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Your search keyword '"Lu, Zhijian"' showing total 4 results
Start Over Author "Lu, Zhijian" Topic protease inhibitors
4 results on '"Lu, Zhijian"'

1. Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus

Author

Raghavan, Subharekha, Lu, Zhijian, Beeson, Teresa, Chapman, Kevin T., Schleif, William A., Olsen, David B., Stahlhut, Mark, Rutkowski, Carrie A., Gabryelski, Lori, Emini, Emilio, and Tata, James R.

Subjects
*HIV, *HTLV, *ENZYME inhibitors, *PROTEASE inhibitors
Abstract

Abstract: A series of HIV protease inhibitors with modifications on the P3 position have been designed and synthesized. These compounds exhibit excellent antiviral activity against both the wild type enzyme and PI-resistant clinical viral isolates. The synthesis and biological activity of the compounds are described. [Copyright &y& Elsevier]

Published
2007
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2. Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus

Author

Lu, Zhijian, Bohn, Joann, Rano, Tom, Rutkowski, Carrie A., Simcoe, Amy L., Olsen, David B., Schleif, William A., Carella, Anthony, Gabryelski, Lori, Jin, Lixia, Lin, Jiunn H., Emini, Emilio, Chapman, Kevin, and Tata, James R.

Subjects
*PROTEASE inhibitors, *PHYSICAL sciences, *LIFE sciences, *STRUGGLE
Abstract

Abstract: Efforts directed to identifying potent HIV protease inhibitors (PI) have yielded a class of compounds that are not only very active against wild-type (NL4-3) HIV virus but also very potent against a panel of PI-resistant viral isolates. Chemistry and biology are described. [Copyright &y& Elsevier]

Published
2005
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3. Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus

Author

Lu, Zhijian, Raghavan, Subharekha, Bohn, Joann, Charest, Mark, Stahlhut, Mark W., Rutkowski, Carrie A., Simcoe, Amy L., Olsen, David B., Schleif, William A., Carella, Anthony, Gabryelski, Lori, Jin, Lixia, Lin, Jiunn H., Emini, Emilio, Chapman, Kevin, and Tata, James R.

Subjects
*PROTEASE inhibitors, *HIV, *VIROLOGY
Abstract

A series of highly potent HIV protease inhibitors have been designed and synthesized. These compounds are active against various clinical viral isolates as well as wild-type virus. The synthesis and biological activity of these HIV protease inhibitors are discussed. [Copyright &y& Elsevier]

Published
2003
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4. Indinavir analogues with blocked metabolism sites as HIV protease inhibitors with improved pharmacological profiles and high potency against PI-Resistant viral strains

Author

Cheng, Yuan, Zhang, Fengqi, Rano, Thomas A., Lu, Zhijian, Schleif, William A., Gabryelski, Lori, Olsen, David B., Stahlhut, Mark, Rutkowski, Carrie A., Lin, Jiunn H., Jin, Lixia, Emini, Emilio A., Chapman, Kevin T., and Tata, James R.

Subjects
*PHARMACOKINETICS, *PROTEASE inhibitors
Abstract

Indinavir analogues with blocked metabolism sites show highly improved pharmacokinetic profiles in animals. The cis-aminochromanol substituted analogues exhibited excellent potency against both the wild-type (NL4-3) virus and protease inhibitor-resistant HIV strains. [Copyright &y& Elsevier]

Published
2002
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