1. A Randomized Controlled Trial of Interventions for Growth Suppression in Children With Attention-Deficit/Hyperactivity Disorder Treated With Central Nervous System Stimulants
- Author
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James G. Waxmonsky, William E. Pelham, Adriana Campa, Daniel A. Waschbusch, Tan Li, Rebecca Marshall, Lysett Babocsai, Hugh Humphery, Elizabeth Gnagy, James Swanson, Tomasz Hanć, and Negar Fallahazad
- Subjects
Pediatrics ,medicine.medical_treatment ,Psychological intervention ,Medical and Health Sciences ,law.invention ,Body Mass Index ,Randomized controlled trial ,law ,Developmental and Educational Psychology ,Child ,Pediatric ,05 social sciences ,Drug holiday ,Psychiatry and Mental health ,medicine.anatomical_structure ,Treatment Outcome ,Mental Health ,Child, Preschool ,6.1 Pharmaceuticals ,050104 developmental & child psychology ,medicine.medical_specialty ,growth ,Central nervous system ,Clinical Trials and Supportive Activities ,Developmental & Child Psychology ,CNS stimulants ,attention-deficit/hyperactivity disorder ,Clinical Research ,medicine ,Attention deficit hyperactivity disorder ,Humans ,0501 psychology and cognitive sciences ,Obesity ,Preschool ,Nutrition ,business.industry ,Prevention ,Body Weight ,Psychology and Cognitive Sciences ,Neurosciences ,Evaluation of treatments and therapeutic interventions ,medicine.disease ,Attention Deficit Hyperactivity Disorder (ADHD) ,Stimulant ,Clinical trial ,Good Health and Well Being ,Attention Deficit Disorder with Hyperactivity ,Methylphenidate ,Central Nervous System Stimulants ,business ,Body mass index - Abstract
ObjectiveTo examine the impact of central nervous system (CNS) stimulants on the growth of children with attention-deficit/hyperactivity disorder (ADHD), and to assess the efficacy and feasibility of weight recovery interventions on growth.MethodA total of 230 children aged 5 to 12 years with ADHD with no history of chronic CNS stimulant use were randomly assigned to receive daily CNS stimulants (78%, primarily osmotic release oral system-methylphenidate [OROS-MPH]) or behavioral treatment (22%) for 30 months. After 6 months, children evidencing a decline in body mass index (BMI) of >0.5 z-units were randomized to 1 of 3 weight recovery treatments (WRTs): monthly monitoring of height/weight (MON) plus continued daily medication; drug holidays (DH) with medication limited to school days; or daily caloric supplementation (CS) with a 150-kcal supplement plus daily medication.ResultsBefore WRT assignment, medication was associated with significant reductions in standardized weight and height (p values 
- Published
- 2020