1. Cathepsin K activity controls cachexia‐induced muscle atrophy via the modulation of IRS1 ubiquitination
- Author
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Xiangkun Meng, Zhe Huang, Aiko Inoue, Hailong Wang, Ying Wan, Xueling Yue, Shengnan Xu, Xueying Jin, Guo‐Ping Shi, Masafumi Kuzuya, and Xian Wu Cheng
- Subjects
Male ,Carcinoma, Lewis Lung ,Mice ,Muscular Atrophy ,Cachexia ,Physiology (medical) ,Cathepsin K ,Insulin Receptor Substrate Proteins ,Ubiquitination ,Animals ,Orthopedics and Sports Medicine - Abstract
Cachexia is a complicated metabolic disorder that is characterize by progressive atrophy of skeletal muscle. Cathepsin K (CTSK) is a widely expressed cysteine protease that has garnered attention because of its enzymatic and non-enzymatic functions in signalling in various pathological conditions. Here, we examined whether CTSK participates in cancer-induced skeletal muscle loss and dysfunction, focusing on protein metabolic imbalance.Male 9-week-old wild-type (CTSKCTSKThese results demonstrate that CTSK plays a novel role in IRS1 ubiquitination in LLC-induced muscle wasting, and suggest that CTSK could be an effective therapeutic target for cancer-related cachexia.
- Published
- 2022