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Researchers at the College of Mechanical and Electrical Engineering in Changsha, China, have developed bone scaffolds with enhanced photocatalytic antibacterial properties using titanium dioxide and reduced graphene oxide composites. The study found that the composites improved the efficiency of reactive oxygen species production, leading to effective antibacterial activity against Escherichia coli and Staphylococcus aureus. Additionally, the scaffolds showed improved mechanical properties and biocompatibility, making them promising for bone defect repair applications. This research was funded by various organizations and has been peer-reviewed. [Extracted from the article]

A recent study conducted at Tehran University of Medical Sciences focused on the synthesis and evaluation of 3D-printed bone scaffolds made of carboxymethyl chitosan/gelatin/Akermanite (CMC/GEL/AK) for bone tissue regeneration. The scaffolds containing AK showed increased degradation rate, swelling ratio, and mechanical properties, with interconnected networks and a pore size of 300-900 µm. Cell viability studies demonstrated up to 80% viability, indicating the potential of these biocomposites for non-load-bearing bone defect regeneration. The research was peer-reviewed and can be accessed through the Journal of Polymers and the Environment. [Extracted from the article]

A recent study conducted at Amirkabir University of Technology in Tehran, Iran, focused on the synthesis and modification of biodegradable poly(sodium sulfonated butylene fumarate-co-acrylic acid)/hydroxyapatite nanocomposite scaffolds for bone tissue engineering. The research found that incorporating hydrophilic sulfonate and carboxylic acid groups led to improved mechanical stability, nanoparticle dispersion, and biocompatibility of the scaffolds. These results suggest that the developed nanocomposite scaffolds show promise for applications in bone tissue regeneration. For more information, readers can refer to the article "Wet Chemical Synthesis of Nanohydroxyapatite Within Poly(Sodium Sulfonated Butylene Fumarate-co-acrylic Acid) As Bone Scaffold: Effects of Sulfonate and Carboxylic Acid Groups" published in Polymer International in 2024. [Extracted from the article]

Researchers at the Pdpm Indian Institute of Information Technology Design & Manufacturing in Madhya Pradesh, India, have focused on the design and development of biomimetic bone scaffolds using Triply Periodic Minimal Surfaces (TPMS) lattice structures. These scaffolds aim to mimic the heterogeneous and anisotropic nature of bone structures, crucial for tissue engineering. By utilizing TPMS unit cells made of composite materials like polymer Poly Lactic Acid (PLA) and ceramic Hydroxyapatite (HA), researchers have enhanced the surface area to volume ratio, aiding in vascularization and cell proliferation. The study emphasizes the importance of material heterogeneity in scaffold design and proposes a hybridization of TPMS structures to create scaffolds that closely resemble human bone structures. [Extracted from the article]

Central South University researchers have developed a new bone scaffold for synergistic cancer therapy, utilizing a combination of photodynamic and photothermal effects. The scaffold, made from CeO2-loaded Ti3C2 nano-sheets in poly-L-lactic acid, showed promising results in enhancing tumor therapy by increasing oxygen concentration and singlet oxygen levels while consuming overexpressed glutathione. This innovative approach holds potential for developing bone scaffolds with multimodal anti-tumor functions, offering a new avenue for cancer treatment. [Extracted from the article]

Research conducted at Kunming University in the People's Republic of China has provided new insights into bone scaffolds, specifically focusing on the mass transport characteristics of radial gradient porous scaffolds manufactured by Selective Laser Melting technology. The study found that the permeability of these scaffolds significantly influences the material exchange process following implantation and the restoration of injured bone tissue. By designing radial gradient scaffolds with Triply Periodic Minimal Surface Gyroid structure, researchers were able to improve fluid transport capability, with permeability increasing by 8.65% to 44.2% compared to uniform scaffolds. The study decouples porosity and permeability, offering valuable insights for optimizing the performance of bone scaffolds. [Extracted from the article]

Researchers at the University of North Dakota have developed a hierarchically porous bone scaffold that releases the Slit3 protein, which promotes bone formation and healing. The scaffold was created using a combination of materials and techniques to optimize its physicochemical properties, mechanical strength, and biocompatibility for mesenchymal stem cell culture. This innovative scaffold shows promise for bone tissue engineering applications and further in vitro studies to evaluate its potential for osteogenesis. [Extracted from the article]

Researchers at Shandong Jianzhu University in Jinan, China, conducted a study on the effects of heat treatment cooling methods on the properties of 316L negative re-entrant hexagonal honeycomb porous bone scaffolds. The study found that the cooling mode significantly influenced microstructural evolution, phase transformation, residual stress, mechanical properties, and corrosion resistance of the scaffolds. The research concluded that corrosion resistance improved after water-cooling heat treatment at 800 degrees Celsius. This peer-reviewed study was supported by the Key R&D Program of Shandong Province, China, and provides valuable insights for the field of bone research and tissue engineering. [Extracted from the article]

A recent study conducted by researchers at Imperial College London focused on the development of bone scaffolds using inorganic/organic hybrid biomaterials for implant and 3D printed scaffold applications. By incorporating various calcium sources, such as calcium ethoxyethoxide (CEE), the researchers were able to enhance the mechanical properties and printability of the hybrid scaffolds. The study concluded that the optimized hybrid scaffolds showed promising mechanical properties and bioactivity, making them potentially suitable for bone regeneration applications. For more information, readers can refer to the original article published in RSC Advances. [Extracted from the article]

Researchers at Iran University of Science and Technology have developed a calcium-based triphasic powder to strengthen 3D printed bone scaffolds. The study aims to enhance the mechanical properties of biocompatible ceramic materials for better integration with bones, particularly in weight-bearing areas. The research, supported by the Iran National Science Foundation, involves synthesizing hydroxyapatite powder, coating it with silicon dioxide, and optimizing it for 3D printing, resulting in a significant increase in compressive strength. This peer-reviewed study provides valuable insights for biomedical applications and tissue engineering. [Extracted from the article]

Researchers at Mississippi State University have conducted a study on optimizing the 3D printing process parameters for composite bone scaffolds. The study focused on improving the geometric accuracy of the printed scaffolds, particularly the strut width, by analyzing different process parameters such as nozzle temperature, pressure, and printing speed. The research, supported by the National Science Foundation, demonstrated significant potential in bioprinting process parameter optimization, with the findings published in the Journal of Manufacturing Processes. The study highlights the importance of accurate and repeatable 3D printing techniques in creating porous scaffolds that mimic bone properties for tissue regeneration. [Extracted from the article]

A study conducted at Xinjiang University in Urumqi, People's Republic of China, focused on improving the infection resistance and biocompatibility of 3D printed TC4 titanium alloy bone scaffolds by coating them with TNTs-VA-PLGA composite. The research found that the composite scaffolds with controlled morphology and drug release capabilities showed promising results in increasing cell proliferation by 65.33% compared to unmodified scaffolds. The study was funded by the National Natural Science Foundation of China and the State Key Laboratory of Mechanical Manufacturing Systems Engineering at Xi'an Jiaotong University. The findings suggest potential applications for orthopedic implants. [Extracted from the article]

Researchers from Queensland University of Technology have developed a new modular design workflow for 3D printable bioresorbable patient-specific bone scaffolds. This extended workflow includes features such as a virtual surgical resection tool, cavity fill module, and segmental defect fill module. The study successfully applied this workflow to clinical cases, demonstrating its ability to generate scaffolds without obstructions for surgical insertion. The research, published in Frontiers in Bioengineering and Biotechnology, highlights the potential of this approach for a broad range of diverse clinical cases. [Extracted from the article]

Researchers at Guangxi Medical University Cancer Hospital in Nanning, China, have developed all-natural ceramic composite bone scaffolds using whitlockite and wollastonite fibers through desktop-level DLP 3D printing. The study found that the addition of wollastonite fiber enhanced the mechanical strength and degradation rate of the scaffolds, leading to improved biomineralization and cellular response. This research highlights the potential of using all-natural ceramic materials for bone scaffolds and validates the effectiveness of desktop-level DLP printing in fabricating such structures. [Extracted from the article]

Researchers at Guangxi University have conducted a study on bone scaffolds, focusing on the use of bredigite doping to enhance the performance of hydroxyapatite (HA) scaffolds. The study utilized desktop-level DLP to create TPMS porous HA scaffolds, which were then doped with bredigite to adjust microstructure through ion substitution. The research demonstrated the potential of using ion substitution to modulate the microstructure and performance of ceramic scaffolds, showing promising results for future applications in tissue engineering and biomedicine. The study was supported by various funding sources and published in Virtual and Physical Prototyping. [Extracted from the article]

A recent study from Hanyang University in Seoul, South Korea, focuses on the development of 3D-printed tissue-specific nanospike-based adhesive materials for tumor therapy and tissue regeneration. The research addresses the need for multifaceted bone scaffolds that can provide tumor therapy, bacterial therapy, and effective vascularized bone reconstruction. By incorporating innovative theragenerative platforms utilizing nanospikes, the study aims to create implantable biomaterials that integrate therapeutic and regenerative functions. The research findings have been peer-reviewed and show promise for future applications in tumor therapy and tissue regeneration. [Extracted from the article]

Researchers at the National Autonomous University of Mexico (UNAM) have conducted a study on demineralized bone matrix (DBM) combined with magnesium to create degradable composite materials for bone scaffolds. The study found that the composite materials exhibited promising mechanical properties and reduced corrosion rates compared to pure magnesium. The research suggests that these materials could be used for temporary bone fixation applications. Financial support for the study came from UNAM, and the findings have been peer-reviewed. [Extracted from the article]

A recent study conducted at Eberhard-Karls-University Tuebingen in Germany focused on establishing a human 3D in vitro liver-bone model to screen for drug toxicity. The research highlighted the impact of diclofenac, a common non-steroidal anti-inflammatory drug, on liver and bone health. The study found that chronic exposure to diclofenac led to increased osteoclast activity, reduced mineral content, and stiffness in bone scaffolds co-cultured with liver spheroids. This research provides valuable insights into the interaction between the liver and bone, serving as a model for studying drug toxicity on bone homeostasis. [Extracted from the article]

A recent report from Xi'an Jiaotong University discusses the impact of structure on osteogenesis in bone scaffolds, highlighting the importance of mechanical and biological properties in treating bone defects. The study utilized a tissue regeneration algorithm based on mechanical regulation theory to evaluate the osteogenesis of different types of scaffolds, with in vivo experiments confirming the simulation results. The research concludes that the mechanical responses mediated by structure significantly influence the osteogenesis of bone scaffolds, providing a more efficient and economical method for analyzing tissue healing in bioengineering. [Extracted from the article]

A recent report from Tongji University discusses research findings on bone scaffolds, focusing on the challenges posed by bone damage from trauma and tumors. The study emphasizes the importance of developing 3D scaffolding materials to enhance bone tissue regeneration, highlighting the selection of materials and preparation processes for optimal results. The research reviews advancements in bone tissue engineering scaffolds and explores potential paths and obstacles for clinical applications. For more information, readers can access the full article titled "Raising the Bar: Progress in 3D-Printed Hybrid Bone Scaffolds for Clinical Applications: A Review" in Cell Transplantation. [Extracted from the article]

Researchers at Shanghai University have developed a new bone scaffold that utilizes 3D printing technology to deliver copper ions and dexamethasone for the regulation of angiogenesis and osteogenesis. This scaffold aims to mimic the natural healing cascade by promoting early angiogenesis and later-stage osteogenesis. The study highlights the potential of this vascularized bone scaffold for repairing large bone defects, offering a promising solution to a complex clinical problem. Financial support for the research came from the National Natural Science Foundation of China. [Extracted from the article]

Researchers at Dalian Medical University in Liaoning, China, have conducted a study on 3D-printed bone scaffolds with enhanced bioactivity. The study focused on the design and performance of biomimetic lattice structures for bone regeneration. The research found that the graded minimal surface bone scaffolds showed improved mechanical properties and promoted early-stage bone regeneration. This work provides insights into fabricating artificial scaffolds with bioactive factors and biomimetic structures, contributing to advancements in tissue engineering and regenerative medicine. [Extracted from the article]

A report from the Polytechnic University of Catalonia discusses research on enhancing the mechanical performance of 3D-printed self-hardening calcium phosphate bone scaffolds using PLGA-based strategies. The study compares two methods of incorporating PLGA into the scaffolds and assesses the physical-chemical properties, mechanical performance, and biological properties. The addition of PLGA improves the strength and plastic deformation capacity of the scaffolds without compromising cytocompatibility. The research concludes that incorporating PLGA in the ink is the best option for enhancing mechanical performance and osteogenic cell response. [Extracted from the article]

A study conducted at the University of Louisville focused on the microstructure and mechanical properties of 3D-printed zirconia bone scaffolds. The research highlighted the development of a novel binder system for zirconia paste printing and analyzed the effects of sintering conditions on the scaffolds' properties. The study concluded with a unique finite element analysis predicting the mechanical behavior of the printed scaffolds. This peer-reviewed research provides valuable insights for bone scaffold applications and tissue engineering. [Extracted from the article]

A patent has been issued for an implantable bone scaffold that can be printed at the point of service. The patent describes a three-dimensional (3D) printing apparatus that includes a sterile cartridge, a heater, and a cartridge receiver. The printing material remains sterile during the printing process, and the apparatus maintains an aseptic environment. The method involves receiving a sterile cartridge, receiving a printing instruction, maintaining an aseptic environment, activating a heater, extruding the printing material, and printing the implantable bone scaffold. This technology has potential applications in biotechnology, tissue engineering, and biomedical engineering. The patent was filed on May 31, 2023, and published online on September 24, 2024. [Extracted from the article]

A study conducted by researchers at the University of Electronic Science and Technology of China explores the design considerations for bone scaffolds in biomedical engineering. The researchers propose a novel body-centered cubic (BCC) lattice with modified horsetail-inspired cross-section strut members as the building block for synthetic bone scaffold applications. Through their work, they were able to create lattices that match the mechanical performance of native bone and provide desirable mechanical properties. The research concludes that the tuning of the mechanical properties is made possible through geometrical variations. This study has been peer-reviewed and published in the International Journal of Bioprinting. [Extracted from the article]

A recent study on bone scaffolds for the treatment of osteosarcoma, a common malignant bone neoplasm in teenagers, has been published. The study highlights the use of bone scaffolds as drug delivery systems (DDSs) to load cargos such as growth factors or drugs for postoperative management of osteosarcoma. Surgical resection often fails to completely eradicate tumors, leading to high rates of recurrence and metastasis. The study provides insights into the different types of bone scaffolds available and discusses the challenges and perspectives of using scaffold-based DDSs. This research may contribute to the development of efficient and secure treatment plans for osteosarcoma. [Extracted from the article]

A study conducted by researchers at Xi'an Jiaotong University in Shaanxi, China, explores the design and fabrication of bone scaffolds for comprehensive bone regeneration. The researchers propose a biomimetic approach that closely replicates the composition, structure, strength, and physiological process of natural bone repair. They discuss comprehensive strategies for biomimetic scaffold fabrication and advocate for the biomimetic concept as a guiding principle for future scaffold design and fabrication. The study emphasizes the importance of bone scaffolds in bone tissue engineering and highlights the need for scaffolds that support the natural bone repair process. [Extracted from the article]

A study conducted by researchers at Universiti Malaysia Perlis explores the drilling process in bone scaffolds. The study investigates the invasiveness of drilling techniques on polyurethane foam blocks that mimic human bone properties. Different drill bit types, drilling speeds, and feed rates were examined to assess temperature elevation during drilling. The results indicate that standard twist drill bits with smaller point angles, lower drilling speeds, and higher feed rates effectively minimize temperature elevation during drilling. This research provides valuable insights for the development of biomimetic bone scaffolds. [Extracted from the article]

New research from Technological University in Athlone, Ireland explores the potential of P28 peptide-loaded hybrid scaffolds for bone regeneration. The study investigates the ability of these scaffolds to mimic the natural bone structure and enhance the bone healing process. The researchers found that the hybrid scaffold could enhance osteoblast differentiation and significantly improve the therapeutic effects of the scaffold in bone regeneration. This research contributes to the development of bone graft substitutes and addresses the limitations of traditional bone grafting methods. [Extracted from the article]

A study conducted at Jinzhou Medical University in Liaoning, China, has found that incorporating carbon nanotubes into three-dimensional printed polycaprolactone/beta-tricalcium phosphate (PCL/beta-TCP) scaffolds significantly enhances their mechanical properties for bone tissue engineering applications. The aligned PCL/beta-TCP/carbon nanotube scaffold showed a 125% increase in compressive modulus and a 123% increase in strength compared to the PCL/beta-TCP scaffold. The study also found that the scaffolds maintained high porosity, wide pore size distribution, excellent biocompatibility, and promoted stem cell proliferation and mineralization. The research has been peer-reviewed and provides valuable insights into the development of bone scaffolds for regenerative medicine. [Extracted from the article]

Researchers from Shanghai University have developed a new technology for preparing bone scaffolds that can meet the needs of bone defect repair. The technology, called the dual-phase composite forming process, involves the use of multiple biomaterials to create a bionic natural long bone structure with gradient changes in pore structure and material concentration. The researchers found that the bone scaffolds prepared using this process had better compressive strength compared to those prepared using traditional methods. In addition, the scaffolds showed good biocompatibility in in vitro cell culture tests and in a rat experimental model. This study lays the foundation for further research on the bone repair effect of these scaffolds in larger animals. [Extracted from the article]

A recent article from Blood Weekly discusses the field of tissue engineering, specifically focusing on bone tissue engineering scaffolds. The researchers from Assam Don Bosco University in Gauhati, India, highlight the importance of developing new technologies to improve patient-specific treatment and care in the areas of biomedical engineering, regenerative medicine, and surgical techniques. The article provides an overview of bone scaffolding materials, 3D techniques for fabricating these scaffolds, and the characteristics targeted by researchers to create tissue-engineered bone scaffolds. The research aims to contribute to the understanding and advancement of bone regeneration and the treatment of bone diseases. [Extracted from the article]

A recent study conducted by the University of Airlangga in Surabaya, Indonesia, focused on the fabrication and biocompatibility evaluation of hydroxyapatite-polycaprolactone-gelatin composite nanofibers as a bone scaffold. The researchers aimed to create scaffolds with properties similar to natural bone, including pore size, porosity, mechanical attributes, degradation rate, and biocompatibility. The study found that the hydroxyapatite-polycaprolactone-gelatin nanofiber scaffold showed promising results in terms of cell proliferation and viability, making it a potential candidate for treating bone damage. The research was supported by the Ministry of Education and Culture, Republic of Indonesia. [Extracted from the article]

A recent study conducted by researchers at Edith Cowan University in Australia investigated the fatigue performance of 3D-printed poly-lactic-acid (PLA) bone scaffolds with different pore structures. The study found that the Gyroid topology had the highest compressive strength, while the Voronoi structure exhibited the highest normalized fatigue performance. The researchers concluded that the Gyroid topology was the superior choice overall due to its enhanced static and fatigue strength. This research provides valuable insights for tissue engineering and bone regeneration. [Extracted from the article]

A research report from the College of Mechanical and Electrical Engineering in Changsha, People's Republic of China, discusses the findings on bone scaffolds in the field of biomedical engineering. The report focuses on the use of amino-functionalized nano-hydroxyapatite (nano-HAP) to enhance the interfacial bonding of poly (l-lactic acid) (PLLA) in bone scaffolds. The researchers found that grafting PLLA chains onto nano-HAP with a coupling reagent called 3-aminopropyltriethoxysilane improved the interfacial bonding and resulted in improved mechanical properties of the scaffold. The modified scaffold also showed compatibility with cells, making it a promising candidate for bone defect repair. [Extracted from the article]

Researchers from the Preclinical Research Center in Daegu, South Korea, have published a new report on the use of 3D bioprinting to enhance bone healing. The study focuses on the challenge of angiogenesis, the formation of blood vessels necessary for successful bone healing. The researchers investigated the sustained release of a molecule called StemRegenin-1 (SR1) from a collagen-based scaffold integrated with mesoporous silica nanoparticles (MSNs) to promote angiogenesis and enhance bone healing. While in vitro studies have shown promising results, further in vivo investigations are needed to establish the clinical efficacy of this approach. The study contributes to the development of novel therapies targeting CD34+ cells and demonstrates the potential of SR1 as a promising agent for promoting angiogenesis and enhancing bone healing in critical defects. [Extracted from the article]

Researchers at Hasanuddin University in Makassar, Indonesia have conducted a study on the synthesis and characterization of hydroxyapatite/SiO2/gelatin composites as bone scaffold candidates. The study found that the composites exhibited the necessary characteristics for bone scaffolds, including a high hydroxyapatite phase, optimal pore size for cell attachment, and suitable compressive strength and porosity. The research suggests that these composites have potential for use in tissue engineering and could contribute to the development of scaffold materials in the field. The study was published in Communications in Science and Technology. [Extracted from the article]

A recent study conducted in Hunan, People's Republic of China, focused on improving the mechanical and osteogenic induction properties of bone scaffolds. The researchers encapsulated graphene oxide (GO) with polydopamine (PDA) and loaded strontium (Sr) onto GO through the chelation of PDA. The modified GO was added to the bone scaffold, resulting in significant improvements in tensile and compressive strengths. The presence of Sr in the scaffold also promoted the proliferation and differentiation of osteoblasts, enhancing its osteogenic induction properties. This research has been peer-reviewed and provides valuable insights into the development of more effective bone scaffolds. [Extracted from the article]

A recent report from the University of Leeds in the United Kingdom discusses the need for biodegradable scaffolds to repair bone defects. The researchers describe the synthesis and freeze-drying methods of ferric-ion (Fe3+)-doped brushite mineral cancellous bone scaffolds. They explore the role of chitosan in enhancing antimicrobial properties, scaffold pore distribution, and mechanical properties. The study concludes by characterizing the structural, microstructural, and mechanical properties of the freeze-dried materials. This research provides valuable insights into the development of bone scaffolds for tissue engineering and biomedical applications. [Extracted from the article]

A new report from Dalian, People's Republic of China, discusses the design of novel bone scaffolds to meet the mechanical and biological requirements of bone repair. The researchers designed triply periodic minimal surface (TPMS)-based bone scaffolds with multi-functional pores to improve performance. Finite element (FE) analysis and mechanical experiments were used to evaluate the scaffolds, which showed reduced stress shielding and increased mass transport capacity. The study concludes that these novel TPMS scaffolds with multi-functional pores have the potential to be ideal candidates for bone repair and expand the design possibilities for high-performance bone scaffolds. [Extracted from the article]

A study conducted at Xinjiang University explores the development of a photothermally responsive composite bone scaffold for bone tissue regeneration and treatment of bone defects. The scaffold, made with photothermal-sensitive nanoparticles, demonstrated desirable mechanical and photothermal properties. When exposed to near-infrared light, the scaffold achieved a temperature range conducive to promoting osteogenic differentiation. This research presents a promising avenue for advancing bone tissue cell proliferation and addressing bone defect rehabilitation. [Extracted from the article]

Researchers from the Yancheng Institute of Technology in Jiangsu, China have conducted a study on bone scaffolds. They focused on the continuous gradient triply periodic minimal surface (TPMS) porous structure, which has been found to be suitable for bone implants due to its mechanical properties and high porosity. The researchers developed a parametric modeling method for this structure and optimized it with a continuous gradient change in porosity. They also studied the mechanical properties and permeability of the TPMS porous structure and designed a bone implant model suitable for human trabecular bone. This research provides technical support for further testing and application of bone implants. [Extracted from the article]

A study conducted by researchers at Jinzhou Medical University in China focuses on the development of bone scaffolds for bone tissue engineering. The researchers combined polycaprolactone (PCL) and chitosan to create versatile bone scaffolds with improved mechanical properties and biological activity. They also incorporated MXene nanosheets into the scaffolds to enhance their osteogenic impact and modify their mechanical behavior. The study found that the scaffolds with an optimized ratio of MXene nanoparticles showed suitable characteristics for the generation of new bone tissues, including cell attachment, proliferation, and differentiation. [Extracted from the article]

A recent study conducted by the Korea Institute of Machinery and Materials in Daejeon, South Korea, has explored the use of polyhydroxyalkanoates (PHAs) as an alternative to conventional plastic bone scaffolds. PHAs have gained attention due to their biocompatibility and biodegradability, but their water resistance can interfere with cell interactions. The researchers developed a three-dimensional-printed PHA scaffold coated with polydopamine (pDA) and/or hydroxyapatite (HA) to enhance cell viability, proliferation, and differentiation. This study suggests that the PHA-pDA-HA scaffold could be a versatile platform for bone tissue engineering applications. [Extracted from the article]