1. Direct Comparison of [18F]F-DPA with [18F]DPA-714 and [11C]PBR28 for Neuroinflammation Imaging in the same Alzheimer's Disease Model Mice and Healthy Controls.
- Author
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López-Picón, Francisco R., Keller, Thomas, Bocancea, Diana, Helin, Jatta S., Krzyczmonik, Anna, Helin, Semi, Damont, Annelaure, Dollé, Frédéric, Rinne, Juha O., Haaparanta-Solin, Merja, and Solin, Olof
- Subjects
RADIOACTIVE tracers ,ALZHEIMER'S disease ,MEDICAL model ,ANIMAL disease models ,NEUROINFLAMMATION ,LABORATORY mice ,BIOLOGICAL models ,ANIMAL experimentation ,INFLAMMATION ,CEREBELLUM ,POSITRON emission tomography ,MICE - Abstract
Purpose: In this study we compared the recently developed TSPO tracer [
18 F]F-DPA, with [18 F]DPA-714 and [11 C]PBR28 by performing in vivo PET imaging on the same Alzheimer's disease mouse model APP/PS1-21 (TG) and wild-type (WT) mice with all three radiotracers. Procedures: To compare the radiotracer uptake, percentage of injected dose/mL (%ID/mL), standardized uptake value ratios to cerebellum (SUVRCB ), and voxel-wise analyses were performed. Results: The peak uptake of [18 F]F-DPA was higher than 4.3% ID/mL, while [18 F]DPA-714 reached just over 3% ID/mL, and [11 C]PBR28 was over 4% ID/mL in only one brain region in the WT mice. The peak/60-min uptake ratios of [18 F]F-DPA were significantly higher (p < 0.001) than those of [18 F]DPA-714 and [11 C]PBR28. The differences in [18 F]F-DPA SUVRCB between WT and TG mice were highly significant (p < 0.001) in the three studied time periods after injection. [18 F]DPA-714 uptake was significantly higher in TG mice starting in the 20–40-min timeframe and increased thereafter, whereas [11 C]PBR28 uptake became significant at 10–20 min (p < 0.05). The voxel-wise analysis confirmed the differences between the radiotracers. Conclusions: [18 F]F-DPA displays higher brain uptake, higher TG-to-WT SUVRCB ratios, and faster clearance than [18 F]DPA-714 and [11 C]PBR28, and could prove useful for detecting low levels of inflammation and allow for shorter dynamic PET scans. [ABSTRACT FROM AUTHOR]- Published
- 2022
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