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81 results on '"Boehnke, Michael"'

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1. Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.

2. Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences

3. Association of structural variation with cardiometabolic traits in Finns

4. Large-scale association analyses identify host factors influencing human gut microbiome composition

5. Identification of type 2 diabetes loci in 433,540 East Asian individuals

6. Complement genes contribute sex-biased vulnerability in diverse disorders.

7. Colocalization of GWAS and eQTL signals at loci with multiple signals identifies additional candidate genes for body fat distribution.

8. New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

9. GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores

10. Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology

11. Genetic Determinants of Circulating Glycine Levels and Risk of Coronary Artery Disease

12. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

13. Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

14. Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees

15. Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes

16. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

17. Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci

18. Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes

19. Distribution and medical impact of loss-of-function variants in the Finnish founder population.

20. Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity

21. Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol

22. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

23. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.

24. Comprehensive Association Study of Type 2 Diabetes and Related Quantitative Traits With 222 Candidate Genes

25. Association of Polygenic Liabilities for Major Depression, Bipolar Disorder, and Schizophrenia With Risk for Depression in the Danish Population

26. Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

27. Rare and low-frequency coding variants alter human adult height

28. Congenital cataracts: de novo gene conversion event in CRYBB2

29. Genetic studies of body mass index yield new insights for obesity biology

30. Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms

31. New genetic loci link adipose and insulin biology to body fat distribution

32. The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

33. Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry. : combined analysis of 111,421 individuals of European ancestry

34. Human longevity and common variations in the LMNA gene: a meta-analysis

35. A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans

36. Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study

37. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

38. Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

39. The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

40. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

41. Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

42. A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

43. Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

44. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

45. Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

46. Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

47. Distribution and medical impact of loss-of-function variants in the Finnish founder population

48. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

49. Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

50. Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

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