patients with different fibrosis severity determined by fibrosis-4 score. The protective association was more evident in those with triglycerides ≥1.7 mmol/L [odds ratio (95 % confidence interval) of tertile 3 vs. tertile 1: 0.40 (0.22,0.75)]. We found a non-significant U-shaped relationship between Mn and NAFLD in women. There may exist sex differences for the association between blood Mn and NAFLD. Higher blood Mn may be a potential protective factor for NAFLD in males. The subjects with TG ≥ 1.7 mmol/L would benefit more from higher blood Mn levels. [Display omitted] •Blood manganese levels were sex-specific associated with NAFLD in Chinese adults. •Higher blood manganese correlated with lower NAFLD risk in males. •Triglycerides may modify the association between blood manganese and NAFLD in males. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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25. Fate of dissolved organic matter substructure in a full-scale wastewater treatment plant by using size exclusion chromatography multi-excitation-emission matrix analysis.
- Author
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Chen, Xinfu, Yu, Minda, He, Xiaosong, Zheng, Mingxia, Xi, Beidou, Sun, Yuanyuan, Fu, Xuemei, and Su, Jing
- Subjects
- *
DISSOLVED organic matter , *SEWAGE disposal plants , *GEL permeation chromatography , *PLANT size , *WATER purification , *TRYPTOPHAN - Abstract
Dissolved organic matter (DOM) in wastewater treatment plant (WWTP) effluent threats aquatic environment and challenges engineered aquatic systems. In order to predict its environmental risk and guide the selection of suitable strategy and technology, understanding the removal efficiency and the fate of DOM along the treatment is helpful. Herein, to qualitatively and quantitatively estimate the composition of DOM in a full-scale WWTP in northern China, a combined approach of chromatography and spectroscopy was employed, and the contribution of size-dependent substructure to the global feature of DOM was discussed simultaneously. The results suggest that the WWTP could remove the free proteins of low molecular size by physical treatment with removal ratios of 46.4% and 41.0% for tyrosine and tryptophan, respectively, whereas humic-like and humic-protein complex accumulate in the effluent of treatment with a ratio of 40.6%. Biotreatment is of importance for changing the proportion of different types of DOM, especially for anaerobic tank and the anoxic tank, which results in the increase of humification. Size exclusive chromatography (SEC) coupled with multi emission maps identifies six DOM substructures. Two protein-like DOM were removed by the WWTP, except the composition with the molecular weight ranging from 0.75 to 0.25 kDa, whereas humic-like DOM with whole size range accumulated to varying extent. The standard deviation analysis states that the structure variation of bulk DOM in the WWTP is primarily contributed by the decrease of small-sized proteins and the increase of humic-like DOM. This study presents insight into the fate and behavior of DOM components during the full-scale WWTP treatment and provides guidelines for altering DOM-treating technologies. Besides, innovative strategies suggest using DOM as a resource based on the critical review of previous research. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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26. Effects of nearly four decades of long-term fertilization on the availability, fraction and environmental risk of cadmium and arsenic in red soils.
- Author
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Gao, Peng, Huang, Jing, Wang, Yu, Li, Lijuan, Sun, Yuanyuan, Zhang, Tuo, and Peng, Fuyuan
- Subjects
- *
RED soils , *ENVIRONMENTAL risk , *PHOSPHATE fertilizers , *CADMIUM , *CATTLE manure , *ARSENIC - Abstract
Fertilizers are important for agricultural production because they can effectively promote crop productivity. However, long-term fertilization can cause heavy metal accumulation in soils and crops. This study utilized sequential extraction, the diffusive gradient in the thin films (DGT) technique and risk assessment models to estimate the effects of the longest long-term fertilization (38 years) in China on cadmium (Cd) and arsenic (As) accumulation in soils. The treatments included no fertilization (CK); inorganic nitrogen, phosphorus, and potassium fertilization (NPK); manure fertilization (M); and NPK plus M cofertilization (NPKM). The results indicated that the soils treated with NPKM, M and NPK had significantly increased total and available concentrations of Cd and As after 38 years of long-term fertilization. Cd mainly originates from cattle manure, while As originates from phosphate fertilizer. Sequential extraction results indicated that the application of manure increased the acid/exchangeable fraction (F1) and organic matter-bound fraction (F3) of Cd and As. The risk assessment results showed that the environmental risks of both Cd and As increased during long-term fertilization, and Cd contamination in the soil was at a moderate-high level, while As remained at a relatively low level. According to the calculations of the maximum numbers of years of soil productivity and rice production, Cd was labile and accumulated in the soils, and As was more labile than Cd in terms of accumulating in rice, indicating that the true risk from As in rice is higher than that from Cd. Controlling the heavy metals in fertilizers, mitigating effective amendments, and identifying plant types that accumulate low amounts of contaminants may be good choices for cleaner crop production. [Display omitted] • 38 years long-term fertilization leaded to a significant increment of cadmium and arsenic in soils. • Manure and phosphate fertilizer were the sources for cadmium arsenic input. • Cadmium and arsenic posed a medium-strong and low environmental risk to the farmland respectively. • Cadmium tended to accumulate in soil and arsenic was labile to accumulate in rice seeds. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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27. Clinical practice guideline on treating influenza in adult patients with Chinese patent medicines.
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Wu, Lei, Chen, Yaolong, Ma, Yanfang, Yang, Zifeng, Yang, Nan, Deng, Wenze, Chen, Yuanbin, Sun, Yuanyuan, Li, Yimin, and Lin, Lin
- Subjects
- *
CHINESE medicine , *INFLUENZA , *DELPHI method , *PILLS , *EXPERT evidence - Abstract
Influenza is a major public health problem worldwide. Mutations and resistance development make the use of antiviral therapy challenging. Chinese patent medicines are often used to treat influenza in China and well tolerable. However, the misuse of Chinese patent medicines is common. We therefore aimed to develop an evidence-based guideline on treating influenza with Chinese patent medicines in adults to guide clinical practice. We formed a steering committee, a consensus panel, a consultants' group and an evidence synthesis team to guide the development of the guideline. We formulated the clinical questions through two rounds of survey, and finally selected five questions. We then systematically searched the related evidence and conducted meta-analyses, evidence summaries and GRADE decision tables to draft the recommendations, which the consensus panel then voted on using the Delphi method. Finally, we formulated six recommendations based on the evidence synthesis and experts' consensus. For treating mild influenza, we suggest either Lianhua Qingwen capsule, Jinhua Qinggan granule, Banlangen granule, Shufeng Jiedu capsule, or Jinfang Baidu pill, depending on the manifestations. For severe influenza, or mild influenza in patients at high risk of developing severe influenza, we suggest Lianhua Qingwen capsule in combination with antiviral medications and supportive therapy. The strength of all recommendations was weak. Traditional Chinese medicine has great potential to help in the fight against influenza worldwide, but more high-quality studies are still needed to strengthen the evidence. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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28. An armoured marine reptile from the Early Triassic of South China and its phylogenetic and evolutionary implications.
- Author
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Wolniewicz AS, Shen Y, Li Q, Sun Y, Qiao Y, Chen Y, Hu YW, and Liu J
- Subjects
- Animals, Phylogeny, Vertebrates, China, Fossils, Biological Evolution, Reptiles anatomy & histology
- Abstract
Sauropterygia was a taxonomically and ecomorphologically diverse clade of Mesozoic marine reptiles spanning the Early Triassic to the Late Cretaceous. Sauropterygians are traditionally divided into two groups representing two markedly different body plans - the short-necked, durophagous Placodontia and the long-necked Eosauropterygia - whereas Saurosphargidae, a small clade of armoured marine reptiles, is generally considered as the sauropterygian sister-group. However, the early evolutionary history of sauropterygians and their phylogenetic relationships with other groups within Diapsida are still incompletely understood. Here, we report a new saurosphargid from the Early Triassic (Olenekian) of South China - Prosaurosphargis yingzishanensis gen. et sp. nov. - representing the earliest known occurrence of the clade. An updated phylogenetic analysis focussing on the interrelationships among diapsid reptiles recovers saurosphargids as nested within sauropterygians, forming a clade with eosauropterygians to the exclusion of placodonts. Furthermore, a clade comprising Eusaurosphargis and Palatodonta is recovered as the sauropterygian sister-group within Sauropterygomorpha tax. nov. The phylogenetic position of several Early and Middle Triassic sauropterygians of previously uncertain phylogenetic affinity, such as Atopodentatus , Hanosaurus , Majiashanosaurus, and Corosaurus , is also clarified, elucidating the early evolutionary assembly of the sauropterygian body plan. Finally, our phylogenetic analysis supports the placement of Testudines and Archosauromorpha within Archelosauria, a result strongly corroborated by molecular data, but only recently recovered in a phylogenetic analysis using a morphology-only dataset. Our study provides evidence for the rapid diversification of sauropterygians in the aftermath of the Permo-Triassic mass extinction event and emphasises the importance of broad taxonomic sampling in reconstructing phylogenetic relationships among extinct taxa., Competing Interests: AW, YS, QL, YS, YQ, YC, YH, JL No competing interests declared, (© 2023, Wolniewicz et al.)
- Published
- 2023
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29. Metabolic Dysfunction-associated Fatty Liver Disease and Mortality Among Chinese Adults: a Prospective Cohort Study.
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Wang X, Wu S, Yuan X, Chen S, Fu Q, Sun Y, Lan Y, Hu S, Wang Y, Lu Y, Qu S, and Wang L
- Subjects
- Adolescent, Adult, Age Factors, Cause of Death, China epidemiology, Diabetes Mellitus metabolism, Follow-Up Studies, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Non-alcoholic Fatty Liver Disease metabolism, Overweight metabolism, Prevalence, Prospective Studies, Sex Factors, Young Adult, Diabetes Mellitus epidemiology, Fatty Liver, Alcoholic epidemiology, Non-alcoholic Fatty Liver Disease epidemiology, Overweight epidemiology
- Abstract
Context: Nonalcoholic fatty liver disease (NAFLD) was renamed metabolic dysfunction associated with fatty liver disease (MAFLD) recently., Objective: We aimed to explore the risk of all-cause deaths in MAFLD participants and compare it with NAFLD in Chinese adults., Methods: We enrolled 152 139 participants with abdominal ultrasonography in the Kailuan Cohort from 2006 to 2012. We categorized the participants into MAFLD and non-MAFLD, NAFLD and non-NAFLD, and 4 groups of Neither FLD, MAFLD only, NAFLD only, and MAFLD-NAFLD, respectively. We used Cox regression models to estimate the hazard ratios (HRs) and 95% CI of death., Results: The prevalence of MAFLD and NAFLD was 31.5% and 27.3%, respectively. After a median follow-up of 12.7 years, MAFLD and NAFLD both were associated with increased mortality, especially in men younger than 40 years, with HR (95% CI) of 1.51 (1.19-1.93) and 1.37 (1.06-1.78), respectively. The MAFLD-only group had higher mortality than the NAFLD-only in males 60 years or older (adjusted HR = 1.43; 95% CI, 1.00-2.03) and lower risk in males aged 40 to 59 years (adjusted HR = 0.65; 95% CI, 0.48-0.90). MAFLD with overweight/obesity-only decreased, but those with diabetes and/or metabolic dysregulation increased the risk of death. MAFLD with positive hepatitis B surface antigen and/or excessive alcohol consumption further increased the risk of death, especially in men younger than 40 years (HR = 9.86; 95% CI, 2.44-39.98)., Conclusion: MAFLD was associated with increased all-cause mortality among the Chinese population, which was different according to the status of overweight/obesity, diabetes, other metabolic indicators, and second causes. MAFLD patients should be managed by metabolic indicators and second causes to fulfill precise treatment and management., (© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2022
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30. Controlling Non-Grain Production Based on Cultivated Land Multifunction Assessment.
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Su Y, Su C, Xie Y, Li T, Li Y, and Sun Y
- Subjects
- China, Cities, Edible Grain, Farmers, Humans, Agriculture, Conservation of Natural Resources methods
- Abstract
The control of non-grain production (NGP) has become a great challenge for cultivated land protection in China in recent years. A control method for NGP that can coordinate the conflicts between cultivated land protection and farmers' interest is urgently needed. Taking Tongxiang City as an example, this research proposed a solution for the control and management of NGP based on cultivated land multifunctional assessment. The GIS and AHP approach were used to assess production function via a comprehensive evaluation index. The InVEST and FMSPA models were applied to assess ecological function while, the Maxent model was applied to assess recreational function, then multifunctional comprehensive zoning was conducted through natural breakpoint method and spatial overlay analysis. Five development-oriented function zones were considered, including the core area of grain production plus areas for ecological agriculture, leisure agriculture, compound agriculture, and general farmland. Differentiated control measures for NGPs in each functional subarea are proposed considering the current NGP distribution of Tongxiang city. This research can provide a reference for subsequent improvement of land management policies and can aid the achievement of sustainable agricultural development and rural revitalization.
- Published
- 2022
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31. Biochar can improve biological nitrogen fixation by altering the root growth strategy of soybean in Albic soil.
- Author
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Xiu L, Zhang W, Wu D, Sun Y, Zhang H, Gu W, Wang Y, Meng J, and Chen W
- Subjects
- Charcoal, China, Nitrogen Fixation, Soil, Glycine max
- Abstract
Albic soil is a low-yielding soil that is widely distributed in Northeast China. The high viscosity and acidity and the lack of nutrients in the Albic layer limit the growth of crop. In our previous studies, we found that applying biochar as a soil amendment could improve the properties of Albic soil and promote soybean growth. Increases in the nitrogen contents of the soil and the soybeans were key aspects of these improvements. Soybean is a nitrogen-fixing crop, the increase in nitrogen in the Albic soil may have been due to an improvement in biological nitrogen fixation by the soybean with biochar amendment, but the function mechanism was still uncertain. We hypothesized that biochar could improve biological nitrogen fixation of soybean by affecting soybean root growth in the Albic soil. Therefore, we conducted pot experiments with five treatment levels (0, 10, 20, 30, and 40 g·kg
-1 biochar) for two years to study how biochar affects the root growth strategy and biological nitrogen fixation of soybean based on its root structure and root nutrient acquisition ability at different stages. The soybean root structure and activity indexes, nodulation ability and nitrogen uptake were measured at different growth stages; in the second year, at the late seed-filling stage, the stable15 N isotope method was used to elucidate the biological nitrogen fixation process. Regarding root structure at the pod-setting stage, biochar resulted in increases in root length density, specific root length, root diameter and specific tip density but a decrease in root tissue mass density at the pod-setting stage. Biochar improved root nutrient acquisition by increasing root activity, root tip number and root-bleeding sap amount. The change in root growth strategy contributed to the promotion of biological nitrogen fixation by the rhizobia that live symbiotically with soybean, thereby increasing crop yield., Competing Interests: Declaration of competing interest We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, there is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in or the review of, the manuscript entitled., (Copyright © 2021 Elsevier B.V. All rights reserved.)- Published
- 2021
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32. Associations Between Nonalcoholic Fatty Liver Disease and Cancers in a Large Cohort in China.
- Author
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Wang Z, Zhao X, Chen S, Wang Y, Cao L, Liao W, Sun Y, Wang X, Zheng Y, Wu S, and Wang L
- Subjects
- Adult, China epidemiology, Cohort Studies, Humans, Male, Prospective Studies, Risk Factors, Carcinoma, Hepatocellular epidemiology, Non-alcoholic Fatty Liver Disease complications, Non-alcoholic Fatty Liver Disease epidemiology
- Abstract
Background & Aims: The relationship between nonalcoholic fatty liver disease (NAFLD) and cancer, especially extrahepatic cancers, has not been fully clarified. We analyzed data from a large prospective cohort study to determine the relationship between NAFLD and development of cancers in men., Methods: We collected data from the Kailuan cohort, a community-based cohort of 54,187 adult men in China, from June 2006 through October 2007. NAFLD was diagnosed by ultrasonography after excluding other causes related to chronic liver disease. Fine and Gray competing risk regression model was used to evaluate associations between NAFLD (without cirrhosis) and cancers., Results: The prevalence of NAFLD was 32.3%. NAFLD was associated with increased risk of all cancers (hazard ratio [HR], 1.22; 95% CI, 1.10-1.36; P = .0001), thyroid cancer (HR, 2.79; 95% CI, 1.25-6.21; P = .01), and lung cancer (HR, 1.23; 95% CI, 1.02-1.49; P = .03). The association between NAFLD and risk of thyroid cancer increased with level of alanine aminotransferase (ALT). In men with NAFLD, level of ALT 80 U/L or more was associated with hepatocellular carcinoma (HR, 8.08; 95% CI, 2.46-26.56; P = .0006). NAFLD increased risk of colorectal cancer (HR, 1.96; 95% CI, 1.17-3.27) and lung cancer (HR, 1.38; 95% CI, 1.03-1.84) only in smokers. An association between NAFLD and kidney cancer (HR, 1.57; 95% CI, 1.03-2.40) was only observed in men without diabetes., Conclusions: A cohort study from China found that men with NAFLD have a higher risk of extrahepatic cancers, including thyroid and lung cancer. In men with NAFLD, higher levels of ALT were associated with higher risk of thyroid and hepatocellular cancer. NAFLD increased risk of colorectal and lung cancer only in smokers, and increased risk of kidney cancer in men without diabetes., (Copyright © 2021 AGA Institute. Published by Elsevier Inc. All rights reserved.)
- Published
- 2021
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33. Hepatitis B virus infection and diabetes mellitus: the Kailuan prospective cohort study in China.
- Author
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Lei S, Chen S, Zhao X, Zhang Y, Cheng K, Zhang X, Wang Z, Sun Y, Wu S, and Wang L
- Subjects
- Age Factors, Body Mass Index, China epidemiology, Correlation of Data, Female, Humans, Incidence, Male, Metabolism, Middle Aged, Prospective Studies, Risk Assessment, Risk Factors, Cholesterol, HDL blood, Diabetes Mellitus diagnosis, Diabetes Mellitus epidemiology, Hepatitis B Antibodies blood, Hepatitis B, Chronic diagnosis, Hepatitis B, Chronic epidemiology
- Abstract
Background and Aims: The effect of hepatitis B virus (HBV) infection on diabetes has remained unclear. We thus conducted a prospective cohort study to investigate the association between different HBV infection status and new-onset diabetes in a Chinese population., Methods: We enrolled 55,520 participants with HBV serological markers and diabetes free in 2010 in Kailuan cohort. Cox regression models were used to analyze the relationship between different HBV infection status and incidence of diabetes after adjusting different confounders., Results: During an average follow-up of 5.6 years, we identified 6008 incident patients with diabetes. Compared to the participants with hepatitis B surface antigen (HBsAg) negative/hepatitis B surface antibody (anti-HBs) negative/hepatitis B core antibody (anti-HBc) negative, those with chronic HBV infection or with HBsAg negative/anti-HBc positive had a higher risk to occur diabetes. The hazard ratios were 1.18 (95% CI 0.99-1.40, p = 0.0588) and 1.22 (95% CI 1.08-1.36, p = 0.0009), respectively. The association between chronic HBV infection, anti-HBc positive and diabetes was different between those with different levels of high density lipoprotein cholesterol, blood pressure, body mass index, and age., Conclusion: The individuals with chronic HBV infection or anti-HBc positive may have an increased risk of diabetes, and the association may be modified by the different status of metabolism related variables and age. Effective management of HBV infection may contribute to the reduction of the burden of both hepatitis B and diabetes.
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- 2020
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34. TBX3 deficiency accelerates apoptosis in cardiomyoblasts through regulation of P21 expression.
- Author
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Cao M, Zhu B, Sun Y, Zhao X, Qiu G, Fu W, and Jiang H
- Subjects
- Animals, Apoptosis drug effects, Apoptosis physiology, Cell Cycle Checkpoints drug effects, Cell Line, Cell Proliferation drug effects, China, Cyclin-Dependent Kinase Inhibitor p21 genetics, Cyclin-Dependent Kinase Inhibitor p21 metabolism, Fetus, Gene Expression Regulation genetics, Heart Defects, Congenital metabolism, Humans, Mitochondria drug effects, Myocytes, Cardiac physiology, Promoter Regions, Genetic genetics, RNA, Messenger genetics, Rats, T-Box Domain Proteins physiology, Transcription Factors metabolism, Myocytes, Cardiac metabolism, T-Box Domain Proteins metabolism
- Abstract
Congenital heart disease (CHD) is the most common birth defect in newborns. There is increasing evidence that apoptosis and remodeling of the cardiomyoblasts are the major pathology of CHD. Previous research found that T-box transcription factor 3 (TBX3) was compulsory for the regulation of proliferation, cell cycle arrest and apoptosis in various cells. Hence, TBX3 might be involved in the treatment of CHD. The primary aim of this study was to study the effects of TBX3 on apoptosis in aged cardiomyoblasts and investigate the latent mechanism. In the present study, we found TBX3 knockdown induced proliferation inhibition, cell cycle arrest and apoptosis accompanied by mitochondrial dysfunction in cardiomyoblasts at passage 10 to 15. Apoptosis-inducing effects of TBX3 silence could be neutralized by silencing P21 using specific siRNA. In addition, the mRNA and protein expression levels of TBX3 in the heart tissues of sporadic type CHD donors were obviously down-regulated. In conclusion, we demonstrated that TBX3 deficiency accelerated apoptosis via directly regulating P21 expression in senescent cardiomyoblasts., (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Published
- 2019
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35. Research and development of mAb drugs in China: a look from policy perspectives.
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Jiang R, Sun Y, Ung C, Dong X, Kong X, Hu Y, and Shao R
- Subjects
- China, Clinical Trials as Topic, Drug Industry, European Union, Humans, Marketing legislation & jurisprudence, Research trends, Antibodies, Monoclonal therapeutic use, Drug Approval legislation & jurisprudence, Drug Development trends, Research legislation & jurisprudence
- Abstract
Background : Monoclonal antibody (mAb) drugs are increasingly important for the pharmaceutical industry across the globe. In China, mAb drug developments face many challenges. Multiple policies have been implemented recently to reinforce support in various areas. This study aims to investigate the latest landscape of mAb drugs in China from policy perspectives encompassing R&D, clinical trials, marketing approval, and talent pools. Methods : Information about mAb drugs approved in the United States, the European Union, Japan, and China by 2017 and mAb-related policies in China were retrieved from government websites and third-party statistical databases for descriptive, statistical, and comparative analysis. Results and discussion : In China, 21 mAb drugs (10 locally-developed and 11 imported) have so far been approved. For the 11 imported mAb drugs in China, the median drug lag in the marketing approval was estimated at 87.1 months, compared with the U.S. (0 months), the EU (8.9 months), and Japan (43.4 months). However, as far as the dramatically changing innovation supporting system in China is concerned, emergence of new biopharmaceutical companies, transformation of the current drug companies and their shift to antibody therapy, and the pooling of high-level talent contribute to mAb development in China. The number of clinical trials and marketing applications and approvals involving mAb drugs is also growing. Favorable policies will continue to play a role in the sustainable development of mAb drugs in China. Conclusion : The research showed that the reform of multiple policies and incentives for attracting/retaining high-level talent has evidently been effective in addressing the drug lag of mAb drugs in China. In future development, China should actively monitor the global R&D outcomes and industrial development trends of mAb drugs and make the policy environment more attractive to enable more mAb drugs to be marketed in China as soon as possible.
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- 2019
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36. Optimal Nitrogen Fertilization Management of Seed-sowing Rapeseed in Yangtze River Basin of China.
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Li H, Ghafoor A, Karim H, Guo S, Li Z, Wu Y, Sun Y, and Yan F
- Subjects
- China, Environmental Pollutants chemistry, Plant Shoots growth & development, Rivers, Seasons, Soil, Soil Pollutants, Agriculture methods, Brassica napus growth & development, Fertilizers, Nitrogen chemistry, Seeds growth & development
- Abstract
Background and Objective: For cultivation and high yield of oilseed rape (Brassica napus L.) in China, traditional seedling transplanting is replaced by seed-sowing but, better nitrogen management is crucial and not established yet. This study aimed to adapt N management to the seed-sowing method for the winter oilseed rape and to minimize the N fertilizer-derived pollution potential in the upper reaches of Yangtze River Basin., Materials and Methods: Three field experiments were conducted to check effect of different doses of N fertilizers, split doses of N and different types of N fertilizers for seed-sowing winter oilseed rape with high plant density in upper reaches of Yangtze River Basin in Sichuan province of China., Results: In first experiment, among four doses (0, 90, 180 and 270 kg N ha-1) on average 3.54 t ha-1 was in 180 kg N ha-1 and 3.61 t ha-1 in 270 kg N ha-1 while cultivars dy6 and cn3 produced 3.23 and 3.29 t ha-1 which is significantly higher than zs11. There was no significant difference in N-use efficiency among three cultivars tested and second experiment showed no significant difference in seed yield with split N application. The third experiment compared the effects of different fertilizer types (urea, coated urea, 1:1 mixture of urea and coated urea and compound nitrogen fertilizer) on seed yield and get no significant difference in seed yield., Conclusion: This experiment proved that seed sowing method with higher nitrogen had high yield in the upper reaches of Yangtze River Basin in China, but higher N application may cause environment pollution. So, seed sowing method with nitrogen 180 kg N ha-1 was proved to be more effective.
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- 2019
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37. Short-term immunogenicity of standard and accelerated hepatitis B virus vaccination schedules in healthy adults: a comparative field study in China.
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Zhang X, Wang J, Chen X, Yu M, Yu S, Sun Y, Duan J, Sun H, and Yuan P
- Subjects
- Adolescent, Adult, China, Female, Hepatitis B immunology, Hepatitis B Antibodies immunology, Hepatitis B Surface Antigens immunology, Hepatitis B Vaccines immunology, Hepatitis B virus pathogenicity, Humans, Immunization Schedule, Immunogenicity, Vaccine, Male, Middle Aged, Young Adult, Hepatitis B prevention & control, Hepatitis B Vaccines therapeutic use, Hepatitis B virus immunology, Vaccination
- Abstract
World Health Organization recommends hepatitis B virus (HBV) immunization at 0, 1, and 6 months. However, studies have suggested that shortening the interval between the first and last HBV immunization can improve completion rates. Less clear is whether accelerated immunization is as immunogenic as standard immunization. Thus, the present study aimed to compare the short-term immunogenicity of yeast-derived hepatitis B vaccine in healthy adults immunized on an accelerated or standard schedule. Between June 2013 and March 2014, individuals from Jinfeng and Longmen, China were randomly assigned to receive the vaccine on an accelerated schedule (at 0, 1, and 2 months; n =201) or a standard schedule (at 0, 1, and 6 months; n =206). Subjects filled out a questionnaire asking about demographic and other health data, and they underwent physical examination. Blood was assayed for HBV surface antigen and HBV surface antibody (HBsAb) at 1-2 months after the three-dose schedule. Multivariate binary logistic regression was used to determine whether the rate of anti-HBs seroconversion differed with immunization schedule. Covariance analysis was used to compare geometric mean HBsAb concentration between the two schedules. The anti-HBs seroconversion rate was 84.6% in the accelerated group and 90.3% in the standard group. After controlling for several potential confounders, the accelerated schedule was associated with significantly lower anti-HBs seroconversion rate (OR: 0.560, 95% CI: 0.318-0.988). Similarly, the accelerated schedule was associated with significantly lower geometric mean HBsAb concentration. These results suggest that the standard schedule is more likely to lead to anti-HBs seroconversion and higher HBsAb levels in adults., (© 2018 The Author(s).)
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- 2018
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38. Time trends of esophageal and gastric cancer mortality in China, 1991-2009: an age-period-cohort analysis.
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Li M, Wan X, Wang Y, Sun Y, Yang G, and Wang L
- Subjects
- Adult, Age Factors, Aged, Aged, 80 and over, China, Female, Humans, Male, Middle Aged, Rural Population statistics & numerical data, Esophageal Neoplasms mortality, Stomach Neoplasms mortality
- Abstract
Esophageal and gastric cancers share some risk factors. This study aimed to compare the long-term trends in mortality rates of esophageal and gastric cancers in China to provide evidence for cancer prevention and control. Mortality data were derived from 103 continuous points of the Disease Surveillance Points system during 1991-2009, stratified by gender and urban-rural locations. Age-period-cohort models were used to disentangle the time trends of esophageal and gastric cancer mortality. The downward slope of the period effect for esophageal cancer was steeper than that for gastric cancer in rural areas. Cohort effect patterns were similar between esophageal and gastric cancers, with an inverse U-shape peaking around the late 1920s and early 1930s. A second peak, appearing around the 1950s, was weaker than the first but apparent in males, especially for esophageal cancer. The more marked changes in period effect for esophageal cancer in rural areas suggest esophageal cancer screening practices are effective in reducing mortality, and similar programs targeting gastric cancer should be implemented. The similarities of the cohort effects in these two cancers support the implication of nutrition deficiency in early childhood in the development of upper gastrointestinal cancer.
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- 2017
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39. Clinical validation of a novel urine-based metabolomic test for the detection of colonic polyps on Chinese population.
- Author
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Deng L, Fang H, Tso VK, Sun Y, Foshaug RR, Krahn SC, Zhang F, Yan Y, Xu H, Chang D, Zhang Y, and Fedorak RN
- Subjects
- Aged, China, Colonic Polyps diagnosis, Feces, Female, Humans, Male, Sensitivity and Specificity, Asian People, Colonic Polyps metabolism, Colonic Polyps urine, Metabolomics methods
- Abstract
Purpose: Colorectal cancer is the fifth leading cause of cancer-related deaths in China. When detected early, with the removal of adenomatous polyps, precursors of colorectal cancer, it is preventable. The aim of this study was to evaluate a novel urine-based metabolomic diagnostic test for the detection of adenomatous polyps, PolypDx™, that was originally developed and validated using 1000 samples from Canadian Cohort, on Chinese population., Methods: Prospective urine samples were collected from 1000 participants undergoing colonoscopy examination, from March 2013 to July 2014 at Minhang District, Shanghai Centre for Disease Control and Prevention. One-dimensional nuclear magnetic resonance spectra of urine metabolites were analyzed to determine the concentrations of three key metabolites used in PolypDx™. The predicted results were then compared to the gold standard for colorectal cancer diagnostic, colonoscopy. Area under curve (AUC) was calculated specifically for the Chinese population and compared with the Canadian dataset. Sensitivity and specificity of this urine-based metabolomic diagnostic test were also compared with three commercially available fecal-based tests., Results: An AUC of 0.717 for PolypDx™ was calculated on Chinese dataset which is slightly lower than the AUC on the Canadian dataset. A sensitivity of 82.6% and a specificity of 42.4% were achieved on Chinese dataset., Conclusions: Here, we validated a novel urine-based metabolomic diagnostic test for the detection of adenomatous polyps, PolypDx™, on Chinese population through a sample size of 1000 participants with a greater level of sensitivity than fecal-based tests.
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- 2017
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40. Folate Deficiency Was Associated with Increased Alanine Aminotransferase and Glutamyl Transpeptidase Concentrations in a Chinese Hypertensive Population: A Cross-Sectional Study.
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Li WX, Li W, Cao JQ, Yan H, Sun Y, Zhang H, Zhang Q, Tang L, Wang M, Huang JF, and Liu D
- Subjects
- Adult, Aged, Aspartate Aminotransferases blood, China, Cross-Sectional Studies, Female, Folic Acid blood, Genotype, Homocysteine blood, Humans, Hypertension genetics, Male, Middle Aged, Polymorphism, Single Nucleotide, Alanine Transaminase blood, Asian People genetics, Folic Acid Deficiency blood, Hypertension blood, Methylenetetrahydrofolate Reductase (NADPH2) genetics, gamma-Glutamyltransferase blood
- Abstract
Alanine aminotransferase (ALT), aspartate transaminase (AST), and glutamyl transpeptidase (GGT) were three key enzymes in the hepatic metabolism. This study aimed to investigate the effect of homocysteine (Hcy) metabolism gene polymorphisms and serum Hcy and folate level on the hepatic functions in a Chinese hypertensive population. A representative sample with 480 subjects aged 28-75 was enrolled in 2005.9-2005.12 from six hospitals in different Chinese regions. Serum ALT, AST and GGT were measured by using an automatic biochemistry analyzer. Serum Hcy was measured by high-performance liquid chromatography, and serum folate was measured by chemiluminescent immunoassay. Known genotypes were detected by PCR-RFLP methods. The results showed that the MTHFR C677T mutation was related a decreased serum AST level (r=-0.11, p=0.026), whereas the MTHFR A1298C mutation elevated serum AST level (r=0.11, p=0.032). Furthermore, multiple regression analysis showed that folate deficiency was associated with higher serum ALT (β (SE): 0.13 (0.06), p=0.031) and GGT level (β (SE): 0.18 (0.07), p=0.011). However, serum Hcy level may not affect the hepatic functions. Our data suggested that hepatic functions were affected by MTHFR gene polymorphisms and serum folate level. Further studies are needed to confirm these correlations in a larger population.
- Published
- 2016
- Full Text
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