1. Full surface embedding of gold clusters on silicon nanowires for efficient capture and photothermal therapy of circulating tumor cells.
- Author
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Park GS, Kwon H, Kwak DW, Park SY, Kim M, Lee JH, Han H, Heo S, Li XS, Lee JH, Kim YH, Lee JG, Yang W, Cho HY, Kim SK, and Kim K
- Subjects
- Cell Line, Tumor, Gold radiation effects, Humans, Light, Nanostructures radiation effects, Silicon radiation effects, Gold chemistry, Hyperthermia, Induced methods, Nanostructures chemistry, Neoplasms, Experimental therapy, Neoplastic Cells, Circulating radiation effects, Phototherapy methods, Silicon chemistry
- Abstract
We report on rapid thermal chemical vapor deposition growth of silicon nanowires (Si NWs) that contain a high density of gold nanoclusters (Au NCs) with a uniform coverage over the entire length of the nanowire sidewalls. The Au NC-coated Si NWs with an antibody-coated surface obtain the unique capability to capture breast cancer cells at twice the highest efficiency currently achievable (~88% at 40 min cell incubation time) from a nanostructured substrate. We also found that irradiation of breast cancer cells captured on Au NC-coated Si NWs with a near-infrared light resulted in a high mortality rate of these cancer cells, raising a fine prospect for simultaneous capture and plasmonic photothermal therapy for circulating tumor cells., (© 2012 American Chemical Society)
- Published
- 2012
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