1. Investigation of aflatoxins contamination in herbal materia medica in a Taiwan pharmaceutical factory
- Author
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Chih-Min Yang, Chao-Hsiang Chen, Mei-Yin Chien, and Chih-Min Huang
- Subjects
0301 basic medicine ,Aflatoxin ,030106 microbiology ,Polygalae radix ,Materia medica ,Taiwan ,lcsh:TX341-641 ,Semen ,Nelumbinis Semen ,Coicis Semen ,03 medical and health sciences ,Aflatoxins ,Medicine ,Chromatography, High Pressure Liquid ,Pharmacology ,Plants, Medicinal ,biology ,Traditional medicine ,business.industry ,lcsh:RM1-950 ,Corydalis ,Contamination ,biology.organism_classification ,lcsh:Therapeutics. Pharmacology ,030104 developmental biology ,Materia Medica ,business ,Drug Contamination ,lcsh:Nutrition. Foods and food supply ,Food Science - Abstract
During the years 2005–2016, a total of 1067 samples for 24 types of herbal materia medica were investigated for the presence of aflatoxins (AFs) using immunoaffinity column cleanup and HPLC-coupled to a fluorescence detector after post-column derivatization. AFs were detected in 373 (35%) out of the total samples. Among them, Platycladi Semen (65% for total AFs and 79% for AFB1), Corydalis Rhizoma (53% for total AFs and 32% for AFB1), Corni Fructus (3% for total AFs), Coicis Semen (3% for total AFs and AFB1), Nelumbinis Semen (6% for total AFs and 9% for AFB1), Arecae Semen (18% for AFB1), Polygalae Radix (5% for total AFs and AFB1), and Cassiae Semen (25% for total AFs and 38% for AFB1) exceeded the official limits of 5 and 10 μg/kg, for AFB1 and total AFs (the sum of AFB1, AFB2, AFG1, and AFG2), respectively, set by the Taiwan government. We concluded that Platycladi Semen, Corydalis Rhizoma, and Cassiae Semen are the most commonly contaminated by AFs. Keywords: Aflatoxins' contamination, Corydalis rhizoma, Herbal materia medica, Platycladi semen
- Published
- 2017