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To prepare an herbal ointment using an ethanolic extract of Berberis aristata and assess the anti-psoriatic effectiveness of the finished product. We were able to make multiple ointments that were each categorized as F-1, F-2, and F-3 by adding varying concentrations of stearic acid and cetyl alcohol by learning about various formulation types, such as oil in water. The analysis of many factors, including pH, viscosity, spreadability, and stability, was used to evaluate all formulations. A formulation of ethanolic extract (F-3) showed antipsoriatic action. No evidence of a separate phase or ease of removal was found in any of the formations, but they all demonstrated good spreadability, consistency, appearance, and pH. Additionally, during irritancy trials, the formulation F-3 did not cause redness, oedema, erythema, or irritation. The use of this formulation on the skin is safe. As a result, the study implies that the extract's and the ointment's base's compositions are safer and more stable, however, they might also have synergistic effects.

Berberis aristata commonly known as Daruhaldi, which is traditionally used in the various treatment such as inflammation, irritation, wound and other skin aliments. During the tribal time period, Indian people were use the crused from of root-bark directly on infected parts of skin. Most of the people used the matured root bark in crused form and directly apply a thick paste on the inflammated surface. In this investigation, quantify the important marker compound (Berberine and Tetrahydropalmatine) by the HPTLC-densitometry method and further evaluate the anti-inflammatory activity of EEBA and also done the molecular docking, which was done by using Auto-Dock software. Croton oil induced ear oedema and carrageenan induced paw oedema model was used to evaluate the anti-inflammatory efficacy. Auto-Dock software was used to determine the molecular mechanism. The finding of the HPTLC-densitometry validated method revealed that the RSD for interday (0.113-0.343 and 0.116-0.342) and intraday (0.101-0.304 and 0.105-0.296) are as per ICH guidelines. The pharmacological evaluation of anti-inflammatory activity revealed a significant reduction of oedema when using 4% formulation. On behlf of molecular docking berberine and tetrahydropalmatine inhibit the of COX-1 and COX 2 levels. It was concluded that the application of the extract in animals to be used as an anti-inflammatory agent for topical formulations and the phytoconstituent have potentcy to inhibit the effect of COX-1 & 2.

Introduction: The root bark of Berberis aristata has been utilized by indigenous peoples for wound treatment for centuries. The mature root barks are crushed into a paste and applied to the wound's surface. Objective: The focus of this research is to analyse the wound healing activities of an ethanolic extract of Berberis aristata, as well as to use molecular docking to establish the likely mechanism of the potent phytochemical. There is no scientific evidence to support the usage of root bark extract of Berberis aristata. Method: The Herbal ointment, which comprises (1%, 2%, and 4% w/w) ethanolic extract of root bark, was developed to test the wound healing ability of incision and excision wounds, and the molecular mechanism was established using Auto-Dock software. Result: Epithelization stage, wound index, % wound contraction area, hydroxyproline content, DNA estimate, and histopathological assessments were performed on the incision wound model. Tensile strength was assessed in an excision wound model. TLC was used to identify the samples after successive extractions with different solvents based on polarity. Conclusion: Berberine and Tetrahydropalmatine were major active phytoconstituent found in root barks of Berberis aristata as secondary metabolites. Animals treated with 4% w/w formulation demonstrated considerable wound contraction, epithelization time, and wound index in the excision model. In contrast, to control and standardize the concentrations of hydroxyproline, total amino acids, and DNA in recovering tissue were higher. At 4% w/w extract formulation, the parameters studied indicated a substantial result. Berberine and tetrahydropalmatine, active metabolites which are present in the ethanolic extract of Berberis aristata, were found to be responsible for wound healing. Based on ligand interactions, the findings verified Berberis aristata ethnomedicinal claim in a wound healing capacity.

Aims: The aim of present investigation was to evaluate the traditional claim of Ficus retusa as an anti-diarrheal and anti-spasmodic agent using different pharmacological models. Background: Diarrhea is considered as major cause of mortality, especially in children and aged persons. Because of diarrhoea, 17% of admitted children get die. In order to treat the diarrhea, natural drugs may be useful. Objective: In order to prove the traditional claim of Ficus retusa, present work was undertaken with objective to prove antidiarrheal and antispasmodic activity. Methods: The anti-diarrhoeal activity was evaluated by magnesium sulphate induced diarrhea and 5-hydroxy tryptamine(5HT) induced diarrhea. Further, the exact were subjected to gastrointestinal motility test using standard procedure. Conclusion: The response towards bioactivity was dose dependent. It was concluded that 400mg/kg bw of ethanolic extract is most potent in antidiarrhoeal and antispasmodic activity.

A stroke causes serious and long term brain disability due to disruption in the blood flow to the brain. Clinically major changes occur in brain functions are seen after brain ischemia and reperfusion. Patients show emotional, behavioural, and cognitive alterations during retrieval time. Cerebral injury by transient ischemia distresses the number of patients globally with death or long term disability. In recent years a great deal of research has been carried out to find the effectiveness of the herbal drug for the treatment of stroke. Both thrombolytic and neuro-protective activities of herbal drugs may be a new strategy for effective stroke treatment. This article reviews the list of universally used plants effective for brain stroke therapies. The purpose of this article was to collect the herbal drugs useful in brain stroke therapies. Keywords: ischemia-reperfusion, brain injury, stroke, herbal drugs, tissue

Equisetum ramosissimum (Roxb. Ex Voucher) Hauke commonly known as field horsetail is a plant with wide prospectus, In folk medicine, Equisetum ramosissimum is used for tuberculosis, as a catarrh in the kidney and bladder regions, as a hemostatic for profuse menstruation, nasal, pulmonary and gastric hemorrhages, for brittle fingernails and loss of hair, for rheumatic diseases, for CNS system, for diuretics, HIV and immune system, for cytotoxic, vasorelaxant, hepatoprotective, cosmetics, astringents and anti-cancer disease, swelling and fractures and for frostbite (PDR for herbal Medicines) etc. The plant is reported to contain a number flavonoids, alkaloids, phenolic proteins, triterpenoids, saponins, phytosterols; the present review is an attempt to generate interest among the masses regarding its immense potential in preventing and treating several disorders. Keywords Equisetum ramosissimum, Diabetic, flavonoids, Plant

This review presents an overview on plants identified to possess hair growth activity in various ethno-botanical studies and surveys of tradition medicinal plants. There are various causes for hair loss and the phenomenon is still not fully understood. The treatments offered include both natural or synthetic products to treat the condition of hair loss (alopecia), nonetheless natural products are continuously gaining popularity mainly due to their fewer side effects and better formulation strategies for natural product extracts. Plants have been widely used for hair growth promotion since ancient times as reported in Ayurveda, Chinese and Unani systems of medicine. This review covers information about different herbs and herbal formulation that are believed to be able to reduce the rate of hair loss and at the same time stimulate new hair growth. A focus is placed on their mechanism of action and the review also covers various isolated phytoconstituents possessing hair growth promoting effect. Keywords: Alopecia, ayurveda, hair, herbal formulation.

Objective: Abies webbiana and Berberis aristata is an herbal plant that has several therapeutic effects. It also heals depression, grief, nervous stress and tension. In the present study we evaluated anti-depressant effect of ethanolic extract from Abies webbiana and Berberis aristata by using Forced Swimming Test (FST) and Tail Suspension Test (TST). Methods: Two doses of ethanolic extract of Abies webbiana and berberis aristata (200 mg/kg and 400 mg/kg) was given orally. Immobility time were measured after 30 min after the dosing and compared with control group and Flouxetine (25mg/kg) as a standard group. Results: The ethanolic extract of BA and AW (400 mg/kg) was found to be effective and it exhibited activity similar to that of the conventional drug Flouxetine (25mg/kg) (p

Introduction The wound is defined as an injury of a living tissue, arose due to either an accidental injury like cut of the cells or skin or sometime, maybe broken the tissue, which may cause the anomalies in the cellular ability to exhibit the protective mechanism. Wound healing is process of regaining the integrity of cell structure and layers of the skin. The normal healing process of wounds are categorized in 4 phases which includes hemostatic, inflammatory, fibrolastic and maturation. Purpose The present manuscript embarks on up to date information on different methods being used for wound healing assessment including incision, excision, burn wound and dead space models. The biochemical parameter which acts as wound healing markers are collagen estimation (hydroxyproline), hexosamine, DNA estimation, total protein estimation, wound Index, contraction area, epithelization period and tensile strength etc. Histologic evaluations is also an integral part of wound healing evaluation which, help in evaluating the cellular and matrix detail within the wound. Conclusion At present, molecular approaches are important to heal the wound. For assessment of potential of any herbal drug/synthetic compound, incision wound model, excision wound model, burn wound model and dead space model and their parameter are used.

The aim of present investigation was to evaluate the traditional claim of Ficus retusa as an anti-diarrheal and anti-spasmodic agent using different pharmacological models.Diarrhea is considered as major cause of mortality, especially in children and aged persons. Because of diarrhoea, 17% of admitted children get die. In order to treat the diarrhea, natural drugs may be useful.In order to prove the traditional claim of Ficus retusa, present work was undertaken with objective to prove antidiarrheal and antispasmodic activity.The anti-diarrhoeal activity was evaluated by magnesium sulphate induced diarrhea and 5-hydroxy tryptamine(5HT) induced diarrhea. Further, the exact were subjected to gastrointestinal motility test using standard procedure.Finding of the present study suggested that significant response was exhibited by ethanolic extract (400mg/kg bw.) of Ficus retusa.The response towards bioactivity was dose dependent. It was concluded that 400mg/kg bw of ethanolic extract is most potent in antidiarrhoeal and antispasmodic activity.

Background Tridax procumbens(L.) leaves are traditionally used in wound healing by tribal people. The matured leaves are crushed to make a paste and applied on the surface of the wound. Purpose The aim of the present investigation was to evaluate the wound healing activity of ethanolic extract of Tridax procumbens (L.) (EETP) in streptozotocin induced diabetic and non- diabetic laboratory animals. There is no scientific literature, claiming the use of leaves of Tridax procumbens (L.) in diabetic wounds. Study Design The simple ointment base (2.5 % and 5% w/w) of EETP was formulated to evaluate the wound healing potential on diabetic and non-diabetic rats, using incision, excision and burn wound model. Methods In incision wound model, epithelization period, wound index, % contraction area, hydroxyproline content, DNA estimation, total protein and histopathological evaluations were done. In excision wound model, tensile strength was measured. In burn model, contraction rate, wound contraction (%) and epithelization period were evaluated. Results Secondary metabolite as tannin, flavonoids were present. In the excision model, animals treated with 2.5 % and 5% w/w EETP showed significant result in wound contraction, epithelization period and wound index. Hydroxyproline, total protein and DNA concentration in healing tissue were more in comparison to control and as well as standard in diabetic and non- diabetic. The parameters evaluated showed significant response at 2.5 % and 5% w/w EETP. Conclusion Flavonoids and tannin were accountable for wound healing. The findings confirmed the ethanomedicinal claim of Tridax procumbens(L.) in wound healing in diabetic and nondiabetic conditions.