1. Walnut-Enriched Diet Elevated α-Linolenic Acid, Phytoprostanes, and Phytofurans in Rat Liver and Heart Tissues and Modulated Anti-inflammatory Lipid Mediators in the Liver
- Author
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Camille Oger, Jean-Marie Galano, Jetty Chung-Yung Lee, Thierry Durand, Kin Sum Leung, Yu Fung Yau, The University of Hong Kong (HKU), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
0106 biological sciences ,medicine.medical_specialty ,medicine.drug_class ,walnut ,α-linolenic acid ,Anti-Inflammatory Agents ,Juglans ,01 natural sciences ,Anti-inflammatory ,In vivo ,phytofurans ,Internal medicine ,medicine ,Animals ,Nuts ,2. Zero hunger ,Autoxidation ,Chemistry ,010401 analytical chemistry ,alpha-Linolenic Acid ,General Chemistry ,Lipid signaling ,phytoprostanes ,[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism ,Eicosapentaenoic acid ,Diet ,Rats ,0104 chemical sciences ,Endocrinology ,Liver ,Heart tissues ,Neuroprostanes ,General Agricultural and Biological Sciences ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,neuroprostanes ,010606 plant biology & botany - Abstract
International audience; α-Linolenic acid (ALA) and its non-enzymatic oxidized products, namely, phytoprostanes and phytofurans, are found in some nuts. The uptake and deposition of these compounds are not well-defined. Walnut has high ALA and a considerable amount of phytoprostanes and phytofurans compared to other common nuts. When fed to rodents, ALA and eicosapentaenoic acid levels increased in the liver and heart tissues compared to the control diet. Furthermore, phytoprostanes and phytofurans were elevated 3fold in both tissues after a walnut diet, indicating that they are not only contributed from the diet but also generated through in vivo autoxidation of ALA found in the walnuts. It was further noted that a walnut diet reduced 5-F 2t-isoprostanes and 12hydroxyeicosatetraenoic acid and induced 4-F 4t-neuroprostane and significant amounts of anti-inflammatory hydroxydocosahexaenoic acid in the liver only. Altogether, high ALA in a walnut diet elevated phytoprostanes and phytofurans in the liver and heart tissues and showed the regulation of anti-inflammatory lipid mediators in the liver only.
- Published
- 2020