1. Fecal Fatty Acid Profiling as a Potential New Screening Biomarker in Patients with Colorectal Cancer.
- Author
-
Song, Eun Mi, Byeon, Jeong-Sik, Lee, Sun Mi, Yoo, Hyun Ju, Kim, Su Jung, Lee, Sun-Ho, Chang, Kiju, Hwang, Sung Wook, Yang, Dong-Hoon, and Jeong, Jin-Yong
- Subjects
- *
COLON cancer patients , *TUMOR markers , *FATTY acids , *FECAL analysis , *MEDICAL screening , *METABOLOMICS , *COLON tumors , *COMPARATIVE studies , *FECES , *GAS chromatography , *LONGITUDINAL method , *MASS spectrometry , *MEDICAL cooperation , *METABOLISM , *RESEARCH , *LOGISTIC regression analysis , *PILOT projects , *EVALUATION research , *CASE-control method , *EARLY detection of cancer , *DIAGNOSIS ,RECTUM tumors - Abstract
Background: The fatty acid profile of the fecal metabolome and its association with colorectal cancer (CRC) has not been fully evaluated.Aims: We aimed to compare the fecal fatty acid profiles of CRC patients and healthy controls.Methods: We enrolled 26 newly diagnosed CRC patients and 28 healthy individuals between July 2014 and August 2014 from our institute. Long- and short-chain fatty acids were extracted from fecal samples and analyzed using gas chromatography-mass spectrometry.Results: Regarding fecal long-chain fatty acids, the levels of total ω-6 polyunsaturated fatty acids and, particularly, of linoleic acid (C18:2ω-6) were significantly higher in male CRC patients than in healthy men (2.750 ± 2.583 vs. 1.254 ± 0.966 µg/mg feces, P = 0.040; 2.670 ± 2.507 vs. 1.226 ± 0.940 µg/mg feces, P = 0.034, respectively). In addition, the levels of total monounsaturated fatty acid and, particularly, of oleic acid (C18:1ω-9) were significantly higher in male CRC patients than in healthy men (1.802 ± 1.331 vs. 0.977 ± 0.625 µg/mg feces, P = 0.027; 1.749 ± 1.320 vs. 0.932 ± 0.626 µg/mg feces, P = 0.011, respectively). However, those differences were not shown in female gender. The level of fecal short-chain fatty acids was not different between CRC patients and healthy controls.Conclusions: There were changes in the profiles of fecal fatty acid metabolomes in CRC patients compared to healthy controls, implying that fecal fatty acids could be used as a novel screening tool for CRC. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF