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The article reports new findings from Guangzhou Medical University on inflammatory bowel disease (IBD). Topics include the role of 17β-estradiol in promoting myeloid-derived suppressor cells (MDSCs) and alleviating IBD symptoms, the impact of estrogen on the progression of IBD in mouse models, and the molecular mechanisms involving STAT3 and NF-κB activation in this process.

The article focuses on evaluating the tolerance of 17α-estradiol dosing in male common marmosets to understand its effects including the pilot study's design and methods, dosing tolerability outcomes, and implications for future geriatric and gerontology research.

The article focuses on the approval of the Corina Intrauterine Drug-Eluting System in China for treating moderate-to-severe intrauterine adhesions (IUA). Topics include the device's efficacy in preventing re-adhesion post-surgery, its innovative drug-delivery mechanism using estradiol, and the high incidence of IUA in China following intrauterine interventions.

A patent application by inventors from Shimadzu Corporation has been made available online for a method of analyzing steroid compounds in a sample using liquid chromatograph mass spectrometry (LC/MS). The method involves dividing the sample into multiple liquid fractions, treating each fraction differently, mixing the fractions together, and analyzing the mixed sample solution with a liquid chromatograph mass spectrometer. This method aims to shorten the analysis time for steroid compounds in a sample. The inventors propose using a solid-phase extraction column to divide the sample into liquid fractions and suggest the use of an organic acid or organic acid salt in the solvent of the mixed sample solution. [Extracted from the article]

This document provides information about a clinical trial that is currently recruiting participants. The trial aims to study the effects of estrogen replacement therapy in women with Turner syndrome (TS), a genetic disorder that affects females. The trial is open to women between the ages of 18 and 50 who have already been receiving estrogen treatment. The study will exclude individuals with certain medical conditions or contraindications to estrogen therapy. The trial is being conducted in Denmark by the University of Aarhus. [Extracted from the article]

A clinical trial, NCT06546397, is currently recruiting participants to study the effects of combined estrogen and progesterone therapy on endometrial repair and ovarian function recovery after induced abortion. The trial aims to address potential risks associated with repeated induced abortions, such as uterine damage and infertility. The study will evaluate the thickness of the endometrium, cycle normalization rate, duration of vaginal bleeding after surgery, and menstrual flow volume as primary and secondary outcome measures. The study is being conducted in China and is expected to be completed by December 2025. [Extracted from the article]

A recent report from Chonbuk National University Hospital in South Korea discusses research on polycystic ovary syndrome (PCOS). The study analyzed the medication use patterns and safety of drugs among patients diagnosed with PCOS. The research found that the most prescribed medications for PCOS were medroxyprogesterone acetate (MPA) and ethinyl estradiol with drospirenone. Adverse drug reactions occurred in 7.1% of patients, with 4.8% being adolescents and 9.3% being adults. The study also noted that some patients changed prescriptions or discontinued medications. [Extracted from the article]

A recent study conducted by researchers at Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU) in Germany focused on the development and evaluation of estradiol derivatives for the positron emission tomography (PET) imaging of estrogen receptor-positive (ER+) breast cancer. The current FDA-approved imaging probe for ER+ breast cancer, 16a-[18F]fluoroestradiol (FES), has limitations due to high retention in the liver. The study aimed to address this issue by developing estradiol derivatives with different lipophilicity. The researchers found that one derivative, 18F-TA-Glyco-EE, showed promising results with high uptake in ER+ tumor cells and rapid clearance from non-target tissues. This derivative may serve as an alternative to FES for PET imaging of breast cancer. [Extracted from the article]

A study conducted at Beirut Arab University explored the impact of Gundelia tournefortii extract on polycystic ovarian syndrome (PCOS). PCOS is a common endocrine disorder that affects women and increases the risk of infertility, cardiovascular diseases, and hypertension. The study used female mice with induced PCOS and treated them with the extract. The results showed that the extract reduced follicular cysts in the ovaries, decreased testosterone and estradiol levels, normalized markers of oxidative stress, and restored the expression of certain enzymes. The researchers concluded that Gundelia tournefortii extract could be a potential therapeutic agent for PCOS. [Extracted from the article]

The article discusses a new study from Islamic Azad University exploring the effects of high-intensity interval training and yoga on serum estradiol levels and sexual function in postpartum women. Topics include the significance of sexual health in marital relationships, the impact of postpartum changes on sexual function, and the effectiveness of specific physical training programs in improving sexual outcomes.

A study conducted by researchers at Pusan National University School of Medicine in South Korea examined the effects of hormone replacement therapy (HT) on cardiovascular and metabolic parameters in a mouse model of primary ovarian insufficiency (POI). The study found that on-time, continuous estradiol treatment immediately after estrogen deprivation significantly reduced metabolic and cardiovascular risks in the mouse models, as well as decreased levels of pro-inflammatory cytokines. The findings suggest that HT may have potential benefits for young, pre-menarche females with POI. Further research is needed to explore these effects in humans. [Extracted from the article]

A study conducted in Urumqi, China explored the impact of biomimetic electrical stimulation combined with Femoston (estradiol and dydrogesterone tablets) on pregnancy rate and endometrium characteristics in patients with infertility and a thin endometrium. The study enrolled 120 patients who were divided into two groups: one receiving Femoston alone and the other receiving Femoston combined with biomimetic electrical stimulation. The results showed that the endometrium of patients in the electrotherapy group was thicker and had a higher percentage of patients with favorable endometrial types compared to the Femoston group. However, there was no significant improvement in pregnancy rates. The researchers suggest that further confirmation is needed. [Extracted from the article]

A recent study conducted by the Medical University of Silesia in Poland examined the impact of hypothyroidism during pregnancy on the reproductive development of infant girls. The study found that non-substituted or inadequately treated hypothyroidism during pregnancy may impair the course of minipuberty in female offspring. The researchers measured salivary concentrations of hormones and urine levels of gonadotropins in three groups of infant girls: those born to women with hypothyroidism, those born to women with adequately substituted hypothyroidism, and those born to healthy women. The study concluded that there were significant differences in hormone levels and the size of reproductive structures between the groups. [Extracted from the article]

A recent study conducted by researchers at Renmin Hospital of Wuhan University in China explored the efficacy of a combination treatment for preventing ovarian hyperstimulation syndrome (OHSS) in high-risk women. The treatment involved a cocktail of GnRH-antagonist, letrozole, and mifepristone. The study, which included 170 women, found that the combination treatment significantly reduced the incidence of moderate and severe OHSS compared to a group that received only mifepristone. The treatment also resulted in decreased serum estradiol levels, ovarian diameter, and luteal phase. However, there was no significant difference in cumulative live birth rates between the two groups. [Extracted from the article]

A study conducted by researchers at the Indian Institute of Technology Roorkee investigated the degradation of four emerging contaminants in water and sediment systems. The compounds studied were estrone, progesterone, sulfamethoxazole, and trimethoprim. The research found that bio-photodegradation was the most effective method of removing these contaminants. The study also identified transformation products in the Yamuna River, confirming the presence of degradation pathways in the environment. The research was supported by the Department of Science & Technology in India and has been peer-reviewed. [Extracted from the article]

A recent study conducted by researchers from the National Autonomous University of Mexico (UNAM) examined the role of sex steroids in colorectal cancer. The study found that men have a higher incidence of colorectal cancer compared to women, and there is a disturbance in the levels of sex steroids in patients with this disease. In animal models, males also exhibited greater tumor growth than females. The researchers used a chemical method to induce colorectal tumors in mice and found that males developed a greater number of tumors with larger sizes compared to females. The study also revealed that estradiol decreased the proliferation of colon cancer cells in vitro, while testosterone increased proliferation. Dihydrotestosterone did not have an influence on proliferation. These findings suggest a sexual dimorphism in colorectal cancer and highlight the potential role of sex steroids in the development and progression of the disease. [Extracted from the article]

A recent report from Leipzig University Medical Center discusses the role of sex hormones in regulating lipid metabolism genes in primary human hepatocytes. The study found that there are differences in gene expression levels and responsiveness to sex hormones between male and female hepatocytes. These findings suggest that considering cellular sex is important when studying the mechanisms of metabolic dysfunction-associated steatotic liver disease (MASLD). Further research in this area could help to better understand the hormonal and genetic causes of sex differences in MASLD. [Extracted from the article]

A recent report from Yale University discusses the potential molecular mechanisms behind survival differences in colorectal cancer (CRC) patients based on sex and disease stage. The study found that asparagine synthetase (ASNS) and G protein-coupled estrogen receptor-1 (GPER1) are critical sensors of nutrient depletion and are linked to poorer outcomes for females with CRC. The research suggests that KRAS mutant cells have mechanisms in place to respond to decreased nutrient supply by increasing the expression of ASNS and GPER1 to drive cell growth. These findings shed light on the mechanisms underlying sex differences in metabolism and growth in CRC and have implications for the precision management of KRAS mutant CRC. [Extracted from the article]

A recent study conducted at the First Hospital of Lanzhou University focused on congenital adrenal hyperplasia (CAH), a rare autosomal recessive disorder caused by enzyme deficiency in the adrenal corticosteroid synthesis pathway. Specifically, the study examined a case of CAH due to 17a-hydroxylase deficiency (17a-OHD). The patient, a 24-year-old female, presented with limb numbness and weakness, and was diagnosed with 17a-OHD through molecular mutation detection. Treatment with prednisone acetate and estradiol valerate resulted in improved symptoms and hormone levels. The study concluded that genetic detection can be used to diagnose CAH with 17a-OHD. [Extracted from the article]

A recent study conducted by researchers at the University of Texas Southwestern Medical Center explored the hormonal and microbial landscapes in postmenopausal females with vulvar lichen sclerosus (VLS), a progressive skin disease of unknown cause. The study found that patients with VLS had lower levels of groin cutaneous estrone and higher levels of cutaneous progesterone compared to controls. Treatment with topical steroids normalized the levels of estrone and progesterone, but testosterone remained suppressed. The study also revealed alterations in the bacterial and fungal microbiome in patients with VLS. These findings suggest that hormonal and microbial changes may be associated with VLS in postmenopausal females. [Extracted from the article]

A study conducted by researchers at the Sixth Affiliated Hospital of Guangzhou Medical University explores the role of aspartic acid 262 on estrogen receptor alpha (ERa) in both genomic and non-genomic effects of estradiol (E2). The study found that a mutation of this aspartic acid disrupted uterine development, follicular development, and the dilation of the aorta in mice. Additionally, the mutation affected the expression of various estrogen genomic and non-genomic effectors. These findings provide insights into the importance of aspartic acid 262 in the estradiol signaling pathway and may contribute to the development of estrogen non-genomic effect inhibitors. [Extracted from the article]

A recent study conducted by researchers at the University of California Los Angeles (UCLA) has found that parasympathetic dysfunction after a chronic heart attack (myocardial infarction) can lead to ventricular tachyarrhythmias (ventricular tachycardia/ventricular fibrillation) and that this condition is more common in males than females. The study used optogenetic approaches and found that glutamatergic vagal afferent neurons were impaired in male mice following a heart attack, resulting in reduced reflex efferent parasympathetic function. However, in female mice, vagal sensory impairment was reduced, and treatment with 17 beta-estradiol improved vagal neurotransmission in male mice. The research suggests that a decrease in efferent vagal tone after a heart attack is due to reduced glutamatergic afferent vagal signaling, which may be caused by impaired redox homeostasis in the vagal ganglia. The study concludes that estrogen can prevent pathological remodeling and improve parasympathetic function following a heart attack. [Extracted from the article]

Researchers at Beijing University of Chinese Medicine have conducted a study exploring the relationship between estradiol (E2) and the incidence of hyperuricemia (HUA) in adult women. The study, which included 2,941 participants aged 20-65 years, found that E2 levels were negatively associated with HUA in female individuals but not in male individuals. Additionally, markers of glucolipid metabolism, such as total cholesterol (TC), triglyceride (TG), and the triglyceride-glucose index (TyG), were found to mediate the relationship between E2 and HUA. The study suggests that women aged 45-65 years with lower E2 levels have a greater incidence of HUA. [Extracted from the article]

Researchers from Pontifical University Javeriana in Bogota, Colombia have conducted a case-control study to determine the association between the estradiol-to-testosterone ratio and erectile dysfunction (ED) and libido in adult male patients with chronic pathologies. The study found that there were no significant differences in estradiol or estradiol-to-testosterone ratio between cases and controls. However, when analyzed in subgroups based on LH response, differences were observed, suggesting that the estradiol-to-testosterone ratio may be useful in studying inappropriate LH response. The researchers recommend a larger sample size to further validate these findings. [Extracted from the article]

The article details research from the First Affiliated Hospital investigating the role of sexual hormone binding globulin (SHBG) in ovulation. Topics include the association between elevated SHBG levels and increased ovulation rates, the impact of various reproductive hormones on ovulation, and the findings from a secondary analysis of the PCOSAct study involving women with polycystic ovary syndrome (PCOS).

A study conducted at Tokushima University Graduate School in Japan explored the effects of testosterone on oxytocin levels in female rats. The researchers hypothesized that androgens may influence oxytocin, a hormone that affects appetite, and that this relationship may be influenced by estrogen levels. The study found that testosterone increased oxytocin levels and reduced food intake, body weight gain, and fat weight in rats without estrogen supplementation. However, these effects were not observed in rats with estrogen supplementation. The findings suggest that the effects of androgens on oxytocin may be influenced by estrogen levels, and elevated oxytocin levels may be associated with decreased appetite and prevention of obesity in estrogen-deficient conditions. [Extracted from the article]

This document provides information about a clinical trial, NCT06525155, that is currently being conducted in Indonesia to study the effectiveness of triptorelin in treating endometriosis. Endometriosis is a chronic disease that affects a significant number of women and causes pelvic pain. Triptorelin has shown promise in treating the symptoms of endometriosis, but patient compliance is low due to cost and side effects. The trial will compare two groups receiving triptorelin at different intervals and measure pain levels, hormone levels, and evaluate the condition of the uterus and cysts during surgery. The study is currently recruiting participants and is projected to be completed in December 2024. [Extracted from the article]

A study conducted at the University of Mosul in Iraq investigated the effects of metformin treatment on zinc and magnesium levels in women with polycystic ovary syndrome (PCOS). The study involved 23 women with PCOS who were not taking metformin and 16 women with PCOS who were taking metformin. The results showed that the patients without metformin had significant increases in LH, LH:SH ratio, and free testosterone levels. Zinc levels were found to have a direct correlation with estradiol in patients not on metformin and an indirect correlation with body mass index in patients on metformin treatment. However, metformin treatment did not have an effect on the levels of magnesium and zinc in women with PCOS. The study suggests that zinc is important for female fertility and may enhance estradiol levels. The increase in zinc levels also had an inverse effect on body mass index. [Extracted from the article]

A recent study conducted at Jean Verdier Hospital in Bondy, France, examined the effects of luteal estradiol (E2) pretreatment on the number of retrieved oocytes in advanced-aged women undergoing in vitro fertilization (IVF) treatment. The study found that programming antagonist cycles with luteal E2 pretreatment resulted in a similar number of retrieved oocytes compared to no pretreatment in women aged 38-42 years. The research also indicated that E2 pretreatment may be beneficial in scheduling oocyte retrievals on working days. However, further research is needed to determine the potential benefits of E2 pretreatment in a larger population with decreased ovarian reserve. The study was supported by a research grant from MSD (Organon, France). [Extracted from the article]

A study conducted by researchers at Islamic Azad University in Iran explored the effects of combined exercises and Tribulus supplementation on sex hormones in overweight postmenopausal women. The study involved 60 inactive postmenopausal women who were divided into four groups: combined exercise, supplement, combined exercise with supplement, and control. The results showed a significant decrease in cortisol levels and a significant increase in the testosterone-to-cortisol ratio among the experimental groups. However, no significant difference was observed in other sex hormones. The study suggests that combined exercises with Tribulus supplementation may be an effective intervention to improve sex hormones in overweight postmenopausal women. [Extracted from the article]

A study conducted by researchers at the University of California Santa Barbara explored the relationship between hormone fluctuations during the menstrual cycle and changes in the structure of the brain. The study involved 30 women and used imaging techniques to examine white matter microstructure, cortical thickness, and brain volume during different phases of the menstrual cycle. The results showed that hormone concentrations, such as 17 beta-estradiol and luteinizing hormone, were directly proportional to diffusion anisotropy, while follicle-stimulating hormone was directly proportional to cortical thickness. The study suggests that hormonal fluctuations may have significant structural impacts on the entire brain. [Extracted from the article]

A recent study conducted at the First Affiliated Hospital of Chongqing Medical University explored the genetic effects of hormones on the risk of developing venous thromboembolism (VTE). The study used a two-sample Mendelian randomization design and found that a genetic predisposition to higher free thyroxine (FT4) concentrations and hyperthyroidism was associated with an increased risk of developing VTE. Additionally, genetically predicted estradiol concentrations were positively associated with the risk of developing VTE in females. The study suggests that these hormone-related genetic factors may play a role in the development of VTE and could potentially be targeted for prevention and treatment. [Extracted from the article]

A recent study examined the potential causal links between lifetime estradiol exposure and brain and mental health in females. The study used Mendelian randomization analyses to overcome the challenges of observational studies and found no significant causal associations between estradiol levels or factors related to lifetime estradiol exposure and brain age gap, Alzheimer's disease risk, or depression risk. These results do not support the idea that estradiol has a causal impact on mental and brain health in females. The study suggests that future research should explore other influencing factors and implement sex-specific, causal frameworks to investigate the effects of hormonal fluctuations. [Extracted from the article]

A recent study conducted by researchers at Lancaster University in the United Kingdom has revealed new findings on hormones. The study focused on the use of microneedle arrays, which are minimally invasive devices, for the transdermal/intradermal delivery of drugs and bioactives. The researchers demonstrated the release of bioactive molecules, such as estradiol, melatonin, and meropenem, from poly(2-hydroxyethyl methacrylate) hydrogel-based microneedle patches. The study suggests that these microneedles have potential applications in the transdermal delivery of bioactives for the treatment of various conditions. [Extracted from the article]

A new report from researchers at Instituto Politecnico Nacional discusses the effects of Arthrospira maxima phycobiliproteins (PBPs), rosiglitazone (RSG), and 17b-estradiol (E) on the differentiation process of 3T3-L1 cells and their regulation of lipogenic and inflammatory gene expression. The study found that phycobiliproteins promoted cell proliferation after 24 hours of treatment and reduced lipid droplet accumulation during the adipogenic process. The researchers concluded that phycobiliproteins have an anti-adipogenic and anti-inflammatory effect by reducing the expression of adipogenic, lipogenic, and inflammatory genes in 3T3-L1 cells at different stages of the differentiation process. [Extracted from the article]

Researchers at the University of Texas Rio Grande Valley have developed a novel electrochemical biosensor that uses laser engraving to induce graphene formation on a polyimide substrate. The biosensor, which was modified with graphene-based ink, demonstrated effective enhancement of electrical signals. The sensor was able to successfully detect alpha-fetoprotein (AFP) and 17b-Estradiol (E2) in both buffer and human serum environments, with a limit of detection of 1.15 ng/mL for AFP and 0.96 pg/mL for estrogen. The researchers concluded that this low-cost and rapid detection approach holds promise for clinical applications in healthcare. [Extracted from the article]

A study conducted by researchers at the University of Illinois Chicago explored the relationship between endogenous estrogens and verbal memory performance in postmenopausal women. The study found that higher levels of endogenous estradiol were associated with increased activation in certain brain regions during verbal memory encoding, while lower levels were associated with activation in other regions during recognition. Additionally, the study found that endogenous estrone was positively associated with activation in various brain areas during encoding. These findings suggest that estrogen levels may play a role in memory performance in postmenopausal women. The research was funded by the National Institute on Aging and the National Science Foundation Graduate Research Fellowship Program. [Extracted from the article]

Researchers from the First Affiliated Hospital of Harbin Medical University in China have conducted a study on the effects of high serum estradiol (E2) levels and the duration of vaginal E2 administration on reproductive outcomes in frozen-thawed embryo transfer (FET) cycles. The study involved 627 patients aged 40 years old who underwent FET cycles. The results showed that high E2 levels on the embryo transfer day did not reduce clinical pregnancy and live birth rates. Additionally, the study found no benefit in continuing vaginal E2 administration until the pregnancy testing day. The research suggests that vaginal E2 could be stopped on the embryo transfer day. [Extracted from the article]

A recent study conducted by researchers at the Department of Ophthalmology in Ashdod, Israel, explores the association between elevated blood estradiol levels and corneal ectasia in premenopausal women. The study involved three groups of women: those with keratoconus, those with post refractive surgery ectasia (PRSE), and a control group. The researchers found that higher blood estradiol levels were associated with an increased risk of ectasia. This research suggests that measuring estradiol levels could be useful for women with keratoconus or those undergoing refractive surgery. [Extracted from the article]

A recent study conducted at Women University in Multan, Pakistan, explored the association between demographic variables, lipid and hormonal levels, and polycystic ovarian syndrome (PCOS) in Pakistani women. The study found that socio-demographic factors such as geographical area, diet, monthly income, and education were significantly associated with PCOS in both obese and non-obese individuals. Additionally, differences in body mass index, lipid profile, and endocrine profile were observed between obese cases and controls. The researchers concluded that further studies with larger cohorts are needed to better understand the multiple factors contributing to the occurrence and prevalence of PCOS. [Extracted from the article]

A report from the University of Michigan discusses the impact of sex steroids on bone architecture and fracture prevention throughout a person's lifespan. The research highlights the importance of sex steroids, such as estrogen and testosterone, in bone development and maintenance. It also explores the effects of declining sex steroid levels during menopause in women and androgen deprivation therapies in men. The review suggests that therapies to prevent bone loss should be tailored based on individual bone size and architecture. The research is published in Endocrine Practice and is available under an open access license. [Extracted from the article]

Researchers from American University in Sharjah, United Arab Emirates, have developed a new method for synthesizing estrone liposomes, which are used in targeted drug delivery for cancer gene therapy. The researchers used a herringbone micromixer to simplify and speed up the process of synthesizing the liposomes. The liposomes produced using this method were stable in size and showed improved reproducibility compared to conventional techniques. This research has been peer-reviewed and published in IEEE Transactions on NanoBioscience. [Extracted from the article]

A new report from the National University of Rosario in Argentina discusses the role of oxidative stress in cholestasis induced by estradiol 17 b-D-glucuronide (E17G), an endogenous metabolite of estradiol. The researchers found that antioxidant compounds and the NADPH oxidase (NOX) inhibitor apocynin prevented E17G-induced impairment of bile flow and activity of the Mrp2 transporter. They also discovered that NOX-generated reactive oxygen species (ROS) play a crucial role in the internalization of canalicular transporters like Mrp2. Overall, the study suggests that E17G-induced cholestasis is partially mediated by NOX-generated ROS, with ERK1/2 and p38MAPK being necessary for NOX activation. [Extracted from the article]

A recent study conducted by researchers at the University of North Texas Health Science Center has found that a prodrug called DHED, which produces 17b-estradiol (E2) in the retina after topical administration, can protect retinal ganglion cells and preserve visual function in a male rat model of glaucoma. The study used targeted retina proteomics and biomarkers to evaluate the neuroprotective effects of DHED-derived E2. The findings suggest that this ocular neuroprotective approach could have potential therapeutic benefits for glaucoma treatment. Further information on the study can be found in the journal article "The Prodrug DHED Delivers 17b-Estradiol into the Retina for Protection of Retinal Ganglion Cells and Preservation of Visual Function in an Animal Model of Glaucoma." [Extracted from the article]