67 results on '"Kidney histology"'
Search Results
2. The Evolving Spectrum of Kidney Histology in HIV-Positive Patients in South Africa
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Nicola Wearne, Kathryn Manning, Brendon Price, Brian L. Rayner, Bianca Davidson, Erika SW Jones, Ruan Spies, Carol Cunningham, Aadil Omar, Samantha Ash, Raphaela Bohmer, Luca Kennedy, and Frank Post
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HIV ,HIV-associated nephropathy ,kidney failure ,kidney histology ,tuberculosis ,tubulointerstitial disease ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Introduction: Sub-Saharan Africa remains challenged by the highest burden of human immunodeficiency virus (HIV), an epidemic of tuberculosis (TB), and increasing number of people with HIV (PWH) on antiretroviral therapy (ART), all of which may result in kidney injury. Methods: This observational cohort study describes the spectrum of kidney disease in PWH in South Africa, between 2005 and 2020. Kidney biopsies were analyzed in 4 time periods as follows: early ART rollout (2005–2009), tenofovir disoproxil (TDF) introduction (2010–2012), TDF-based fixed dose combination (2013–2015), and ART at HIV diagnosis (2016–2020). Logistic regression was used to identify factors associated with HIV-associated nephropathy or focal segmental glomerulosclerosis (HIVAN/FSGS) and tubulointerstitial disease (TID). Results: We included 671 participants (median age 36, interquartile range, 21–44 years; 49% female; median CD4 cell count 162 [interquartile range, 63–345] cells/mm3). Over time, ART (31%–65%, P < 0.001), rate of HIV suppression (20%–43%, P < 0.001), nonelective biopsies (53%–72%, P < 0.001), and creatinine at biopsy (242–449 μmol/l, P < 0.001) increased. A decrease in HIVAN (45%–29% P < 0.001) was accompanied by an increase in TID (13%–33%, P < 0.001). Granulomatous interstitial nephritis accounted for 48% of TID, mostly because of TB. Exposure to TDF was strongly associated with TID (adjusted odds ratio 2.99, 95% confidence interval 1.89–4.73 P < 0.001). Conclusion: As ART programs intensified and increasingly used TDF, the spectrum of kidney histology in PWH evolved from a predominance of HIVAN in the early ART era to TID in recent times. The increase in TID is likely due to multiple exposures that include TB, sepsis, and TDF as well as other insults.
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- 2023
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3. Preparation Cupcake Samples Fortified with some Herbs for Kidney Patients.
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ELsaid, Amira E. F., El Tanahy, H. H., Sharoba, A. M. A., and ELanany, A. M. M.
- Abstract
Copyright of Journal of Food & Dairy Sciences is the property of Egyptian National Agricultural Library (ENAL) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2023
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4. Heterogeneity in Kidney Histology and Its Clinical Indicators in Type 2 Diabetes Mellitus: A Retrospective Study.
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Singh, Shivendra, Patel, Prem Shankar, and Archana, Archana
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TYPE 2 diabetes , *DIABETIC nephropathies , *IGA glomerulonephritis , *SYMPTOMS , *KIDNEY diseases , *RENAL biopsy , *KIDNEY disease diagnosis - Abstract
The heterogeneous spectrum of kidney disease in diabetes ranges from albuminuric or non-albuminuric diabetic kidney disease to non-diabetic kidney diseases. Presumptive clinical diagnosis of diabetic kidney disease may lead to an erroneous diagnosis. Material and Method: We analyzed the clinical profile and kidney biopsy of a total of 66 type 2 diabetes patients. Based on kidney histology, they were divided into—Class I (Diabetic Nephropathy), Class II (Non-diabetic kidney disease), and Class III (Mixed lesion). Demographic data, clinical presentation, and laboratory values were collected and analyzed. This study tried to examine the heterogeneity in kidney disease, its clinical indicator, and the role of kidney biopsy in the diagnosis of kidney disease in diabetes. Results: Class I consisted of 36(54.5%), class II 17(25.8%), and class III 13(19.7%) patients. The commonest clinical presentation was nephrotic syndrome 33(50%) followed by chronic kidney disease 16(24.4%) and asymptomatic urinary abnormality 8(12.1%). Diabetic retinopathy (DR) was present in 27(41%) cases. DR was significantly higher in the class I patients (p < 0.05). Specificity and positive predictive values of DR for DN were 0.83 and 0.81, respectively (sensitivity 0.61; negative predictive values 0.64). The Association of the duration of diabetes and the level of proteinuria with DN was statistically not significant (p > 0.05). Idiopathic MN (6) and Amyloidosis (2) were the most common isolated NDKD; whereas diffuse proliferative glomerulonephritis (DPGN) (7) was the commonest NDKD in mixed disease. Another common form of NDKD in mixed disease was Thrombotic Microangiopathy (2) and IgA nephropathy (2). NDKD was observed in 5(18.5%) cases in presence of DR. We noted biopsy-proven DN even in 14(35.9%) cases without DR, in 4(50%) cases with microalbuminuria and 14(38.9%) cases with a short duration of diabetes. Conclusion: Almost half (45%) of cases with atypical presentation have non-diabetic kidney disease (NDKD), though even among these cases with atypical presentation diabetic nephropathy (either alone or in mixed form) is commonly seen in 74.2% of cases. DN has been seen in a subset of cases without DR, with microalbuminuria, and with a short duration of diabetes. Clinical indicators were insensitive in distinguishing DN Vs NDKD. Hence, a kidney biopsy may be a potential tool for the accurate diagnosis of kidney disease. [ABSTRACT FROM AUTHOR]
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- 2023
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5. Antioxidant Effect of Jatropha dioica Extract on Immunoreactivity of Claudin 2 in the Kidney of Rats with Induced Diabetes.
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Ramírez-Moreno, Agustina, García Garza, Rubén, Pedroza Escobar, David, Soto Dominguez, Adolfo, Flores-Loyola, Erika, Castillo Maldonado, Irais, Keita, Hady, Núñez, Ibrahim Sharara, and Delgadillo Guzmán, Dealmy
- Abstract
Introduction: Diabetes is related to different complications, such as nephropathy. In kidneys, the tight junctions (TJ) regulate the paracellular transport of solutes and water. The claudins are the most significant component in the TJ and are expressed throughout the epithelium and modulated permeability. Objective: To evaluate the antioxidant effect of Jatropha dioica (JD) extract and claudin 2 (CLDN 2) in the kidney of rats with induced diabetes. Methods: It is an experimental, explanatory, prospective, longitudinal, and analytical study. The effect of hydro-alcoholic extract from JD root on the presence of CLDN 2 in rats with induced diabetes was evaluated. The experiment lasting 21 days, treated 40 rats with and without induced diabetes by an intraperitoneal (IP) injection of alloxan. The study groups were exposed to JD extract at 25, 50, and 100 mg/kg. There was no significant morphological difference in the renal tissue morphology of the treated and control groups. Conclusion: These results demonstrate that JD extract at 50 mg/kg ameliorated the tubular damage induced by diabetes, and the mechanism might be related to the CLDN2 expression. Finally, JD could also increase total antioxidant capacity to protect the kidney from oxidative stress. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Heterogeneity in Kidney Histology and Its Clinical Indicators in Type 2 Diabetes Mellitus: A Retrospective Study
- Author
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Shivendra Singh, Prem Shankar Patel, and Archana Archana
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diabetes mellitus (DM) ,diabetic retinopathy (DR) ,diabetic nephropathy (DN) ,non-diabetic kidney disease (NDKD) ,kidney histology ,clinical indicator ,Medicine - Abstract
The heterogeneous spectrum of kidney disease in diabetes ranges from albuminuric or non-albuminuric diabetic kidney disease to non-diabetic kidney diseases. Presumptive clinical diagnosis of diabetic kidney disease may lead to an erroneous diagnosis. Material and Method: We analyzed the clinical profile and kidney biopsy of a total of 66 type 2 diabetes patients. Based on kidney histology, they were divided into—Class I (Diabetic Nephropathy), Class II (Non-diabetic kidney disease), and Class III (Mixed lesion). Demographic data, clinical presentation, and laboratory values were collected and analyzed. This study tried to examine the heterogeneity in kidney disease, its clinical indicator, and the role of kidney biopsy in the diagnosis of kidney disease in diabetes. Results: Class I consisted of 36(54.5%), class II 17(25.8%), and class III 13(19.7%) patients. The commonest clinical presentation was nephrotic syndrome 33(50%) followed by chronic kidney disease 16(24.4%) and asymptomatic urinary abnormality 8(12.1%). Diabetic retinopathy (DR) was present in 27(41%) cases. DR was significantly higher in the class I patients (p < 0.05). Specificity and positive predictive values of DR for DN were 0.83 and 0.81, respectively (sensitivity 0.61; negative predictive values 0.64). The Association of the duration of diabetes and the level of proteinuria with DN was statistically not significant (p > 0.05). Idiopathic MN (6) and Amyloidosis (2) were the most common isolated NDKD; whereas diffuse proliferative glomerulonephritis (DPGN) (7) was the commonest NDKD in mixed disease. Another common form of NDKD in mixed disease was Thrombotic Microangiopathy (2) and IgA nephropathy (2). NDKD was observed in 5(18.5%) cases in presence of DR. We noted biopsy-proven DN even in 14(35.9%) cases without DR, in 4(50%) cases with microalbuminuria and 14(38.9%) cases with a short duration of diabetes. Conclusion: Almost half (45%) of cases with atypical presentation have non-diabetic kidney disease (NDKD), though even among these cases with atypical presentation diabetic nephropathy (either alone or in mixed form) is commonly seen in 74.2% of cases. DN has been seen in a subset of cases without DR, with microalbuminuria, and with a short duration of diabetes. Clinical indicators were insensitive in distinguishing DN Vs NDKD. Hence, a kidney biopsy may be a potential tool for the accurate diagnosis of kidney disease.
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- 2023
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7. Overview of the Current Approach to Glomerular Disease Classification
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Mejia-Vilet, Juan M., Parikh, Samir V., Trachtman, Howard, editor, Herlitz, Leal C., editor, Lerma, Edgar V., editor, and Hogan, Jonathan J., editor
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- 2019
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8. Embryology, Anatomy, and Histology of the Kidney
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McBride, Jennifer M., Hansel, Donna E., editor, Kane, Christopher J., editor, Paner, Gladell P., editor, and Chang, Sam S., editor
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- 2016
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9. Kidney damage induced by sub-chronic fine particulate matter exposure.
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Tavera Busso, Iván, Mateos, Ana Carolina, Juncos, Luis Isaías, Canals, Norma, and Carreras, Hebe Alejandra
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PARTICULATE matter , *KIDNEY abnormalities , *CARDIOVASCULAR diseases , *HYPERTENSIVE crisis , *GLOMERULAR filtration rate - Abstract
Abstract According to the WHO, about 3 million people die each year due to ambient air pollution. Most of the in vivo studies on the PM 2.5 effects have been done on respiratory and cardiovascular tissues. However, little is known about the effects on the tissues involved on xenobiotic removal, such as kidneys. In the present study we assess the harmful effects of sub-chronic exposure to PM 2.5 on the kidney, by investigating histologic and serum alterations in healthy and hypertensive rat models. Mean PM 2.5 concentrations during exposures were slightly above the daily WHO standard. Exposed animals showed fibrosis, mesangial expansion, decrease glomerular and tubular lumen volumes in kidneys, with an elevated BUN. Hypertensive animals also exhibited much more severe alterations than healthy animals. We conclude that PM 2.5 induces minimal or small-scale abnormalities that can be determinant for renal health preservation. Highlights • Exposure to PM 2.5 may induce fibrosis and mesangial expansion. • Exposure may also induce BUN elevation. • Particles' concentrations were below the WHO reference levels most days. • Hypertensive animals display much more severe alterations than healthy animals. [ABSTRACT FROM AUTHOR]
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- 2018
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10. ADVERSE EFFECTS OF NON-BRANDED SOFT DRINK; ADVERSE EFFECTS OF NON-BRANDED SOFT DRINK ON THE RENAL HISTOLOGY - AN EXPERIMENTAL STUDY IN AN ALBINO RAT MODEL.
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Almani, Sajjad Ali, Memon, Shoukat Ali, and Shaikh, Aftab Ahmed
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PHYSIOLOGICAL effects of soft drinks , *HISTOLOGY , *GLOMERULAR filtration rate - Abstract
Objectives: Investigating the Adverse effects of non-branded soft drink on the renal histology in an albino rat model. Study Design: Experimental study. Place and Duration: Department of Anatomy, Isra University, in collaboration with Animal House, Department of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University Tando Jam over six months duration 2014. Methodology: A sample of 30 adult Wistar albino rats of was selected according to criteria. Animals were randomly divided into 3 groups. Group A (n=10) control rats, Group B (n=10) control rats given normal diet (12 hours fasting) and Group C (n=10) experimental rats. 3- 5 µ thick renal tissue sections were prepared, stained with H & E and examined by light microscopy. Data was analyzed on statistical software SPSS 21.0 ver (IBM, incorporation, USA) at 95% (a)-level significance was taken at P-value = 0.05. Results: Experimental group C showed an increase in kidney size and weight observed even after 12 hours of fasting (P=0.0001). Histological examination of experimental kidneys show gaping Bowman's capsules, interstitial edema, glomerular distortion, calcifications, acidophilic hyalinization of renal tubules, vacuolization of epithelial cell, pyknotic nuclei and necrosis. Epithelial cells revealed fragmentation and sloughing in experimental rat kidney. Conclusion: The present study reports deleterious adverse effects of non-branded soft drink on the renal histology in an experimental albino rat model. [ABSTRACT FROM AUTHOR]
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- 2018
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11. Impact of Pregnancy on GFR Decline and Kidney Histology in Kidney Transplant Recipients
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Hasan Khamash, Fernando G. Cosio, Santosh Parashuram, Sam Albadri, Andrea G. Kattah, Byron H. Smith, Marin L. Mai, Vesna D. Garovic, and Mariam P. Alexander
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kidney transplant ,allograft ,glomerular filtration rate ,medicine.medical_specialty ,Pregnancy ,Obstetrics ,business.industry ,Renal function ,medicine.disease ,Kidney transplant ,histology ,Kidney histology ,Clinical Research ,Nephrology ,Chart review ,Cohort ,medicine ,Gestation ,pregnancy ,business ,vascular injury ,Kidney disease - Abstract
Introduction Women with advanced kidney disease are advised to wait until after transplant to pursue pregnancy, but the impact of pregnancy on estimated glomerular filtration rate (eGFR) decline and kidney histology is unclear. Methods We identified a cohort of women aged 18 to 44 years at transplant from 1996 to 2014 at our 3-site program (N = 816) and determined whether they had a pregnancy >20 weeks gestation post-transplant by chart review. Outcomes included rate of change in eGFR after pregnancy, changes in kidney histology before and after pregnancy, graft failure, and 50% reduction in eGFR. Results There were 37 women with one or more pregnancies lasting longer than 20 weeks gestation post-transplant. Comparing women with and without pregnancy post-transplant, there was a significant increase in the rate of eGFR decline after pregnancy (−2.4 ml/min per 1.73 m2 per year vs. −1.9 ml/min per 1.73 m2 per year in women with no pregnancy, P < 0.001). Pregnancy did not affect the risk of graft failure, death-censored graft failure, or 50% reduction in eGFR. Conclusion Pregnancy affects the rate of eGFR decline in the allograft. Postpregnancy biopsy findings revealed an increase in vascular injury, which could be a potential mechanism. We did not find a significant increase in risk of graft failure or reduction in eGFR by 50% owing to pregnancy., Graphical abstract
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- 2022
12. A Novel Missense GLA Mutation (p.G35V) Detected in Hemodialysis Screening Leads to Severe Systemic Manifestations of Fabry Disease in Men and Women.
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Veloso, Valeria Soares Pigozzi, Ataides, Thiago Lacerda, Canziani, Maria Eugênia Fernandes, Veloso, Mariana Pigozzi, da Silva, Nilzio Antônio, Barreto, Daniela Veit, Pereira, Edna Regina Silva, de Moura, Luiz Antonio Ribeiro, and Barreto, Fellype Carvalho
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KIDNEY disease diagnosis , *CARDIOMYOPATHIES , *CRANIAL nerve diseases , *ANGIOKERATOMA corporis diffusum , *BRAIN diseases , *ALBUMINURIA , *BIOPSY , *GENETIC polymorphisms , *GLOMERULAR filtration rate , *HEART conduction system , *HEMODIALYSIS , *ISCHEMIA , *KIDNEYS , *MAGNETIC resonance imaging , *GENETIC mutation , *STROKE , *THALAMUS , *MICROBIAL virulence , *FIBROSIS , *LEFT ventricular hypertrophy , *DIAGNOSIS , *ANATOMY - Abstract
Background/Aims: Fabry disease (FD), an X-linked lysosomal storage disorder, leads to accumulation of globotriaosylceramide. Screening in dialysis patients may identify genetic variants of unknown clinical significance. We aimed to characterize the pathogenicity of a novel GLA gene mutation identified during hemodialysis screening and the histologic findings of early Fabry nephropathy. Methods: One out of 108 male hemodialysis patients screened for FD presented low α-galactosidase A activity. A novel missense mutation (p.G35V) in the GLA gene was detected. Family screening identified 11 additional cases (8 women). Clinical investigation was conducted in 10 patients (index case and 9 relatives). Pathogenicity of the new mutation was investigated by clinical and laboratory tests, cardiac and cranial magnetic resonance imaging, and kidney biopsy. Results: Cardiac manifestations were detected in most patient from both genders, such as left ventricular hypertrophy and short PR interval. White matter lesion was present in 3 women. Pulvinar lesion of the thalamus and ischemic stroke were detected in male patients. Abnormal glomerular filtration rate (GFR) and/or albuminuria were present in 5 patients (3 women). Renal biopsies (n = 7) revealed globotriaosylceramide deposits in different cell types and foot processes effacement in all patients, including women with normal albuminuria. Despite a normal GFR, tubulointerstitial fibrosis ranging from 5 to 20% was present in young women and men with normal or high albuminuria, respectively. Conclusion: The novel missense mutation p.G35V leads to severe systemic manifestations of FD in men and women. Kidney histological changes, including tubulointerstitial fibrosis, may predate albuminuria and GFR changes in adult women. Novel non-invasive markers are required for early detection of Fabry nephropathy. [ABSTRACT FROM AUTHOR]
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- 2018
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13. Effects of Aflatoxin on Kidney and Protective Effectiveness of Esterified Glucomannan in Ram.
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ÇOLAKOĞLU, Fatma and DÖNMEZ, Hasan Hüseyin
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In this study, the effects of total aflatoxin (AF) given orally on kidney in Merino rams were studied. In addition, this study was conducted in order to evaluate the efficacy of an esterified glucomannan (EG) for protection against to aflatoxicosis. One year-old 32 Merino rams were divided into four equal groups. Rams were fed through the 92 days. Control group (C) fed with the commercial feed. AF group fed with commercial feed added 250 µg/day of total AF. EG group fed with commercial feed added 2 g/day of EG. AF+EG group fed with commercial feed added 250 µg/day of total AF and 2 g/day of EG. At the end of the 92 day after cessation of the animals, tissue samples were taken from the kidney in order to perform histological structure. Degeneration and spills in the tubular epithelial cells of kidney were observed in the AF group. Massive hyperemia was observed in the renal vessels. In conclusion, the adverse effects causing by aflatoxicosis on the kidney could be ameliorated by adding EG to the ration. [ABSTRACT FROM AUTHOR]
- Published
- 2017
14. Nephropathology: A Cornerstone for Understanding and Estimation of Recent Advances in Glomerular Diseases.
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Capusa, Cristina, Mehedinti, Ana-Maria, Leh, Sabine, and Marti, Hans-Peter
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NEPHROLOGY , *KIDNEY diseases - Abstract
The developments in the field of kidney pathology are major objectives for nephrology worldwide, since the histopathologic diagnosis is a cornerstone for all glomerulopathies (either primary or secondary related to systemic diseases-for tubulointerstitial and vascular lesions as well as renal allograft nephropathy). Moreover, the correct interpretation of kidney tissue samples is a challenge for pathologists too. Consequently, a new subspecialty - nephropathology, was accepted by many medical schools in various universities, while dedicated scientific meetings, journals and websites were also created. In the following few pages, a short overview on the history, classic and novel meanings of the renal pathology for the understanding of glomerular pathophysiology will be discussed. [ABSTRACT FROM AUTHOR]
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- 2016
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15. ZD9331 : Preclinical and Clinical Studies
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Boyle, F. Thomas, Stephens, Trevor C., Averbuch, S. D., Jackman, Ann L., and Jackman, Ann L., editor
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- 1999
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16. The modulatory effect of Moringa oleifera leaf extract on endogenous antioxidant systems and inflammatory markers in an acetaminophen-induced nephrotoxic mice model
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Govindarajan Karthivashan, Aminu Umar Kura, Palanisamy Arulselvan, Norhaszalina Md. Isa, and Sharida Fakurazi
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Moringa oleifera ,Acetaminophen nephrotoxicity ,Serum biochemical markers ,Antioxidant enzymes ,Inflammatory cytokines ,Kidney histology ,Medicine ,Biology (General) ,QH301-705.5 - Abstract
N-Acetyl-p-Aminophenol (APAP), also known as acetaminophen, is the most commonly used over-the counter analgesic and antipyretic medication. However, its overdose leads to both liver and kidney damage. APAP-induced toxicity is considered as one of the primary causes of acute liver failure; numerous scientific reports have focused majorly on APAP hepatotoxicity. Alternatively, not many works approach APAP nephrotoxicity focusing on both its mechanisms of action and therapeutic exploration. Moringa oleifera (MO) is pervasive in nature, is reported to possess a surplus amount of nutrients, and is enriched with several bioactive candidates including trace elements that act as curatives for various clinical conditions. In this study, we evaluated the nephro-protective potential of MO leaf extract against APAP nephrotoxicity in male Balb/c mice. A single-dose acute oral toxicity design was implemented in this study. Group 2, 3, 4 and 5 received a toxic dose of APAP (400 mg/kg of bw, i.p) and after an hour, these groups were administered with saline (10 mL/kg), silymarin—positive control (100 mg/kg of bw, i.p), MO leaf extract (100 mg/kg of bw, i.p), and MO leaf extract (200 mg/kg bw, i.p) respectively. Group 1 was administered saline (10 mL/kg) during both the sessions. APAP-treated mice exhibited a significant elevation of serum creatinine, blood urea nitrogen, sodium, potassium and chloride levels. A remarkable depletion of antioxidant enzymes such as SOD, CAT and GSH-Px with elevated MDA levels has been observed in APAP treated kidney tissues. They also exhibited a significant rise in pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and decreased anti-inflammatory (IL-10) cytokine level in the kidney tissues. Disorganized glomerulus and dilated tubules with inflammatory cell infiltration were clearly observed in the histology of APAP treated mice kidneys. All these pathological changes were reversed in a dose-dependent manner after MO leaf extract treatment. Therefore, MO leaf extract has demonstrated some therapeutic effectiveness against APAP-induced nephrotoxicity through enhancement of the endogenous antioxidant system and a modulatory effect on specific inflammatory cytokines in kidney tissues.
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- 2016
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17. Therapeutic Artemether-Lumefantrine Modulated Monosodium Glutamate-Related Adversity on Rats’ Kidney Histology and Antioxidant Response Bio-Indicators
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J.C. Uzoechi, C.N. Uchukwu, D.D.C. Uwandu, A.C.C. Egbuonu, C.P. Nwuke, P.O. Alaebo, and I.M. Orji
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chemistry.chemical_compound ,Kidney histology ,Artemether/lumefantrine ,chemistry ,business.industry ,Monosodium glutamate ,Medicine ,Antioxidant response element ,Pharmacology ,business ,medicine.drug - Abstract
Co-intake-related interactive-synergistic influence of artemether-lumefantrine, AL and monosodium glutamate, MSG that separately mediated oxidative stress could be significant on the kidney actively involved in xenobiotic detoxification and elimination. Thus, influence of AL on rats’ kidney histomorphology and antioxidant bio-indicators following MSG-challenge was assessed. For 7 days, thirty rats (n = 5) were respectively exposed to vehicle (distilled water), therapeutic AL (TAL), high AL (HAL), MSG, MSG plus TAL or MSG plus HAL. Significant (P0.05).Rats’ kidney photomicrographs (H&E × 400) revealed normal histo-architecture in control but varied degree of fibroplasias (TAL- ,HAL- and MSG plus TAL-fed) and necrosis with infiltrations (MSG plus HAL-and MSG-fed), rats. These demonstrated MSG-related adversity and significant modulation response of TAL, unlike HAL, on the rats’ kidney histology and studied antioxidant response bio-indicators.
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- 2021
18. Effects of Clove Syrup Therapy on Creatinine, Urea, and Kidney Histology of Diabetes Mellitus Rat
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Sembiring, Firly, Unitly, Adrien Jems Akiles, and Eddy, La
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Clove Syrup ,Rat ,Diabetes Mellitus ,Diabetes Nephropathy ,Blood Glucose ,Urea ,Creatinine ,Kidney Histology - Abstract
This study aims to determine the effect of clove syrup on creatinine, urea, and kidney histology of diabetic rats induced by streptozotocin. Eighteen male rats were divided into six groups: N, C (-), and C (+) were the control groups, and groups 1.8, 3.6, and 7.2 were the experimental groups. Groups C (-), C (+), 1.8, 3.6, and 7.2 were injected with streptozotocin 45 mg/kg BW in a single intraperitoneal injection. Normal control group or N and negative control group or C (-) were left untreated; positive control group or C (+) were treated with glibenclamide 0.09 mg/kg BW; groups 1.8, 3.6, and 7.2 were given clove syrup with doses of 1.8, 3.6, and 7.2 ml/rat/day respectively for 14 days. The obtained data were analyzed using a one-way ANOVA test, followed by the Duncan test at the significant level of 95% (a = 0.05). Kidney histology was observed by Hematoxylin-Eosin staining using Microscope. The result showed that clove syrup therapy with a dose of 3.6 ml/rat/day significantly decreases glucose, urea, and creatinine levels. Also, it showed that the dose of 3.6 has a regeneration effect to repair the damaged kidney. However, the higher amount of 7,2 ml/rat/day was toxic, causing an increase in blood glucose, urea, and creatinine levels and impairing kidney cells. In conclusion, clove syrup consumption at the right dose gave the best result in decreasing glucose, urea, and creatinine levels and regenerating the damaged kidney.
- Published
- 2021
19. Kidney Histology, Kidney Function, and Age
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Andrew D. Rule, Richard J. Glassock, and Aleksandar Denic
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Pathology ,medicine.medical_specialty ,Kidney histology ,Nephrology ,business.industry ,MEDLINE ,Humans ,Medicine ,Renal function ,Kidney ,business ,Nephrectomy - Published
- 2021
20. Description of Kidney Histology of Mus Musculus After Giving Nano Hebal Rhodomyrtus tomentosa (Haramounting)
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Syafruddin Ilyas
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Rhodomyrtus tomentosa ,Pathology ,medicine.medical_specialty ,Research use ,biology ,Chemistry ,Significant difference ,H&E stain ,Histology ,biology.organism_classification ,Staining ,Kidney histology ,medicine ,Completely randomized design - Abstract
The objective of this study was to determine the description of kidney histology of Mus musculus after giving Nano Herbal Rhodomyrtus tomentosa (Haramonting). R.tomentosa (Haramonting) is made on a nanoscale using High Energy Milling (HEM). This research use the Completely Randomized Design (CRD), which consists of six groups of CMC 0.5% and Nano- R.tomentosa (Haramonting) at dosage of (100; 141,42; 200; 282,82; 400)mg/20g body weight. The kidneys were made into preparations by using the paraffin method and Hematoxylin Erlich-Eosin staining (HE). The results of histological kidneys showed that there is a significant difference (P0,05).
- Published
- 2019
21. Renal-Biofunction Potentials of Ethanolic Extract of Solanum Melongena Linn Fruit on Monosodium Glutamate- Intoxicated Rats and Kidney Histology
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Obinna Jeremiah, Ijere D. Nwanne, Uchendu O. Mbah, and Anthony Cemaluk C. Egbuonu
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chemistry.chemical_compound ,Kidney histology ,Melongena ,biology ,chemistry ,Monosodium glutamate ,Solanum ,Pharmacology ,biology.organism_classification - Published
- 2019
22. Kidney damage induced by sub-chronic fine particulate matter exposure
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Luis Isaías Juncos, Norma Canals, Ana Carolina Mateos, Iván Tavera Busso, and Hebe Alejandra Carreras
- Subjects
Male ,CIENCIAS MÉDICAS Y DE LA SALUD ,Fine particulate ,Ciencias de la Salud ,Physiology ,Lumen (anatomy) ,Salud Pública y Medioambiental ,030204 cardiovascular system & hematology ,010501 environmental sciences ,Kidney ,01 natural sciences ,complex mixtures ,purl.org/becyt/ford/3.3 [https] ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Fibrosis ,In vivo ,Rats, Inbred SHR ,BUN ,medicine ,Animals ,Sub chronic ,Respiratory system ,KIDNEY HISTOLOGY ,lcsh:Environmental sciences ,0105 earth and related environmental sciences ,General Environmental Science ,lcsh:GE1-350 ,Air Pollutants ,HYPERTENSION ,business.industry ,urogenital system ,ELEMENTAL COMPOSITION ,Environmental Exposure ,medicine.disease ,Rats ,medicine.anatomical_structure ,chemistry ,PM 2.5 ,purl.org/becyt/ford/3 [https] ,Kidney Diseases ,Particulate Matter ,Xenobiotic ,business - Abstract
According to the WHO, about 3 million people die each year due to ambient air pollution. Most of the in vivo studies on the PM 2.5 effects have been done on respiratory and cardiovascular tissues. However, little is known about the effects on the tissues involved on xenobiotic removal, such as kidneys. In the present study we assess the harmful effects of sub-chronic exposure to PM 2.5 on the kidney, by investigating histologic and serum alterations in healthy and hypertensive rat models. Mean PM 2.5 concentrations during exposures were slightly above the daily WHO standard. Exposed animals showed fibrosis, mesangial expansion, decrease glomerular and tubular lumen volumes in kidneys, with an elevated BUN. Hypertensive animals also exhibited much more severe alterations than healthy animals. We conclude that PM 2.5 induces minimal or small-scale abnormalities that can be determinant for renal health preservation. Fil: Tavera Busso, Iván. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina Fil: Mateos, Ana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina Fil: Juncos, Luis Isaias. Fundación J. Robert Cade; Argentina Fil: Canals, Norma. Oulton-inst D/diag y Tratamiento Ambulatorio; Argentina Fil: Carreras, Hebe Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
- Published
- 2018
23. Automated assessment of glomerulosclerosis and tubular atrophy using deep learning
- Author
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Antonella Barreca, Alessandro Gambella, Mauro Papotti, Massimo Salvi, Filippo Molinari, Alessandro Mogetta, and Luca Molinaro
- Subjects
Pathology ,medicine.medical_specialty ,Tubular atrophy ,Glomeruli segmentation ,Health Informatics ,Nephron ,Deep learning ,Digital pathology ,Kidney histology ,Kidney ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Image Processing, Computer-Assisted ,Humans ,Radiology, Nuclear Medicine and imaging ,Segmentation ,Radiological and Ultrasound Technology ,urogenital system ,business.industry ,Glomerulosclerosis ,medicine.disease ,Computer Graphics and Computer-Aided Design ,medicine.anatomical_structure ,Fully automated ,Automated algorithm ,Computer Vision and Pattern Recognition ,Artificial intelligence ,Neural Networks, Computer ,Atrophy ,business ,030217 neurology & neurosurgery ,Algorithms - Abstract
In kidney transplantations, pathologists evaluate the architecture of both glomeruli, interstitium and tubules to assess the nephron status. An accurate assessment of glomerulosclerosis and tubular atrophy is crucial for determining kidney acceptance, which is currently based on the pathologists’ histological evaluations on renal biopsies in addition to clinical data. In this work, we present an automated algorithm, called RENTAG (Robust EvaluatioN of Tubular Atrophy & Glomerulosclerosis), for the segmentation and classification of glomerular and tubular structures in histopathological images. The proposed novel strategy combines the accuracy of a level-set with the semantic segmentation of convolutional neural networks to detect the glomeruli and tubules contours. In the TEST set, our method exhibited excellent performance in both glomeruli (dice score: 0.9529) and tubule (dice score: 0.9174) detection and outperformed all the compared methods. To the best of our knowledge, the RENTAG algorithm is the first fully automated method capable of quantifying glomerulosclerosis and tubular atrophy in digital histological images. The developed software can be employed for the analysis of pre-transplantation biopsies to support the pathologists' diagnostic activity.
- Published
- 2021
24. Assessment of the Utility of Kidney Histology as a Basis for Discarding Organs in the United States: A Comparison of International Transplant Practices and Outcomes
- Author
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Dirk Kuypers, Stanley C. Jordan, Yassine Bouatou, Antoine Bouquegneau, Christophe Legendre, Xavier Jouven, Carmen Lefaucheur, Jean-Philippe Empana, Ashley Vo, Maarten Naesens, Peter P. Reese, Gillian Divard, Olivier Aubert, Alexandre Loupy, Edmund Huang, Vishnu S. Potluri, Denis Glotz, and Marc Raynaud
- Subjects
education.field_of_study ,medicine.medical_specialty ,Kidney ,Proportional hazards model ,business.industry ,Population ,030232 urology & nephrology ,Histology ,General Medicine ,030230 surgery ,medicine.disease ,Surgery ,Transplantation ,03 medical and health sciences ,0302 clinical medicine ,Kidney histology ,medicine.anatomical_structure ,Nephrology ,Cohort ,medicine ,Clinical Epidemiology ,education ,business ,Kidney transplantation - Abstract
Background Many kidneys donated for transplant in the United States are discarded because of abnormal histology. Whether histology adds incremental value beyond usual donor attributes in assessing allograft quality is unknown. Methods This population-based study included patients who received a deceased donor kidney that had been biopsied before implantation according to a prespecified protocol in France and Belgium, where preimplantation biopsy findings are generally not used for decision making in the allocation process. We also studied kidneys that had been acquired from deceased United States donors for transplantation that were biopsied during allocation and discarded because of low organ quality. Using donor and recipient characteristics, we fit multivariable Cox models for death-censored graft failure and examined whether predictive accuracy (C index) improved after adding donor histology. We matched the discarded United States kidneys to similar kidneys transplanted in Europe and calculated predicted allograft survival. Results In the development cohort of 1629 kidney recipients at two French centers, adding donor histology to the model did not significantly improve prediction of long-term allograft failure. Analyses using an external validation cohort from two Belgian centers confirmed the lack of improved accuracy from adding histology. About 45% of 1103 United States kidneys discarded because of histologic findings could be accurately matched to very similar kidneys that had been transplanted in France; these discarded kidneys would be expected to have allograft survival of 93.1% at 1 year, 80.7% at 5 years, and 68.9% at 10 years. Conclusions In this multicenter study, donor kidney histology assessment during allocation did not provide substantial incremental value in ascertaining organ quality. Many kidneys discarded on the basis of biopsy findings would likely benefit United States patients who are wait listed.
- Published
- 2020
25. StyPath: Style-Transfer Data Augmentation for Robust Histology Image Classification
- Author
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Aryan Mobiny, Pengyu Yuan, Chandra Mohan, Pietro Antonio Cicalese, Hien M. Nguyen, and Jan U. Becker
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Contextual image classification ,business.industry ,Computer science ,Histology ,Pattern recognition ,Kidney transplant ,Stain ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Kidney histology ,Qualitative analysis ,030220 oncology & carcinogenesis ,Antibody mediated rejection ,Artificial intelligence ,business - Abstract
The classification of Antibody Mediated Rejection (AMR) in kidney transplant remains challenging even for experienced nephropathologists; this is partly because histological tissue stain analysis is often characterized by low inter-observer agreement and poor reproducibility. One of the implicated causes for inter-observer disagreement is the variability of tissue stain quality between (and within) pathology labs, coupled with the gradual fading of archival sections. Variations in stain colors and intensities can make tissue evaluation difficult for pathologists, ultimately affecting their ability to describe relevant morphological features. Being able to accurately predict the AMR status based on kidney histology images is crucial for improving patient treatment and care. We propose a novel pipeline to build robust deep neural networks for AMR classification based on StyPath, a histological data augmentation technique that leverages a light weight style-transfer algorithm as a means to reduce sample-specific bias. Each image was generated in \(1.84 \pm 0.03\) s using a single GTX TITAN V gpu and pytorch, making it faster than other popular histological data augmentation techniques. We evaluated our model using a Monte Carlo (MC) estimate of Bayesian performance and generate an epistemic measure of uncertainty to compare both the baseline and StyPath augmented models. We also generated Grad-CAM representations of the results which were assessed by an experienced nephropathologist; we used this qualitative analysis to elucidate on the assumptions being made by each model. Our results imply that our style-transfer augmentation technique improves histological classification performance (reducing error from 14.8% to 11.5%) and generalization ability.
- Published
- 2020
26. Foetal serum but not urinary β2-microglobulin correlates with histological injury to the kidney.
- Author
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Luton, D., Delezoide, A.L., Leguy, M.C., Gobeaux, C., Vuillard, E., Grangé, G., and Guibourdenche, J.
- Subjects
- *
FETAL blood supply , *MICROGLOBULINS , *KIDNEY injuries , *SERUM , *BIOMARKERS , *ULTRASONIC imaging , *DYSPLASIA - Abstract
Abstract: In a context of foetal obstructive uropathies, biochemical markers can be helpful to assess the renal function, but most studies to date have focused on their correlation with ultrasound findings and neonatal outcome. Our aim was to evaluate foetal β2-microglobulin as an index of histological injury to the kidney. β2-microglobulin was measured in serum and/or urine from 27 foetuses with bilateral obstructive uropathy, and compared to the findings of kidney examination following the termination of pregnancy. In serum, increased β2-microglobulin levels correlated to a decreased number of glomeruli, a reduction in the blastema and the presence of primitive ducts reflecting renal hypoplasia and dysplasia. However, elevated β2-microglobulin levels in the urine correlated only to a decreased number of glomeruli. [Copyright &y& Elsevier]
- Published
- 2013
- Full Text
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27. Decreased Body Fat, Elevated Plasma Transforming Growth Factor-β Levels, and Impaired BMP4-Like Signaling in Biglycan-Deficient Mice.
- Author
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Tang, Tao, Thompson, Joel C., Wilson, Patricia G., Nelson, Christina, Williams, Kevin Jon, and Tannock, Lisa R.
- Abstract
Biglycan (BGN), a small leucine-rich proteoglycan, binds the pro-fibrotic cytokine transforming growth factor β (TGFβ) and inhibits its bioactivity in vitro. Nevertheless, it is controversial whether BGN plays an inhibitory role in vivo. Therefore, the purpose of this study was to evaluate the effect of BGN deficiency on TGFβ activity in vivo by studying 1-year-old Bgn null and wild-type (WT) mice on an Ldlr-null background. Phenotypic and metabolic characterization showed that the Bgn null mice had lower body weight, shorter body length, and shorter femur length (all p < 0.05). Surprisingly, the Bgn null mice also exhibited a striking reduction in percent body fat compared to WT mice ( p == 0.006), but no changes were observed in plasma triglycerides, total cholesterol, or glycohemoglobin. Both total and bioactive TGFβ1 concentrations in plasma were markedly elevated in Bgn null mice compared to WT mice (4-fold and 11-fold increase, respectively, both p < 0.001), but no changes were found in hepatic levels of mRNA for Tgfβ1 or its receptors. Bgn null mice exhibited elevated expression of hepatic fibronectin protein ( p = 0.034) without changes in hepatic or renal histology, and Bgn null mice had decreased urinary albumin/creatinine ratio ( p = 0.01). Two key downstream targets of bone morphogenetic protein 4-like signaling, SMAD1/3/5 phosphorylation and Id2 gene expression, were found dramatically reduced in Bgn null livers ( p = 0.034). Thus, BGN deficiency decreases body fat in this hyperlipidemic mouse model without changing liver or kidney histology. Overall, we propose that this unexpected phenotype arises from the effects of BGN deficiency in vivo to elevate TGFβ levels while decreasing bone morphogenetic protein 4-like signaling. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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- View/download PDF
28. Tissue fluoride accumulation and kidney lesions in freshwater-reared Atlantic salmon ( Salmo salar) fed with high dietary fluoride concentrations.
- Author
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HANSEN, J.Ø., PENN, M.H., SHEARER, K.D., STOREBAKKEN, T., and ØVERLAND, M.
- Subjects
- *
ATLANTIC salmon , *FRESHWATER fishes , *FISH feeds , *ZOOPLANKTON , *FLUORIDES , *FISH growth , *FISH nutrition , *FISH physiology - Abstract
Antarctic krill ( Euphausia superba) and other marine zooplankton may contain high levels of fluoride. The aim of the present experiment was to determine whether dietary fluoride from Antarctic krill at levels similar to the old and the new EU allowable limits in fish feeds (150 and 350 mg kg−1) would induce kidney lesions in freshwater-reared Atlantic salmon ( Salmo salar). In addition to the diets containing krill, two high-sodium fluoride (NaF) diets (1500 and 3500 mg kg−1) were used to investigate the effect on growth, feed intake, faecal excretion of minerals and accumulation of fluoride in various tissues. No major effects on growth or feed intake were observed. A higher proportion of the ingested fluoride was absorbed in salmon fed with the NaF diets compared with fish fed with krill shell diets. Fluoride accumulated in liver, kidney and especially bone. Faecal excretion of calcium and magnesium was higher for the NaF-fed fish compared with fish fed with the control and krill shell diets, whereas the levels of these minerals in plasma were unaffected. Dietary fluoride from krill shells did not induce kidney lesions. One-third of the salmon fed with the highest NaF diet showed signs of crystal formation within the distal tubules and/or collecting ducts in the kidney. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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- View/download PDF
29. Pulverized Mangifera Indica (mango) Seed kernel Mitigated Monosodium Glutamate-Intoxicated rats’ Kidney Histology and Bio-functions
- Author
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Anthony Cemaluk C Egbuonu and Sandra O Oriji
- Subjects
Horticulture ,chemistry.chemical_compound ,Kidney histology ,chemistry ,Monosodium glutamate ,Kernel (statistics) ,Mangifera ,Biology - Published
- 2017
30. Nephropathology: A Cornerstone for Understanding and Estimation of Recent Advances in Glomerular Diseases
- Author
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Sabine Leh, Ana-Maria Mehedinti, Cristina Capusa, and Hans-Peter Marti
- Subjects
Estimation ,Nephrology ,Transplantation ,medicine.medical_specialty ,business.industry ,030232 urology & nephrology ,Cornerstone ,kidney histology ,nephropathology ,glomerulopathies ,RC31-1245 ,03 medical and health sciences ,0302 clinical medicine ,proliferative pattern ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,Intensive care medicine ,business ,Glomerular diseases ,chronic kidney disease - Abstract
The developments in the field of kidney pathology are major objectives for nephrology worldwide, since the histopathologic diagnosis is a cornerstone for all glomerulopathies (either primary or secondary related to systemic diseases-for tubulointerstitial and vascular lesions as well as renal allograft nephropathy). Moreover, the correct interpretation of kidney tissue samples is a challenge for pathologists too. Consequently, a new subspecialty - nephropathology, was accepted by many medical schools in various universities, while dedicated scientific meetings, journals and websites were also created. In the following few pages, a short overview on the history, classic and novel meanings of the renal pathology for the understanding of glomerular pathophysiology will be discussed.
- Published
- 2016
31. Hexamethyldisiloxane: A 13-Week Subchronic Whole-Body Vapor Inhalation Toxicity Study in Fischer 344 Rats.
- Author
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Cassidy, Simon L., Dotti, Antonio, Kolesar, Gary B., Dochterman, L. Wayne, Meeks, Robert G., and Chevalier, H. J.
- Abstract
Hexamethyldisiloxane (HMDS) is a volatile linear siloxane dimer used in many applications, including precision cleaning, active ingredient carrier, and as a manufacturing intermediate. The purpose of this study was to characterize the subchronic vapor inhalation toxicity of the material as part of a comprehensive toxicology program. Groups of 20 male and 20 female Fischer 344 (F344) rats were exposed to nominal (and mean actual) vapor concentrations of 0, 50 (50), 200 (194), 600 (593), 1500 (1509) and 5000 (5012) ppm of HMDS, 6 hours per day, 5 days per week, for 13 weeks. No treatment-related signs of clinical toxicity or mortality, statistically significant effects upon body weight gain or food consumption, ophthahnoscopic changes, gross macroscopic necropsy findings, or organ weight changes were noted. Minor hematological, clinical biochemical, and urinalysis changes were seen but were not considered to be of toxicological relevance. Histological lesions in the kidney apparently consistent with male rat-specific α-2-urinary globulin nephropathy were observed in male rats exposed to 593, 1509, and 5012 ppm of HMDS, accompanied by slightly increased plasma urea and creatinine concentrations. No other treatment-related histological changes were seen in HMDS-exposed rats. [ABSTRACT FROM PUBLISHER]
- Published
- 2001
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32. Study of Shark Kidney Histology (Carcharhinus sorrah)
- Author
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Zakia Darajat
- Subjects
Carcharhinus sorrah ,biology ,Cartilaginous fish ,chemical and pharmacologic phenomena ,Histology ,General Medicine ,Anatomy ,biology.organism_classification ,Microscopic observation ,Kidney histology ,Elasmobranchii ,%22">Fish ,Animal species ,human activities - Abstract
Shark is a fish widespread in the tropical Indo-Pacific Ocean with a depth of 75 to 130 meters. Shark is a cartilaginous fish (Elasmobranchii). The fish is an ancient animal species that are still alive and also have different characteristics with bony fishes. Research on the histology of the shark's kidneys is still rare. The purpose of this study was to describe the histology of the shark kidneys (Carcharhinus sorrah). In this study we used one individual shark (Carcharhinus sorrah) from Depok Beach, Yogyakarta. The method used in this research was paraffin method with Hematoxylin-Eosin staining. From microscopic observation, the kidneys consist of glomerular parts, proximal tubules, distal tubules and lymphoid tissue.
- Published
- 2017
33. Automated assessment of glomerulosclerosis and tubular atrophy using deep learning.
- Author
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Salvi, Massimo, Mogetta, Alessandro, Gambella, Alessandro, Molinaro, Luca, Barreca, Antonella, Papotti, Mauro, and Molinari, Filippo
- Subjects
- *
GLOMERULOSCLEROSIS , *ATROPHY , *CONVOLUTIONAL neural networks , *HISTOPATHOLOGY , *KIDNEY transplantation , *DEEP learning - Abstract
• Architecture of glomeruli and tubules play a crucial role during transplantations. • Histological assessment is subjected to inter- and intra-observer variability. • A new deep learning method is presented for kidney histopathological images. • A Dice of 95.29 % and 91.74 % was achieved for glomeruli and tubules, respectively. • Our approach could improve the diagnostic workflow in kidney transplantation. In kidney transplantations, pathologists evaluate the architecture of both glomeruli, interstitium and tubules to assess the nephron status. An accurate assessment of glomerulosclerosis and tubular atrophy is crucial for determining kidney acceptance, which is currently based on the pathologists' histological evaluations on renal biopsies in addition to clinical data. In this work, we present an automated algorithm, called RENTAG (Robust EvaluatioN of Tubular Atrophy & Glomerulosclerosis), for the segmentation and classification of glomerular and tubular structures in histopathological images. The proposed novel strategy combines the accuracy of a level-set with the semantic segmentation of convolutional neural networks to detect the glomeruli and tubules contours. In the TEST set, our method exhibited excellent performance in both glomeruli (dice score: 0.9529) and tubule (dice score: 0.9174) detection and outperformed all the compared methods. To the best of our knowledge, the RENTAG algorithm is the first fully automated method capable of quantifying glomerulosclerosis and tubular atrophy in digital histological images. The developed software can be employed for the analysis of pre-transplantation biopsies to support the pathologists' diagnostic activity. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
34. Effect of Vitamin E on Adriamycin- Induced Nephrotoxicity at the Ultrastructural Level in Guinea Pigs.
- Author
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Görgün, M., Erdo&gcaron;an, D., Abban, G., Türközkan, N., and Elbeg, Ş.
- Abstract
It is known that Adriamycin, which is widely used in the treatment of various neoplastic conditions, exerts toxic effects in several organs. In this study, we have established that vitamin E has some beneficial effects on the kidney by protecting it from some of the toxcity induced by Adriamycin. A study was carried out which comprised one control group and two experimental groups of guinea pigs. In the experiment Adriamycin was administered either alone (group II) or together with vitamin E (group III). The results of groups II and III were compared with controls (group I). The kidneys were subsequently removed and examined by routine electron microscopic techniques. We found that vitamin E administered together with Adriamycin could reverse some of the degenerative changes caused by Adriamycin. [ABSTRACT FROM AUTHOR]
- Published
- 1999
- Full Text
- View/download PDF
35. Nephroprotective activity of okra pods extract (Abelmoschus esculentus L.) in sodium nitrite-induced mice
- Author
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Elma Sakinatus Sajidah, Baiq Naili Dewi Atika, Dwi Winarni, and Sri Puji Astuti Wahyuningsih
- Subjects
medicine.medical_specialty ,biology ,Chemistry ,Pharmacology ,biology.organism_classification ,Nephrotoxicity ,chemistry.chemical_compound ,Kidney histology ,medicine ,Pharmacology (medical) ,Abelmoschus ,Histopathology ,Sodium nitrite ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) - Published
- 2020
36. Nephrotoxicity of ridomil and chlorpyriphos: A preliminary investigation of pesticides interaction
- Author
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Ibiang Young Bassey, Nta Abo Iso, Udoh Akpan George, Ekpo Paul Bassey, Ekaluo Utip Benjamin, and Peter Abasiama Samuel
- Subjects
Creatinine ,Health, Toxicology and Mutagenesis ,Renal function ,Pesticide ,Toxicology ,Serum urea ,Nephrotoxicity ,chemistry.chemical_compound ,Kidney histology ,Animal science ,chemistry ,Urea ,Completely randomized design - Abstract
This study investigated the effect of Ridomil and Chlorpyriphos, singly and in combination, on serum kidney function parameters and kidney histology in male albino rat. In a completely randomized design, experimental subjects were constituted into treatment groups: A (control); CH1 (25 mg of Chlorpyriphos/kg bw); CH2 (50 mg of Chlorpyriphos/kg bw); R1 (25 mg of Ridomil/kg bw); R2 (50 mg of Ridomil/kg bw); COM1 (12.5 mg of Chlorpyriphos/kg bw+12.5 mg of Ridomil /kg bw); and COM2 (25 mg of Chlorpyriphos/kg bw+25 mg of Ridomil/kg bw); which orally received the stated pesticide treatments, thrice a week, at forty eight hour intervals for eight weeks. Serum urea and creatinine were reduced in the Chlorpyriphos only treatment groups. Treatment with Ridomil only, led to elevated urea and creatinine, especially in R2. Combination of both pesticides led to much higher elevation in serum urea and creatinine, especially in COM2, as well as in potassium, sodium and chloride levels. Kidney micrographs were suggestive of pathology in all pesticide treated groups except R1. We conclude that Ridomil and Chlorpyriphos individually pose notable nephrotoxicity threat, which could be heightened in a case of their combined exposure.
- Published
- 2014
37. Protective Effects of Prunus armeniaca L (Apricot) on Low Dose Radiation-Induced Kidney Damage in Rats
- Author
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Murat Ugras, Hulya Elbe, Ali Otlu, Elif Taslidere, and Meltem Kuruş
- Subjects
medicine.medical_specialty ,Kidney ,Antioxidant ,biology ,business.industry ,Urology ,medicine.medical_treatment ,Interstitial fibrosis ,biology.organism_classification ,Prunus armeniaca ,Kidney histology ,Endocrinology ,medicine.anatomical_structure ,Internal medicine ,Sprague dawley rats ,Medicine ,Surgery ,Regular diet ,business ,Low Dose Radiation - Abstract
Oz (Ingilizce):OBJECTIVE: This experimental study was designed to evaluate radiation-induced kidney damage and the protective effect of apricot against it using histological parameters. MATERIAL and METHODS: Rats were divided into 6 groups each containing 10 Sprague Dawley rats as follows: Regc: Rats on a regular diet (control diet) for 28 weeks; control group. Regx: Rats on a regular diet for 28 weeks, XRE on last day of eighth week. Aprc: Rats on an apricot diet for 28 weeks; control for no XRE. Aprx: Rats on an apricot diet for 28 weeks, XRE on last day of eighth week. Reg+Aprc: Rats on a regular diet for 8 weeks, followed by an apricot diet for the following 20 weeks; control. Reg + Aprx: Rats on a regular diet for 8 weeks, XRE on last day of eighth week, followed by an apricot diet for 20 weeks. RESULTS: The kidneys of the control groups showed normal kidney histology, whereas Regx group showed major histopathological changes, such as glomerular collapse, hemorrhage, interstitial fibrosis and inflammatory infiltrates. The Aprx and Reg+Aprx groups showed smaller amounts of degeneration. CONCLUSION: In conclusion, we suggest that agents with antioxidant properties such as apricot may have a positive effect in the treatment of renal diseases.
- Published
- 2014
38. Effect of Turmeric Rhizome Extract (Curcuma longa L.) on Liver Histology of Preeclampsia Rat (Rattus norvegicus L.)
- Author
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S. R. N. Panjaitan, Elimasni, Syafruddin Ilyas, and Salomo Hutahaean
- Subjects
Kidney histology ,biology ,Traditional medicine ,medicine ,Curcuma ,biology.organism_classification ,medicine.disease ,Rhizome ,Preeclampsia - Abstract
Turmeric is usually consumed routinely and for a long time, so it cannot be ascertained that the use of turmeric is safe or toxic especially in the liver because there are as many as 64 compounds in turmeric which are thought to be hepatotoxic, The prevalence of preeclampsia is around 5% -15% of all pregnancies in the world, where cases of hypertension in pregnancy including preeclampsia are found in numbers that tend to increase and are the most common medical complication in pregnancy. About 70% of women diagnosed with hypertension in pregnancy are cases of preeclampsia. This study used a type of analytic research with quasi-experimental design in pregnant female rats consisting of 4 treatments with 6 replications each. This study consisted of a negative control group (k-) with only feed given ad libitum, positive control (k +) in injection of LPS intervena with a group dose of 0.2 / kgBW and a group giving turmeric extract (Curcuma longa L.) with doses of 400mg / kgBW (P1) and 600mg / kgBW (P2) respectively. After that, histological preparations were carried out on the liver of rats (Rattusnovergicus). From the results of observations of the liver morphology in the negative (-) and P2 treatment the liver color was found to be dark red, whereas in the positive control group (k +) a pale red color was found. Then histological observations showed an increase in the percentage of liver necrosis from P1 and a decrease in necrosis in P2.
- Published
- 2019
39. Effect of Combination of Nano Herbal Andaliman (Zanthoxylum acanthopodium DC.) and Extra Virgin Olive Oil (EVOO) to Kidney Histology of Preeclampsia Rats
- Author
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Syafruddin Ilyas, Salomo Hutahaean, and Putri Cahaya Situmorang
- Subjects
Kidney histology ,Traditional medicine ,biology ,Zanthoxylum ,Chemistry ,medicine ,Andaliman ,medicine.disease ,biology.organism_classification ,Preeclampsia ,Olive oil - Abstract
Preeclampsia is a pregnancy disorder that can cause interference in the kidneys. This study aims to determine the safety effects of the combination of Nano herbal Andaliman (Zanthoxylum acanthopodium) and Extra Virgin Olive Oil (EVOO) in preeclampsia. This study consisted of 5 groups ie K(-): Pregnant Rats, K(+):PE model Rats, P1: PE model Rats + 0,45g EVOO/day/200gBW at 13rd-19th days pregnancy, P2: PE mode Rats + Nano-Andaliman 100mg/200gBW at 13rd-19th days pregnancy and P3: PE model Rats + 0,45g EVOO/day/200gBW + Nano-Andaliman 100mg/200gBW at 13rd-19th days pregnancy. This study showed no differences in kidney weight (p>0,05) but there were significant differences in Necrosis in kidneys (p < 0.05). Combination of Nano herbal Andaliman (Zanthoxylum acanthopodium) and Extra Virgin Olive Oil (EVOO) in preeclampsia can effect in histology kidneys.
- Published
- 2019
40. Effect of Mahkota Dewa Ethanolic Extract (Phaleria macrocarpa) to Kidney Histology of Preeclampsia Rats
- Author
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I. Nurahyuni, E. Zahara, S. Ilyas, and M. Tanjung
- Subjects
Phaleria macrocarpa ,Kidney histology ,biology ,Traditional medicine ,business.industry ,Medicine ,business ,biology.organism_classification ,medicine.disease ,Preeclampsia - Abstract
Hypertension is an increase in systolic and diastolic pressure, the height of which depends on the age of the individual affected. Hypertension can also cause terminal kidney failure (GGT). One of the herbs that has the effect of reducing blood pressure is the mahkota dewa. This study aims to determine the effect of mahkota dewa extract on histological and morphological features of the kidneys in preeclampsia rat. In this study using a type of analytic research with quasi-experimental design in pregnant rat (Rattus novergicus) as many as 24 rats and consisted of 4 treatments (each treatment was divided into 6 rats). control group, P1 (pregnant rats injected by LPS) P2 (pregnant rats injected with LPS given 100 mg / BW of mahkota dewa extract once a day) and P3 (pregnant rats injected with LPS and given 200 mg/BW of deity extract twice a day). On the 17th day the pregnancies of the rat were dissected and taken by kidney organs and then made a paraffin method preparation using Hematoxylin-Eosin (HE) staining. Morphological observations showed a change in color in group K (control) = blackish red, at P1 = pale red, P2 = brownish red and P2 = thick red While the results of kidney histology on tubular narrowing and necrosis obtained significant results (P
- Published
- 2019
41. Oral hypoglycaemic agent metformin reduces oxidative stress and improves kidney histologyin streptozotocin-induced diabetic rats
- Author
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Ainul Bhiyah Binti Abu Bakar, Aminu Ishaka, Mahaneem Mohamed, and Umar Zayyanu Usman
- Subjects
Kidney ,medicine.medical_specialty ,endocrine system diseases ,business.industry ,Diabetes, Metformin, Oxidative stress, Streptozotocin, Kidney ,nutritional and metabolic diseases ,Histology ,medicine.disease ,Streptozotocin ,medicine.disease_cause ,Metformin ,medicine.anatomical_structure ,Kidney histology ,Endocrinology ,Distilled water ,Diabetes mellitus ,Internal medicine ,medicine ,business ,Oxidative stress ,medicine.drug - Abstract
ABSTRACT Background: Persistent hyperglycaemia results in complications in diabetes mellitus (DM) and metformin is the baseline drug used in diabetic management. The effect of metformin on fasting blood glucose (FBG), homogenized kidney tissue malonyldehyde (MDA), protein carbonyls (PCO), total antioxidant capacity (TAC) and histology in streptozotocin-induced diabetic rats was investigated. Methods: Eighteen Sprague Dawley rats were assigned into three groups (n= 6 rats per group i.e. A; negative control on distilled water, B; positive control on distilled water and C; on 100 mg/kg/day metformin groups. Diabetes mellitus (DM) was induced using streptozotocin 65 mg/kg intraperitoneally and treatments were given daily by oral gavage for 3 weeks. Plasma fasting blood glucose (FBG), kidney tissue oxidative stress markers and histology were determined. Results: The results showed that FBG, MDA, and PCO levels were significantly higher in B group compared to A group, and lower in C group compared to B. The TAC level was significantly lower in B compared to A and higher in C compared to B group of rats. However, though histological study shows improvement in kidney histology in all treatments, kidney weight did not differ. Conclution: The results suggest that, metformin reduces oxidative stress in streptozotocin-induced diabetic rats possibly through its antihyperglycaemic effect.
- Published
- 2019
42. Systematic Kidney Biopsies After Acute Allograft Pyelonephritis
- Author
-
Federico Sallusto, Céline Guilbeau-Frugier, Olivier Cointault, Claire Cartery, Joelle Guitard, Nassim Kamar, Xavier Gamé, Laure Esposito, Isabelle Cardeau-Desangles, and Lionel Rostaing
- Subjects
Adult ,Graft Rejection ,Male ,medicine.medical_specialty ,Time Factors ,Biopsy ,Urology ,Renal function ,Kidney ,Kidney transplant ,Young Adult ,Kidney histology ,Predictive Value of Tests ,medicine ,Humans ,In patient ,Aged ,Transplantation ,Pyelonephritis ,Graft rejection ,medicine.diagnostic_test ,urogenital system ,business.industry ,Graft Survival ,Immunosuppressive regimen ,Recovery of Function ,Middle Aged ,Prognosis ,Kidney Transplantation ,surgical procedures, operative ,medicine.anatomical_structure ,Case-Control Studies ,Acute Disease ,Female ,business ,Glomerular Filtration Rate - Abstract
OBJECTIVES Scarce data exist regarding the effect of acute graft pyelonephritis on kidney histology after a kidney transplant. This study sought to assess the kidney histology at 1 month, and kidney function at 1 year, after acute graft pyelonephritis in kidney transplant patients. MATERIALS AND METHODS All kidney transplant patients with acute graft pyelonephritis between October 2006, and December 2008, underwent a kidney biopsy 1 month later (n=28). Histologic findings were compared with those observed in a control group (n=28) who underwent a protocol kidney biopsy at 1 year posttransplant and did not present with acute graft pyelonephritis. Patients were matched according to age, sex, and immunosuppressive regimen. RESULTS Kidney function was impaired by the acute graft pyelonephritis episodes at the time of biopsy. In 40% of patients, the estimated glomerular filtration rate did not return to baseline by 1 month after acute graft pyelonephritis and remained impaired thereafter. Three patients had features of acute rejection. Tubulitis was seen more frequently in the acute graft pyelonephritis group, especially in patients in whom estimated glomerular filtration rate did not completely recover by 1 month after acute graft pyelonephritis. Patients with acute graft pyelonephritis who had inflammatory infiltrate of > 20% 1 month after acute graft pyelonephritis had worse kidney function 1 year later. CONCLUSIONS After transplant, when kidney function remains impaired 1 month after acute graft pyelonephritis, kidney biopsies allowed graft rejection diagnosis and predicted kidney function recovery.
- Published
- 2013
43. The modulatory effect of Moringa oleifera leaf extract on endogenous antioxidant systems and inflammatory markers in an acetaminophen-induced nephrotoxic mice model
- Author
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Norhaszalina Md. Isa, Sharida Fakurazi, Palanisamy Arulselvan, Govindarajan Karthivashan, and Aminu Umar Kura
- Subjects
0301 basic medicine ,Antioxidant ,medicine.medical_treatment ,lcsh:Medicine ,010501 environmental sciences ,Pharmacology ,Toxicology ,01 natural sciences ,General Biochemistry, Genetics and Molecular Biology ,Nephrotoxicity ,03 medical and health sciences ,chemistry.chemical_compound ,Serum biochemical markers ,Kidney histology ,Pathology ,medicine ,Antipyretic ,Blood urea nitrogen ,0105 earth and related environmental sciences ,Moringa oleifera ,Kidney ,Creatinine ,Chemistry ,General Neuroscience ,digestive, oral, and skin physiology ,lcsh:R ,General Medicine ,Acetaminophen nephrotoxicity ,Food Science and Technology ,Inflammatory cytokines ,Acetaminophen ,030104 developmental biology ,medicine.anatomical_structure ,Immunology ,Toxicity ,Antioxidant enzymes ,General Agricultural and Biological Sciences ,Neuroscience ,medicine.drug - Abstract
N-Acetyl-p-Aminophenol (APAP), aka acetaminophen, is the most commonly used over-the counter analgesic and antipyretic medication. However, its overdose leads to both liver and kidney damage. APAP-induced toxicity is considered as one of the primary causes of acute liver failure; numerous scientific reports have focused majorly on APAP hepatotoxicity. Alternatively, not many works approach APAP nephrotoxicity focusing on both its mechanisms of action and therapeutic exploration.Moringa oleifera(MO) is pervasive in nature, is reported to possess a surplus amount of nutrients, and is enriched with several bioactive candidates including trace elements that act as curatives for various clinical conditions. In this study, we evaluated the nephro-protective potential of MO leaf extract against APAP nephrotoxicity in male Balb/c mice. A single-dose acute oral toxicity design was implemented in this study. Group 2, 3, 4 and 5 received a toxic dose of APAP (400 mg/kg of bw, i.p) and after an hour, these groups were administered with saline (10 mL/kg), silymarin—positive control (100 mg/kg of bw, i.p), MO leaf extract (100 mg/kg of bw, i.p), and MO leaf extract (200 mg/kg bw, i.p) respectively. Group 1 was administered saline (10 mL/kg) during both the sessions. APAP-treated mice exhibited a significant elevation of serum creatinine, blood urea nitrogen, sodium, potassium and chloride levels. A remarkable depletion of antioxidant enzymes such as SOD, CAT and GSH-Px with elevated MDA levels has been observed in APAP treated kidney tissues. They also exhibited a significant rise in pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and decreased anti-inflammatory (IL-10) cytokine level in the kidney tissues. Disorganized glomerulus and dilated tubules with inflammatory cell infiltration were clearly observed in the histology of APAP treated mice kidneys. All these pathological changes were reversed in a dose-dependent manner after MO leaf extract treatment. Therefore, MO leaf extract has demonstrated some therapeutic effectiveness against APAP-induced nephrotoxicity through enhancement of the endogenous antioxidant system and a modulatory effect on specific inflammatory cytokines in kidney tissues.
- Published
- 2016
44. Biomarkers of lupus nephritis histology and flare: deciphering the relevant amidst the noise
- Author
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Brad H. Rovin, Jon B. Klein, Michael L. Merchant, Daniel J. Birmingham, Sushrut S. Waikar, and Haikady N. Nagaraja
- Subjects
Oncology ,medicine.medical_specialty ,030232 urology & nephrology ,Lupus nephritis ,CLINICAL SCIENCE REVIEWS ,Disease ,Disease activity ,03 medical and health sciences ,0302 clinical medicine ,Kidney histology ,Internal medicine ,medicine ,Animals ,Humans ,In patient ,Longitudinal cohort ,030203 arthritis & rheumatology ,Transplantation ,business.industry ,medicine.disease ,Lupus Nephritis ,Nephrology ,Immunology ,Biomarker (medicine) ,business ,Biomarkers - Abstract
Biomarker development in lupus nephritis (LN) has traditionally relied on comparing the characteristics of candidate markers to clinical findings in patients and controls from cross-sectional cohorts. In this work, two additional strategies for LN biomarker development that are gaining ground will be discussed. One approach compares analytes directly to kidney histology. The second strategy utilizes longitudinal measurements of biomarker levels at regular intervals as patients move from disease quiescence to disease flare. These approaches have begun to empower biomarkers as diagnostic and prognostic tools in LN and have revealed novel and sometimes unexpected roles for these biomarkers in the pathogenesis and prediction of LN disease activity.
- Published
- 2016
45. Time course of saltwater adaptation in Spotted Scat (Scatophagus argus) (Pisces): A histomorphometric approach
- Author
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F. Chenary, H. Zolgarneine, Amir Ghazilou, and Hassan Morovvati
- Subjects
Kidney ,animal structures ,medicine.anatomical_structure ,Kidney histology ,biology ,Scatophagus argus ,Time course ,medicine ,Animal Science and Zoology ,Anatomy ,Adaptation ,biology.organism_classification ,Acclimatization - Abstract
Freshwater acclimatized spotted scat (Scatophagus argus) adults were adapted to 5, 10, 20 or 30 g/l seawater and observed for morphometric changes in gill and kidney histology at time points 1, 2, 10, 15 and 30 days. The overall histomorphological changes displayed by gill and kidney suggest two different phases of successful saltwater acclimation: an adaptive phase with adjustments in the abundance of gill chloride cells and renal collecting tubules, the diameter of glomerulus and collecting tubules, and the thickness of the muscular tissue of the collecting tubules; this gives way to a period with no further significant morphometric modifications.
- Published
- 2011
46. Changes in blood parameters and kidney histology due to cadmium and selenium exposure of Female rat
- Author
-
Ahmed Ali
- Subjects
inorganic chemicals ,Cadmium ,blood parameter ,cadmium ,chemistry.chemical_element ,Physiology ,Kidney histology ,chemistry ,histopathology ,Blood parameters ,lcsh:L ,lcsh:Science (General) ,Selenium ,lcsh:Education ,lcsh:Q1-390 - Abstract
The purpose of the study was to investigate the effect of Cadmium and selenium on blood parameters and the subsequent effect in the tissue of female rat kidney . Female rats were divided into a control group andtow experimental groups treated with Cadmium, and Cadmium +Selenium. A control and tested animals were fed with the same standard chow , but Cadmium chloride, and Cadmium+ Selenium mixture were orally gavaged daily for 28 days .At the end of the experimental period, blood samples were analyzed ,and packed cell volume ( PCV % ) , hemoglobin ( Hb ) , number of total erythrocytes count and total leucocytes count were determined . Blood analyses carried out in the present study showed that cadmium treatment causes different alterations in blood parameters as indicated by significant decrease in erythrocytes count , hemoglobin value and packed cell volume percentage as compared to control and Cd+selenium treated group . A number of histopathological change were observed in the kidney , including glomerular shrinkage, karyolysis , degenerative cell and cell necrosis at cadmium treatment and pronounced recovery after selenium cosupplemented showing a considerable antagonistic effects of Selenium + cadmium treatment . It can be concluded that the Cd exposure impair certain hematological mechanism and increase kidney tissue damage .Selenium showed beneficial effects to some extend. This study provide data on toxic effect in female rats after dietary sub lethal supplementation to heavy metals.
- Published
- 2007
47. Rapid changes in renal morphometrics in silver sea bream Sparus sarba on exposure to different salinities
- Author
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Marty Kwok-Shing Wong and N. Y. S. Woo
- Subjects
Morphometrics ,Kidney ,Sparidae ,biology ,Columnar Cell ,Anatomy ,Aquatic Science ,Renal morphology ,Water excretion ,urologic and male genital diseases ,biology.organism_classification ,Andrology ,Broad spectrum ,medicine.anatomical_structure ,Kidney histology ,medicine ,Ecology, Evolution, Behavior and Systematics - Abstract
The kidney histology of silver sea bream Sparus sarba adapted to different salinities was studied. Renal glomeruli in silver sea bream were grouped into clusters and two distinct types of glomeruli could be discerned. Expanded glomeruli were highly vascular, probably related to an active filtering role, while collapsed glomeruli had a shrunken appearance, probably related to an abated filtering role. Collecting tubules were lined by tall columnar cells and were more prominent and muscular in hypo-osmotic media. Chronic adaptation across a broad spectrum of salinities (0, 6, 12, 33 and 50) caused significant modifications in renal morphology. In hypo-osmotic media, a significant increase in glomerular number, size and percentage expanded glomeruli were found, which could facilitate water excretion. Collecting tubules exhibited an increase in thickness, diameter and muscularity that tended to favour a faster glomerular filtrate flow upon hypo-osmotic adaptation. Abrupt hypo-osmotic exposure induced rapid changes in the morphology of renal tubules. There was an increase in diameter and thickness of collecting tubules, suggesting increased glomerular filtrate flow was stimulated by hypo-osmotic exposure. The data suggested that the rapid change in kidney morphology is one of the osmoregulatory strategies of silver sea bream that may contribute to its ability to withstand abrupt hypo-osmotic challenge. A fast-acting mechanism that could be triggered within several hours could reorganize silver sea bream kidney so that the renal machinery is highly responsive to changes in environmental salinities.
- Published
- 2006
48. Studies of cadmium uptake in bone and its environmental distribution
- Author
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J. E. Harrison, Robert E. Jervis, S. M. W. Lui, and S. S. Krishnan
- Subjects
inorganic chemicals ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Biological Transport, Active ,chemistry.chemical_element ,Food Contamination ,Itai-itai disease ,Biochemistry ,Bone and Bones ,Inorganic Chemistry ,Kidney histology ,Internal medicine ,medicine ,Animals ,Distribution (pharmacology) ,Ingestion ,Cadmium ,Kidney ,Chemistry ,Liver and kidney ,Biochemistry (medical) ,Rats, Inbred Strains ,General Medicine ,medicine.disease ,Rats ,Oral ingestion ,Endocrinology ,medicine.anatomical_structure ,Environmental chemistry ,Environmental Pollutants ,Female - Abstract
Rat experiments indicate that oral ingestion of cadmium through drinking water leads to an accumulation of cadmium in bone, in addition to liver and kidney. After five weeks of cadmium intake in drinking water (50 to 100 mg/L), the bone cadmium levels increased in proportion to the intake concentration. Bone and kidney histology showed no signs of bone or kidney damage up to 5 wk of cadmium ingestion. Cadmium accumulation in bone was a primary phenomenon and not secondary to renal failure. In addition, cadmium levels have been estimated in a variety of sources, e.g., foodstuff, fertilizer, and sewage sludge, using neutron and proton activation analyses and atomic absorption spectrophotometry. Cadmium levels of Canadian foods are in the range of 0.002-0.07 mg/kg, and soils are in the range of 0.55 to 1.72 mg/kg. Fertilizers contain cadmium from 0.3 to 1.25 mg/kg, whereas sewage sludge contains up to 122 mg/kg.
- Published
- 1990
49. Teratogenic effect of maternal administration of aloe vera extract on foetal morphology and the histology of the foetal kidney
- Author
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GO Otung, OE Mesembe, Theresa B. Ekanem, Mokutima A. Eluwa, Aligwekwe Au, and G Udo-Affah
- Subjects
aloe vera extract ,foetal morphology ,kidney histology ,Pathology ,medicine.medical_specialty ,Kidney ,biology ,business.industry ,Histology ,biology.organism_classification ,Teratology ,Aloe vera ,Kidney histology ,medicine.anatomical_structure ,medicine ,business - Abstract
No Abstract. Global Journal of Medical Sciences Vol. 5(1) 2006: 41-44
- Published
- 2006
50. Associations Between Metabolic Syndrome and Kidney Histology, Anatomy and Function among Living Kidney Donors
- Author
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Jesse D. Schold, Y. Ohashi, Emilio D. Poggio, George Thomas, and Titte R. Srinivas
- Subjects
Transplantation ,Pathology ,medicine.medical_specialty ,Kidney ,medicine.anatomical_structure ,Kidney histology ,business.industry ,Medicine ,Metabolic syndrome ,business ,medicine.disease ,Function (biology) - Published
- 2012
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