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3. Relationship between clinical-epidemiological parameters and outcomes of patients with COVID-19 admitted to the intensive care unit: a report from a Brazilian hospital

Author

D’Carmo Sodré, Maisah Meyhr, primary, dos Santos, Uener Ribeiro, additional, Povoas, Heitor Portella, additional, Guzmán, Júlio Lenin, additional, Junqueira, Caroline, additional, Trindade, Tayana Oliveira, additional, Gadelha, Sandra Rocha, additional, Romano, Carla Cristina, additional, da Conceição, Aline Oliveira, additional, Gross, Eduardo, additional, Silva, Aline, additional, Rezende, Rachel Passos, additional, Fontana, Renato, additional, da Mata, Camila Pacheco Silveira Martins, additional, Marin, Lauro Juliano, additional, and de Carvalho, Luciana Debortoli, additional

Published
2023
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4. SARS-CoV-2 Infection in Cities from the Southern Region of Bahia State, Brazil: Analysis of Variables Associated in Both Individual and Community Level

Author

da Silva, Murillo Ferreira, primary, dos Santos, Uener Ribeiro, additional, Ferreira, Fabrício Barbosa, additional, Albuquerque, George Rego, additional, Mariano, Ana Paula Melo, additional, Fehlberg, Hllytchaikra Ferraz, additional, Santos de Santana, Íris Terezinha, additional, dos Santos, Pérola Rodrigues, additional, Santos, Luciano Cardoso, additional, Silva de Jesus, Laine Lopes, additional, Piton, Karoline Almeida, additional, Costa, Beatriz Santos, additional, Gomes, Beatriz Sena Moreira, additional, Porto, Vinicius Moreira, additional, Oliveira, Emanuelly da Silva, additional, Oliveira, Cibele Luz, additional, Fontana, Renato, additional, Maciel, Bianca Mendes, additional, Silva, Mylene de Melo, additional, Marin, Lauro Juliano, additional, and Gadelha, Sandra Rocha, additional

Published
2023
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5. Ex-vivo mucolytic and anti-inflammatory activity of BromAc in tracheal aspirates from COVID-19

Author

Coelho dos Reis, Jordana Grazziela A., primary, Ferreira, Geovane Marques, additional, Lourenço, Alice Aparecida, additional, Ribeiro, Ágata Lopes, additional, da Mata, Camila Pacheco da Silveira Martins, additional, de Melo Oliveira, Patrícia, additional, Marques, Daisymara Priscila de Almeida, additional, Ferreira, Linziane Lopes, additional, Clarindo, Felipe Alves, additional, da Silva, Murillo Ferreira, additional, Filho, Heitor Portella Póvoas, additional, Oliveira, Nilson Roberto Ribeiro, additional, Sodré, Maisah Meyhr D’Carmo, additional, Gadelha, Sandra Rocha, additional, Albuquerque, George Rego, additional, Maciel, Bianca Mendes, additional, Mariano, Ana Paula Melo, additional, Silva, Mylene de Melo, additional, Fontana, Renato, additional, Marin, Lauro Juliano, additional, Carlos, Renata Santiago Alberto, additional, Lopes, Amanda Teixeira Sampaio, additional, Ferreira, Fabrício Barbosa, additional, dos Santos, Uener Ribeiro, additional, Santana, Íris Terezinha Santos de, additional, Fehlberg, Hllytchaikra Ferraz, additional, Rezende, Rachel Passos, additional, Dias, João Carlos T., additional, Gross, Eduardo, additional, Goulart, Gisele Assis Castro, additional, Santiago, Marie Gabriele, additional, de Lemos, Ana Paula Motta Lavigne, additional, da Conceição, Aline O., additional, Romano, Carla Cristina, additional, de Carvalho, Luciana Debortoli, additional, Filho, Olindo Assis Martins, additional, Quadros, Claudio Almeida, additional, Morris, David L., additional, and Valle, Sarah J., additional

Published
2022
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6. Ex-vivo mucolytic and anti-inflammatory activity of BromAc in tracheal aspirates from COVID-19

Author

Coelho dos Reis, Jordana Grazziela A., primary, Marques Ferreira, Geovane, additional, Aparecida Lourenco, Alice, additional, Lopes Ribeiro, Agata, additional, Pacheco da Silveira Martins da Mata, Camila, additional, de Melo Oliveira, Patricia, additional, de Almeida Marques, Daisymara Priscila, additional, Lopes Ferreira, Linziane, additional, Alves Clarindo, Felipe, additional, Ferreira da Silva, Murillo, additional, Portella Povoas Filho, Heitor, additional, Ribeiro Oliveira, Nilson Roberto, additional, Meyhr D Carmo Sodre, Maisah, additional, Rocha Gadelha, Sandra, additional, Albuquerque, George Rego, additional, Mendes Maciel, Bianca, additional, Melo Mariano, Ana Paula, additional, de Melo Silva, Mylene, additional, Fontana, Renato, additional, Marin, Lauro Juliano, additional, Santiago Alberto Carlos, Renata, additional, Teixeira Sampaio Lopes, Amanda, additional, Barbosa Ferreira, Fabricio, additional, Ribeiro dos Santos, Uener, additional, Santos de Santana, Iris Terezinha, additional, Ferraz Fehlberg, Hllytchaikra, additional, Passos Rezende, Rachel, additional, Dias, Joao Carlos T, additional, Gross, Eduardo, additional, Castro Goulart, Gisele Assis, additional, Santiago, Marie Gabriele, additional, Motta Lavigne de Lemos, Ana Paula, additional, da Conceicao, Aline O, additional, Romano, Carla Cristina, additional, Debortoli de Carvalho, Luciana, additional, Martins Filho, Olindo Assis, additional, Quadros, Claudio Almeida, additional, Valle, Sarah J, additional, and Morris, David L, additional

Published
2021
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7. Prenatal is Still Neglected in Resource-Limited Areas despite the Use of Tests That Optimize the Diagnosis of Infectious Diseases in Brazil

Author

Gadelha Sandra Rocha, Purificacao Antônio Conceicao da, Sorte Ney Cristian Amaral Boa, Santos Beneli Miranda dos, Bastos Raquel Gois, Costa Galileu Barbosa, Vaz Sara Nunez, Galvao-Castro Bernardo, and Marin Lauro Juliano

Subjects
medicine.medical_specialty, business.industry, Medicine, business, Intensive care medicine, Limited resources
Published
2020

12. The origin of HTLV-1 in southern Bahia by phylogenetic, mtDNA and β-globin analysis

Author

Aleluia, Milena Magalhães, primary, Mello, Marco Antônio Gomes, additional, Alcântara, Luiz Carlos Junior, additional, Rego, Filipe Ferreira Almeida, additional, de Souza Santos, Lucas Pereira, additional, Galvão-Castro, Bernardo, additional, de Souza Gonçalves, Marilda, additional, de Oliveira, Túlio, additional, Marin, Lauro Juliano, additional, Sousa, Sandra Mara Bispo, additional, and Gadelha, Sandra Rocha, additional

Published
2015
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14. The use of qualitative and quantitative polymerase chain reactions for diagnosis of cytomegalovirus infections in bone marrow and kidney transplant recipients

Author

Marin, Lauro Juliano, Cunha, Aldo Albuquerque, Aquino, Victor Hugo, and Figueiredo, Luiz Tadeu Moraes

Subjects
Quantitative PCR, Bone marrow transplant, Qualitative PCR, PCR qualitativa, Transplantados de rim, virus diseases, PCR quantitativa, Transplantados de medula óssea, Kidney transplant, CMV infection, Infecção por CMV
Abstract

The purpose of this work was to test a cytomegalovirus qualitative PCR and a semi-quantitative PCR on the determination of CMV load in leukocytes of bone marrow and kidney transplanted (RT) patients. Thirty three BMT and 35 RT patients participated of the study. The DNA was subjected to a qualitative PCR using primers that amplify part of CMV gB gene. CMV load of positive samples was determined by a semi-quantitative PCR using quantified plasmids inserted with part of the gB gene of CMV as controls. The sensitivity of the test was determined to be 867 plasmid copies/µg DNA. CMV loads between 2,118 and 72,443 copies/µg DNA were observed in 12.1% BMT recipients and between 1,246 and 58,613 copies/µg DNA in 22.9% RT recipients. Further studies are necessary to confirm the usefulness of this CMV semi-quantitative PCR in transplanted patients. O objetivo deste trabalho foi testar uma PCR qualitativa e uma PCR semiquantitativa para CMV para determinar a carga de CMV nos leucócitos de pacientes transplantados de medula óssea e transplantados de rim. Trinta e três pacientes TMO e 35 TR participaram deste estudo. O DNA foi testado pela PCR qualitativa utilizando primers que amplificam parte do gene gB de CMV. As cargas de CMV das amostras positivas foram determinadas pela PCR semi-quantitativa utilizando como controle plasmídios quantificáveis inseridos com parte do gene gB de CMV. A sensibilidade do teste foi de 867 plamídios/µg DNA. Cargas de CMV entre 2.118 e 72.443 copias/µg DNA foram observadas em 12,1% dos TMO entre 1,246 e 58,613 cópias/µg DNA foram observadas em 22,9% dos TR. Futuros estudos, com maiores casuísticas são necessários para confirmar a utilidade desta PCR semiquantitativa para CMV em pacientes transplantados.

Published
2004

15. HTLV-1 in pregnant women from the Southern Bahia, Brazil: a neglected condition despite the high prevalence

Author

Mello, Marco Antônio Gomes, primary, da Conceição, Aline Ferreira, additional, Sousa, Sandra Mara Bispo, additional, Alcântara, Luiz Carlos, additional, Marin, Lauro Juliano, additional, Regina da Silva Raiol, Mônica, additional, Boa-Sorte, Ney, additional, Santos, Lucas Pereira Souza, additional, de Almeida, Maria da Conceição Chagas, additional, Galvão, Tâmara Coutinho, additional, Bastos, Raquel Gois, additional, Lázaro, Noilson, additional, Galvão-Castro, Bernardo, additional, and Gadelha, Sandra Rocha, additional

Published
2014
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16. Diagnosis of cytomegalovirus infections by qualitative and quantitative PCR in HIV infected patients

Author

CUNHA, Aldo de Albuquerque, MARIN, Lauro Juliano, AQUINO, Victor Hugo, and FIGUEIREDO, Luiz Tadeu Moraes

Subjects
HIV patients, CMV, Semiquantitative PCR, virus diseases
Abstract

A high incidence of cytomegalovirus (CMV) infections is observed in Brazil. These viruses are causatives of significant morbidity and mortality among patients with advanced human immunodeficiency virus (HIV) infection. This work, shows the application of a PCR on determination of CMV load in the buffy coat and plasma. We analyzed the samples of 247 HIV infected patients in order to diagnose CMV infection and disease. We developed a semi-quantitative PCR that amplifies part of the glycoprotein B (gB) gene of CMV. The semi-quantitative PCR was carried out only in positive clinical samples in a qualitative PCR confirmed by a nested-PCR. CD4 lymphocyte count, HIV viral load and CMV disease symptom were correlated with CMV load. CMV genome was detected in the buffy coat of 82 of 237 (34.6%) patients, in 10 of these the CMV load was determined varying between 928 and 332 880 viral copies/mug DNA. None of these 237 patients developed any suggestive manifestation of CMV disease. For the other 10 HIV infected patients selected based on the suspicion of CMV disease, CMV genome was detected in only one case. This patient presented a high CMV load, 8 000 000 copies/mug DNA, and developed a disseminated form of CMV disease including hepatitis and retinitis. Our results were greatly influenced by the impact of the highly active antiretroviral therapy that reduced incidence of CMV viremia and occurrence of CMV disease in the HIV infected patients. Uma alta incidência de infecção pelo citomegalovirus (CMV) é observada no Brasil. Este vírus é responsável por significante morbi-mortalidade entre pacientes infectados pelo vírus da imunodeficiência humana (HIV). Neste estudo, mostramos a aplicação de uma PCR quantitativa para determinar a carga de CMV nos leucócitos do sangue periférico e no plasma de 247 pacientes infectados pelo HIV. As amostras clínicas foram previamente testadas por uma PCR qualitativa e confirmadas por uma nested-PCR para posteriormente serem quantificados. Contagem de linfócitos T CD4, carga viral do HIV e sintomas de doença citomegálica foram correlacionados com carga de CMV. O genoma de CMV foi detectado nos leucócitos do sangue periférico em 82 de um total de 237 (34%) pacientes, em 10 destes a carga de CMV foi detectada variando de 928 a 332880 cópias virais/mig de DNA. Nenhum destes 237 pacientes desenvolveu manifestação clínica sugestiva de doença pelo citomegalovírus. Para outro grupo de 10 pacientes infectados pelo HIV e selecionados com base na suspeita de doença pelo CMV, o genoma do CMV foi detectado em apenas um caso. Este paciente apresentava alta carga de CMV (8 000 000 de cópias virais/mig de DNA), desenvolvendo forma disseminada de doença pelo CMV o que incluiu hepatite e retinite. Nossos resultados foram fortemente influenciados pelo impacto da terapia antiretroviral que reduziu a incidência da viremia por CMV, bem como a ocorrência de doença citomegálica em pacientes infectados pelo HIV.

Published
2002

19. HTLV-1 in pregnant women from the Southern Bahia, Brazil: a neglected condition despite the high prevalence.

Author

Gomes Mello, Marco Antônio, da Conceição, Aline Ferreira, Bispo Sousa, Sandra Mara, Alcântara, Luiz Carlos, Marin, Lauro Juliano, da Silva Raiol, Mônica Regina, Boa-Sorte, Ney, Souza Santos, Lucas Pereira, da Conceição Chagas de Almeida, Maria, Galvão, Tâmara Coutinho, Bastos, Raquel Gois, Lázaro, Noilson, Galvão-Castro, Bernardo, and Gadelha, Sandra Rocha

Subjects
HTLV-I, DISEASES in women, IMMUNOGLOBULINS, SEROPREVALENCE, WESTERN immunoblotting
Abstract

Background As the most frequent pathway of vertical transmission of HTLV-1 is breast-feeding, and considering the higher prevalence in women, it is very important to perform screening examinations for anti-HTLV-1 antibodies as part of routine prenatal care. So far, no studies of HTLV-1 seroprevalence in pregnant women in the Southern region of Bahia, Brazil, have been described. Methods Pregnant women were selected at the two regional reference centers for health care from Southern Bahia. A total of 2766 pregnant women attending the antenatal unit between November 2008 and May 2010 have been analyzed. An extra blood sample was drawn during their routine antenatal testing. A standardized questionnaire was applied and all positive plasma samples were tested by ELISA and were confirmed by Western Blot and PCR. Besides that, positive women were contacted and visited. The family members that were present during the visit were asked to be serologically screened to the virus. A prospective study was also carried out and newborns were followed up to two years for evaluation of vertical transmission. Results HTLV prevalence was 1.05% (CI95%:0.70-1.50). There was no association of HTLV-1 infection with age, education, income and ethnic differences. The association with marital status was borderline (OR = 7.99; 95%CI 1.07-59.3; p = 0.042). In addition, 43 family members of the HTLV-1 seropositive women have been analyzed and specific reactivity was observed in 32.56%, including two children from previous pregnancy. Conclusion: It is very important to emphasize that the lack of HTLV-1 screening in pregnant women can promote HTLV transmission especially in endemic areas. HTLV screening in this vulnerable population and the promotion of bottle-feeding for children of seropositive mothers could be important cost-effective methods to limit the vertical transmission. Besides that, our data reinforce the need to establish strategies of active surveillance in household and family contacts as important epidemiological surveillance actions for the early detection of virus infection and the prevention of transmission by sexual or and parenteral contact. [ABSTRACT FROM AUTHOR]

Published
2014
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21. Relationship between clinical-epidemiological parameters and outcomes of patients with COVID-19 admitted to the intensive care unit: a report from a Brazilian hospital.

Author

D'Carmo Sodré MM, Dos Santos UR, Povoas HP, Guzmán JL, Junqueira C, Trindade TO, Gadelha SR, Romano CC, da Conceição AO, Gross E, Silva A, Rezende RP, Fontana R, da Mata CPSM, Marin LJ, and de Carvalho LD

Subjects
Humans, Brazil epidemiology, SARS-CoV-2, COVID-19 Drug Treatment, Cross-Sectional Studies, Intensive Care Units, Hospitals, COVID-19 epidemiology
Abstract

Background: People in low-income countries, especially those with low socio-economic conditions, are likelier to test positive for SARS-CoV-2. The unequal conditions of public health systems also increase the infection rate and make early identification and treatment of at-risk patients difficult. Here, we aimed to characterize the epidemiological profile of COVID-19 patients in intensive care and identify laboratory and clinical markers associated with death., Materials and Methods: We conducted an observational, descriptive, and cross-sectional study in a reference hospital for COVID-19 treatment in the Southern Region of Bahia State, in Brazil, to evaluate the epidemiological, clinical, and laboratory characteristics of COVID-19 patients admitted to the intensive care unit (ICU). Additionally, we used the area under the curve (AUC) to classify survivors and non-survivors and a multivariate logistic regression analysis to assess factors associated with death. Data was collected from the hospital databases between April 2020 and July 2021., Results: The use of bladder catheters (OR 79.30; p  < 0.0001) and central venous catheters (OR, 45.12; p  < 0.0001) were the main factors associated with death in ICU COVID-19 patients. Additionally, the number of non-survivors increased with age ( p  < 0.0001) and prolonged ICU stay ( p  < 0.0001). Besides, SAPS3 presents a higher sensibility (77.9%) and specificity (63.1%) to discriminate between survivors and non-survivor with an AUC of 0.79 ( p  < 0.0001)., Conclusion: We suggest that multi-laboratory parameters can predict patient prognosis and guide healthcare teams toward more assertive clinical management, better resource allocation, and improved survival of COVID-19 patients admitted to the ICU., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 D’Carmo Sodré, dos Santos, Povoas, Guzmán, Junqueira, Trindade, Gadelha, Romano, da Conceição, Gross, Silva, Rezende, Fontana, da Mata, Marin and de Carvalho.)

Published
2023
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22. The use of saliva as a practical and feasible alternative to urine in large-scale screening for congenital cytomegalovirus infection increases inclusion and detection rates.

Author

Cardoso ES, Jesus BL, Gomes LG, Sousa SM, Gadelha SR, and Marin LJ

Subjects
Cytomegalovirus genetics, DNA, Viral analysis, Humans, Infant, Newborn, Polymerase Chain Reaction, Reproducibility of Results, Sensitivity and Specificity, Cytomegalovirus isolation & purification, Cytomegalovirus Infections congenital, Cytomegalovirus Infections diagnosis, Neonatal Screening methods, Saliva virology, Urine virology
Abstract

Introduction: Although urine is considered the gold-standard material for the detection of congenital cytomegalovirus (CMV) infection, it can be difficult to obtain in newborns. The aim of this study was to compare the efficiency of detection of congenital CMV infection in saliva and urine samples., Methods: One thousand newborns were included in the study. Congenital cytomegalovirus deoxyribonucleic acid (DNA) was detected by polymerase chain reaction (PCR)., Results: Saliva samples were obtained from all the newborns, whereas urine collection was successful in only 333 cases. There was no statistically significant difference between the use of saliva alone or saliva and urine collected simultaneously for the detection of CMV infection., Conclusions: Saliva samples can be used in large-scale neonatal screening for CMV infection.

Published
2015
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