1. Quercetin Prevents Radiation-Induced Oral Mucositis by Upregulating BMI-1
- Author
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Hai Liu, Yiyang Hong, Guanyu Wang, Haozhe Li, Xingjian Dong, Jingjing Tao, Anyong Xie, Yili Feng, Yihong Wang, Zhenyu Liuyang, Qinghua Dong, Jing Zhang, and Zhongyang Jiang
- Subjects
Aging ,Antioxidant ,Article Subject ,medicine.medical_treatment ,Flavonoid ,Pharmacology ,Biochemistry ,Antioxidants ,Proinflammatory cytokine ,Mice ,Random Allocation ,chemistry.chemical_compound ,Proto-Oncogene Proteins ,medicine ,Mucositis ,Animals ,Humans ,heterocyclic compounds ,Polycomb Repressive Complex 1 ,chemistry.chemical_classification ,Stomatitis ,QH573-671 ,business.industry ,Cancer ,Cell Biology ,General Medicine ,medicine.disease ,Up-Regulation ,Mice, Inbred C57BL ,Radiation therapy ,Radiation Injuries, Experimental ,chemistry ,Female ,Quercetin ,Cytology ,Wound healing ,business ,Research Article - Abstract
Radiation-induced oral mucositis is a major adverse event of radiotherapy. Severe oral mucositis may cause unwanted interruption in radiotherapy and reduce long-term survival in cancer patients receiving radiotherapy, but until now, there have been no effective options for preventing radiation-induced oral mucositis. Quercetin is a flavonoid that is widely found in food species and has anti-inflammatory, antioxidant, and anticancer activities. In this study, we investigated a new role of quercetin in preventing radiation-induced oral mucositis. Quercetin exerted preventive effects against radiation-induced oral mucositis induced by single-dose (25 Gy) ionizing radiation or fractionated ionizing radiation ( 8 Gy × 3 ) in C57BL/6 mice and maintained the proliferation ability of basal epithelial cells. Quercetin pretreatment alleviated reactive oxygen species generation, NF-κB pathway activation, and downstream proinflammatory cytokine production and reduced DNA double-strand breaks and cellular senescence induced by ionizing radiation. Quercetin also upregulated BMI-1 expression in oral epithelial cells and promoted ulcer repair. In addition, quercetin exerted similar radioprotective effects in irradiated primary cultured normal human keratinocytes, reduced reactive oxygen species generation and proinflammatory cytokine release, and promoted DNA double-strand break repair and wound healing by upregulating the expression of BMI-1, which is a polycomb group protein. Thus, quercetin can block multiple pathological processes of radiation-induced oral mucositis by targeting BMI-1 and may be a potential treatment option for preventing radiation-induced oral mucositis.
- Published
- 2021