27 results on '"Rosidah, R."'
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2. Influencing sustainable consumer behavior on electricity consumption - Insights from an environmental documentary
- Author
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Rosidah, R, primary
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- 2022
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3. Chemical Compounds Of Granulated Palm Sugar Made From Sap Of Nipa Palm (Nypa Fruticans Wurmb) Growing In Three Different Places
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Rosidah R Radam, Hj. Noor Mirad Sari, and Hj. Lusyani Lusyani
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Geography. Anthropology. Recreation ,Environmental sciences ,GE1-350 - Abstract
Production of granulated sugar from sap of nipa palms in South Kalimantan Province is a new innovation. The purpose of this study was to find out the chemical compounds contained in granulated sugar made from sap of nipa palms growing in 3 different places, which was expected to benefit wider community as a source of alternative sweetener. The chemical compound test of granulated nipa palm sugar was conducted at the Laboratory of Institute for Research and Standardization of Industry, Banjarbaru. Chemical parameters tested were water, sucrose, reducing sugar, fat, protein, phosphorus, and potassium content. The test results showed that the water content of granulated nipa palm sugar in treatment A1, A2, and A3 was 3.69%, 4.04%, and 2.31%, respectively; the protein content 0.65%, 2.19%, and 1.10%; the fat content 0.27 %, 0.34 %, and 0.20 %; the reducing sugar content 2.39%, 0.51%, and 0.52%; the sucrose content 75.14%, 68.15%, and 88.46%; the phosphorus content 1.1342%, 1.1196%, and 1.138%; and the potassium content 1.60%, 1.40%, and 1.58%, respectively. The test parameters of granulated nipa palm sugar that met the Mandatory Indonesia National Standard (SNI) 01-3743-1995 were the water content of granulated sugar from sap of nipa palms growing in dry place (land), the reducing sugar content and sucrose content in all treatments. It can be concluded from the three required parameters that granulated nipa palm sugar is able to become the source of new sweetener in addition to block arenga palm sugar and crystal cane sugar for the community in South Kalimantan.
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- 2016
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4. Phytoplankton community structure in Menjer Lake, Central Java
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Sulawesty, F, primary, Yoga, G P, additional, Subehi, L, additional, and Rosidah, R, additional
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- 2021
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5. Government Response to Handling Covid-19 Study Comparation: Lessons Learned from Taiwan and Indonesia
- Author
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Aminah, Sitti, primary, Gunawan, G, primary, Josep, J, primary, and Rosidah, R, primary
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- 2021
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6. PEMBUATAN PAPAN PARTIKEL DARI SERBUK GERGAJIAN KAYU AKASIA MANGIUM (Acacia mangium) DAN KAYU SUNGKAI (Peronema canescens) MENGGUNAKAN PEREKAT RESIN POLYESTER
- Author
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Supriyanto, Agus, primary, Sari, Noor Mirad, additional, and Radam, Rosidah R, additional
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- 2020
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7. FITOKIMIA 5 JENIS POHON DI KHDTK UNIVERSITAS LAMBUNG MANGKURAT MANDIANGIN KALIMANTAN SELATAN
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Wibisono, Agung, primary, Sunardi, Sunardi, additional, and Radam, Rosidah R, additional
- Published
- 2020
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8. PENGOLAHAN GULA AREN (Arrenga Pinnata Merr) DI DESA BANUA HANYAR KABUPATEN HULU SUNGAI TENGAH
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Rosidah R Radam and Arfa Agustina Rezekiah
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pengolahan ,gula aren ,palm Sugar ,lcsh:SD1-669.5 ,processing ,lcsh:Forestry - Abstract
Gula aren salah satu pemanis yang telah diproduksi oleh bangsa Indonesia sejak lama. Gula aren sebagai alternatif bahan pemanis makanan dan merupakan mata pencaharian sampingan bagi kebanyakan masyarakat di Desa Banua Hanyar. Tujuan penelitian ini untuk mengetahui produktivitas dan kontribusi terhadap pendapatan masyarakat. Objek penelitian ini adalah pembuat gula aren. Data yang dikumpulkan terdiri dari karakteristik responden, proses pembuatan gula aren, perhitungan produktivitas dan kontribusinya terhadap pendapatan masyarakat. Produktivitas gula aren (Arenga pinnata Merr) berkisar antara 0,465 Kg/hari hingga 1,137 kg/hari. Kontribusi dari pengolahan gula aren sebesar 60,48% dari pendapatan masyarakat. Tingkat kesejahteraan masyarakat termasuk dalam golongan termiskin dengan pendapatan tahunan per kapita Rp.962 919,- atau setara dengan 148 kg beras. Disarankan perlu pembentukan kelompok tani dengan tujuan keseragaman dalam harga pasar gula aren. Peningkatan kualitas dengan peningkatan bentuk cetakan, kemasan dan aneka rasa. Sehingga produk gula aren dapat dijual di pasar modern. Palm sugar is a sweetener that has been produced by the nation of Indonesia since long ago. Palm sugar as an alternative sweetener foodstuffs as well as an second job for most people in the Banua Hanyar village. The purpose of this research to know the productivity and contribution to community income. The object of this research is the maker of palm sugar. Data collected as data characteristics, the process of making palm sugar, calculation of productivity and its contribution to household income. Productivity sugar palm (Arenga pinnata Merr) ranged from 0.465 Kg / day up to 1,137 kg / day. Contributions from processing palm sugar by 60.48% of household income. The level of welfare including in the poorest of the poor with annual income per capita of IDR 962 919, - or the equivalent of 148 kg of rice. Need formation of farmer groups with the goal of uniformity in the market price of palm sugar. Improved quality with improved shape of the mold, packaging and various flavors. So that the products of palm sugar can be sold on the modern markets.
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- 2016
9. PEMBUATAN PAPAN PARTIKEL DARI SERBUK GERGAJIAN KAYU AKASIA MANGIUM (Acacia mangium) DAN KAYU SUNGKAI (Peronema canescens) MENGGUNAKAN PEREKAT RESIN POLYESTER
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Agus Supriyanto, Noor Mirad Sari, and Rosidah R Radam
- Abstract
This research was to determine the physical and mechanical properties of particle board from acacia sawdust and sawn wood sawdust. The results of water content ranged from 6.85 to 9.22%, density ranged from 0.39 to 0.47 g / cm3, thickness development ranged from 2.21 to 7.04%, flexural strength (modulus of elasticity or MOE ) ranges between 1000.33 - 16127.48 kgf / cm² and the strength of the fracture (modulus of Rupture or MOR) ranges from 1.10 - 1.73 kgf / cm². MOE and MOR values and densities in treatment C that do not meet SNI 03-2105-2006 while in testing other treatments have meet SNI 03-2105-2006. The composition of raw materials has a very significant effect on the treatment of water content, density, thickness development and MOE. Physical and mechanical properties had no significant effect on the treatment of MOR values. The physical properties of particle board on average meet ISN 03-2105-2006. There are no mechanical properties that meet SNI 03-2105-2006.Keywords: Particle board; waste; polyester resin
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- 2020
10. FITOKIMIA 5 JENIS POHON DI KHDTK UNIVERSITAS LAMBUNG MANGKURAT MANDIANGIN KALIMANTAN SELATAN
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Agung Wibisono, Sunardi Sunardi, and Rosidah R Radam
- Abstract
Aims of the study is to identify phytochemical components (alkaloid, flavonoid, saponin, quinone, triterpenoid, and tannin) of 5 species growth in University of Lambung Mangkurat (ULM) Kawasan Hutan Dengan Tujuan Khusus (KHDTK = Education and Training Forest) area. These species are Madang Pirawas, Margatahan, Alaban Timbasu, Rawa Rawa Pipit, and Pulantan. Chemical analysis conducted in Wood Chemistry Laboratory, Faculty of Forestry ULM. The result shows that alkaloid component is found in Madang Pirawas, Margatahan, Alaban Timbasu, Rawa Rawa Pipit, and Pulantan’s leaves. Alaban Timbasu has more alkaloid than the others. Flavonoid component is found in Madang Pirawas, Margatahan, Rawa Rawa Pipit, and Pulantan’s leaves.Rawa Rawa Pipit has more flavonoid than the others. Saponin component is found in Madang Pirawas, Margatahan, Alaban Timbasu, Rawa Rawa Pipit, and Pulantan’s leaves. Pulantan has more saponin than the others. Quinone component is found in Madang Pirawas, Margatahan, Alaban Timbasu, Rawa Rawa Pipit, and Pulantan’s leaves. Madang Pirawas has more quinone than the others. Steroid component is found in Margatahan, Alaban Timbasu, and Rawa Rawa Pipit’s leaves. Alaban Timbasu has more steroid than the others.Triterpenoids component is found in Margatahan, Alaban Timbasu, and Rawa Rawa Pipit’s leaves. Alaban Timbasu has more triterpenoid than the others.Tannin component is found in Madang Pirawas, Margatahan, Rawa Rawa Pipit and Pulantan’s leaves. Rawa Rawa Pipit has more tannin than the others.
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- 2020
11. PRODUKTIVITAS DAN KONTRIBUSI PETERNAKAN LEBAH MADU TERHADAP PENDAPATAN MASYARAKAT
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Rosidah R Radam
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lcsh:SD1-669.5 ,lcsh:Forestry - Abstract
Research aims to know immensity productivity honeybees and roles against earnings societys in muara pamangkih village, labuan amas sub-district. Objects in this research is farmers reaper honeybees natural as a by-product in an effort to increase family income. Productivity 5,32 a bottle of honey produced with the productivity sarang / 7 / largest phial sarang and the smallest 4.6 phial / the nest . Productivity influenced by the amount of honey bees hive bee in a colony of climate the weather , / factors source of food , the presence of despoliation food by the other bees the lack of food . A contribution to operating income , total natural honey against earnings reached 83 % . Keywords: Productivity, Contribution, Honey Bee, Revenue ABSTRAK. Penelitian ini bertujuan untuk mengetahui besarnya produktivitas lebah madu dan peranannya terhadap pendapatan masyarakat di Desa Muara Pamangkih Kecamatan Labuan Amas Utara. Objek dalam penelitian ini adalah petani penuai lebah madu alami sebagai usaha sampingan dalam upaya dalam menambah pendapatan keluarga. Produktivitas madu yang dihasilkan sebesar 5,32 botol/sarang dengan produktivitas terbesar 7 botol/sarang dan yang terkecil 4,6 botol/sarang. Produktivitas lebah madu dipengaruhi oleh besarnya sarang dalam satu koloni lebah faktor iklim/cuaca, sumber makanan, adanya perampokan makanan oleh lebah lain yang kekurangan makanan. Kontribusi pendapatan usaha madu alami terhadap pendapatan total sebesar 83 %. Kata kunci : Produktivitas, kontribusi, lebah madu, Pendapatan
- Published
- 2016
12. STUDI PRODUKTIVITAS DAN RENDEMEN INDUSTRI PENGGERGAJIAN KAYU AKASIA DAUN LEBAR (Acacia mangium Willd) DI KECAMATAN LANDASAN ULIN KOTA BANJARBARU KALIMANTAN SELATAN
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Rosidah R Radam
- Subjects
lcsh:SD1-669.5 ,lcsh:Forestry - Abstract
The activity of sawmill have been long enough done by local society because very assistive and add production socialize, some of owner of bandsaw/sawmill also make this effort as effort remain to and there is also making it as effort peripheral. Intention of this research is to know industrial and rendemen productivity of sawmill of acacia wide leaf wood (Acacia mangium Willd). The method that being used is method of direct measurement and observation in industrial location of sawmill of acacia wide leaf wood and method of direct interview and also record data that related to this research. The analyse data is productivity calculation, rendemen and waste. Productivity mean of industrial sawmill of acacia wide leaf wood is equal to 6,38 m3/day or 0,0160 m3/hours. Rendemen mean of industrial sawmill of acacia wide leaf wood is equal to 80,011%. Mean of industrial disposal of sawmill of acacia wide leaf wood is equal to 19,99% (1,62 m3), this matter is caused by a quality wood of good Acacia (not many experiencing of handicap of wood). From result of research suggested to conduct research of continuation hit influence of other factor to productivity and rendemen at acacia wide leaf wood sawmill like age, environmental work (arrange situation), and the worker education. Keyords : productivity, rendemen, waste, sawmill, acacia wide leaf wood (Acacia mangium Willd)
- Published
- 2016
13. EFFECT OF HEXANE FRACTION FROM PAPAYA (CARICA PAPAYA L.) MALE FLOWER ON CELL CYCLE OF COLON ADENOCARCINOMA (WIDR) CELL AND ITS COMBINATION INDEX WITH DOXORUBICIN
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Masfria Masfria, Rosidah R, Iksen Iksen, and Yusnita Y
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Pharmacology ,biology ,Chemistry ,Cell ,Pharmaceutical Science ,Combination index ,Fraction (chemistry) ,Cell cycle ,biology.organism_classification ,Molecular biology ,digestive system diseases ,Hexane ,chemistry.chemical_compound ,medicine.anatomical_structure ,mental disorders ,medicine ,Pharmacology (medical) ,Doxorubicin ,Colon adenocarcinoma ,Carica ,medicine.drug - Abstract
Objective: This study aimed to evaluate the effects of papaya (Carica papaya L.) male flower hexane fraction (PHF) on cell cycle of colon adenocarcinoma (WiDr) cell and its combination index (CI) with doxorubicin.Methods: Flow cytometer and the CI were used to show the PHF on cell cycle of colon adenocarcinoma (WiDr) cell and to calculate the synergism potential, respectively.Result: The result showed that the PHF giving inhibition on cell cycle of colon adenocarcinoma (WiDr) cell in G0-G1, S, G2-M phase. Furthermore, the combination of PHF with doxorubicin in colon adenocarcinoma (WiDr) cell gave a strong synergistic effect with optimal concentration of 8 μg/ml–50 nM (PHF-Doxorubicin) with the IC score lower than 1.Conclusion: This study provides evidence that PHF could be a new potential co-chemotherapeutic agent with doxorubicin on colon adenocarcinoma cell.
- Published
- 2018
14. UJI FITOKIMIA SENYAWA KIMIA AKTIF AKAR NIPAH (Nyfa Fruticans WURMB) SEBAGAI TUMBUHAN OBAT DI KALIMANTAN SELATAN
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Radam, Rosidah R, primary and Purnamasari, Erni, additional
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- 2017
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15. Chemical Compounds Of Granulated Palm Sugar Made From Sap Of Nipa Palm (Nypa Fruticans Wurmb) Growing In Three Different Places
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Radam, Rosidah R, primary, Sari, Hj. Noor Mirad, additional, and Lusyani, Hj. Lusyani, additional
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- 2016
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16. Contextualizing injury severity from occupational accident reports using an optimized deep learning prediction model.
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Khairuddin MZF, Sankaranarayanan S, Hasikin K, Abd Razak NA, and Omar R
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Background: This study introduced a novel approach for predicting occupational injury severity by leveraging deep learning-based text classification techniques to analyze unstructured narratives. Unlike conventional methods that rely on structured data, our approach recognizes the richness of information within injury narrative descriptions with the aim of extracting valuable insights for improved occupational injury severity assessment., Methods: Natural language processing (NLP) techniques were harnessed to preprocess the occupational injury narratives obtained from the US Occupational Safety and Health Administration (OSHA) from January 2015 to June 2023. The methodology involved meticulous preprocessing of textual narratives to standardize text and eliminate noise, followed by the innovative integration of Term Frequency-Inverse Document Frequency (TF-IDF) and Global Vector (GloVe) word embeddings for effective text representation. The proposed predictive model adopts a novel Bidirectional Long Short-Term Memory (Bi-LSTM) architecture and is further refined through model optimization, including random search hyperparameters and in-depth feature importance analysis. The optimized Bi-LSTM model has been compared and validated against other machine learning classifiers which are naïve Bayes, support vector machine, random forest, decision trees, and K-nearest neighbor., Results: The proposed optimized Bi-LSTM models' superior predictability, boasted an accuracy of 0.95 for hospitalization and 0.98 for amputation cases with faster model processing times. Interestingly, the feature importance analysis revealed predictive keywords related to the causal factors of occupational injuries thereby providing valuable insights to enhance model interpretability., Conclusion: Our proposed optimized Bi-LSTM model offers safety and health practitioners an effective tool to empower workplace safety proactive measures, thereby contributing to business productivity and sustainability. This study lays the foundation for further exploration of predictive analytics in the occupational safety and health domain., Competing Interests: The authors declare that they have no competing interests., (© 2024 Khairuddin et al.)
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- 2024
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17. Outdoor Inclined Plastic Column Photobioreactor: Growth, and Biochemicals Response of Arthrospira platensis Culture on Daily Solar Irradiance in a Tropical Place.
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Chrismadha T, Satya A, Satya IA, Rosidah R, Satya ADM, Pangestuti R, Harimawan A, Setiadi T, Chew KW, and Show PL
- Abstract
Implementation of outdoor photobioreactors has been challenged by an extremely oversaturated daily peak of solar irradiance. This study aims to understand the role of column size and paranet shading as well as to investigate the most convenient light control in outdoor cyanobacterial culture. The photobioreactor (PBR) consisted of plastic columns with a diameter of 12.74 cm (PBRd-20) and 31.85 cm (PBRd-50) laid outdoors and inclined at 158.22° upwards against solar radiation, while paranet shading was provided at 0%, 50%, 70%, and 90% shading capacity. A semi-continuous culture of cyanobacterium Arthrospira (Spirulina) platensis was conducted for 6 weeks with weekly monitoring of the growth parameter as well as the proximate and pigments content, while the daily irradiance and culture maximum temperature were recorded. The result shows that the column diameter of 12.74 cm had a lethal risk of 44.7% and this decreased to 10.5% by widening the column diameter to 31.85 cm. This lethal risk can be eliminated by the application of a paranet at a 50% reduction level for the column diameter of 31.85 cm and a 70% reduction level for the column diameter of 12.74 cm. The highest culture productivity of 149.03 mg/(L·day) was achieved with a PBRd-20 with 50% shading treatment, but a PBRd-50 with 90% shading treatment led to an increase in the protein and phycocyanin content by 66.7% and 14.91%, respectively.
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- 2022
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18. Factors Associated with COVID-19 among Healthcare Workers in Kedah in 2021: A Cross-Sectional Study.
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Omar R, Mahjom M, Haron NH, Mat Lazim R, and Kamal FSQ
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- Humans, Cross-Sectional Studies, SARS-CoV-2, Health Personnel, COVID-19 epidemiology, Occupational Health
- Abstract
This study aimed to examine the characteristics of HCWs infected with COVID-19 and factors associated with healthcare-associated infection. A cross-sectional study, using secondary data of COVID-19 HCW cases from a registry developed by the Occupational and Environmental Health Unit (OEHU) in Kedah State Health Department, Malaysia, was analysed using Excel and STATA version 14.0. Descriptive analysis and multiple logistic regression were conducted to identify the factors for healthcare-associated COVID-19 infection. A total of 1679 HCWs tested positive for COVID-19 between 1 January 2021 and 19 September 2021. The infection was mainly non-healthcare-associated (67.0%), with healthcare-associated cases contributing to only 33% of the cases. The significant factors associated with healthcare-associated transmission were the following: doctor (aOR = 1.433; 95% CI = 1.044, 1.968), hospital setting (aOR = 1.439; 95% CI = 1.080, 1.917), asymptomatic (aOR = 1.848; 95% CI = 1.604, 2.130), incompletely or not vaccinated (aOR = 1.400; 95% CI = 1.050, 1.866) and CT-value ≥ 30 (aOR = 2.494; 95% CI = 1.927, 3.226). Identifying factors of healthcare-associated infection would help in planning control measures preventing healthcare-associated transmission in the workplace. However, more than half of COVID-19 cases among HCWs involved non-healthcare-associated COVID-19 infection, and, thus, requires further study to identify high-risk behaviours.
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- 2022
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19. Correlation of Myc Expression with Wee1 Expression by Zanthoxylum acanthopodium in Cervical Carcinoma Histology.
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Ilyas S, Simanullang RH, Hutahaean S, Rosidah R, and Situmorang PC
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- Animals, Rats, Female, Humans, Benzo(a)pyrene, Benzopyrenes, Cell Differentiation, Protein-Tyrosine Kinases, Cell Cycle Proteins, Uterine Cervical Neoplasms drug therapy, Uterine Cervical Neoplasms genetics, Zanthoxylum
- Abstract
<b>Background and Objective:</b> Natural herbs and molecular therapy can be used to treat cervical cancer. The Myc and Wee1 control tumour cell fate and microenvironmental changes like angiogenesis activation and host immune response suppression. The study aims to know about the correlation of Myc and Wee1 expressions as a molecular therapy given by <i>Zanthoxylum acanthopodium</i>. <b>Materials and Methods:</b> There are five rat groups: Group K<sup></sup> is the untreated group, Group K<sup>+</sup> is the rats injected with benzopyrene, Group P<sub>1</sub> is the administration of <i>Zanthoxylum acanthopodium</i> 100 mg kg<sup>1</sup> b.wt., Group P<sub>2</sub> is the administration of <i>Zanthoxylum acanthopodium</i> 200 mg kg<sup>1</sup> b.wt. and Group P<sub>3</sub> is the administration of <i>Zanthoxylum acanthopodium</i> 400 mg kg<sup>1</sup> b.wt. The rats are dissected 30 days after receiving <i>Zanthoxylum acanthopodium</i>. To stain the cervical tissues, immunohistochemistry is performed. <b>Results:</b> <i>Zanthoxylum acanthopodium</i> administration caused epithelial thickening and decreased Myc expression in previously uncontrolled carcinomas from untreated malignancies, which now slowed and stopped growing into the normal epithelium. Wee1 expression revealed that this herb could repair tissue by drastically reducing Wee1 expression at a dose of 100-400 mg kg<sup>1</sup> b.wt. Similarly, at the highest dose, cervical carcinoma stops growing and the nucleus begins to form normally (p<0.01). <b>Conclusion:</b> The higher Myc expression on andaliman administration in cervical carcinoma decreases Wee1 expression in cervical carcinoma so these two proteins have a strong and significant correlation. <i>Zanthoxylum acanthopodium</i> can be administered at various dosages to lower the number of positive indexes of Myc and Wee1 expression in cervical carcinoma.
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- 2022
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20. Suppression of Wnt Expression by Increasing PI3K in Rats Cervical Carcinoma by Andaliman ( Zanthoxylum acanthopodium ).
- Author
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Ilyas S, Simanullang RH, Hutahaean S, Rosidah R, and C Situmorang P
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- Animals, Disease Models, Animal, Female, Gene Expression drug effects, Gene Expression physiology, Indonesia, Rats, Wnt Proteins therapeutic use, Uterine Cervical Neoplasms drug therapy, Wnt Proteins antagonists & inhibitors, Zanthoxylum metabolism
- Abstract
<b>Background and Objective:</b> Cervical cancer is the leading cause of death for women in the world and Indonesia. This disease originates from a malignant tumour of squamous epithelial cells caused by infection with the Human Papilloma Virus (HPV). Antioxidants can reduce oxidative stress in and there are plants from Indonesia that have high antioxidants, namely andaliman (<i>Zanthoxylum acanthopodium</i>). This study aimed to analyze the role of andaliman on PI3K and Wnt signalling in cervical cancer histology. <b>Materials and Methods:</b> The study includes 5 treatments. The control group (K-), rats cancer model (K+), rats cancer model+the dose is 100 mg/b.wt. of ZAM (P<sub>1</sub>), rats cancer model+the dose is 200 mg/b.wt. of ZAM (P<sub>2</sub>) and rats cancer model+the dosage is 400 mg/b.wt. ZAM (P<sub>3</sub>). On the 30th day after ZAM administration, the rats were dissected for the paraffin block and Wnt and PI3K immunohistochemical staining was prepared. <b>Results:</b> There was a significant difference between all groups (p<0.001) in Wnt and PI3K expression. The real role of ZAM in cervical cancer tissue was seen at the highest ZAM dose (P<sub>3</sub>). Irregular mucosal folds and stretched interstitial connective tissue in the K+ group can return to regularity and improve at the P<sub>3</sub> dose. The administration of ZAM showed a significant difference in cervical tissue after benzopyrene injection. <b>Conclusion:</b> Andaliman (<i>Zanthoxylum acanthopodium</i>) extract increases PI3K expression through suppression of Wnt expression. It can be developed therapy molecularly to prevent cell growth into cancer.
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- 2022
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21. Histological changes in placental rat apoptosis via FasL and cytochrome c by the nano-herbal Zanthoxylum acanthopodium .
- Author
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Situmorang PC, Ilyas S, Hutahaean S, and Rosidah R
- Abstract
Zanthoxylum acanthopodium has several biological activities, such as antimicrobial, anti-inflammatory, and antioxidant properties. This strong antioxidant herb can be used as a drug for hypertension. FasL and cytochrome c expression play roles in the apoptotic pathway in the placenta. This study focused on the histological change in apoptosis via cytochrome c and Fas ligand expression by investigating whether Zanthoxylum acanthopodium (ZA) fruits affect apoptosis. The present study consisted of five treatments: Normal pregnant rats (C), Hypertension rats (C + ), hypertension rats + extra virgin olive oil (EVOO) (T1), Hypertension rats + ZA (T2), and hypertension rats + EVOO + ZA (T3). Hypertension was induced in rats by injecting 3 mlml of 6% NaCl. Nanoherbal of ZA (100 mg/kg BW) and EVOO (1 ml) were given on the 13th-19th days of pregnancy. Pregnant rats were dissected on the 20th day of pregnancy by cervical dislocation. ELISA assays were performed for the analysis of HSP-70 expression. Immunohistochemistry and TUNEL assays were used to analyse the histological changes in placental tissue. The results showed that cytochrome c and FasL protein exposure levels in the labyrinth, basal, and yolk sac zones were increased during hypertensive pregnancy (P < 0.0001) in rats. The administration of nanoherbal of ZA decreased the expression of cytochrome c and FasL. A significant difference was found in the combination of nanoherbal of ZA and EVOO., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2021 The Authors.)
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- 2021
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22. Diabetic Wound Healing in FGF Expression by Nano Herbal of Rhodomyrtus tomentosa L. and Zanthoxylum acanthopodium Fruits.
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D Manurung R, Ilyas S, Hutahaean S, Rosidah R, and Situmorang PC
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- Animals, Disease Models, Animal, Immunohistochemistry methods, Indonesia, Plant Extracts pharmacology, Rats, Diabetes Complications drug therapy, Plant Extracts therapeutic use, Wounds and Injuries drug therapy, Zanthoxylum metabolism
- Abstract
<b>Background and Objective:</b> Increased glucose levels in diabetes mellitus patients affect angiogenesis which triggers the duration of the wound to heal. <i>Rhodomyrtus tomentosa</i> leaves (haramonting) and <i>Zanthoxylum acanthopodium </i>fruits (andaliman) are an endemic plant with an antioxidant in Indonesia. This study was aimed to determine histology changes of diabetic wound healing in FGF expression by Nano herbal of haramonting and andaliman. <b>Materials and Methods:</b> This study consisted of 4 groups for each treatment, K<sub>1</sub>: Negative control, K<sub>2</sub>: MEBO, K<sub>3</sub>: Nano herbal of andaliman and K<sub>4</sub>: Nano herbal of haramonting. The treatments were observed on days 0, 4, 8, 12 and 16. Diabetic model rats with alloxan injection (120 mg kg<sup>1</sup>. IP) and rats were declared diabetes mellitus when blood glucose levels reached <u>></u>200 mg dL<sup>1</sup>. The tissue was prepared on paraffin blocks and given Immunohistochemistry staining for FGF analysis. <b>Results:</b> There was a significant difference between all groups (p<0.001) in FGF expression. The proliferation of fibroblasts and collagen was formed by administering nano herbal andaliman and haramonting in rat's skin. The proliferation of cells that occur in the injured skin layer indicates the compounds contained in the nano herbal haramonting and andaliman stimulate cell division and growth to form wound tissue. <b>Conclusion:</b> Nano herbal andaliman and haramonting can be developed into herbs that can be used to treat wounds in diabetes. Another molecular gene analysis is required to get higher yields to further study for diabetic wounds against these two herbs.
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- 2021
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23. Preliminary Large Scale Mitigation of 3-Monochloropropane-1, 2-diol (3-MCPD) Esters and Glycidyl Esters in Palm Oil.
- Author
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Ramli MR, Tarmizi AHA, Hammid ANA, Razak RAA, Kuntom A, Lin SW, and Radzian R
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- Diglycerides analysis, Fatty Acids, Nonesterified analysis, Food Quality, Chemical Fractionation methods, Chlorine isolation & purification, Esters isolation & purification, Food Contamination analysis, Food Contamination prevention & control, Food Handling methods, Hot Temperature, Palm Oil chemistry, Water, alpha-Chlorohydrin isolation & purification
- Abstract
Approximately 900 tonne of crude palm oil (CPO) underwent washing using 5 to 10% hot water (90 to 95°C) at a palm oil mill. The aim of the CPO washing was to eliminate and/or reduce total chlorine content present in the conventional CPO, as it is known as the main precursor for the formation of 3-monochloropropane-1, 2-diol esters (3-MCPDE). By a simple hot water washing, more than 85% of the total chlorine was removed. However, washing did not have significant (p > 0.05) effect on other oil quality parameters such as the deterioration of bleachability index (DOBI), free fatty acid (FFA) content and diacylglycerol (DAG) content of the oil. The latter has been established as the main precursor for glycidyl esters (GE) formation. The treated CPO was then transported using tankers and further refined at a commercial refinery. Refining of washed CPO resulted in significantly (p < 0.05) lower formation of 3-MCPDE, but GE content remained slightly high. Post-treatment of refined oil significantly reduced the GE content (p < 0.05) to an acceptable level whilst almost maintaining the low 3-MCPDE level. The study has proven that water washing of CPO prior to refining and subsequent post-refining is so far the most effective way to produce good quality refined oil with considerably low 3-MCPDE and GE contents. Dry fractionation of refined palm oil showed these contaminants partitioned more into the liquid olein fraction compared to the stearin fraction.
- Published
- 2020
- Full Text
- View/download PDF
24. The Inhibitory Activity of Picria fel-terrae Lour Herbs Extract on Nitric Oxide Production toward RAW 264.7 Cells Induced by Lipopolysaccharide.
- Author
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Auliafendri N, Rosidah R, Yuandani Y, Suryani S, and Satria D
- Abstract
Aim: The objective of this study was to evaluate the inhibitory activity of Picria fel-terrae Lour on Nitric Oxide production toward RAW 264.7 cells., Methods: The extraction was obtained by maceration method using n -hexane, ethyl acetate and ethanol solvents and then nitric oxide (NO) production was obtained using Griess reagent., Results: Extract of Picria fel-terrae Lour herbs can reduce the NO production toward RAW 264.7 cells with induced by lipopolysaccharide has obtained nitric concentrations 12.5 and 25 μg/mL from n -hexane extract (72.50 ± 4.51 and 10.42 ± 1.82), ethyl acetate extract: (88.33 ± 6.51 and 30.83 ± 6.86), ethanol extract: (75.00 ± 1.91 and 22.08 ± 2.53)., Conclusion: n -hexane extract of Picria fel-terrae Lour Herbs has a high potential to reduce the NO production in LPS-stimulated RAW 264.7 cells compared to ethyl acetate and ethanol extracts of Picria fel-terrae Lour Herbs., (Copyright: © 2019 Novycha Auliafendri, Rosidah Rosidah, Yuandani Yuandani, Sri Suryani, Denny Satria.)
- Published
- 2019
- Full Text
- View/download PDF
25. Evaluation of Cytotoxic Activity Alkaloid Fractions of Zanthoxylum acanthopodium DC. Fruits.
- Author
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Syari DM, Rosidah R, Hasibuan PAZ, Haro G, and Satria D
- Abstract
Aim: This study was carried out to investigate cytotoxic activity towards T47D, 4T1, MCF-7, HeLa, and Raji cells of alkaloid fractions of Zanthoxylum acanthopodium DC. fruits. Zanthoxylum acanthopodium DC., Methods: The fruit was extracted by maceration. The ethanol extract was fractionated with liquid-liquid extraction using n-hexane, chloroform at pH 3, 7, and 9 to obtained alkaloid fractions. Cytotoxic activity for fraction chloroform at pH 7 and 9 was determined with MTT assay., Results: The IC
50 of fraction chloroform at pH 7 and 9 was (92.67 ± 1.37; 71.87 ± 1.04; 159.87 ± 0.63; 123.39 ± 0.81; and 103.09 ± 0.58 µg/mLfor pH 7) and (451.29 ± 25.48; 247.18 ± 2.82; 318.46 ± 5.40; 303.96 ± 8.75; and 181.45 ± 1.35 µg/mL for pH 9) respectively., Conclusion: The results reveal that alkaloid fractions at pH 7 and 9 of Zanthoxylum acanthopodium DC. Fruits have cytotoxic activity. Our further study is to isolate and assesses anticancer activity from alkaloid compounds., (Copyright: © 2019 Dina Maya Syari, Rosidah Rosidah, Poppy Anjelisa Zaitun Hasibuan, Ginda Haro, Denny Satria.)- Published
- 2019
- Full Text
- View/download PDF
26. Effect of Nanoherbal Andaliman (Zanthoxylum acanthopodium) and Extra Virgin Olive Oil Combination on Preeclamptic Rats Liver Histology.
- Author
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Situmorang PC, Ilyas S, Hutahaean S, and Rosidah R
- Abstract
Background: Andaliman ( Zanthoxylum acanthopodium ) is a spice traditional Northen Sumatera, Indonesia and these fruits contain alkaloids, steroids and terpenoids. Extra Virgin Olive Oil (EVOO) contains antioxidants. Combination of this plant have activities to reduce preeclampsia., Aim: To know the safety of the combination of nano herbal andaliman and Extra virgin olive oil (EVOO) on preeclampsia patients' liver., Methods: Pregnant rats were made to have preeclampsia with 3 ml of NaCl 6% injections. This research consists of 5 groups: K- (negative control): normal pregnant rats, K+: preeclampsia rats; P1: PE rats were given nano herbal andaliman 1 ml EVOO / day / 20 gBW from the 13th to the 19th day of pregnancy, P2: PE rats were given nano herbal andaliman 100 mg/day / 200 gBW from the 13th to the 19th day of pregnancy, P3: PE was given the combination of 1 ml EVOO/day / 200 gBW and andaliman nano herbal 100 mg/day/200 gBW on the 13th day of pregnancy to the 19th day given orally. Then on the 20th day of pregnancy, the subjects were dissected., Results: There were significant differences (p < 0.05) on the value of SGOT, SGPT, and the average damage of the hepatocyte cells except parenchymatous degeneration after being given the nano herbal andaliman and EVOO. The compared mean of normal hepatocytes cell, hydropic degeneration and necrosis value between all groups were p < 0.05 and p < 0.01 compared to (K-). The non-significant difference was found in the mean of parenchymatous degeneration between the groups (p = 0.058)., Conclusion: The combination of nano herbal andaliman ( Zanthoxylum acanthopodium ) and EVOO affected the level of necrosis in hepatocyte cells on preeclampsia rats., (Copyright: © 2019 Putri Cahaya Situmorang, Syafruddin Ilyas, Salomo Hutahaean, Rosidah Rosidah.)
- Published
- 2019
- Full Text
- View/download PDF
27. Pullout strength of cancellous screws in human femoral heads depends on applied insertion torque, trabecular bone microarchitecture and areal bone mineral density.
- Author
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Ab-Lazid R, Perilli E, Ryan MK, Costi JJ, and Reynolds KJ
- Subjects
- Aged, Aged, 80 and over, Biomechanical Phenomena physiology, Female, Femur Head surgery, Humans, Male, Middle Aged, Radiography, Torque, Bone Density physiology, Bone Screws, Femur Head diagnostic imaging
- Abstract
For cancellous bone screws, the respective roles of the applied insertion torque (TInsert) and of the quality of the host bone (microarchitecture, areal bone mineral density (aBMD)), in contributing to the mechanical holding strength of the bone-screw construct (FPullout), are still unclear. During orthopaedic surgery screws are tightened, typically manually, until adequate compression is attained, depending on surgeons' manual feel. This corresponds to a subjective insertion torque control, and can lead to variable levels of tightening, including screw stripping. The aim of this study, performed on cancellous screws inserted in human femoral heads, was to investigate which, among the measurements of aBMD, bone microarchitecture, and the applied TInsert, has the strongest correlation with FPullout. Forty six femoral heads were obtained, over which microarchitecture and aBMD were evaluated using micro-computed tomography and dual X-ray absorptiometry. Using an automated micro-mechanical test device, a cancellous screw was inserted in the femoral heads at TInsert set to 55% to 99% of the predicted stripping torque beyond screw head contact, after which FPullout was measured. FPullout exhibited strongest correlations with TInsert (R=0.88, p<0.001), followed by structure model index (SMI, R=-0.81, p<0.001), bone volume fraction (BV/TV, R=0.73, p<0.001) and aBMD (R=0.66, p<0.01). Combinations of TInsert with microarchitectural parameters and/or aBMD did not improve the prediction of FPullout. These results indicate that, for cancellous screws, FPullout depends most strongly on the applied TInsert, followed by microarchitecture and aBMD of the host bone. In trabecular bone, screw tightening increases the holding strength of the screw-bone construct., (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
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