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Objective: To investigate the changes of plasma endothelin-1 (ET-1) and NO before and after balloon angioplasty in patients with atherosclerotic occlusive disease (ASO) below the knee and its clinical significance. Method: A total of 38 patients with ASO below the knee, who underwent balloon angioplasty in department of vascular surgery of Tsitsihar First Hospital from February 2013 to February 2014, were selected. The changes of plasma ET-1 and NO levels before operation and 6 hours, 24 hours, 1 week, 1 month and 3 months after operation were compared. All the patients were checked with CT angiography(CTA) 1 month and 3 months after operation respectively to observed whether vascular restenosis occurred or not, and the relationship between vascular restenosis and plasma ET-1 and NO levels was analyzed. Results: Compared with before operation, the plasma ET-1 levels 6 hours after operation increased significantly and decreased slightly from 24 hours to 1 week after operation in all the patients, but still kept at a high level, while the changes of NO was opposite to plasma ET-1.There were 33 patients without vascular restenosis after checked with CTA, the plasma ET-1 and NO levels resumed to preoperative level 1 month after operation and kept till 3 months after operation; however, there were 5 patients with vascular restenosis, the plasma ET-1 level kept at high level from 1 month to 3 months after operation, and the changes of NO was opposite to plasma ET-1 level. Conclusion: The plasma ET-1 and NO levels was related with vascular restenosis after balloon angioplasty in patients with ASO below the knee. [ABSTRACT FROM AUTHOR]

Objective To investigate the clinical effect of trimetazidine combined with carvedilolin in treating chronic heart failure(CHF),and to study its influence on serum NT-pro BNP and c Tn I. Methods A total of 108 patients diagnosed with CHF in our hospital from January 2012 to December 2014 were selected and randomly divided into the routine therapy group(control group),carvedilol group and carvedilol combined with trimetazidine treatment group(combined therapy group),36 cases in each group. The continuous medication treatment lasted for 6 months. The serum NT-pro BNP and c Tn I levels,ultrasound cardiographic indexes in the three groups were compared before and after treatment. Results The total effective rate after 6-month treatment was 88.9% in the combined therapy group and 75.0% in the carvedilol group respectively,which were higher than61.1% in the control group,moreover the combined therapy group was higher than the carvedilol group,the differences were statistically significant(P<0.05);the serum NT-pro BNP and c Tn I levels in the three groups were decreased,the left ventricular enddiastolic diameter(LVEDD) and the left ventricular end systolic diameter(LVESD) were shrunk,and the left ventricular ejection fraction(LVEF) was significantly increased,the differences were statistically significant compared with before treatment(P<0.05);the serum NT-pro BNP and c Tn I levels,LVEDD,LVESD and LVEF had statistically significant differences between the carvedilol group and the combined therapy group with the control group(P<0.05);moreover the NT-pro BNP and c Tn I levels in the combined therapy group were more remarkable than those in the carvedilol group,the differences were statistically significant(P>0.05).Conclusion Trimetazidine combined with carvedilol in treating CHF can improve the clinical therapeutic,reduces the NT-pro BNP and c Tn I levels,protects the myocardial resistance to inflammation,thus effectively improves the cardiac function. [ABSTRACT FROM AUTHOR]

The gold grade of cyanide tailings from a gold mine in Liaoning is 2.01 g/t, with a silver grade of 36.23 g/t, copper grade of 0.33%, lead grade of 1.91%, and zine grade of 3.01%. Copper-lead zinc mixed flo- tation tests and tests on preferential separation of lead - zinc flotation from the tailings were conducted on the cyanide tailings. The copper - lead zinc mixed flotation test yielded a mixed concentrate with gold grade of 13.72 g/t, silver grade of 281.70 g/t, copper grade of 3.63%, lead grade of 16.01%, and zinc grade of 36.92%. The recovery rates for gold, silver, copper, lead, and zinc were 50.09%,57.22%, 80.69%,61.33%, and 90.88%, respectively. The process of preferential separation of lead zinc flotation from the tailings produced a lead concentrate with a grade of 48.95% and a recovery rate of 52. 29%, and a zine concentrate with a grade of 43.21% and a recovery rate of 89.45%. In the lead concentrate, the gold grade, silver grade, and copper grade, were 54.02 g/t, 891.42 g/t, 5.92%, respectively. In the zinc concentrate, the gold grade, silver grade, and copper grade, were 2. 43 g/t, 134. 79 g/t, and 2.19%, respectively. The total recovery rates for gold, silver, and copper were 62.39%, 73.43%, and 77.76%, respectively. The separation indices were favorable, providing a reference basis for the comprehensive utilization of similar cyanide tailings resources. [ABSTRACT FROM AUTHOR]

OCC pulp was treated with xylanase and cellulase. The effects of xylanase and cellulase on the water filtration performance of the pulp were studied, and the effects of xylanase and cellulase on the strength of paper were investigated. The results showed that both xylanase and cellulase could effectively improve the water filtration performance of pulp. Under the optimum conditions, the water filtration performance of the pulp treated by cellulase and xylanase increased by 20.7% and 9.1% respectively. In the process of improving the water filtration performance of paper pulp, the physical strength of the paper will be adversely affected. The optimal conditions for improving the water filtration performance of OCC pulp by cellulase were as follows:1.1 U/g dry pulp, pH 5.0, temperature 75°C and time 90 min. The optimum conditions for improving the water filtration performance of OCC pulp by xylanase were: 140 U/g dry pulp, pH 5.0, temperature 65°C, time 90 min. [ABSTRACT FROM AUTHOR]

This article aims to solve the problem of residual pollution of soil inputs in irrigation areas caused by industrial development, a soil pollution monitoring and early warning system based on geographic information system (GIS) was proposed. The system combined a VOC-PF1 sensor, an STM32 master chip, and a GSM communication module to achieve efficient data collection and communication functions. The spatial analysis was carried out by the in-verse distance weighted (IDW) interpolation method, and the early warning threshold was established to realize the real-time monitoring and early warning of soil input residual pollution in the irrigation area. The experimental results show that the monitoring accuracy of the system is as high as 98%, and the monitoring time is up to 49 s, which has high practicability and efficiency. This study not only provides an effective means for the monitoring of soil input residue pollution in irrigation areas, but also provides strong support for environmental protection and sustainable agricultural development. [ABSTRACT FROM AUTHOR]

Objective To analyze the changes of morphology of mandibular angle after bilateral sagittal split ramus osteotomy (BSSRO). To study the effect of BSSRO on facial contour of patients. Methods The clinical data of 35 patients with skeletal class Ⅲ malocclusion from June 2018 to June 2020 were retrospectively analyzed. Three-dimensional CT was taken at 1 week before operation (T1) and 8 to 12 months after operation (T2). The Adobe Photoshop CS6 and MaterialiseProPlan CMF 3.0 were used for image processing and measurement. Results Compared with mandibular width before operation, the mandibular width increased 2.47 mm after BSSRO. The paired t-test showed that the difference before and after operation was statistical significant (P<0.01). The mandibular angle decreased, the mandibular plane angle and the angle between mandibular branch plane and Frankfurt horizontal plane (F-H plane) increased. Conclusion For patients with skeletal Class Ⅲ malocclusion, the width of mandibular angle after BSSRO tends to increase. [ABSTRACT FROM AUTHOR]

目的 探讨下蹲位导致呼吸困难在不同程度心力衰竭患者中发生比例和对住院时间的评价.方法 根据美国纽约心脏病学会(NYHA)心功能分级标准,选取2014年10月至2016年1月该院心内科收治的分级为Ⅱ、Ⅲ、Ⅳ级的心力衰竭患者,各45例,入院时测量各组下蹲位导致短促呼吸困难出现的人次,所有患者给予标准抗心力衰竭治疗,比较不同的心力衰竭程度与出现症状比例的关系,观察各组内有症状和无症状患者平均住院时间的差异.结果 心力衰竭程度更重的患者下蹲位所致呼吸困难的比例更高,差异有统计学意义(P<0.05);三组入院时检测有症状的患者平均住院时间多于无症状的患者,差异有统计学意义(P<0.05).结论 下蹲位出现短促呼吸困难在严重心功能不全的患者中更易出现,有此症状的患者住院时间更长,预后更差. [ABSTRACT FROM AUTHOR]

目的 探讨超声乳化三焦点人工晶体植入联合精细化囊膜处理对近视合并白内障患者的临床疗效。方 法 选取近视合并白内障患者80例，按是否行精细化囊膜处理分为 A 组和 B 组各 40 例，两组性别、年龄、眼球轴长、 角膜曲率、屈光度、晶状体核硬度分级比较差异均无统计学意义。A 组行白内障超声乳化联合多焦点人工晶体植入 术，术中予以后囊膜环形撕囊后及抛光，B 组除未进行后囊膜连续环形撕囊及囊膜抛光外，其他治疗与 A 组相同。 术后 6个月，检查两组 5 m、80 cm、40 cm处裸眼远视力、中视力、近视力，在明光、明光眩光、暗光和暗光眩光 4 种状 态下空间频率分别为 1. 5、3. 0、6. 0、12. 0 cpd 的对比敏感度（CS）；运用 OQASⅡ 系统检查客观视觉质量指标：散射指 数（OSI）、调制传递函数截止频率（MTF cut off）、三种对比度下（100%、20%、9%）的模拟对比度视力（OV），采用问卷 形式调查患者主观视觉干扰症状、脱镜情况及视觉满意度。结果 A 组远视力、中视力、近视力均优于 B 组（P 均 < 0. 05），4 种状态下空间频率分别为 3. 0、6. 0、12. 0 cpd 的 CS 均高于 B 组（P 均 <0. 05）；A 组 OSI 低于 B 组，MTF cut off 及三种对比度下（100%、20%、9%）的 OV 均高于 B 组（P 均 <0. 05）；A组感觉眩光或光晕发生率低及视觉满意度高， 与 B 组比较差异有统计学意义（P 均 <0. 05）。结论 超声乳化三焦点人工晶体植入术中进行精细化囊膜处理可明 显改善近视合并白内障患者的视力，提高视觉质量。 [ABSTRACT FROM AUTHOR]

In order to reveal the risk characteristics of engineering diseases induced by long time series temperature difference in the section from Yiwu to Balikun of Beijing-Urumqi Expressway, the temperature distribution characteristics of pavement structure layer were obtained by analyzing the interannual monitoring data of the ground temperature monitoring section of Balikun, and the quantitative relationship between pavement structure layer temperature and asphalt pavement temperature was retrieved by numerical method. The time evolution law of isothermal diseases of high temperature rutting, temperature fatigue crack and temperature shrinkage crack were also investigated. The results show that the highest temperature of the pavement above 50 ℃ in this section only occurs in June and July, and its occurrence probability is low either, so the road pavement of study area has low high temperature rutting risk simultaneously. In hot season ( from June to September), the proportion of pavement and asphalt upper layer' s daily temperature variation range exceeding 20 ℃ is 51. 9% and 35. 3%, respectively. Therefore, the possibility of temperature fatigue cracks in the asphalt layer of this section is relatively large. Comparably, the semi-rigid base keeps low temperature state in the cold season, and its temperature varies most drastically during February to March. The monthly temperature variation of the semi-rigid layer reaches up to 12. 4 ° C which induces the high temperature shrinkage crack risk in winter. [ABSTRACT FROM AUTHOR]

Feeding systems can dominate the primary efficiency and cost in aquaculture. The high management efficiency of feeding can also alleviate ecological environmental pollution. However, artificial identification has been widely used for fish feeding in the pond so far, leading to the time-consuming and laborious. Empirical feeding management cannot fully meet the large-scale pond aquaculture, in terms of production efficiency, environmental pressure, and aquaculture risk. In this study, a set of precision feeding systems was developed using fish feeding welfare. Four modules included water quality monitoring, decision control, drive execution, and remote monitoring. A systematic investigation was also implemented to clarify the effects of environmental factors on the physiology and energetics of fish. The affecting factors were then determined by the feeding demand of fish. The dissolved oxygen, temperature, and body growth were taken as the input parameters, whereas, the target demand was as the output parameters of the feeding system. The fuzzy PID control was combined with the particle swarm optimization (PSO) to realize the precision feeding operation. A comparative test of pond culture was carried out with the intensive grass carp as the research object, in order to verify the practicability and effectiveness of the system. A comprehensive evaluation was made from the aspects of regulation, growth performance, and economic and environmental benefits. The results showed that a stable and reliable control performance was achieved in the constructed precision feeding system, where the control error was less than 7%. The nash-sutcliffe (NS) index increased to 0.913 in the decision-making performance of the feeding system. whereas, the root mean squared error (RMSE) was reduced by 16.10, compared with the traditional. The feed conversion rate was significantly reduced by 11.73 % (P<0.05). Importantly, the aquaculture income increased by about 14 600 yuan/hm², whereas, the pollution was reduced by 241.40 kg per ton of fish produced. When the feed coefficient was 1.0, per ton of aquatic products brought about 500 kg of organic waste, 26 kg of nitrogen, and 13 kg of phosphorus. When the feed coefficient was 2.5, per ton of aquatic products produced 1 625 kg of organic waste, 117 kg of nitrogen, and 38 kg of phosphorus. By contrast, the grass carp produced per ton was equivalent to about 1 250 kg of organic waste, 86.70 kg of nitrogen, and 29.70 kg of phosphorus under the traditional feeding model. The total production of national grass carp in 2021 was 5.76×106 t. If all grass carp farming was adopted as the precise feeding system, it was equivalent to reducing the pollution emissions of 1.17×106 t organic waste, 9.43×104 t nitrogen, and 2.59×104 t phosphorus. The developed system can be expected to alleviate the environmental and ecological pollution caused by aquaculture. Strong comprehensive application performance can provide the theoretical reference and technical support for the research and development of other aquaculture modes and farmed fish. The feeding system should be further improved from three aspects in the future: monitoring quality and efficiency, decision-making model, and implementation cost. The sensor detection accuracy can be improved to optimize the processing efficiency of models. Systematic research of multiple feeding can be integrated using the logic line of “when to eat (feeding rhythm)-how much to eat (feeding demand characteristics)-how to eat”, in order to achieve an efficient and unified mode of breeding objects, feed, and machine. [ABSTRACT FROM AUTHOR]

Objective ♦ To detect T cell immunoglobulin mucin 3 (Tim-3) and galectin 9 (Gal-9) expression as well as CD3+ T cells and CD8+ T cells infiltration in the tumor tissues of adenocarcinoma of the esophagogastric jimction (AEG), and analyze their correlations with the patients，clinical characteristics and survival prognosis. Methods. A retrospective case study was used to collect clinical data and follow-up data of 116 AEG patients who were admitted to Renji Hospital, Shanghai Jiao Tong University School of Medicine from Dec. 2005 to Dec. 2013. Tim-3, Gal-9, CD3, and CDS protein expressions were detected by immunohistochemistry in the tumor tissues, and the clinical characteristics and prognosis were compared among the patients with different levels of protein expression 皿d T cells infiltration. Results • The results of immunohistochemistry showed that Tim-3 mainly expressed in the infiltrating immune cells, and Gal-9 mainly eressed in the tumor cells. The analysis on the clinical characteristics revealed that Tim-3 expression level was related to the Siewert classification (P=0.030) and CD8+T cells infiltration level was related to the tumor TNM stage (7M).O42). The results of survival analysis showed lhat the patients with high level of CD8+T cells infiltration had a better survival prognosis (/MJ.047). However, there was no difference in the prognosis among the patients with difirent Tlm-S and/or Gal-9 expression levels or with different CD3+ T cell infiltration levels. Conclusion - AEG patients with high level of CD8+T cells infiltration usually have earlier TNM stages and better prognosis. There is no significant difference in the prognosis of AEG patients with different Tlm-3ZGal-9 expression levels. [ABSTRACT FROM AUTHOR]

[Objectives] This experiment was conducted to investigate the effects of soluble corn fiber(Fibersol-2, Fib2)on cecum microbial diversity, organic acids and intestinal barrier function in piglets. [Methods] 448 hybrid(Duroc×Landrace×Large white)piglets with an initial body weight of(9.65±0.44)kg at age of 28 d were randomly allotted to 4 groups with 8 replicates of 14 piglets per pen. The piglets in the four groups were fed a basal diet supplemented with 0(control group), 1, 2 and 4 g·kg-1 Fib2, respectively. Pre-test was 7 d and the test was 28 d. [Results] Dietary Fib2 supplementation significantly decreased the relative abundances of Tenericutes and Actinobacteria(P < 0.05, linear), increased the relative abundance of Bacteroidetes and decreased the relative abundances of Firmicutes and Proteobacteria(P < 0.05, linear and quadratic)at the phylum level. At the family level, Fib2 significantly enhanced the relative abundances of Prevotellaceae, Bacteroidaceae and Porphyromonadaceae and reduced the relative abundances of Ruminococcaceae, Lachnospiraceae, Clostridiaceae 1, Erysipelotrichaceae and unclassified Mollicutes RF9(P < 0.05, linear), enhanced the relative abundance of Bacteroidales S24-7 group(P < 0.05, quadratic), enhanced the relative abundance of Lactobacillaceae and reduced the relative abundance of Peptostreptococcaceae(P < 0.05, linear and quadratic). At the genus level, Fib2 significantly increased the relative abundances of Prevotella, Alloprevotella, Bacteroides and Parabacteroides and decreased the relative abundances of Ruminococcus 1, Lachnospiraceae NK4A136 group, Clostridium sensu stricto 1 and unknown genus(P < 0.05, linear), increased the abundance of unclassified Bacteroidales S24-7 group(P < 0.05, quadratic), increased the relative abundances of Lactobacillus and Prevotellaceae UCG and decreased the relative abundances of Eubacterium coprostanoligenes group, Subdoligranulum and Terrisporobacter(P < 0.05, linear and quadratic). Fib2 significantly increased the contents of lactate, acetate, propionate, valerate, total volatile fatty acids(P < 0.05, linear), isobutyrate and isovalerate(P < 0.05, linear and quadratic). On day 14, Fib2 significantly reduced serum D-lactate and endotoxin contents(P < 0.05, linear), and diamine oxidase activity(P < 0.05, linear and quadratic). Pearson correlation analysis showed that there was a correlation between cecum microbiota and organic acids or intestinal permeability. [Conclusions] Under the conditions of this experiment, dietary Fib2 supplementation altered the structure of cecum microbiota, increased the contents of organic acids, and reduced the permeability of intestine, ultimately ameliorating the intestinal health of piglets. [ABSTRACT FROM AUTHOR]

In this work,conversions of hierarchical structure of collagen fibers modified by La-ponite clay nanoparticles including molecular structure,aggregate structure and morphological structure under UV irradiation are investigated using multiple analysis approaches. UV-vis diffuse reflectance spectroscopy (UV-vis DRS),attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy and wide angle X-Ray diffraction (WAXD) results show that disruptions of hydrogen bonds between collagen molecules and amino groups of polypeptide chains in collagen molecules occur under UV irradiation leading to destructions of trip-helical conformation of collagen molecules; whereas, under the same irradiation, the modification of Laponite can mitigate photo degradation of the collagen molecules without destroying their polypeptide chains and trip-helical conformation. Further atomic force microscopy (AFM) and scanning electron microscopy (SEM) observations reveal that D-peri-odic structure of fibrils and fiber networks are destroyed under the irradiation, hut the collagen fibers modified with Laponite maintain their natural D-periodic structure without obvious changes of fiber networks. These findings can provide theoretical basis for further understanding the effect of modification of Laponite on the anti-UV property of collagen fibers. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of anti-cancer drug POMHEX on sperm function in mature mice. Methods Mouse epididymal sperm were exposed to POMHEX (0. 1-100 juumol/L) in vitro. Total and progressive motility of sperms were assessed using computer-as sis ted semen analysis system (CASA), and their viability was evaluated by Eosin-nigrosine staining. ATP level of sperm was detected by luciferin-luciferase system. Western blot analysis was performed to assess protein phosphorylation, and Coomassie brilliant blue G250 staining was used to estimate acrosome integrity. Results POMHEX with concentrations of 0. 1 |xmol/L significantly attenuated total and progressive motility of sperms (P < 0. 05), exhibiting a dose-dependent effect, but no effect on sperm viability. Additionally, POMHEX with concentrations of M 1 |xmol/L significantly inhibited ATP level in sperms and protein tyrosine phosphorylation during sperm capacitation in mice (Pc 0. 01). Although there was no effect on the spontaneous acrosome reaction of mouse sperm, POMHEX with concentrations of P5 pjnol/L inhibited Ca2+ ionophore A23187-induced acrosome reaction (P < 0. 01). Conclusion Our results reveal that the POMHEX can impede sperm motility and capacitation in vitro, and then potentially result in reproductive toxicity in mouse sperm. Our findings suggest that patients undergoing POMHEX treatment should consider fertility preservation options in advance. [ABSTRACT FROM AUTHOR]

China has a huge output of vegetables and fruits, and processed vegetable and fruit residue is rich in nutrients, rich in crude protein, crude fiber, vitamins, polyphenols, polysaccharides, flavonoids and other components, but it is not easy to preserve and has poor palatability, so it can not be directly used as animal feed. Screening of high-quality yeast and other probiotics can improve the nutritional value of vegetable and fruit residue feed and reduce feed cost, which has a positive effect on fruit and vegetable processing industry and livestock and poultry breeding industry. The paper reviewed the yeast species screening, fermentation technology and application of fermented vegetable and fruit residue in animal feed, aiming to provide reference for the research and application of fermented vegetable and fruit residue in livestock and poultry breeding. [ABSTRACT FROM AUTHOR]

Objective · To investigate the clinicopathological features, diagnosis and prognosis of rectal neuroendocrine neoplasms (R-NENs). Methods · The clinical data of 113 cases of R-NENs, January 2008 to June 2017, were collected in Renji Hospital, Shanghai Jiao Tong University School of Medicine, and the clinicopathological features and prognostic factors were retrospectively analyzed. The of synapsin (Syn), neural cell adhesion molecule (CD56), and chromogranin A (CgA) were observedimmunohistochemistry in the R-NENs specimens. The specimens were also observed after hematoxylin-eosin staining. Results · In 113 cases of R-NENs, there were 59 males and 54 females, and their ages ranged 25 to 83 with an average age of (52.3±13.3) years old. All the patients had no obvious clinical manifestations. The main symptoms included changes in bowel habits (21.3%), abdominal pain (8.9%) and anal symptoms (6.2 %), and 63.7% of cases were found in routine medical examinations. The R-NENs were diagnosed as G1 (79.6%), G2 (11.5%), and G3 (8.8%). Immunohistochemistry results demonstrated that 94.7% of tumors were positive for Syn, 80.9% for CD56, and 48.6% for CgA. Till November 2017, the median survival time was 33.10 months (0.40–114.67 months), with 1-year, 3-year, and 5-year survival rates of 93.8%, 90.0%, and 85.9%, respectively. The pathological grade, depth of tumor invasion, lymph node metastasis or distant metastasis, tumor size, and age were all associated with prognosis of patients with R-NENs. Conclusion · Most of R-NENs are low-grade malignant tumors with good overall prognosis and have a lack of specificity in clinical manifestations. [ABSTRACT FROM AUTHOR]

According to the standard method and procedures for the development of evidence-based medicine guidelines, a multi-disciplinary guideline development working group was established. Through the process of guideline registration, guideline plan writing, analysis of relevant guidelines, clinical problem screening and determination, clinical evidence retrieval and evaluation, forming of recommendation, etc. and after three rounds of discussions by the consensus expert group, a new evidence-based guideline for diagnosis and treatment of senile osteoporosis in China (2018) was developed. The grading of recommendations assessment, development and evaluation (GRADE) system was used to rate the quality of evidence and the strength of recommendations. Recommendations were derived from body of evidence, and at the same time considered the balance of benefits and harms as well as values and preferences of Chinese patients. The guideline development working group developed 15 recommendations for the diagnosis and treatment of senile osteoporosis. The guideline covered the screening for senile osteoporosis, risk assessment, diagnosis, basic treatment, multiple anti-osteoporosis drugs, therapeutic effect monitoring and evaluation of senile osteoporosis. This guideline aims to provide scientific evidence for clinicians and patients in China. [ABSTRACT FROM AUTHOR]

In order to solve the problem of dynamic change of discrete transfer function model parameters of double-sided permanent magnet synchronous linear motor and low identification accuracy of traditional methods, a system identification method based on stochastic model was proposed. The system characteristics in the motion process were analyzed, and the Box-Jenkins model with random disturbance term was used to identify the parameters of the dynamic system transfer function model. By injecting different frequency inverse M sequence current signals, the system response was fully stimulated, and system identification results under different experimental conditions were compared and analyzed. The prediction error method was selected to define the variance cost function, and the Levenberg Marquardt algorithm was used to iteratively optimize the parameters of the transfer function model. The optimal identification model was obtained by comparing and analyzing the system identification under different sampling frequencies, different injection current amplitudes and different motor speed. The results show that when sampling frequency is 1 000 Hz, injection current amplitude is 2. 0 A and motor speed is 50 mm/ s, the optimal identification simulation output matching degree is 94. 81% and the square difference is 7. 84 × 10- 4. [ABSTRACT FROM AUTHOR]

Introduction: Inertial measurement units (IMUs) have accurately detected kinematic parameters during baseball batting. This study aimed to investigate differences in hip, upper torso, and hand kinematics between elite and sub-elite college baseball batters during the stride and swing batting phases. Methods: Six elite and six sub-elite college players participated in this study. Three IMUs were attached to the hip, upper torso, and back of the batting hand to detect the timing of stride and swing phases, peak hip horizontal acceleration, peak rotational angular velocity, and peak upper torso rotational angular velocity at the foot-off and foot-on of the front foot. During the swing phase, peak hip velocity, peak upper torso velocity, peak hand velocity, and the duration from the three different body position's peak rotational angular velocity to contact between the bat and the ball were collected. Kinematic differences between elite and sub-elite batters were assessed using Mann- Whitney U tests. Result: The stride phase was shorter in elite college batters than in sub-elite players (p < .01), while the swing phase was longer in elite players than in sub-elite batters (p < .01). The hip horizontal acceleration, hip angular velocity, and chest angular velocity at foot-on were lower in elite batters than in sub-elite batters (p < .01). However, hip, chest, and hand angular velocities during the swing phase were higher in elite batters than in sub-elite batters (p < .01). Moreover, a shorter duration between each body segment's peak velocity and contact between the bat and the ball was observed in elite batters than in sub-elite batters (p < .01). Conclusion: Elite and sub-elite college batters showed differences in timings, front foot-on, and kinematics of the hip, upper torso and hand during the swing phase. Specifically, a shorter stride phase and reduced hip and chest rotation at foot planting were found for elite batters compared to sub-elite batters. In contrast, elite batters prolonged the swing phase and developed higher hip, chest, and hand velocities closer to impact. This study's findings and applied method of IMU usage may contribute to performance assessment practices and improving batting skills. [ABSTRACT FROM AUTHOR]

To prevent hypothermia in transurethral resection of the prostate (TURP), Dandong First Hospital introduced the low-temperature protector in January 2017. In this study, 45 elderly patients with TURP without the protector from June 2016 to December 2016 were selected as the control group, and 45 patients with TURP used with the protector from January 2017 to June 2017 as the experimental group. The body temperature and chill occurrence before spinal anesthesia; 30 min, 60 min and 90 min after the anesthesia; and at the end of the operation were recorded. It was found that the hypothermia in the experimental group was significantly less than that of the control group (P<0.05), and the chill incidence of the experimental group was also lower (P<0.05). it is concluded that, the usage of warming blanket and heated rinse. etc can effectively reduce the incidence of hypothermia and improve the operation effect and nursing quality. [ABSTRACT FROM AUTHOR]

Objective: To establish a HPLC-MS/MS method for simultaneous determination of baicalin, jasminoidin, cholic: acid, hyodeoxycholic acid and chlorogenic acid in Qingkailing granules. Methods: Separation was performed on an Agilent Zorbax Extend-Cis column(100 mmX2.10 mm, 3.5 μm).The mobile phase was composed of acetonitrile (phase A) and 10 mmol L ammonium acetate water solution (phase B) with gradient elution (0-1 min, 5% →5% phase A, 1〜5 min.5%→52% phase A, 5-8 min, 52% →0% phase A) at a flow rate of 0.6 ml min. Detection was performed on a triple quadrupole tandem mass spectrometer by multiple reactions monitoring (M HM) via electrospray ionization (ESI) source in negative ionization mode. Results: Method showed good linearity in baicalin. jasminoidin, cholic acid. hyodeoxyeholic acid and chlorogenic acid (r>0. 999 0). Mean recoveries were (98. 6 ±2.42)%-(104.4 ±4.03)%. The precision, reproducibility and stability were all good. The contents of baicalin,jasminoidin, cholic acid. hyodeoxyeholic acid and chlorogenic acid in the 4 batches of Qingkailing granules were 5.56-7.10, 0.61-0.76,5.74-7.64,7.08-8.81.0.17-0. 35 mg/g. respectively. Conclusion: The method was proved to be simple. accurate and reproducible. and could be used for quality control of Qingkailing granules. [ABSTRACT FROM AUTHOR]

Objective To observe the expression levels of epicardial adipose tissue (EAT) thickness and interleukin-1β(IL-1β) in ETA of patients with unstable angina and to analysis their correlations with coronary vulnerable plaque (VP). Methods Sixty-three patients with unstable angina were enrolled, including 24 patients with VP (VP group) and 39 patients without VP (NVP group) according to intravascular ultrasound imaging. In addition,45 patients requiring valve replacement surgery but without coronary artery disease (CAD) were enrolled as the control group. Transthoracic echocardiography was used to measure EAT thickness. Plasma IL-1β from fasting elbow vein blood was detected by ELISA. IL-1β protein and mRNA expression levels in EAT were tested by immunostaining and RT-PCR, respectively. Re⁃ sults EAT thickness was in the following order VP group>NVP group>control group (P<0. 05). No significant difference in the plasma IL-1β level was found among the three groups (P>0. 05). Immunostaining showed that IL-1β expression increased in EAT of patients with VP. The mRNA level of IL-1β in EAT was higher in the VP group than those of the NVP group and the control group (all P<0. 05). Spearman correlation analysis showed that both EAT thickness and IL-1β were positively correlated with coronary VP (r=0. 34 and 0. 67, respectively). Multivariate Logistic regression analysis showed that IL-1β and EAT thickness were the independent risk factors of VP. Receiver operating characteristic curve analysis showed that the area under the curve of EAT thickness in predicting VP was 0. 74(95%CI: 0. 64-0. 84). When the cut-off value of EAT thickness was 4. 4 mm, the sensitivity and specificity in predicting VP were 95. 8% and 45. 2%, respectively. Conclusion Both EAT thickness and IL-1β are positively correlated with coronary VP, which are independent risk factors of VP. [ABSTRACT FROM AUTHOR]

In order to study the influence of dry-wet cycles on the anti-cracking performance of asphalt mixture, a meso numerical model of asphalt mixture was established by using digital image processing technology, and the moisture diffusion coefficients of aggregate and asphalt mortar at different temperatures were measured. Based on Fick's law, the wet state of asphalt concrete under the coupling action of temperature and dry-wet cycles is analyzed. The USDFLD subroutine was used to realize the coupling of moisture concentration and mechanical parameters, the bending failure behavior and crack development of asphalt mixture after dry-wet cycles were simulated and analyzed. The results show that the cohesive damage of asphalt mortar significantly affects the flexural strength of asphalt mixture. During the conditioning of dry-wet cycles, moisture concentration inside of the mixture increases monotonously. Moisture also diffuses to the interior in the drying stage, causing internal damage. With the increasing of dry-wet cycles, the mixture will crack at a small load level, and the propagation rate of the main crack is accelerated. [ABSTRACT FROM AUTHOR]

Rheumatoid arthritis( RA) is a common autoimmune disease in which inflammation is the main manifestation of the disease. In addition, hypoxia-inducible factor and glycolysis are closely related to the pathogenesis of RA. In this paper, we reviewed the role of HIF-lα and glycolysis in the pathogenesis of RA, and explained that HIF-lα can play a role in inflammation, pus formation, cartilage destruction and other aspects through regulating glycolysis, and play a role in alleviating RA symptoms. In order to provide new ideas for the clinical and basic research of RA and improve the clinical efficacy of the disease. [ABSTRACT FROM AUTHOR]

Objective · To investigate the clinicopathologic characteristics and prognosis of adult rhabdomyosarcoma (RMS). Methods · The clinical and pathological data, immunohistochemical test results of 9 RMS were analyzed retrospectively. Results · The information of 6 males and 3 females were collected in this research, whose average age was (46.89±20.09) years old. The tumors had a wide range distribution. The subtypes of histology included 6 cases of embryonal RMS, 1 case of alveolar RMS, 1 case of spindle cell RMS and 1 case of pleomorphic RMS. Immunohistochemically study showed that 6 cases were myogenin positive, 4 cases were MyoD1 positive and 8 cases were desmin positive. During the follow-up period of the 7 cases, only 2 patients survived free of tumors, 2 patients presented with tumor recurrence and metastasis after the operations, and 3 patients died of tumor. Conclusion · In this study, embryonal RMS is the most common type, and immunohistochemistry test is helpful to diagnosis of RMS. [ABSTRACT FROM AUTHOR]

In order to research the propagation properties of impulse radio ultra wideband（IR-UWB）signals in the minefield near-ground environment and provide a technology support for the future development of landmines, the IR-UWB signals were test experimentally in three typical propagation environments. The features of received signals are researched based on the measured data. An analytic method with energy ratio detection and multipath component criterion is proposed. The channel impulse responses (CIRs) and main parameters are statistically calculated and analyzed. The calculated result shows that the path loss coefficient in near-ground environment is smaller than that in free space since the signal reflects from the ground and surrounding obstacles. With the calculation, the path loss coefficients range from 1.50 to 1.85 for the antenna heights of 0.3 m and 0.5 m. According to the CLEAN algorithm with self-adaptive threshold, the error ratios of the original signals and recovered signals from CIRs are not more than 30%. The result shows that the calculated channel parameters correspond with the characteristics of the propagation environment. The feasibility of the proposed method and the accuracy of the channel analysis results were verified. [ABSTRACT FROM AUTHOR]

(1) Background-The reform of collective forest land easements is an important part of collective forest property systems reform and national park systems reform. It helps to promote the high-quality development of forestry, promote the employment and income of forest farmers and achieve common prosperity. Identifying the influence of different institutional arrangements on the willingness of forest farmers to participate in the reform of collective forest land easements is of great significance for making up the lack of cash compensation and optimizing the institutional arrangements of national parks. (2) Methods Based on the field researches on the reform of collective forest land easements in Qianjiangyuan-Baishanzu National Parks in Zhejiang Province, the research data were obtained by questionnaires, interviews and other participatory rural appraisals. The ordered probit model was used to analyze the influence of national park institutional arrangements on the willingness of forest farmers to participate in the reform of collective forest land easements. (3) Results First, 49.61% of forest farmers are willing to participate in the reform of collective forest land easements. In the cognition of the reform benefits of collective forest land easements, the environmental benefits and social benefits are greater than the economic benefits. Second, the main institutional arrangements of national parks have a significant incentive effect on the willingness of forest farmers to participate in the reform of collective forest land easements, and the degree of their contribution is in the following order: they can engage in unlimited forestry production and management activities>they can give priority to forest, ecological tourism and other projects> they can visit the national parks for free. Third, different regions and age levels have different incentive effects on forest farmers. The main institutional arrangements of Qianjiangyuan National Park has a greater incentive effects for forest farmers to participate in the reform of collective forest land easements than that of Baishanzu National Park. The willingness of young and middle-aged forest farmers to participate in the reform of collective forest land easements is stronger than that of middle-aged and old forest farmers. Fourth, most of the control variables are significant at different levels. Among them, social benefits, environmental benefits, education level of the household heads, the regions and the forest farmers' participation in the reform of collective forest land easements are significantly positively correlated, while the age of the household heads and total area of family forest land are significantly negatively correlated with the forest farmers' participation in the reform of collective forest land easements. (4) Conclusions and Discussions In order to deepen the reform policy of collective forest land easements, the following policy suggestions are put forward; First, the relevant departments of national park management should take into account the interests of forest farmers in the reform of collective forest land easements and improve their trust in the system. Second, village organizations should play an active role as a bridge between the forest farmers and the national park administration. Third, the forest farmers should be good at making use of national park incentive policies and measures to achieve common prosperity. [ABSTRACT FROM AUTHOR]

Long noncoding RNA (LncRNA) plays an important role in the occurrence, development and treatment of rheumatoid arthritis (RA). It participates in the occurrence of RA in terms of immune cell differentiation and DNA methylation, and promotes the development of RA in terms of oxidative stress, inflammatory response, RA-FLS proliferation/apoptosis imbalance and bone destruction. Therefore, it affects the occurrence and development of RA by regulating the expression of LncRNA development will become a new way of RA treatment. Traditional Chinese medicine is effective in the treatment of RA, and many studies have confirmed that traditional Chinese medicine can play an important role in the treatment of RA by regulating the expression of LncRNA. This paper reviews the latest research progress on the correlation between LncRNA and RA and the intervention of traditional Chinese medicine, in order to provide reference for the prevention and treatment of RA. [ABSTRACT FROM AUTHOR]

Longitudinal displacement measurement of track is an important inspection item to ensure the safe operation of railway. In order to solve the problem that the general non-contact vision measurement technology cannot distinguish different track monitoring points, a method for measuring the longitudinal displacement of the track was proposed based on binocular vision. Firstly, a coded marker was designed and fixed at the waist of the track at several monitoring points. Binocular camera was used to take images of the coded marker before and after displacement. In terms of algorithm realization, the spatial coordinates of the center of the template are obtained by means of zero-mean normalized cross-correlation method and coordinate system conversion model to measure the longitudinal displacement of the track. At the same time, a one-dimensional pixel scanning method is proposed to analyze the coding information carried by markers to identify the coding values corresponding to different orbital monitoring points. A reasonable and effective simulation test was carried out in the laboratory. The results show that the average error rate of the proposed method is 1.90% and the coding recognition rate is 100% at the working distance of 2.0 m, which proves the accuracy and feasibility of the proposed method and lays a foundation for the subsequent evaluation of the overall ride comfort of orbit geometry. [ABSTRACT FROM AUTHOR]

A method of measuring the main geometric parameters of wheel by laser displacement sensor and eddy current displacement sensor was proposed. The principle of measuring flange diameter by laser displacement sensor is analyzed, and the geometric parameters such as tread diameter, flange height, flange thickness and rim width are calculated. According to the proposed measurement method, an online dynamic measurement system for wheel geometric parameters is designed. The measurement system has simple overall structure, low cost and easy realization. The test results verify the feasibility of the measurement system and realize the on-line dynamic measurement of train wheels. [ABSTRACT FROM AUTHOR]

Nasopharyngeal carcinoma (NPC) is a common malignant tumor in China. Radiotherapy is the firstline treatment. After appropriate radiotherapy, about 5%-15% patients experience recurrence. In view of the poor efficacy and high incidence of severe late toxicities associated with re-irradiation, salvage surgery by the transnasal endoscopic approach is recommended for recurrent NPC (rNPC). Compared with reirradiation, endoscopic surgery can better prolong survival, improve the quality of life, and reduce complications and medical expenses of patients with rNPC. However, the complexity of the nasopharyngeal skull base enhances the difficulty and risk of surgery. Expanding the boundary of surgical resection remains a clinical challenge for otolaryngologists. In this regard, to help more advanced patients with rNPC, the surgical innovative system of NPC needs to be established by multi-disciplinary cooperation, involving skull base anatomy-based investigation, appropriate administration of the internal carotid artery (ICA), repair of skull base defect, and establishment of various types of endoscopic endonasal nasopharyngectomy. [ABSTRACT FROM AUTHOR]

Drought is one of the important limiting factors for the ex situ conservation and landscape application of the plants of Rhododen­dron. In this paper, the effects of drought stress on the physiological characteristics of the mycorrhizal seedlings of Rhododendron moul­mainense were studied by inoculation growth experiment. The results showed that the variations of the leaf relative conductivities and malondialdehyde ( MDA) contents of the mycorrhizal seedlings were less than that of non-inoculated seedlings (CK)，but their proline contents and soluable protein contents were significantly higher than that of CK under drought stress, and the variations of chlorophyll contents among inoc­ulation treatment and CK were not significant. Analysis of subordinate function showed that the inoculation with the endophytic fungi could enhance the seedling drought adaptability of Rhododendron moulmainense，and the drought tolerances of the seedlings inoculated with Phialocephala fortinuii was higher than those inoculated with Aspergillus sydowii. [ABSTRACT FROM AUTHOR]

Objective To investigate the efficacy and safety of surgery combined with radiotherapy for primary retro- peritoneal tumor. Methods A total of 112 cases patients with primary retroperitoneal tumor admitted from January 2012 to January 2014 were selected as the subjects. The patients were divided into the combined group（surgery combined with radio- therapy）and the control group（only the surgical treatment），56 cases in each group. The efficacy and complications of the two groups were compared and analyzed. Results The effective rate of the combined group after treatment [80.36%（45/56）] was higher than that of the control group [51.79%（29/56）]，the difference was statistically significant（P<0.05）. The overall surviv- al rate of the combined group was higher. There were no serious complications such as abdominal bleeding and infection after the treatment. There were no long-term complications such as intestinal necrosis and ureteral stricture. Conclusion Surgical radiotherapy combined with primary peritoneum tumor is safe and effective，and the survival rate of patients can be improved. [ABSTRACT FROM AUTHOR]

本文报道 1 例前降支近端闭塞患者, 根据室性早搏 QRS 波群、ST 段和 T 波改变的心 电图特征, 确诊急性心肌梗死。 在本例急性心肌梗死患者的心电图表现中, 窦性心律 QRS 波 群、T 波基本形态正常, 无异常 Q 波, 未见明显 ST 段损伤性抬高, 但发生的室性早搏 QRS 波群 在相关导联中却呈 QR、QRs、qR 型, ST 段呈损伤性抬高伴 T 波高尖或倒置, 显现出心肌梗死心 电图特征, 结合临床及心电图动态演变确诊为急性心肌梗死。 [ABSTRACT FROM AUTHOR]

[ Objectives] This study investigated the effects of dietary betaine levels on meat quality, glycolysis level and antioxidant ability of Xueshan chicken. [Methods] A total of 400 one-day-old female Xueshan chickens were randomly divided into five groups with eight replicates of ten chickens for a 102-day feeding trial. Broilers were fed a basal diet supplemented with 0( control), 125, 250, 500 and 1 000 mg· kg-1 anhydrous betaine, respectively. [ Results ] Betaine supplementation linearly improved dressed percentage and reduced the percentage of abdominal fat ( P < 0. 05). Dietary betaine linearly decreased cooking loss ( P < 0. 05), linearly and quadratically decreased drip loss( 24 and 48 h postmortem) and shear force( P<0.05), and increased pH24h. value in thigh muscle. Betaine supplementation linearly enhanced the thigh muscle springiness and the ratio of the immobilized water peaks area ( P21 ) ( P<0.05), and linearly reduced free water peaks area( A22 ) and their ratio ( P22 ) ( P<0.05). Additionally, the lactate content and glycolytic potential ( GP ) of thigh muscle were quadratically decreased by betaine supplementation. With increasing betaine levels, the activity of catalase (CAT), total antioxidant capacity ( T-AOC) and the ratio of reduced glutathione/ oxidized glutathione ( GSH/GSSG) linearly increased( P<0.05), and the content of oxidized glutathione( GSSG) linearly decreased( P<0.05), the content of glutathione ( GSH) linearly and quadratically increased ( P < 0. 05). Besides, dietary betaine linearly upregulated thigh muscle mRNA expressions of nuclear factor erythroid 2-related factor 2 ( Nrf2), CAT, glutathione peroxidase gene ( GPx) and γ-glutamate· cysteine ligase catalytic subunit gene(γ-GCLc). [Conclusions] Betaine could improve meat quality by reducing lactate content to increase ultimate pH, altering moisture distribution to enhance muscle springiness, water-holding capacity and tenderness, and regulating enzymatic and non-enzymatic antioxidant systems activated by Nrj2 to improve muscle antioxidant capacity. [ABSTRACT FROM AUTHOR]

Objective: To analyze the reason of upgrade in Gleason score between initial prostate biopsy and final radical prostatectomy specimens and develop a nomogram to predict the probability of pathological upgrade.Methods: From August 2008 to December 2013, a total of 264 prostate cancer patients underwent RP in our department were selected and divided into two groups according to the upgrade of biopsy and final pathology GS. Both a univariate analysis and a Forward conditional multivariate logistic regression model (LRM) analysis were performed to identify the risk factor (s) of pathological upgrade. A nomogram predicting the probability of pathological upgrade was established by using LRM regression coefficients. Results: In total, 238 of the 264 patients were analyzed. Multivariate logistic regression analysis showed that higher prostate specific antigen density (PSAD) (0R=3.854, P=0.001) and low grade (≤ 6) biopsy GS were. The dependent risk factors of the pathological upgrade after radical prostatectomy. The optimal cutoff value of PASD and biopsy score were 0.37 ng/ml 2 and 8 points. A nomogram combining aforementioned two variables to predict pathological upgrading was established.Conclusion: PASD and biopsy Gleason score were independent risk factors for predicting the postoperative pathological upgrade in Chinese population, the nomogram established in the study could well predict the pathological upgrade. [ABSTRACT FROM AUTHOR]

目的探讨对血液净化专业医生、护士实施急救能力培训的方法及效果。方法2015年6~9月，通过科室急救能力培训小组的组建，制订急救流程及考核计划，实施理论授课及实训操作后，对医生、护士急救能力进行评价与考核。培训小组每月每季度进行考核与评价。结果经过全面的培训后，医生、护士的急救理论知识、急救操作技能及急救综合能力得分均高于培训前，差异均有统计学意义（P<0.05）。培训后血管通路血液外渗、血液透析中低血压、血液透析长期留置导管相关感染发生率均低于培训前，差异均有统计学意义（P<0.05）。结论对血液净化专业医生、护士采取专业的急救能力培训，可使从事血液净化专业的医护人员急救综合水平得到显著提高，值得在临床上进一步推广应用。 [ABSTRACT FROM AUTHOR]

To observe the efficacy of pelvic floor muscle rehabilitation training combined with pelvic floor reconstruction in the treatment of female pelvic floor dysfunction (PFD) diseases and its effect on inflammatory response and stress response. 200 patients with PFD who were treated in our hospital from January 2019 to January 2021 were selected, and they were randomly divided into control group (100 cases) and study group (100 cases) by random number table method. Patients in the control group received pelvic floor reconstruction, and patients in the study group received pelvic floor muscle rehabilitation training combined with pelvic floor reconstruction. The efficacy and postoperative complications of the two groups were observed, and the related scale scores, inflammatory response and stress response indexes of the two groups were compared. After treatment, the scores of pelvic floor impact questionnaire short form (PFIQ-7), pelvic floor distress inventory short form (PFDI-20) in the study group were lower than those in the control group (P<0.05). The pelvic floor class I muscle fiber voltage and pelvic floor class II muscle fiber voltage in the study group were higher than those in the control group after treatment (P<0.05). Interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) and high sensitivity C-reactive protein (hs-CRP) in the study group after treatment were lower than those in the control group (P<0.05). Cortisol (COR), norepinephrine (NE) and prostaglandin E2 (PGE2) in the study group after treatment were lower than those in the control group (P<0.05). The incidence of postoperative complications in the study group was lower than that in the control group (P<0.05). Pelvic floor muscle rehabilitation training combined with pelvic floor reconstruction in the treatment of PFD can promote the recovery of pelvic floor function, reduce inflammatory reaction and stress reaction, and reduce the incidence of postoperative complications. [ABSTRACT FROM AUTHOR]

BACKGROUND: At present, the supervision of antibiotic abuse and its research is being strengthened. In recent years, antibiotics have been detected in varying degrees in water in central China. This reinforces the concern of the pollution of antibiotics in surface and groundwater. OBJECTIVES: To investigate the distribution characteristics of 29 antibiotics in groundwater in Harbin. METHODS: A total of 26 groups of groundwater samples were collected in Harbin, and the sampling scope included habitation and production areas such as densely populated, industrial production, agricultural districts and animal husbandry. The ultra - performance liquid chromatography - triple quadrupole mass spectrometry method was used to analyze 29 kinds of antibiotics covering six types, including sulfonamides, quinolones, macrolides, f3 - lactams, tetracyclines, and lincosamides. RESULTS: Antibiotics in the groundwater of Harbin were mainly composed of sulfonamides, quinolones, macrolides and tetracyclines and the detection rates were 61.5%, 46.2%, 42.3% and 38.5%, respectively. The content of antibiotics detected ranged from 0. 02 to 681 ng/L, and the highest contents of sulfathiazole, sulfadiazine, and lincomycin were more than 100ng/L. The average content of quinolones was low compared with some domestic and international areas (such as Beijing, Tianjin, and Barcelona). Sampling sites with higher antibiotic levels were mainly found in the central, southern and eastern regions of the city. These areas are also relatively densely populated and are generally distributed around pharmaceutical factories, urban sewage outlets, and poultry and livestock farms. CONCLUSIONS: The distribution characteristics of antibiotics in groundwater in Harbin are strongly related to the impact of human production and living activities. [ABSTRACT FROM AUTHOR]

The self-made simulation device was used to simulate pigging referring to oilfield technological process. The influence of pigging and inhibitor injection on the corrosion of 20# steel in simulated liquid of pipeline was analyzed by weight-loss method and corrosion electrochemical method. The results show t hat t he amount of liquid and solid deposit on the surface of 20# steel sample are reduced after pigging with a 3% interference cup pig, and the corrosion rate is significantly reduced. When t he corrosion inhibitor is added into the simulated solution or the sample is prefilmed with inhibitor, the inhibitor molecules will act on the surface of carbon steel to form a layer of corrosion inhibition film, which effectively hinders the direct contact between the sample and corrosion medium. After pigging combined with corrosion inhibitor pre-film, the corrosion rate is reduced to 0. 029 mm/ a, which has a good protection effect on carbon steel. [ABSTRACT FROM AUTHOR]

CRISPs (cysteine rich secretory proteins) family contains four members. CRISP2 is the only member expressed in testicles, with high tissue specificity. CRISP2 is expressed and secreted by spermatocytes. This process won′t be affected by androgen. CRISP2 scatters in the seminiferous epithelium and is located at the junction of spermatocytes and Sertoli cells, helping spermatocytes connect to Sertoli cells. Afterward, CRISP2 goes with round spermatids and elongated spermatids, combines to the tail and the acrosome in the head of spermatozoa. CRISP2 probably modulate the influx of Ca2+ by combining with RyR3. CRISP2 may also act in modulating other receptors like inhibiting K + channels. Research indicates that CRISP2 participates in the maturation and capacitation of spermatozoon all along, and also works in sperm-oocyte fusion. In this review, we will focus on the expression and distribution of CRISP2 in testicles as well as its regulation and function. [ABSTRACT FROM AUTHOR]

Objective To investigate the CT features and clinical significance of pseudo-subarachnoid hemorrhage sign (PSAH) with diffuse brain edema. Methods CT of 13 patients including 5 brain-dead organ donors with non-hemorrhagic disease and 8 non-traumatic critically ill patients with confirmed P-SAH from March 2019 to December 2019 was reviewed. Regions of interest (ROI) were drawn on the cerebral white matter (100 mm²) and fissure (10 mm²) symmetrically on plain CT. The CT values were measured and compared between the 2 groups. The clinical prognosis of non-traumatic critically ill patients was observed. Results On all patients, CT showed diffuse swelling of brain parenchyma, low density, blurred gray-white matter boundary, narrow ventricle under pressure, symmetrically high and linear attenuation in basal cistern and sulci. The CT values in brain death were (26.25±2.28) HU (range: 21.90- 29.8 HU) in the white matter and (41.45±2.42) HU (range: 35.1-45.0 HU) in the fissures. The CT values in non-traumatic critically ill patients were (26.02±2.20) HU (range: 21.9-29.8 HU) in the white matter and (45.07±4.47) HU (range: 35.1-56.9 HU) in the fissures. The average CT value difference of white matter and fissures in all cases were (17.54±3.05) HU. Conclusion In severe diffuse brain edema, typical P-SAH can be seen on plain CT, and the presence of P-SAH often indicates a poor prognosis. [ABSTRACT FROM AUTHOR]

Objective To explore the effect of dopamine reuptake inhibition on sperm motility in mice and humans and its mechanism of action. Methods After the sperm were treated with dopamine reuptake inhibitors GBR 12909 and GBR 12935, the computer-assisted semen analysis system (Computer-Assisted Semen Analysis, CASA) assess sperm motility; eosin-nigrosine staining to detect sperm viability; detect intracellular pH (pHi) and intracellular calcium (Intracellular Calcium, [Ca2+]i) level changes by fluorescent probes; protein Western blotting was used to detect changes in protein phosphorylation; Coomassie Brilliant Blue G250 staining to detect changes in acrosome reaction. Results GBR 12909 and GBR 12935 can significantly inhibit sperm motility in mice and humans without affecting sperm survival, and make sperm cells (Ca2+)i decreases, pHi increases, glycogen synthase kinase 3 alpha (Glycogen Synthase Kinase 3 Alpha, GSK3α) phosphorylation and protein kinase A (Protein Ki-nase A, PKA) substrate phosphorylation levels decrease. Among them, GBR 12909 can promote Sperm capacitation-related protein tyrosine phosphorylation is not observed in GBR 12935; neither affects the incidence of acrosome reaction induced by A23187 after sperm capacitation in mice. Conclusion Dopamine reuptake inhibitors GBR 12909 and GBR 12909 GBR 12935 can reduce sperm [Ca2+]i, increase pHi, and may reduce sperm motility by down-regulating GSK3α phosphorylation and PKA substrate phosphorylation. [ABSTRACT FROM AUTHOR]

Objective To analyze the structure and function of human STN1 protein based on bioinformatics. Methods We obtained the amino acid sequence of human STN1 protein from Uniprot database，used ProtParam online tool to analyze its physical and chemical properties，DNAMAN software to analyze its affinity/hydrophobicity，and checked its distribution in cells through the Genecar website. The secondary structure，tertiary structure，domain and conserved domain of human STN1 protein were predicted by PSIPRED，PDB，Uniprot and NCBI Conserved Domain，respectively. Multiple sequence alignments of human STN1 protein were carried out through NCBI website and DNAMAN software，and a phylogenetic tree was constructed through MEGA software. We employed GPS5. 0 software to predict the phosphorylation and acetylation sites of human STN1 protein，used the AmiGO2 to perform gene ontology（GO）analysis on human STN1 protein，and employed the Reactome online tool to view the signal pathways which they participated in. The interacting proteins of human STN1 protein were predicted by STRING database，and the K-Means algorithm was used to cluster the interacting proteins. Results The human STN1 protein was composed of 368 amino acids. It was an acidic，unstable，and hydrophobic intracellular protein that was highly conserved during evolution. It consisted of an OB domain and two wHTH motifs，where the wHTH region was a conserved region of human STN1 protein；the OB domain covered most（77.8%） phosphorylation sites. GO analysis showed that in terms of molecular function，human STN1 protein mainly had the function of binding to protein and DNA；in terms of biological pathways，human STN1 protein had a negative regulatory effect on telomerase and was also a positive regulator of DNA replication. In addition to forming a complex with TEN1 and CTC1, human STN1 protein could also directly bind to eight mediator complex subunits. Conclusions The human STN1 protein is an acidic，unstable，and hydrophobic intracellular protein. It includes an OB domain and two wHTH motifs. It is an important protein involved in the regulation of genome replication and maintains the telomere homeostasis. [ABSTRACT FROM AUTHOR]

Since the technical progress of SiC power metal oxide semiconductor field effect transistor （ MOSFET） were published in 2017, the device structure design were optimized in view of the high specific on-resistance （只Our research group has improved the key processing technology to reduce the sp of 1 200 V SiC MOSFET from 8 mfl • cm2 to 4.8 mfl • cm2. Using the new design methods and fabrication processes, high performance SiC MOSFET for voltage ratings from 6. 5 kV up to 15 kV were achieved. The is 144 mil • cm2 for the 10 kV devices and 204 mft • cm2 for the 15 kV devices which is close to the SiC theoretical limit. [ABSTRACT FROM AUTHOR]

Focuses on the problem of ranging error diverges with the increase of the starting incidence angle and non-convergence of iteration process at the large incidence angle by using the traditional method to cal-culate the starting incidence angle, this paper proposes a new method of calculating the starting incidencean- gle by Newton method. Firstly, the principle and steps of traditional method are introduced. Secondly, the iteration equation is established according to the relationship between the propagation time and the starting incidence angle. Finally, the two methods are compared by two simulation experiments in deepsea and shal-low sea. The results show that the computational efficiency of the traditional method is higher than our pro-posed method when the starting incidence angle is less than 78°. In addition, it is found out that when the starting incidence angle is greater than 60°, the ranging error calculated by the traditional method begins to diverge. In the shallow water simulation experiment， the traditional method also has the problem of non- convergence in the iteration process when the starting incidence angle is greater than 85°. In contrast, our proposed method can converge to the real value at any starting incidence angle. [ABSTRACT FROM AUTHOR]

Objective ■ To investigate the change of response inhibition function in patients with diug-naive bulimia nervosa (BN) and its relationship with eating disorders and self-reporting impulsiveness. Methods- Thirty-five drug-naive BN patients who accepted psychological counseling in Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine between Aug. 2018 and Jun 2019, and 23 healthy controls (HC) were recruited. The eating disorder and impulsiveness were compared between the two groups by using the Chinese version of Eating Disorder Examination Questiotmaire 6.0 (EDE-Q 6.0) and Barrett Impulsiveness Scale-11 (BIS-11), respectively. The stop signal task (SST) was used to assess response inhibition function. The scale scores and SST results were compared between the two groups, and the correlation of stop signal reaction time (SSRT) with BIS-11 score, EDE-Q 6,0 score, the age of onset and the duration of illness was analyzed. Results* Compared with the HC group, the BN group demonstrated significantly longer SSRT in the SST (P=Q.003)9 and had a higher total score of BIS-11 (7MK004)，attentional impulsiveness score (7M).OO8) and non-planning Impulsiveness scoTe (P=0<002). SSRT was positively associated with the age of onset (r=0.503，P=0.006)，negatively associated with the score of weight concern subscale (r=-0337, P=O.O48), and not correlated with the BIS-11 score and the dumtion of illness in drug-naive BN patients. Conclusion - Drug-naive BN patients have high impulsiveness, and their defects in response inhibition are associated with the age of onset and weight concern. [ABSTRACT FROM AUTHOR]

Objective - To explore the reliability and validity of self-rated Family Burden Scale (FBS) evaluating caregiver burden in families of the patients with anorexia nervosa (AN). Methods* The study included female AN patients (n=103) treated in the Eating Disorder Center of Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine from Jut 2017 to Jul. 2019 and their caregivers (parents, n=148). General demographic information of the patients and their caregivers, the course of illness and body mass index (BMI) of patients, and the time each caregiver spent in caring far the patient per day were recorded- FBS, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and the MOS item short form health survey (SF-36) were self-rated by Ihe caregivers. One-third of the caregivers were selected by random number method for FBS rating by specialists. The reliability of the scale was evaluated by calculating Cronbaclfs a coefficient, self-rating and other-Tating consistency and the consistency between husband and wife (41 couples). The validity of the scale was evaluated by calculating the correlation of FBS score with the course of disease, patients' BMI, the time spent in caring per day, scores of BAI and BDI, and vitality, social function, role-emotion and mental health domain of SF-36. Results- The Cronbachrs a coefficient of FBS was 0.921，the correlation coefficient between self-rating and other-rating by specialists was 0.705 (ZMIOOO)，and the correlation coefficient of consistency score between couples was 0.547 (ZMkOOO). FBS score showed no correlation with the course of disease, %BMI and the time spent in caring per day* Scores of BAI and BDI, and vitality, social fijnetkm，role-emotion and mental health domain of SF-36 showed low correlation with FBS score (all P<0.05). Conclusion - Self-rated FBS shows good reliability when used in families of AN patients. The validity is not as ideal, which suggests further revision of the scale. [ABSTRACT FROM AUTHOR]

Objective • To explore the relationship among depressive symptoms, attributional style and obsessive-compulsive symptoms in patients with obsessive-compulsive disorder. Methods * Seventy patients with obsessive-compulsive disorder who met the diagnostic criteria Qi Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) {DSM- IV) were selected. The Yale-Brown ObsessiveXompulsive Scale (Y-BOCS) was used to evaluate the severity of obsessive-compulsive symptoms, the Beck Depression Inventor-II (BDI-H) was used to measure the depressive symptoms, and the Attributional Style Questionnaire (ASQ) was used to measure the attributional style. The correlations among obsessive-compulsive synptoms， dqjressive symptoms and attributional style as well as the mediating role of obsessive-compulsive symptoms between attributional style and dqjrcssive symptoms were analyzed. Results- The globality dimension of negative events in attributional style was positively correlated with obsessive-compulsive symptoms and depressive symptoms {both P<0.05), and obsessive-compulsive symptoms were also positively correlated with depressive symptoms (JM).000). The mediating effect analysis showed that the mediating role of obsessive-compulsive symptoms between the globality dimension of negative events and depressive symptoms was 0405 (95%CI 0,031--0»218), with an mediating effect ratio of 44.20%. Conclusion - Obsessive-compulsive symptoms in patients with obsessive-compulsive disorder may playa completely mediating effect between the globality dimension of negative events in attribution style and depressive symptoms. [ABSTRACT FROM AUTHOR]

Objective To investigate DKC1 on human glioma U87 cell proliferation, migration and invasion effect and its possible mechanism. Methods Control small interference RNA(siRNA) and DKC1 siRNA were used respectively to transfect human brain glioma U87 cells. The expression levels of DKC1 proteins in human brain glioma U87 cells was detected after DKC1 knockdown by using Western blotting. The expression levels of AKT、p-AKT、p70S6K、p-p70S6K、MMP2、MMP9 proteins in human brain glioma U87 cells were suppressed after DKC1 knockdown by using Western blotting. The influence of DKC1 knockdown by using Western blotting on the proliferation of human brain glioma cells was tested by using cell counting kit-8(CCK-8) assay. The migration and invasion ability of U87 cells were respectively measured by wound-healing assay and transwell migration and invasion assays. Results （1）According to CCK-8 assay, the loss of DKC1 can suppress the proliferation of U87 cells (P＜0.01-0.001).（2）The result of wound-healing assay showed that the migration distance in the DKC1 group was significantly shorter than that in the Ctrl siRNA group (P＜0.01-0.001). （3）The result of transwell detection showed that the number of migration and invasion cells in the DKC1 group was significantly lower than the Ctrl siRNA group (all P＜0.01). （4） Western blot analysis showed that DKC1 gene expression in Ctrl siRNA group was significantly higher than that in DKC1 group. In DKC1 siRNA transfected cells, the expression of p70S6K, p-p70S6K, MMP2 and MMP9 was down-regulated（P＜0.05-0.01）, but the expression of AKT and p-AKT was without any changes（all P＞0.05）. Conclusion (1)DKC1 impacts on the biological behavior of glioma cells hint the DKC1 may participate in the development of glioma. (2)DKC1-targeted siRNA interferes with the expression levels of DKC1. The expression levels of p70S6K、p-p70S6K was down-regulated but the expression levels of AKT 、p-AKT without any change in DKC1 siRNA transfected cells (P＜0.05). (3) As compared with Ctrl siRNA group, lower expression level of MMP2、MMP9 was detected in DKC1 siRNA group. (4)Downregulation of DKC1 expression can inhibit migration and invasion of human glioma U87 cells. [ABSTRACT FROM AUTHOR]