1. Salicylaldehyde derivatives from a marine-derived fungus Eurotium sp. SCSIO F452.
- Author
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Zhong W, Chen Y, Wei X, Wang J, Zhang W, Wang F, and Zhang S
- Subjects
- Aldehydes metabolism, Antioxidants chemistry, Aquatic Organisms, Circular Dichroism, Drug Evaluation, Preclinical, Hep G2 Cells, Humans, Magnetic Resonance Spectroscopy, Molecular Structure, Spectrometry, Mass, Electrospray Ionization, Stereoisomerism, Aldehydes chemistry, Aldehydes pharmacology, Antioxidants pharmacology, Eurotium chemistry
- Abstract
Two pairs of new salicylaldehyde derivative enantiomers, salicylaldehydiums A and B (1 and 2), along with five known analogues were isolated and identified from a marine-derived fungus Eurotium sp. SCSIO F452. Their structures and absolute configuration were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. All the new optical pure enantiomers [(+)-1, (-)-1, (+)-2, (-)-2] were evaluated for their cytotoxic and antioxidative activities. Compound (-)-1 exhibited weak cytotoxic activity.
- Published
- 2021
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