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A recent study from the University of Colorado focused on liver transplantation outcomes for young patients with biliary atresia (BA). The research found that living donor liver transplantation (LDLT) was associated with improved survival rates for BA patients under 2 years old. However, socioeconomic disparities were noted between LDLT recipients and non-LDLT recipients, highlighting the importance of equitable access to LDLT for better outcomes in young children with BA. [Extracted from the article]

A recent study conducted at the University of Colorado focused on stroke-bleeding risk score pairings within individuals with atrial fibrillation (AF). The research aimed to understand the concordance between stroke and bleeding risk scores in AF patients. The study found that most AF patients with high bleeding risk also had high stroke risk, emphasizing the importance of stroke prevention even in patients at risk of bleeding. The research suggests that bleeding scores, along with specific bleeding risk factors, could help identify patients who may benefit from alternative stroke prevention strategies. [Extracted from the article]

Researchers at Children's Hospital Colorado conducted a study on emotional well-being in transition-age adults with pediatric-onset disabilities, such as acquired brain injury, spina bifida, and neuromuscular disorders. The study found that 65.4% of participants reported clinically elevated depressive symptoms, with 45% not receiving psychotherapy services. Poor family functioning and older age were associated with more depressive symptoms, highlighting the need for interventions to support emotional well-being in this population. The research was peer-reviewed and published in Rehabilitation Psychology, emphasizing the importance of addressing emotional challenges in transition-age adults with disabilities. [Extracted from the article]

A recent study conducted at the University of Colorado explored the impact of the gut microbiome on the appearance of green tea compounds in the plasma of mice following acute green tea consumption. The research utilized a combined microbiome analysis and metabolomics approach to investigate the relationship between green tea compounds and gut microbiome composition. The findings suggest that certain green tea compounds in plasma are associated with microbiome presence and diversity, highlighting the importance of considering food products as meta-organisms. This study provides a novel workflow for understanding the connections between individual food compounds and the gut microbiome. [Extracted from the article]

A recent study conducted at the University of Colorado focused on the challenges of community translation of lung cancer screening (LCS) and the importance of informed decision-making in this process. The study evaluated the feasibility and acceptability of a web-based decision aid called LuCaS CHOICES, designed to support informed decision-making about LCS. Results showed that both LuCaS CHOICES and the National Cancer Institute's Lung Cancer Screening website were acceptable to participants, but improvements in intervention engagement are needed. Future research will further evaluate the efficacy and effectiveness of LuCaS CHOICES in supporting high-quality LCS translation into community settings. [Extracted from the article]

A recent study conducted by the University of Colorado focused on comparing immune responses to respiratory syncytial virus (RSV) in infants, children, and adults using an in vitro model of human respiratory infection. The research highlighted differences in cellular immune responses to RSV across different age groups, showing changes in innate and adaptive RSV-specific cellular immune responses over time. Funded by various organizations including the National Institutes of Health, the study sheds light on the impact of RSV on morbidity and mortality in infants. [Extracted from the article]

Researchers at the University of Colorado Denver conducted a study on the relationship between valve frame geometry and the risk of ventricular arrhythmia following self-expanding transcatheter pulmonary valve replacement. The study included 28 patients who underwent the procedure with Harmony TPV25 or Alterra Pre-stent. The findings suggested that patients with congenital pulmonary stenosis were more likely to experience clinically significant ventricular arrhythmia, and larger valve frame perimeter and cross-sectional area were associated with this risk. The researchers recommended further studies with a larger patient cohort to explore these relationships in more detail. [Extracted from the article]

Researchers at the University of Colorado have reported new findings on radiation pneumonitis after partial breast irradiation. The study discusses the development of symptomatic radiation pneumonitis in a healthy woman undergoing treatment for early-stage breast cancer. The research highlights the rarity of radiation pneumonitis and the importance of understanding risk factors, diagnosis, and management. For more information, the study can be found in Practical Radiation Oncology, and additional details can be obtained from the University of Colorado. [Extracted from the article]

Researchers at the University of Colorado conducted a retrospective cohort study to evaluate post-operative atrial fibrillation (POAF) in adult congenital heart disease (ACHD) patients who underwent cardiac surgery. They found that older age, history of supraventricular tachycardia, intra-operative arrhythmia, and post-operative hypokalemia were independent predictors of POAF. POAF was associated with longer hospital stays and recurrence of atrial fibrillation but did not predict mortality, stroke, or bleeding events. Further research is needed to understand the long-term impacts of POAF in ACHD patients. [Extracted from the article]

The University of Colorado conducted research on acute kidney injury caused by cisplatin, a common chemotherapeutic agent. The study focused on understanding the pharmacokinetics and toxicodynamics of cisplatin-induced kidney injury to predict and prevent it. The research highlighted the importance of incorporating both traditional clinical biomarkers and newer subclinical biomarkers in developing models to predict and prevent cisplatin-induced nephrotoxicity. This study was funded by various NIH institutes and was published in the Journal of Pharmacology and Experimental Therapeutics. [Extracted from the article]

A recent study conducted at the University of Colorado explored the association between a family caregiver's relationship to persons with dementia and cardiovascular disease risk factors by race and ethnicity. The research found that spouse caregivers were at higher risk of certain cardiovascular conditions, such as diabetes and stroke, compared to adult children caregivers. The study highlights the importance of developing culturally appropriate cardiovascular preventive health care strategies that consider the caregiving relationship, especially among minoritized racial and ethnic caregiver groups. [Extracted from the article]

A recent systematic review and meta-analysis conducted at the University of Colorado Anschutz Medical Campus focused on capsular contracture in breast reconstruction using silicone implants. The study compared different factors such as implant placement, implant surface, and implant type to evaluate their impact on capsular contracture rates. The research found that patients receiving saline implants had significantly lower capsular contracture rates compared to those with silicone implants, but no significant differences were observed between subpectoral versus prepectoral implant placement and smooth versus textured implants. This peer-reviewed study provides valuable insights for medical professionals in the field of plastic and reconstructive surgery. [Extracted from the article]

Researchers from the University of Colorado Anschutz Medical Campus collaborated with the Colorado Office of Gun Violence Prevention to address firearm injuries in Colorado. The study highlights the importance of research-practice partnerships in developing, testing, and scaling solutions to the public health crisis of firearm injuries. This case study emphasizes the need for enhancing data infrastructure, translating research evidence into practice, and evaluating state prevention strategies to inform quality improvement efforts. The research, funded by the Colorado Department of Public Health and Environment, aims to advance a state-level public health approach to firearm injury prevention in the United States. [Extracted from the article]

A study conducted at the University of Colorado focused on clinical outcomes after a biopsy diagnosis of antibody-mediated rejection in pediatric heart transplant recipients. The research highlighted the importance of distinguishing between cellular and antibody-mediated rejection through biopsy in pediatric heart transplant patients. The study found that antibody-mediated rejection was associated with higher graft loss compared to cellular rejection in the first year post-heart transplant, with predictors of graft loss including younger age at transplant and rejection with hemodynamic compromise. The findings underscore the significance of antibody-mediated rejection on survival outcomes in pediatric heart transplant recipients. [Extracted from the article]

A recent study conducted at the University of Colorado focused on patient comprehension of mammography reports and the use of online resources to aid in report interpretation. Patients who received normal mammogram results were interviewed and completed health literacy questionnaires, with most reporting improved understanding after an internet search. The research concluded that while online resources helped marginally, clearer and more actionable resources are needed to enhance patient understanding in breast oncology. The study was funded by various organizations including the University of Colorado Cancer Center and the Doris Duke Charitable Foundation. [Extracted from the article]

A recent study conducted at the University of Colorado evaluated the usability of MedEd, a patient engagement tool that provides definitions of medical terminology in breast pathology and radiology reports. The study found that participants reported ease of downloading and navigating MedEd, with high acceptability, appropriateness, and feasibility scores. Future steps include evaluating comprehension of real breast reports while using MedEd and expanding patient access to the tool. For more information, readers can refer to the research article published in The American Journal of Surgery. [Extracted from the article]

A recent study conducted at the University of Colorado focused on proteomic analysis to identify multiprotein signatures associated with early diabetic kidney disease in youth with type 2 diabetes mellitus. The research aimed to uncover risk biomarkers for the onset of diabetic kidney disease in young individuals with type 2 diabetes. The study found that proteomic changes early in the course of youth-onset type 2 diabetes could be predictive of diabetic kidney disease outcomes, shedding new light on potential interventions and mechanisms. For more information, readers can refer to the Clinical Journal of the American Society of Nephrology. [Extracted from the article]

A study conducted at the University of Colorado focused on the use of CRISP modifiers to predict adverse events in adults undergoing cardiac catheterization procedures. The study found that a higher CRISP score was associated with an increased risk of adverse events, and the addition of three modifiers (NYHA Class > 2, prior sternotomies > 2, and BMI > 30) improved the prediction of adverse events. The research concluded that the CRISP score, along with adult modifiers, effectively predicted adverse events in adults with congenital heart disease. [Extracted from the article]

A recent study conducted at the University of Colorado analyzed the characteristics and prognosis of patients with pancreatic adenocarcinoma who do not express the carbohydrate antigen 19-9 (CA 19-9). The research found that non-expressors of CA 19-9 had a higher risk of distant metastasis at diagnosis and shorter overall survival compared to patients with normal-range CA 19-9 levels. The study suggests that this subgroup may require alternative biomarkers and more extensive preoperative staging and intensive perioperative systemic therapy. [Extracted from the article]

Researchers from the Colorado School of Public Health have conducted a study on the health effects of high-concentration delta-9-tetrahydrocannabinol (delta-9-THC) products, which are increasingly available in the United States. The study highlights the challenges in conducting research on these products, such as measurement of exposure and outcomes, confounding factors, and generalizability of findings. The researchers emphasize the importance of generating valid evidence to inform public health initiatives and policy decisions regarding the use of high-concentration delta-9-THC products, given their widespread legalization and use. [Extracted from the article]

A recent report from the University of Colorado discusses the guidelines for lung transplant referrals for individuals with cystic fibrosis (CF). The review highlights the importance of considering factors such as airflow limitation, hemoptysis, low body mass index, and extra-pulmonary organ failure when determining the need for a lung transplant. The research emphasizes the need for improved prognostic tools to ensure timely referrals and mentions the potential impact of novel CF therapies on the necessity and timing of lung transplants. [Extracted from the article]

A recent study conducted at the University of Colorado explored the reasons behind skepticism towards information about the benefits and harms of mammography screening for breast cancer. The research found that skepticism was not driven by emotional aversion but rather by conflicting beliefs and past screening messages. The study suggests that consistent and coordinated messaging from health experts may help reduce skepticism and promote a more informed patient population. This peer-reviewed research provides valuable insights into the psychological factors influencing screening preferences among women aged 39-49. [Extracted from the article]

Researchers at the University of Colorado conducted a retrospective analysis on 162 patients who underwent thyroid surgery for thyroid cancer between 2006 and 2022. They found that pre-operative thyroglobulin levels were significantly associated with the risk of recurrence and response to therapy in thyroid cancer patients. The study suggests that pre-operative thyroglobulin measurement may have the potential to guide initial therapy and follow-up management for thyroid cancer patients. This research has been peer-reviewed and published in The American Journal of Surgery. [Extracted from the article]

Researchers at the University of Colorado Anschutz Medical Campus have highlighted the potential utility of cord blood DNA methylation as biomarkers for disease risk identification and stratification in pediatrics. The study emphasizes the associations of parental exposures with the infant/fetal methylome and their impact on chronic health outcomes in children. The research underscores the importance of replicable, validated, and clinically meaningful results for cord blood DNA methylation analyses to be leveraged as biomarkers in pediatric clinical practice. [Extracted from the article]

Researchers from the University of Colorado conducted a study on vitiligo, an autoimmune disease that causes depigmented skin patches. They found an inverse relationship between the genetic risk for vitiligo and the age of onset of the disease. While genetic factors play a role in predicting the age of onset, environmental triggers also contribute to the development of vitiligo. This study was supported by the National Institutes of Health and published in The American Journal of Human Genetics. [Extracted from the article]

A recent study conducted by researchers at the University of Colorado focused on the arrhythmic effects of cannabis in individuals with ischemic heart disease (IHD). The study found that chronic cannabis use led to only mild heart rate changes, which were blunted in individuals with IHD. Additionally, the research suggested that arrhythmias were more frequent in individuals with IHD who were cannabis users compared to healthy subjects. This study was supported by the NIH National Center for Advancing Translational Sciences and the Colorado Department of Public Health and Environment. [Extracted from the article]

A recent study conducted at the University of Colorado focused on understanding physician practices and preferences regarding the use of vaginal stents to prevent postoperative vaginal stenosis in pediatric and adolescent patients. The research involved an online survey distributed to members of the North American Society for Pediatric and Adolescent Gynecology, with most participants being pediatric and adolescent gynecology specialists. The study highlighted the limited options for vaginal stents in this population and emphasized the need for future efforts to develop clinical guidelines to prevent vaginal stenosis. [Extracted from the article]

A study conducted at the University of Colorado explored the effects of oral insulin on early combined glucose and C-peptide endpoints in individuals at high risk for type 1 diabetes. The research found that participants in the oral insulin group showed minimal increases in glucose and increased C-peptide levels, indicating a potential metabolic benefit. These findings suggest that a novel combination of glucose and C-peptide markers could identify therapeutic benefits in high-risk individuals, potentially allowing for shorter trials compared to the standard endpoint of type 1 diabetes diagnosis. [Extracted from the article]

The University of Colorado conducted a study on the impact of diabetes mellitus (DM) on HIV virologic control among individuals with HIV (PWH). The research found that women with DM who are highly adherent to antiretroviral therapy (ART) have a lower risk of viremia compared to women without DM. However, women with poorly controlled DM were at a higher risk of HIV viremia than women with controlled DM. Further research is needed to understand the impact of sex, DM, and ART adherence on HIV viremia. [Extracted from the article]

Researchers from the University of Colorado conducted a study on the effects of cannabis use on heart rate and arrhythmias in individuals with ischemic heart disease (IHD). The study found that chronic cannabis use led to mild changes in heart rate, with more frequent arrhythmias observed in IHD subjects compared to healthy controls. The research was supported by the NIH National Center for Advancing Translational Sciences and the Colorado Department of Public Health and Environment. The findings were published in the journal Cannabis and Cannabinoid Research. [Extracted from the article]

A recent report from the University of Colorado highlights the importance of determining the optimal meniscus repair technique on a tear-by-tear basis. Bucket-handle meniscus tears can significantly increase the risk of osteoarthritis if not preserved, emphasizing the need for repair to optimize knee stability and joint preservation. The study discusses the advantages and disadvantages of inside-out (IO) and all-inside (AI) repair techniques, as well as the potential benefits of using biologics to promote healing in meniscus tears. [Extracted from the article]

A recent report from the University of Colorado discusses the potential of Nintedanib (NTD) in preserving lung growth and preventing pulmonary hypertension in an experimental model of hyperoxia-induced bronchopulmonary dysplasia (BPD) in rats. The study found that NTD treatment restored lung function and structure in hyperoxia-exposed rats without adverse effects in control animals. The research suggests that anti-fibrotic therapies, like NTD, could be a promising strategy for preventing or treating BPD and pulmonary hypertension, although caution is advised regarding high doses of NTD. [Extracted from the article]

A study conducted at the University of Colorado focused on the role of glial-neuronal metabolic crosstalk and horizontal lipid flux in the brain's fatty acid sensing. The research highlighted the importance of non-neuronal glial cells in regulating systemic metabolism and energy homeostasis. By understanding glial lipid metabolism, future studies may target lipid processing in the brain to reduce the risk of obesity and metabolic diseases. The study was supported by the NIH National Institute of Neurological Disorders & Stroke and was published in the journal Biochimie. [Extracted from the article]

A study conducted by researchers at the University of Colorado focused on the lipid metabolism of mesenchymal stem cells (MSCs) in infants born to mothers with obesity or normal weight. The study aimed to understand how maternal metabolic markers influence child adiposity. Results showed that MSC phenotypes are influenced by maternal metabolic milieu, independent of maternal body mass index (BMI), and could potentially serve as predictors of child adiposity at birth and in early childhood. Further validation with larger samples is recommended. [Extracted from the article]

Researchers from the University of Colorado have published new findings on Chromosome 8p Syndromes, highlighting the neurodevelopmental challenges and increased risk of epilepsy associated with rearrangements of the p-arm of Chromosome 8. The study focuses on patients with inverted-duplication deletion rearrangements, deletions, duplications, and mosaic ring changes in 8p, sharing neuro-psychometric values and proposing surveillance care guidelines for caregivers and medical providers. This research, which has been peer-reviewed, aims to enhance the understanding and management of patients with Chromosome 8p Syndromes, offering valuable insights into their specific chromosomal rearrangements and neurodevelopmental outcomes. [Extracted from the article]

Researchers from Children's Hospital Colorado conducted a retrospective analysis to investigate the risk of acute kidney injury (AKI) after lower urinary tract reconstruction with early NSAID therapy. The study aimed to determine if there was a difference in the incidence of postoperative AKI between patients who received NSAIDs and those who did not. The results showed no significant difference in the occurrence of AKI based on specific criteria, suggesting that postoperative NSAIDs were unlikely to be a source of AKI. However, AKI remained a risk following these surgeries, regardless of NSAID use, likely due to underlying disease, longer operations, and fluid shifts. [Extracted from the article]

A recent study conducted by the Department of Veterans Affairs in Aurora, Colorado, has found that women veterans who use reproductive health care services are at an elevated risk for suicide and have a high prevalence of suicidal ideation and suicide attempts. The study aimed to describe the prevalence and characteristics of suicidal ideation and suicide attempts among women veterans using Veterans Health Administration (VHA) reproductive health care services. The findings suggest that post-military suicidal ideation and suicide attempts are common among women veterans accessing VHA reproductive health care services, and those with low parental satisfaction may be at particularly high risk. The study provides valuable information that can guide future research and inform clinical care to facilitate suicide prevention. [Extracted from the article]

A recent report from Kaiser Permanente Colorado discusses the use of rituximab, a medication used to treat autoimmune neuromuscular diseases, as an alternative to intravenous immune globulin (IVIG) therapy. The study found that patients receiving IVIG therapy may have reactive hepatitis B virus (HBV) serologies due to passive transfer of antibodies, which can complicate the interpretation of test results. The researchers recommend checking HBV serologies before starting IVIG therapy to help determine if passive transfer has occurred. They also emphasize the importance of implementing an HBV reactivation prophylaxis management strategy for patients on B-cell-depleting medications. [Extracted from the article]

Researchers from the University of Colorado Denver have conducted studies on rheumatoid arthritis (RA) and have found that distinct mucosal endotypes may be the initiators and drivers of the disease. These endotypes refer to specific mechanisms and microbial alterations at mucosal sites such as the lung, gut, and oral regions. The presence of these endotypes may influence the design of prevention trials and therapeutic responses in patients with RA. Further research is being conducted to understand the inter-relationships and underlying mechanisms of these endotypes. [Extracted from the article]

Researchers at the University of Colorado have developed and validated a risk score to predict the development of atrial fibrillation (AF) after typical atrial flutter (tAFL) ablation. The study identified patients who underwent tAFL ablation with no history of AF and divided them into derivation and validation cohorts. The risk score, called the Atri-Risk Conduction Index (ARCI), was created using atrial conduction parameters and clinical risk factors. The ARCI score can stratify patients into low, moderate, and high-risk categories, which may help guide individualized approaches to AF monitoring and anticoagulation. [Extracted from the article]

New research from the University of Colorado provides data on respiratory syncytial viruses (RSV) and potential strategies for preventing hospitalizations among infants. The study analyzed data from 47 children's hospitals in the United States between 2015 and 2019 and found that infants born at the start of the RSV season were significantly more likely to be hospitalized for RSV compared to those born nine months prior to the season. The study suggests that current prevention strategies, such as the use of nirsevimab and maternal immunization, could be more effective if targeted based on the specific RSV seasons within regions. [Extracted from the article]

Researchers at the University of Colorado have conducted a retrospective review of patients who underwent transcarotid artery revascularization (TCAR) to identify factors that may contribute to restenosis, a known complication of the procedure. Of the 61 interventions analyzed, 18% developed restenosis within a median follow-up period of 345 days. The study found that younger age, prior endarterectomy, and a history of neck radiation were associated with restenosis. The researchers also noted inconsistencies in the diagnosis of restenosis between different imaging modalities, suggesting that current surveillance methods may need to be reconsidered. [Extracted from the article]

A recent report from investigators at the University of Colorado discusses the role of lifestyle factors in stroke prevention. The report emphasizes that the majority of stroke cases can be prevented through lifestyle changes such as diet, exercise, sleep, substance abuse management, stress reduction, and healthy relationships. However, there are barriers to implementing these changes, including lack of emphasis in medical education, inadequate health policies, and reimbursement issues. The report highlights recent interventions that aim to address these barriers and emphasizes the importance of targeting institutional obstacles to reduce the burden of stroke. [Extracted from the article]

A study conducted by researchers at the University of Colorado examined the impact of parents' health behaviors on their preschool children's behaviors in low-income communities in the United States. The study found that parent health behaviors, such as fruit and vegetable intake, beverage intake, physical activity, and screen time, significantly predicted child health behaviors. This relationship did not vary based on ethnicity. The researchers concluded that efforts to promote a healthy lifestyle in children should consider family practices and the wider social context. [Extracted from the article]

The article highlights research from the University of Colorado on dysautonomia, specifically focusing on the role of elevated total serum IgM in predicting antiphospholipid antibodies (aPL). Topics include the predictive value of serum IgM for aPL in dysautonomia, associated risks, and therapeutic responses.

Researchers at the University of Colorado have published a report on the anatomy and pathology of Hallux Rigidus, a condition that affects the big toe joint. The report discusses the signs, symptoms, and presentation of the disease, as well as radiographic findings and predisposing factors such as trauma and family history. The researchers also highlight areas of debate in the field and suggest that emerging technologies may provide further insights into the condition. The research has been peer-reviewed and can be accessed through the Foot and Ankle Clinics journal. [Extracted from the article]

A study conducted by the University of Colorado found that parental conversations focused on weight and health behaviors can have harmful associations with pediatric health and well-being. The research, which used data from a population-based survey of emerging adults aged 18-26, revealed that over two-thirds of mothers and 44% of fathers engaged in weight-focused conversations with their adult children. These weight-focused conversations were associated with higher body mass index (BMI) and disordered eating behaviors in emerging adults. On the other hand, conversations focused on health behaviors were associated with positive outcomes such as lower BMI, higher intake of fruits and vegetables, and better psychosocial well-being. The study suggests the need for public health messaging and interventions to reduce parental weight talk with emerging adult children. [Extracted from the article]

A study conducted at the University of Colorado Anschutz Medical Campus in Aurora, Colorado, examined the relationship between hypogonadism (low testosterone) and cardiovascular disease (CVD) risk factors in men. The researchers found that hypogonadism may accelerate age-related large artery stiffening in middle-aged and older men with low testosterone, independent of traditional CVD risk factors. However, this stiffening was not related to increased oxidative stress or reactive oxygen species. The study suggests that testosterone levels may play a role in arterial health in men. [Extracted from the article]