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1. 28 nm CMOS analog front-end channels for future pixel detectors

Author: L. Gaioni, M. Fratus, A. Galliani, M. Manghisoni, L. Ratti, V. Re, E. Riceputi, and G. Traversi
Subjects: Falaphel project, Nuclear and High Energy Physics, 28 nm CMOS, Front-end electronics, Future HEP experiments, Settore ING-INF/01 - Elettronica, Instrumentation
Published: 2023
Full Text: View/download PDF

2. The complex interplay of Depression, Inflammation and Omega-3: state of the art and progresses in research

Author: M, Mazza, G, Marano, G, Traversi, M, Di Nicola, V, Catalano, and L, Janiri
Subjects: Inflammation, Risk, Depressive Disorder, Oxidative Stress, Depression, Fatty Acids, Omega-3, Animals, Humans
Abstract: Many epidemiological and preclinical studies have proven the potential benefit and critical role of omega-3 PUFAs in the development and management of depressive disorders. Depression may be the consequence of a complex interplay between cell-mediated-immune activation and inflammation evolving in neuroprogression. Associations between n-3 PUFAs, inflammation, oxidative stress and the risk of depression have been demonstrated and clinical and animal supplementation studies have shown the potential of PUFAs to decrease neurodegeneration and inflammation. Future research should focus on the dynamic interactions between the different cell signaling networks and oxidative and nitrosative stress pathways that cause depression.
Published: 2015

3. Radiation effects on the noise parameters of a 0.18 μm CMOS technology for detector front-end applications

Author: G. Traversi, M. Manghisoni, and L. Rattier
Subjects: Physics, Nuclear and High Energy Physics, business.industry, Detector, Integrated circuit, Radiation, Signal, Noise (electronics), Atomic and Molecular Physics, and Optics, law.invention, Front and back ends, CMOS, law, Hardware_INTEGRATEDCIRCUITS, Optoelectronics, business, Electronic circuit
Abstract: This paper presents a study of the effects of ionizing radiation on devices belonging to a 0.18 μ m CMOS process, in view of applications to the design of front-end integrated circuits for detectors in high energy physics experiments. Static, signal and noise performances of devices with various gate dimensions were monitored before and after exposure to γ-rays from a 60 Co source up to a 300 kGy(Si) total dose.
Published: 2003
Full Text: View/download PDF

4. SuperB Progress Reports -- Detector

Author: M. Baszczyk, P. Dorosz, J. Kolodziej, W. Kucewicz, M. Sapor, A. Jeremie, E. Grauges Pous, G. E. Bruno, G. De Robertis, D. Diacono, G. Donvito, P. Fusco, F. Gargano, F. Giordano, F. Loddo, F. Loparco, G. P. Maggi, V. Manzari, M. N. Mazziotta, E. Nappi, A. Palano, B. Santeramo, I. Sgura, L. Silvestris, V. Spinoso, G. Eigen, J. Zalieckas, Z. Zhu, L. Jenkovszky, G. Balbi, M. Boldini, D. Bonacorsi, V. Cafaro, I. D'Antone, G. M. Dallavalle, R. Di Sipio, F. Fabbri, L. Fabbri, A. Gabrielli, D. Galli, P. Giacomelli, V. Giordano, F. M. Giorgi, C. Grandi, I. Lax, S. Lo Meo, U. Marconi, A. Montanari, G. Pellegrini, M. Piccinini, T. Rovelli, N. Semprini Cesari, G. Torromeo, N. Tosi, R. Travaglini, V. M. Vagnoni, S. Valentinetti, M. Villa, A. Zoccoli, J. F. Caron, C. Hearty, P. F. T. Lu, T. S. Mattison, J. A. McKenna, R. Y. C. So, M. Y.u. Barnyakov, V. E. Blinov, A. A. Botov, V. P. Druzhinin, V. B. Golubev, S. A. Kononov, E. A. Kravchenko, E. B. Levichev, A. P. Onuchin, S. I. Serednyakov, D. A. Shtol, Y. I. Skovpen, E. P. Solodov, A. Cardini, M. Carpinelli, D. S. T. Chao, C. H. Cheng, D. A. Doll, B. Echenard, K. Flood, J. Hanson, D. G. Hitlin, P. Ongmongkolkul, F. C. Porter, R. Y. Zhu, N. Randazzo, E. De La Cruz Burelo, Y. Zheng, P. Campos, M. De Silva, A. Kathirgamaraju, B. Meadows, B. Pushpawela, Y. Shi, M. Sokoloff, G. Lopez Castro, V. Ciaschini, P. Franchini, F. Giacomini, A. Paolini, G. A. Calderon Polania, S. Laczek, P. Romanowicz, B. Szybinski, M. Czuchry, L. Flis, D. Harezlak, J. Kocot, M. Radecki, M. Sterzel, T. Szepieniec, T. Szymocha, P. Wójcik, M. Andreotti, W. Baldini, R. Calabrese, V. Carassiti, G. Cibinetto, A. Cotta Ramusino, F. Evangelisti, A. Gianoli, E. Luppi, R. Malaguti, M. Manzali, M. Melchiorri, M. Munerato, C. Padoan, V. Santoro, L. Tomassetti, M. M. Beretta, M. Biagini, M. Boscolo, E. Capitolo, R. de Sangro, M. Esposito, G. Felici, G. Finocchiaro, M. Gatta, C. Gatti, S. Guiducci, S. Lauciani, P. Patteri, I. Peruzzi, M. Piccolo, P. Raimondi, M. Rama, C. Sanelli, S. Tomassini, P. Fabbricatore, D. Delepine, M. A. Reyes Santos, M. Chrzaszcz, R. Grzymkowski, P. Knap, J. Kotula, T. Lesiak, J. Ludwin, J. Michalowski, B. Pawlik, B. Rachwal, M. Stodulski, J. Wiechczynski, M. Witek, L. Zawiejski, M. Zdybal, V. Y. Aushev, A. Ustynov, N. Arnaud, P. Bambade, C. Beigbeder, F. Bogard, M. Borsato, D. Breton, J. Brossard, L. Burmistrov, D. Charlet, V. Chaumat, O. Dadoun, M. El Berni, J. Maalmi, V. Puill, C. Rimbault, A. Stocchi, V. Tocut, A. Variola, S. Wallon, G. Wormser, F. Grancagnolo, E. Ben Haim, S. Sitt, M. Baylac, O. Bourrion, J. M. Deconto, Y. Gomez Martinez, N. Monseu, J. F. Muraz, J. S. Real, C. Vescovi, R. Cenci, A. Jawahery, D. Roberts, E. W. Twedt, R. Cheaib, D. Lindemann, S. Nderitu, P. Patel, S. H. Robertson, D. Swersky, A. Warburton, E. Cuautle Flores, G. Toledo Sanchez, P. Biassoni, L. Bombelli, M. Citterio, S. Coelli, C. Fiorini, V. Liberali, M. Monti, B. Nasri, N. Neri, F. Palombo, F. Sabatini, A. Stabile, A. Berra, A. Giachero, C. Gotti, D. Lietti, M. Maino, G. Pessina, M. Prest, J. P. Martin, M. Simard, N. Starinski, P. Taras, A. Drutskoy, S. Makarychev, A. V. Nefediev, A. Aloisio, G. De Nard, DELLA PIETRA, MASSIMO, A. Doria, GIORDANO, RAFFAELE, A. Ordine, S. Pardi, RUSSO, GUIDO, C. Sciacca, I. I. Bigi, C. P. Jessop, W. Wang, M. Bellato, M. Benettoni, M. Corvo, A. Crescente, F. Dal Corso, U. Dosselli, C. Fanin, A. Gianelle, S. Longo, M. Michelotto, F. Montecassiano, M. Morandin, R. Pengo, M. Posocco, M. Rotondo, G. Simi, R. Stroili, L. Gaioni, A. Manazza, M. Manghisoni, L. Ratti, V. Re, G. Traversi, S. Zucca, S. Bizzaglia, M. Bizzarri, C. Cecchi, S. Germani, M. Lebeau, P. Lubrano, E. Manoni, A. Papi, A. Rossi, G. Scolieri, G. Batignani, S. Bettarini, G. Casarosa, A. Cervelli, A. Fella, F. Forti, M. Giorgi, L. Lilli, A. Lusiani, B. Oberhof, A. Paladino, F. Pantaleo, E. Paoloni, A. L. Perez Perez, G. Rizzo, J. Walsh, A. Fernández Téllez, G. Beck, M. Berman, A. Bevan, F. Gannaway, G. Inguglia, A. J. Martin, J. Morris, V. Bocci, M. Capodiferro, G. Chiodi, I. Dafinei, N. V. Drenska, R. Faccini, F. Ferroni, C. Gargiulo, P. Gauzzi, C. Luci, R. Lunadei, G. Martellotti, F. Pellegrino, V. Pettinacci, D. Pinci, L. Recchia, D. Ruggeri, A. Zullo, P. Camarri, R. Cardarelli, C. De Santis, A. Di Ciaccio, V. Di Felice, F. Di Palma, A. Di Simone, L. Marcelli, R. Messi, D. Moricciani, R. Sparvoli, S. Tammaro, P. Branchini, A. Budano, S. Bussino, M. Ciuchini, F. Nguyen, A. Passeri, F. Ruggieri, E. Spiriti, F. Wilson, I. Leon Monzon, J. R. Millan Almaraz, P. L. M. Podesta Lerma, D. Aston, B. Dey, A. Fisher, P. D. Jackson, D. W. G. S. Leith, S. Luitz, D. MacFarlane, M. McCulloch, S. Metcalfe, A. Novokhatski, S. Osier, R. Prepost, B. Ratcliff, J. Seeman, M. Sullivan, J. Va'vra, U. Wienands, W. Wisniewski, B. D. Altschul, M. V. Purohit, J. Baudot, I. Ripp Baudot, G. A. P. Cirrone, G. Cuttone, O. Bezshyyko, G. Dolinska, A. Soffer, F. Bianchi, F. De Mori, A. Filippi, D. Gamba, S. Marcello, M. Bomben, L. Bosisio, P. Cristaudo, L. Lanceri, B. Liberti, I. Rashevskaya, C. Stella, E. S. Vallazza, L. Vitale, G. Auriemma, C. Satriano, F. Martinez Vidal, J. Mazorra de Cos, A. Oyanguren, P. Ruiz Valls, A. Beaulieu, S. Dejong, J. Franta, M. J. Lewczuk, M. Roney, R. Sobie, CAVALIERE, SERGIO, M. Baszczyk , P. Dorosz, J. Kolodziej, W. Kucewicz, M. Sapor, A. Jeremie, E. Grauges Pous, G.E. Bruno, G. De Robertis, D. Diacono, G. Donvito, P. Fusco, F. Gargano, F. Giordano, F. Loddo, F. Loparco, G.P. Maggi, V. Manzari, M.N. Mazziotta, E. Nappi, A. Palano, B. Santeramo, I. Sgura, L. Silvestris, V. Spinoso, G. Eigen, J. Zalieckas, Z. Zhu, L. Jenkovszky, G. Balbi, M. Boldini, D. Bonacorsi, V. Cafaro, I. D'Antone, G.M. Dallavalle , R. Di Sipio, F. Fabbri, L. Fabbri, A. Gabrielli, D. Galli , P. Giacomelli, V. Giordano, F.M. Giorgi, C. Grandi, I. Lax , S. Lo Meo , U. Marconi, A. Montanari, G. Pellegrini , M. Piccinini, T. Rovelli, N. Semprini Cesari , G. Torromeo , N. Tosi , R. Travaglini, V.M. Vagnoni , S. Valentinetti, M. Villa, A. Zoccoli , J. -F. Caron , C. Hearty, P. F. -T. Lu, T.S. Mattison, J.A. McKenna, R. Y. -C. So , M. Yu. Barnyakov, V.E. Blinov, A.A. Botov, V.P. Druzhinin, V.B. Golubev, S.A. Kononov, E.A. Kravchenko, E.B. Levichev, A.P. Onuchin, S.I. Serednyakov, D.A. Shtol, M., Baszczyk, P., Dorosz, J., Kolodziej, W., Kucewicz, M., Sapor, A., Jeremie, E., Grauges Pou, G. E., Bruno, G., De Roberti, D., Diacono, G., Donvito, P., Fusco, F., Gargano, F., Giordano, F., Loddo, F., Loparco, G. P., Maggi, V., Manzari, M. N., Mazziotta, E., Nappi, A., Palano, B., Santeramo, I., Sgura, L., Silvestri, V., Spinoso, G., Eigen, J., Zaliecka, Z., Zhu, L., Jenkovszky, G., Balbi, M., Boldini, D., Bonacorsi, V., Cafaro, I., D'Antone, G. M., Dallavalle, R., Di Sipio, F., Fabbri, L., Fabbri, A., Gabrielli, D., Galli, P., Giacomelli, V., Giordano, F. M., Giorgi, C., Grandi, I., Lax, S., Lo Meo, U., Marconi, A., Montanari, G., Pellegrini, M., Piccinini, T., Rovelli, N., Semprini Cesari, G., Torromeo, N., Tosi, R., Travaglini, V. M., Vagnoni, S., Valentinetti, M., Villa, A., Zoccoli, J. F., Caron, C., Hearty, P. F. T., Lu, T. S., Mattison, J. A., Mckenna, R. Y. C., So, Barnyakov, M. Y. u., V. E., Blinov, A. A., Botov, V. P., Druzhinin, V. B., Golubev, S. A., Kononov, E. A., Kravchenko, E. B., Levichev, A. P., Onuchin, S. I., Serednyakov, D. A., Shtol, Y. I., Skovpen, E. P., Solodov, A., Cardini, M., Carpinelli, D. S. T., Chao, C. H., Cheng, D. A., Doll, B., Echenard, K., Flood, J., Hanson, D. G., Hitlin, P., Ongmongkolkul, F. C., Porter, R. Y., Zhu, N., Randazzo, E., De La Cruz Burelo, Y., Zheng, P., Campo, M., De Silva, A., Kathirgamaraju, B., Meadow, B., Pushpawela, Y., Shi, M., Sokoloff, G., Lopez Castro, V., Ciaschini, P., Franchini, F., Giacomini, A., Paolini, G. A., Calderon Polania, S., Laczek, P., Romanowicz, B., Szybinski, M., Czuchry, L., Fli, D., Harezlak, J., Kocot, M., Radecki, M., Sterzel, T., Szepieniec, T., Szymocha, P., Wójcik, M., Andreotti, W., Baldini, R., Calabrese, V., Carassiti, G., Cibinetto, A., Cotta Ramusino, F., Evangelisti, A., Gianoli, E., Luppi, R., Malaguti, M., Manzali, M., Melchiorri, M., Munerato, C., Padoan, V., Santoro, L., Tomassetti, M. M., Beretta, M., Biagini, M., Boscolo, E., Capitolo, R., de Sangro, M., Esposito, G., Felici, G., Finocchiaro, M., Gatta, C., Gatti, S., Guiducci, S., Lauciani, P., Patteri, I., Peruzzi, M., Piccolo, P., Raimondi, M., Rama, C., Sanelli, S., Tomassini, P., Fabbricatore, D., Delepine, M. A., Reyes Santo, M., Chrzaszcz, R., Grzymkowski, P., Knap, J., Kotula, T., Lesiak, J., Ludwin, J., Michalowski, B., Pawlik, B., Rachwal, M., Stodulski, J., Wiechczynski, M., Witek, L., Zawiejski, M., Zdybal, V. Y., Aushev, A., Ustynov, N., Arnaud, P., Bambade, C., Beigbeder, F., Bogard, M., Borsato, D., Breton, J., Brossard, L., Burmistrov, D., Charlet, V., Chaumat, O., Dadoun, M., El Berni, J., Maalmi, V., Puill, C., Rimbault, A., Stocchi, V., Tocut, A., Variola, S., Wallon, G., Wormser, F., Grancagnolo, E., Ben Haim, S., Sitt, M., Baylac, O., Bourrion, J. M., Deconto, Y., Gomez Martinez, N., Monseu, J. F., Muraz, J. S., Real, C., Vescovi, R., Cenci, A., Jawahery, D., Robert, E. W., Twedt, R., Cheaib, D., Lindemann, S., Nderitu, P., Patel, S. H., Robertson, D., Swersky, A., Warburton, E., Cuautle Flore, G., Toledo Sanchez, P., Biassoni, L., Bombelli, M., Citterio, S., Coelli, C., Fiorini, V., Liberali, M., Monti, B., Nasri, N., Neri, F., Palombo, F., Sabatini, A., Stabile, A., Berra, A., Giachero, C., Gotti, D., Lietti, M., Maino, G., Pessina, M., Prest, J. P., Martin, M., Simard, N., Starinski, P., Tara, A., Drutskoy, S., Makarychev, A. V., Nefediev, A., Aloisio, Cavaliere, Sergio, G., De Nard, DELLA PIETRA, Massimo, A., Doria, Giordano, Raffaele, A., Ordine, S., Pardi, Russo, Guido, C., Sciacca, I. I., Bigi, C. P., Jessop, W., Wang, M., Bellato, M., Benettoni, M., Corvo, A., Crescente, F., Dal Corso, U., Dosselli, C., Fanin, A., Gianelle, S., Longo, M., Michelotto, F., Montecassiano, M., Morandin, R., Pengo, M., Posocco, M., Rotondo, G., Simi, R., Stroili, L., Gaioni, A., Manazza, M., Manghisoni, L., Ratti, V., Re, G., Traversi, S., Zucca, S., Bizzaglia, M., Bizzarri, C., Cecchi, S., Germani, M., Lebeau, P., Lubrano, E., Manoni, A., Papi, A., Rossi, G., Scolieri, G., Batignani, S., Bettarini, G., Casarosa, A., Cervelli, A., Fella, F., Forti, M., Giorgi, L., Lilli, A., Lusiani, B., Oberhof, A., Paladino, F., Pantaleo, E., Paoloni, A. L., Perez Perez, G., Rizzo, J., Walsh, A., Fernández Téllez, G., Beck, M., Berman, A., Bevan, F., Gannaway, G., Inguglia, A. J., Martin, J., Morri, V., Bocci, M., Capodiferro, G., Chiodi, I., Dafinei, N. V., Drenska, R., Faccini, F., Ferroni, C., Gargiulo, P., Gauzzi, C., Luci, R., Lunadei, G., Martellotti, F., Pellegrino, V., Pettinacci, D., Pinci, L., Recchia, D., Ruggeri, A., Zullo, P., Camarri, R., Cardarelli, C., De Santi, A., Di Ciaccio, V., Di Felice, F., Di Palma, A., Di Simone, L., Marcelli, R., Messi, D., Moricciani, R., Sparvoli, S., Tammaro, P., Branchini, A., Budano, S., Bussino, M., Ciuchini, F., Nguyen, A., Passeri, F., Ruggieri, E., Spiriti, F., Wilson, I., Leon Monzon, J. R., Millan Almaraz, P. L. M., Podesta Lerma, D., Aston, B., Dey, A., Fisher, P. D., Jackson, D. W. G. S., Leith, S., Luitz, D., Macfarlane, M., Mcculloch, S., Metcalfe, A., Novokhatski, S., Osier, R., Prepost, B., Ratcliff, J., Seeman, M., Sullivan, J., Va'Vra, U., Wienand, W., Wisniewski, B. D., Altschul, M. V., Purohit, J., Baudot, I., Ripp Baudot, G. A. P., Cirrone, G., Cuttone, O., Bezshyyko, G., Dolinska, A., Soffer, F., Bianchi, F., De Mori, A., Filippi, D., Gamba, S., Marcello, M., Bomben, L., Bosisio, P., Cristaudo, L., Lanceri, B., Liberti, I., Rashevskaya, C., Stella, E. S., Vallazza, L., Vitale, G., Auriemma, C., Satriano, F., Martinez Vidal, J., Mazorra de Co, A., Oyanguren, P., Ruiz Vall, A., Beaulieu, S., Dejong, J., Franta, M. J., Lewczuk, M., Roney, R., Sobie, Universitat Autònoma de Barcelona (UAB), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratori Nazionali di Frascati (LNF), Istituto Nazionale di Fisica Nucleare (INFN), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), SLAC National Accelerator Laboratory (SLAC), Stanford University, SuperB, and Starita, Sabine
Subjects: [PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], [PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]
Abstract: 95 pages, 48 pdf figures; This report describes the present status of the detector design for SuperB. It is one of four separate progress reports that, taken collectively, describe progress made on the SuperB Project since the publication of the SuperB Conceptual Design Report in 2007 and the Proceedings of SuperB Workshop VI in Valencia in 2008. The other three reports relate to Physics, Accelerator and Computing.
Published: 2010

5. The high rate data acquisition system for the SLIM5 beam test

Author: L. Fabbri, M. Bruschi, R. Di Sipio, B. Giacobbe, A. Gabrielli, F. Giorgi, G. Pellegrini, C. Sbarra, N. Semprini, R. Spighi, S. Valentinetti, M. Villa, A. Zoccoli, C. Avanzini, G. Batignani, S. Bettarini, F. Bosi, G. Calderini, M. Ceccanti, R. Cenci, A. Cervelli, F. Crescioli, M. Dell’Orso, F. Forti, P. Giannetti, M.A. Giorgi, A. Lusiani, S. Gregucci, P. Mammini, G. Marchiori, M. Massa, F. Morsani, N. Neri, E. Paoloni, M. Piendibene, A. Profeti, G. Rizzo, L. Sartori, J. Walsh, E. Yurtsev, M. Manghisoni, V. Re, G. Traversi, C. Andreoli, L. Gaioni, E. Pozzati, L. Ratti, V. Speziali, D. Gamba, G. Giraudo, P. Mereu, G.F. Dalla Betta, G. Soncini, G. Fontana, M. Bomben, L. Bosisio, P. Cristaudo, G. Giacomini, D. Jugovaz, L. Lanceri, I. Rashevskaya, L. Vitale, G. Venier, Bomben, Marco, Bosisio, Luciano, Giacomini, Gabriele, Lanceri, Livio, I., Rachevskaia, Vitale, Lorenzo, SLIM5 Collaboration, et a. l., Fabbri, L, Bruschi, M, Di Sipio, R, Giacobbe, B, Gabrielli, A, Giorgi, F, Pellegrini, G, Sbarra, C, Semprini, N, Spighi, R, Valentinetti, S, Villa, M, Zoccoli, A, Avanzini, C, Batignani, G, Bettarini, S, Bosi, F, Calderini, G, Ceccanti, M, Cenci, R, Cervelli, A, Crescioli, F, Dell'Orso, M, Forti, F, Giannetti, P, Giorgi, Ma, Lusiani, Alberto, Gregucci, S, Mammini, P, Marchiori, G, Massa, M, Morsani, F, Neri, N, Paoloni, E, Piendibene, M, Profeti, A, Rizzo, G, Sartori, L, Walsh, J, Yurtsev, E, Manghisoni, M, Re, V, Traversi, G, Andreoli, C, Gaioni, L, Pozzati, E, Ratti, L, Speziali, V, Gamba, D, Giraudo, G, Mereu, P, Dalla Betta, Gf, Soncini, G, Fontana, G, Bomben, M, Bosisio, L, Cristaudo, P, Giacomini, G, Jugovaz, D, Lanceri, L, Rashevskaya, I, Vitale, L, Venier, G., L. Fabbri, M. Bruschi, R. Di Sipio, B. Giacobbe, A. Gabrielli, F. Giorgi, G. Pellegrini, C. Sbarra, N. Semprini, R. Spighi, S. Valentinetti, M. Villa, A. Zoccoli, C. Avanzini, G. Batignani, S. Bettarini, F. Bosi, G. Calderini, M. Ceccanti, R. Cenci, A. Cervelli, F. Crescioli, M. Dell’Orso, F. Forti, P. Giannetti, M.A. Giorgi, A. Lusiani, S. Gregucci, P. Mammini, G. Marchiori, M. Massa, F. Morsani, N. Neri, E. Paoloni, M. Piendibene, A. Profeti, G. Rizzo, L. Sartori, J. Walsh, E. Yurtsev, M. Manghisoni, V. Re, G. Traversi, C. Andreoli, L. Gaioni, E. Pozzati, L. Ratti, V. Speziali, D. Gamba, G. Giraudo, P. Mereu, G.F. Dalla Betta, G. Soncini, G. Fontana, M. Bomben, L. Bosisio, P. Cristaudo, G. Giacomini, D. Jugovaz, L. Lanceri, I. Rashevskaya, and L. Vitale and G. Venier
Subjects: Physics, Nuclear and High Energy Physics, Large Hadron Collider, Tracking detector, Physics::Instrumentation and Detectors, business.industry, Tracking detectors, Front-end electronics, CMOS technology, DAQ systems, Detector, STRIPS, Settore ING-INF/01 - Elettronica, Microstrip, law.invention, Telescope, Optics, Data acquisition, CMOS, law, business, Instrumentation, Beam (structure), Front-end electronic
Abstract: In September 2008 the Slim5 collaboration submitted a low material budget silicon demonstrator to test with protons at the PS beam at CERN. The beam test setup was composed of a four double sided microstrip reference telescope and different detectors (DUTs) placed inside: a 4k-Pixel Matrix of Deep N Well MAPS, developed in a 130 nm CMOS Technology and a high resistivity double sided silicon detector, with short strips at 45 degrees angle to the detectors edge, read out by the FSSR2 chip. All the systems were self-triggered and read out by a fast DAQ system. In the poster the beam test setup as the data acquisition and the trigger system are explained and the data acquisition performances are shown. (C) 2009 Elsevier B.V. All rights reserved. RI Forti, Francesco/H-3035-2011; Neri, Nicola/G-3991-2012; Fabbri, Laura/H-3442-2012; Gabrielli, Alessandro/H-4931-2012; Villa, Mauro/C-9883-2009; Dalla Betta, Gian-Franco/I-1783-2012; Ratti, Lodovico/I-8836-2012; Giorgi, Filippo Maria/I-7602-2012
Published: 2010

6. Proposal of a sparsification circuit for mixed-mode MAPS detectors

Author: GABRIELLI, ALESSANDRO, SEMPRINI CESARI, NICOLA, SPIGHI, ROBERTO, VILLA, MAURO, ZOCCOLI, ANTONIO, G. Batignani, S. Bettarini, F. Bosi, G. Calderini, R. Cenci, M. Dell’Orso, F. Forti, P. Giannetti, M. A. Giorgi, A. Lusiani, G. Marchiori, F. Morsani, N. Neri, E. Paoloni, G. Rizzo, J. Walsh, C. Andreoli, E. Pozzati, L. Ratti, V. Speziali, M. Manghisoni, V. Re, G. Traversi, L. Bosisio, G. Giacomini, L. Lanceri, I. Rachevskaia, L. Vitale, G. F. Dalla Betta, G. Soncini, G. Fontana, L. Pancheri, G. Verzellesi, D. Gamba, G. Giraudo, P. Mereu, M. Bruschi, B. Giacobbe, A. Gabrielli, G. Batignani, S. Bettarini, F. Bosi, G. Calderini, R. Cenci, M. Dell’Orso, F. Forti, P. Giannetti, M.A. Giorgi, A.Lusiani, G. Marchiori, F. Morsani, N. Neri, E. Paoloni, G. Rizzo, J. Walsh, C. Andreoli, E. Pozzati, L. Ratti, V. Speziali, M. Manghisoni, V. Re, G. Traversi, L. Bosisio, G. Giacomini, L. Lanceri, I. Rachevskaia, L. Vitale, G.F. Dalla Betta, G. Soncini, G. Fontana, L. Pancheri, G. Verzellesi, D. Gamba, G. Giraudo, P. Mereu, M. Bruschi, B. Giacobbe, N. Semprini, R. Spighi, M. Villa, and A. Zoccoli
Subjects: Physics, Nuclear and High Energy Physics, CMOS sensor, Pixel, business.industry, Physics::Instrumentation and Detectors, Sparsification, Detector, Chip, READOUT, HEP, MAPS, Settore ING-INF/01 - Elettronica, Matrix (mathematics), CMOS, VHDL, business, Instrumentation, computer, Computer hardware, Block (data storage), computer.programming_language
Abstract: This paper shows the design of a new mixed-mode chip built up of a bidimensional matrix of Monolithic Active Pixel Sensor (MAPS), and of an off-pixel digital readout sparsiﬁcation circuit. The mixed-mode approach extends the performance of the chip as both the matrix and the readout logic have been developed separately. In particular, the matrix of MAPS has been described with a VHDL model and used as a macro-cell block within a bigger digital design that includes the readout logic. The global placeand-route has been also digitally carried out. The design was submitted via the STM 0.13 mmCMOS technology and readout logic is based on standard cells by implementing an optimized token-like technique. The proposed fast readout architecture should extend the ﬂexibility of the MAPS devices to be also used in ﬁrst level triggers on tracks in vertex detectors. The design, which has been developed within the SLIM5 Collaboration, is aimed at overcoming the readout speed limit of future large-matrix pixel detectors for particle tracking, by matching the requirements of future high-energy physics experiments.
Published: 2008

7. The Associative Memory for the Self-Triggered SLIM5 Silicon Telescope

Author: G. Batignani, S. Bettarini, G. Calderini, R. Cenci, A. Cervelli, F. Crescioli, M. Dell’Orso, F. Forti, P. Giannetti, M. A. Giorgi, A. Lusiani, S. Gregucci, G. Marchiori, F. Morsani, N. Neri, E. Paoloni, M. Piendibene, G. Rizzo, L. Sartori, J. Walsh, E. Yurstev, C. Andreoli, L. Caioni, E. Pozzati, L. Ratti, V. Speziali, M. Manghisoni, V. Re, G. Traversi, M. Bomben, L. Bosisio, P. Cristaudo, G. Giacomini, L. Lanceri, I. Rachevskaia, L. Vitale, G. F. Dalla Betta, G. Soncini, G. Fontana, L. Pancheri, G. Verzellesi, D. Gamba, G. Giraudo, P. Mereu, M. Bruschi, B. Giacobbe, F. Giorgi, G. Pellegrini, DI SIPIO, RICCARDO, GABRIELLI, ALESSANDRO, SBARRA, CARLA, SEMPRINI CESARI, NICOLA, SPIGHI, ROBERTO, VALENTINETTI, SARA, VILLA, MAURO, ZOCCOLI, ANTONIO, PAUL SELLIN, G. Batignani, S. Bettarini, G. Calderini, R. Cenci, A. Cervelli, F. Crescioli, M. Dell’Orso, F. Forti, P. Giannetti, M. A. Giorgi, A. Lusiani, S. Gregucci, G. Marchiori, F. Morsani, N. Neri, E. Paoloni, M. Piendibene, G. Rizzo, L. Sartori, J. Walsh, E. Yurstev, C. Andreoli, L. Caioni, E. Pozzati, L. Ratti, V. Speziali, M. Manghisoni, V. Re, G. Traversi, M. Bomben, L. Bosisio, P. Cristaudo, G. Giacomini, L. Lanceri, I. Rachevskaia, L. Vitale, G. F. Dalla Betta, G. Soncini, G. Fontana, L. Pancheri, G. Verzellesi, D. Gamba, G. Giraudo, P. Mereu, M. Bruschi, R. Di Sipio, B. Giacobbe, A. Gabrielli, F. Giorgi, G. Pellegrini, C. Sbarra, N. Semprini, R. Spighi, S. Valentinetti, M. Villa, and A. Zoccoli
Subjects: BEAM TEST, ASSOCIATIVE MEMORY, PIXELS
Abstract: Modern experiments search for extremely rare processes hidden in much larger background levels. As the experiment complexity, the accelerator backgrounds and luminosity increase we need increasingly exclusive selections to efficiently select the rare events inside the huge background. We present a fast, high-quality, trackbased event selection for the self-triggered SLIM5 silicon telescope. This is an R&D experiment whose innovative trigger will show that high rejection factors and manageable trigger rates can be achieved using finegranularity, low-material tracking detectors. This strategy requires massive computing power to minimize the online execution time of complex tracking algorithms. Affordable latency and rates are provided by a dedicated device, the Associative Memory (AM). The time consuming pattern recognition problem, generally referred to as the “combinatorial challenge”, is beat by the AM exploiting parallelism to the maximum level: it compares the event to precalculated “expectations” (pattern matching) at once. This approach reduces to linear the typical exponential complexity of the CPUbased algorithms. The problem is solved by the time data are loaded into the AM devices. We describe the AM-based trigger and its successful use in the SLIM5 test beam where a silicon detector telescope has been recently tested on the CERN SPS beam.
Published: 2008

8. SuperB: A High-Luminosity Asymmetric e+ e- Super Flavor Factory. Conceptual Design Report

Author: M. BONA, J. GARRA TIC´O, E. GRAUG´ES POUS, P. COLANGELO, F. DE FAZIO, A. PALANO, M. MANGHISONI, V. RE, G. TRAVERSI, M. BRUSCHI, B. GIACOBBE, R. SPIGHI, A. Y. BARNIAKOV, M. Y. BARNIAKOV, V. E. BLINOV, V. P. DRUZHININ, V. B. GOLUBEV, S. A. KONONOV, I. A. KOOP, E. A. KRAVCHENKO, E. B. LEVICHEV, S. A. NIKITIN, A. P. ONUCHIN, P. A. PIMINOV, S. I. SEREDNYAKOV, D. N. SHATILOV, Y. M. SHATUNOV, Y. I. SKOVPEN, E. P. SOLODOV, C. H. CHENG, B. ECHENARD, F. FANG, D. G. HITLIN, F. C. PORTER, R. FLEISCHER, G. F. GIUDICE, T. HURTH, M. MANGANO, G. MANCINELLI, B. T. MEADOWS, A. J. SCHWARTZ, M. D. SOKOLOFF, T. HAAS, R. MANKEL, P. BALL, M. PAPPAGALLO, M. R. PENNINGTON, W. GRADL, S. PLAYFER, A. ABADA, D. BECIREVIC, S. DESCOTES GENON, O. P`ENE, D. ANDREOTTI, M. ANDREOTTI, D. BETTONI, C. BOZZI, R. CALABRESE, A. CECCHI, G. CIBINETTO, P. FRANCHINI, E. LUPPI, M. NEGRINI, A. PETRELLA, L. PIEMONTESE, E. PRENCIPE, V. SANTORO, G. STANCARI, F. ANULLI, R. BALDINI FERROLI, M. E. BIAGINI, M. BOSCOLO, A. CALCATERRA, A. DRAGO, G. FINOCCHIARO, S. GUIDUCCI, G. ISIDORI, S. PACETTI, P. PATTERI, I. M. PERUZZI, M. PICCOLO, M. A. PREGER, P. RAIMONDI, M. RAMA, C. VACCAREZZA, A. ZALLO, M. ZOBOV, R. DE SANGRO, A. BUZZO, M. LO VETERE, M. MACR´, 305, M. R. MONGE, S. PASSAGGIO, C. PATRIGNANI, E. ROBUTTI, S. TOSI, A. LAZZARO, F. PALOMBO, G. BUCHALLA, G. D’AMBROSIO, G. RICCIARDI, I. BIGI, C. P. JESSOP, J. M. LOSECCO, N. ARNAUD, R. CHEHAB, Y. FEDALA, F. POLCI, P. ROUDEAU, V. SORDINI, V. SOSKOV, A. STOCCHI, A. VARIOLA, A. VIVOLI, G. WORMSER, F. ZOMER, A. BERTOLIN, R. BRUGNERA, N. GAGLIARDI, A. GAZ, M. MARGONI, M. MORANDIN, M. POSOCCO, M. ROTONDO, F. SIMONETTO, R. STROILI, G. CALDERINI, L. RATTI, V. SPEZIALI, M. BIASINI, R. COVARELLI, E. MANONI, L. SERVOLI, C. ANGELINI, G. BATIGNANI, S. BETTARINI, F. BOSI, M. CARPINELLI, R. CENCI, A. CERVELLI, M. DELL’ORSO, F. FORTI, P. GIANNETTI, M. GIORGI, A. LUSIANI, G. MARCHIORI, M. MASSA, M. A. MAZUR, F. MORSANI, N. NERI, E. PAOLONI, F. RAFFAELLI, G. RIZZO, J. WALSH, E. BARACCHINI, F. BELLINI, G. CAVOTO, A. D’ORAZIO, D. DEL RE, E. DI MARCO, R. FACCINI, F. FERRAROTTO, M. GASPERO, P. JACKSON, G. MARTINELLI, M. A. MAZZONI, S. MORGANTI, G. PIREDDA, F. RENGA, L. SILVESTRINI, C. VOENA, L. CATANI, A. DI CIACCIO, R. MESSI, E. SANTOVETTI, A. SATTA, M. CIUCHINI, V. LUBICZ, X. CHEN, H. LIU, W. PARK, M. PUROHIT, A. TRIVEDI, R. M. WHITE, J. R. WILSON, M. T. ALLEN, D. ASTON, R. BARTOLDUS, S. J. BRODSKY, Y. CAI, J. COLEMAN, M. R. CONVERY, S. DEBARGER, J. C. DINGFELDER, G. P. DUBOIS FELSMANN, S. ECKLUND, A. S. FISHER, G. HALLER, S. A. HEIFETS, J. KAMINSKI, M. H. KELSEY, M. L. KOCIAN, D. W. G. S. LEITH, N. LI, S. LUITZ, V. LUTH, D. MACFARLANE, R. MESSNER, D. R. MULLER, Y. NOSOCHKOV, A. NOVOKHATSKI, M. PIVI, B. N. RATCLIFF, A. ROODMAN, J. SCHWIENING, J. SEEMAN, A. SNYDER, M. SULLIVAN, J. VA’VRA, U. WIENANDS, W. WISNIEWSKI, F. BIANCHI, D. GAMBA, P. GAMBINO, F. MARCHETTO, E. MENICHETTI, R. MUSSA, M. PELLICCIONI, G. F. DALLA BETTA, M. BOMBEN, L. BOSISIO, C. CARTARO, L. LANCERI, L. VITALE, V. AZZOLINI, J. BERNABEU, N. LOPEZ MARCH, F. MARTINEZ VIDAL, D. A. MILANES, A. OYANGUREN, P. PARADISI, A. PICH, M. A. SANCHIS LOZANO, R. KOWALEWSKI, J. M. RONEY, J. BACK, T. J. GERSHON, P. F. HARRISON, T. E. LATHAM, G. B. MOHANTY, M. PIERINI, DE CASTRO, STEFANO, FACCIOLI, PIETRO, GABRIELLI, ALESSANDRO, SEMPRINI CESARI, NICOLA, VILLA, MAURO, ZOCCOLI, ANTONIO, M. BONA, J. GARRA TIC´O, E. GRAUG´ES POUS, P. COLANGELO, F. DE FAZIO, A. PALANO, M. MANGHISONI, V. RE, G. TRAVERSI, M. BRUSCHI, S. DE CASTRO, P. FACCIOLI, A. GABRIELLI, B. GIACOBBE, N. SEMPRINI CESARI, R. SPIGHI, M. VILLA, A. ZOCCOLI, A.Y. BARNIAKOV, M.Y. BARNIAKOV, V.E. BLINOV, V.P. DRUZHININ, V.B. GOLUBEV, S.A. KONONOV, I.A. KOOP, E.A. KRAVCHENKO, E.B. LEVICHEV, S.A. NIKITIN, A.P. ONUCHIN, P.A. PIMINOV, S.I. SEREDNYAKOV, D.N. SHATILOV, Y.M. SHATUNOV, Y.I. SKOVPEN, E.P. SOLODOV, C.-H. CHENG, B. ECHENARD, F. FANG, D.G. HITLIN, F.C. PORTER, R. FLEISCHER, G.F. GIUDICE, T. HURTH, M. MANGANO, G. MANCINELLI, B.T. MEADOWS, A.J. SCHWARTZ, M.D. SOKOLOFF, T. HAAS, R. MANKEL, P. BALL, M. PAPPAGALLO, M.R. PENNINGTON, W. GRADL, S. PLAYFER, A. ABADA, D. BECIREVIC, S. DESCOTES-GENON, O. P`ENE, D. ANDREOTTI, M. ANDREOTTI, D. BETTONI, C. BOZZI, R. CALABRESE, A. CECCHI, G. CIBINETTO, P. FRANCHINI, E. LUPPI, M. NEGRINI, A. PETRELLA, L. PIEMONTESE, E. PRENCIPE, V. SANTORO, G. STANCARI, F. ANULLI, R. BALDINI-FERROLI, M.E. BIAGINI, M. BOSCOLO, A. CALCATERRA, A. DRAGO, G. FINOCCHIARO, S. GUIDUCCI, G. ISIDORI, S. PACETTI, P. PATTERI, I.M. PERUZZI, M. PICCOLO, M.A. PREGER, P. RAIMONDI, M. RAMA, C. VACCAREZZA, A. ZALLO, M. ZOBOV, R. DE SANGRO, A. BUZZO, M. LO VETERE, M. MACR´&#305, and M.R. MONGE, S. PASSAGGIO, C. PATRIGNANI, E. ROBUTTI, S. TOSI, A. LAZZARO, F. PALOMBO, G. BUCHALLA, G. D’AMBROSIO, G. RICCIARDI, I. BIGI, C.P. JESSOP, J.M. LOSECCO, N. ARNAUD, R. CHEHAB, Y. FEDALA, F. POLCI, P. ROUDEAU, V. SORDINI, V. SOSKOV, A. STOCCHI, A. VARIOLA, A. VIVOLI, G. WORMSER, F. ZOMER, A. BERTOLIN, R. BRUGNERA, N. GAGLIARDI, A. GAZ, M. MARGONI, M. MORANDIN, M. POSOCCO, M. ROTONDO, F. SIMONETTO, R. STROILI, G. CALDERINI, L. RATTI, V. SPEZIALI, M. BIASINI, R. COVARELLI, E. MANONI, L. SERVOLI, C. ANGELINI, G. BATIGNANI, S. BETTARINI, F. BOSI, M. CARPINELLI, R. CENCI, A. CERVELLI, M. DELL’ORSO, F. FORTI, P. GIANNETTI, M. GIORGI, A. LUSIANI, G. MARCHIORI, M. MASSA, M.A. MAZUR, F. MORSANI, N. NERI, E. PAOLONI, F. RAFFAELLI, G. RIZZO, J. WALSH, E. BARACCHINI, F. BELLINI, G. CAVOTO, A. D’ORAZIO, D. DEL RE, E. DI MARCO, R. FACCINI, F. FERRAROTTO, M. GASPERO, P. JACKSON, G. MARTINELLI, M.A. MAZZONI, S. MORGANTI, G. PIREDDA, F. RENGA, L. SILVESTRINI, C. VOENA, L. CATANI, A. DI CIACCIO, R. MESSI, E. SANTOVETTI, A. SATTA, M. CIUCHINI, V. LUBICZ, X. CHEN, H. LIU, W. PARK, M. PUROHIT, A. TRIVEDI, R.M. WHITE, J.R. WILSON, M.T. ALLEN, D. ASTON, R. BARTOLDUS, S.J. BRODSKY, Y. CAI, J. COLEMAN, M.R. CONVERY, S. DEBARGER, J.C. DINGFELDER, G.P. DUBOIS-FELSMANN, S. ECKLUND, A.S. FISHER, G. HALLER, S.A. HEIFETS, J. KAMINSKI, M.H. KELSEY, M.L. KOCIAN, D.W.G.S. LEITH, N. LI, S. LUITZ, V. LUTH, D. MACFARLANE, R. MESSNER, D.R. MULLER, Y. NOSOCHKOV, A. NOVOKHATSKI, M. PIVI, B.N. RATCLIFF, A. ROODMAN, J. SCHWIENING, J. SEEMAN, A. SNYDER, M. SULLIVAN, J. VA’VRA, U. WIENANDS, W. WISNIEWSKI, F. BIANCHI, D. GAMBA, P. GAMBINO, F. MARCHETTO, E. MENICHETTI, R. MUSSA, M. PELLICCIONI, G.F. DALLA BETTA, M. BOMBEN, L. BOSISIO, C. CARTARO, L. LANCERI, L. VITALE, V. AZZOLINI, J. BERNABEU, N. LOPEZ-MARCH, F. MARTINEZ-VIDAL, D.A. MILANES, A. OYANGUREN, P. PARADISI, A. PICH, M.A. SANCHIS-LOZANO, R. KOWALEWSKI, J.M. RONEY, J. BACK, T.J. GERSHON, P.F. HARRISON, T.E. LATHAM, G.B. MOHANTY, M. PIERINI
Subjects: Physics::Instrumentation and Detectors, Physics::Accelerator Physics, High Energy Physics::Experiment
Abstract: The physics objectives of SuperB, an asymmetric electron-positron collider with a luminosity above 10^36/cm^2/s are described, together with the conceptual design of a novel low emittance design that achieves this performance with wallplug power comparable to that of the current B Factories, and an upgraded detector capable of doing the physics in the SuperB environment.
Published: 2007

9. Design of on-chip data sparsification for a mixed-mode MAPS device

Author: GABRIELLI, ALESSANDRO, SEMPRINI CESARI, NICOLA, SPIGHI, ROBERTO, VILLA, MAURO, ZOCCOLI, ANTONIO, G. Batignani, S. Bettarini, F. Bosi, G. Calderini, R. Cenci, M. Dell'Orso, F. Forti, P. Giannetti, M. A. Giorgi, A. Lusiani, G. Marchiori, F. Morsani, N. Neri, E. Paoloni, G. Rizzo, J. Walsh, C. Andreoli, E. Pozzati, L. Ratti, V. Speziali, M. Manghisoni, V. R, G. Traversi, L. Bosisio, G. Giacobini, L. Lanceri, I. Rachevskai, L. Vitale, G. F. Dalla Betta, G. Soncini, G. Fontana, L. Pancheri, G. Verzellesi, D. Gamba, G. Giraudo, P. Mereu, M. Bruschi, B. Giacobbe, A. Gabrielli, G. Batignani, S. Bettarini, F. Bosi, G. Calderini, R. Cenci, M. Dell'Orso, F. Forti, P. Giannetti, M.A. Giorgi, A.Lusiani, G. Marchiori, F. Morsani, N. Neri, E. Paoloni, G. Rizzo, J. Walsh, C. Andreoli, E. Pozzati, L. Ratti, V. Speziali, M. Manghisoni, V. R, G. Traversi, L. Bosisio, G. Giacobini, L. Lanceri, I. Rachevskai, L. Vitale, G.F. Dalla Betta, G. Soncini, G. Fontana, L. Pancheri, G. Verzellesi, D. Gamba, G. Giraudo, P. Mereu, M. Bruschi, B. Giacobbe, N. Semprini, R. Spighi, M. Villa, and A. Zoccoli
Subjects: Physics::Instrumentation and Detectors, PIXEL, MAPS, SPARSIFICATION
Abstract: The device described in the paper is built up of a bidimensional matrix of Monolithic Active Pixel Sensor (MAPS) and an off-pixel digital readout sparsification circuit. The readout logic is based on std-cells and implements an optimised technique aimed at overcoming the readout speed limit of future large-matrix pixel detectors for particle tracking, by matching the requirements of future HEP experiments. In particular, the readout architecture extends the flexibility of the MAPS devices to be also used in first level triggers in vertex detectors. The work extends a first version of a mixed mode device submitted on Nov. 2006 and implemented with the same technology.
Published: 2007

10. Development of Deep N-Well Monolithic Active Pixel Sensors in a 0.13 µm CMOS Technology

Author: S. BETTARINI, A. BARDI, G. BATIGNANI, F. BOSI, G. CALDERINI, R. CENCI, M. DELLORSO, F. FORTI, P. GIANNETTI, M. A. GIORGI, A. LUSIANI, G. MARCHIORI, F. MORSANI, N. NERI, E. PAOLONI, G. RIZZO, J. WALSH, C. ANDREOLI, E. POZZATI, L. RATTI, V. SPEZIALI, M. MANGHISONI, V. RE, G. TRAVERSI, G. GIACOMINI, I. RACHEVSKAIA, VITALE, LORENZO, M. BRUSCHI, B. GIACOBBE, N. SEMPRINI, R. SPIGHI, M. VILLA, A. ZOCCOLI, D. GAMBA, G. GIRAUDO, P. MEREU, G. F. DALLA BETTA, G. SONCINI, G. FONTANA, L. PANCHERI AND G. VERZELLESI, BOSISIO, LUCIANO, LANCERI, LIVIO, S., Bettarini, A., Bardi, G., Batignani, F., Bosi, G., Calderini, R., Cenci, M., Dellorso, F., Forti, P., Giannetti, M. A., Giorgi, A., Lusiani, G., Marchiori, F., Morsani, N., Neri, E., Paoloni, G., Rizzo, J., Walsh, C., Andreoli, E., Pozzati, L., Ratti, V., Speziali, M., Manghisoni, V., Re, G., Traversi, Bosisio, Luciano, G., Giacomini, Lanceri, Livio, I., Rachevskaia, Vitale, Lorenzo, M., Bruschi, B., Giacobbe, N., Semprini, R., Spighi, M., Villa, A., Zoccoli, D., Gamba, G., Giraudo, P., Mereu, G. F., DALLA BETTA, G., Soncini, G., Fontana, and L. PANCHERI AND G., Verzellesi
Published: 2007

11. Recent developments in 130-nm CMOS monolithic active pixel detectors

Author: G. Batignani, S. Bettarini, F. Bosi, G. Calderini, R. Cenci, M. Dell'Orso, F. Forti, P. Giannetti, M. A. Giorgi, A. Lusiani, G. Marchiori, F. Morsani, N. Neri, E. Paoloni, G. Rizzo, J. Walsh, L. Gaioni, M. Manghisoni, V. Re, G. Traversi, M. Bruschi, B. Giacobbe, R. Spighi, G. Verzellesi, C. Andreoli, E. Pozzati, L. Ratti, V. Speziali, D. Gamba, G. Giraudo, P. Mereu, L. Bosisio, G. Giacomini, L. Lancieri, GABRIELLI, ALESSANDRO, SEMPRINI CESARI, NICOLA, VILLA, MAURO, ZOCCOLI, ANTONIO, G. Batignani, S. Bettarini, F. Bosi, G. Calderini, R. Cenci, M. Dell'Orso, F. Forti, P. Giannetti, M.A. Giorgi, A. Lusiani, G. Marchiori, F. Morsani, N. Neri, E. Paoloni, G. Rizzo, J. Walsh, L. Gaioni, M. Manghisoni, V. Re, G. Traversi, M. Bruschi, A. Gabrielli, B. Giacobbe, N. Semprini-Cesari, R. Spighi, M. Villa, A. Zoccoli, G. Verzellesi, C. Andreoli, E.Pozzati, L. Ratti, V. Speziali, D. Gamba, G. Giraudo, P. Mereu, L. Bosisio, G. Giacomini, and L. Lancieri
Subjects: ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION
Abstract: We developed monolithic active pixel detectors, by exploiting the triple well option available in a deep-submicron CMOS process. The novel features are the full analog signal processing and digital functionality implemented at the pixel level. The charge collecting element is realized using the deep N-well (DNW), the full in-pixel signal processing chain includes charge preamplifier, shaper, discriminator and latch. We report on the characterization of the two prototype chips, the first (APSEL0) containing single-channel sensors, with different collecting electrode area, and the latter (APSEL1) with several single pixel structures with improved noise figure implementing also an 8 × 8 matrix of 50 × 50 μm2 pixel area. So far, the pixel matrix has a simple row by row readout, successfully tested with clock frequency up to 30 MHz. The response of the sensors to infra-red laser, β-rays and soft X-rays (from radioactive sources, 90Sr and 55Fe respectively) will be presented. The results achieved so far demonstrate the viability of the technology and suggest new design improvements implemented in the next prototype chips submission (APSEL2).
Published: 2007

12. A new approach to the design of monolithic active pixel detectors in 0.13 µm triple well CMOS technology

Author: S. BETTARINI, G. BATIGNANI, G. CALDERINI, M. CARPINELLI, R. CENCI, F. FORTI, M. A. GIORGI, A. LUSIANI, G. MARCHIORI, F. MORSANI, N. NERI, E. PAOLONI, M. RAMA, G. RIZZO, G. SIMI, J. WALSA, L. RATTI, V. SPEZIALI, M. MANGHISONI, V. RE, G. TRAVERSI, G. GIACOMINI, LANCERI, LIVIO, I. RACHEVSKAIA, VITALE, LORENZO, BOSISIO, LUCIANO, S., Bettarini, G., Batignani, G., Calderini, M., Carpinelli, R., Cenci, F., Forti, M. A., Giorgi, A., Lusiani, G., Marchiori, F., Morsani, N., Neri, E., Paoloni, M., Rama, G., Rizzo, G., Simi, J., Walsa, L., Ratti, V., Speziali, M., Manghisoni, V., Re, G., Traversi, Bosisio, Luciano, G., Giacomini, Lanceri, Livio, I., Rachevskaia, and Vitale, Lorenzo
Subjects: Monolithic active pixel sensors, MAPS, CMOS pixels, charged particle tracking, Settore ING-INF/01 - Elettronica
Published: 2006

13. Omega-3 fatty acids and schizophrenia: evidences and recommendations

Author: G, Marano, G, Traversi, C, Nannarelli, S, Mazza, and M, Mazza
Subjects: Risk Factors, Dietary Supplements, Fatty Acids, Omega-3, Schizophrenia, Humans, Cognition Disorders
Abstract: Schizophrenia is a brain disease that represents a not rare condition, in fact the lifetime risk of developing schizophrenia is widely accepted to be around 1 in 100. Schizophrenia clinically manifests with acute episodes which are associated with hallucinations, delirium, behavioral disorders and a variable range of chronic persistent symptoms, which can be debilitating. The causes of schizophrenia are not clearly understood. It seems that genetic factors may produce a vulnerability to schizophrenia, along with environmental factors that contribute in a different way from individual to individual. In this context schizophrenia constitutes the outcome of a complex interaction between multiple genes and environmental risk factors, none of which on its own causes the disorder itself. Antipsychotic medications represent the first line of psychiatric treatment for schizophrenia. But there is a growing body of evidence that omega-3 fatty acids can prevent the disease or at least mitigate the course and symptoms. Probably, an appropriate dietary supplementation can play a partially therapeutic effect, even in more severe patients, improving some behavioral aspects and, mainly, reducing the cognitive deterioration. In this context the role of omega-3 fatty acids as a treatment for schizophrenia will strengthen the thrust of researchers and clinicians to the integrated approach to the prevention and cure of a disease that for more than a century challenging researchers.
Published: 2014

14. Noise Performances of 0.13 μm CMOS Technologies for Detector Front-end Applications

Author: M. Manghisoni, L. Ratti, V. Re, V. Speziali, and G. Traversi
Subjects: Front and back ends, Noise, Materials science, CMOS, business.industry, Nuclear electronics, Detector, Electrical engineering, Readout electronics, Mixed-signal integrated circuit, White noise, business
Published: 2006
Full Text: View/download PDF

15. Electrical design considerations for a 40 MHz gas ionization chamber

Author: J. Millaud, P.S. Datte, V. Speziali, L. Ratti, P.F. Manfredi, W.C. Turner, M. Placidi, and G. Traversi
Subjects: Physics, Large Hadron Collider, Physics::Instrumentation and Detectors, business.industry, Analytical chemistry, Particle accelerator, Capacitance, Particle detector, law.invention, Optics, law, Ionization, Ionization chamber, Neutral particle, business, Storage ring
Abstract: The front IR quadrupole absorbers (TAS) and the IR neutral particle absorbers (TAN) in the high luminosity insertions of the Large Hadron Collider (LHC) each absorb approximately 1.8 TeV of forward collision products on average per pp interaction (/spl sim/235 W at design luminosity 10/sup 34/ cm/sup -2/ s/sup -1/). This secondary particle flux can be exploited to provide a useful storage ring operations tool for optimization of luminosity. A novel segmented, multi-gap, pressurized gas ionization chambers is being developed for sampling the energy deposited near the maxima of the hadronic/electromagnetic showers in these absorbers. The ionization chamber must be capable of resolving individual bunch crossings at 40 MHz. The ionization chamber is segmented into quadrants; each quadrant consists of sixty (40/spl times/40) mm/sup 2/ Cu plates 1.0 mm thick, with 0.5 mm gaps. The 0.5 mm gap width has been chosen so that the time for the ionization electrons to drift across the gap, is short enough to produce at the output of the shaping amplifier, a signal that returns to the base line is less than the 25 ns bunch spacing of the LHC. From noise considerations in the presence of a cable the stack of plates are connected electrically 10 in parallel, 6 in series to achieve an equivalent detector capacitance C/sub d//spl sim/50 pF. This type connection forms an electrode inductive L/sub e/ and electrode capacitive C/sub e/ network that must be optimized to transfer charge from the chamber to the sensing amplifier. This paper describes the design of the collection electrodes optimized for 40 MHz operation.
Published: 2001
Full Text: View/download PDF

16. The front-end chip of the SuperB SVT detector

Author: B. Oberhof, P. Mammini, Laura Fabbri, A. Profeti, J. J. Walsh, M. Povoli, F. Giorgi, A. Berra, Irina Rashevskaya, John Morris, Carlo Fiorini, N. Semprini-Cesari, M. Citterio, G. A. Beck, M. Prest, F. Ganaway, Valerio Re, L. Lanceri, M.A. Giorgi, G. Rizzo, M. Ceccanti, F. F. Wilson, Lucio Pancheri, Luca Bombelli, Marco Villa, E. Quartieri, M. Monti, F. Forti, A. Perez, S. Coelli, L. Vitale, Alberto Stabile, G.-F. Dalla Betta, A. Bernardelli, Fabio Morsani, Eugenio Paoloni, Alessandro Gabrielli, B. Nasri, G. Petragnani, Filippo Bosi, Massimo Manghisoni, S. Bettarini, G. Batignani, Daniele Comotti, Valentino Liberali, Adrian John Bevan, G. Casarosa, A. Soldani, G. Pellegrini, Giovanni Verzellesi, C. Stella, G. Fontana, Gianluca Traversi, Nicola Neri, Carla Sbarra, Sara Valentinetti, Luigi Gaioni, Alberto Lusiani, Alessia Manazza, R. Cenci, Lodovico Ratti, F. Palombo, Luciano Bosisio, Antonio Zoccoli, Stefano Zucca, G. Balestri, D. Lietti, F. Giorgi, D. Comotti, M. Manghisoni, V. Re, G. Traversi, L. Fabbri, A. Gabrielli, G. Pellegrini, C. Sbarra, N. Semprini Cesari, S. Valentinetti, M. Villa, A. Zoccoli, A. Berra, D. Lietti, M. Prest, A. Bevan, F. Wilson, G. Beck, J. Morri, F. Ganaway, R. Cenci, L. Bombelli, M. Citterio, S. Coelli, C. Fiorini, V. Liberali, M. Monti, B. Nasri, N. Neri, F. Palombo, A. Stabile, G. Balestri, G. Batignani, A. Bernardelli, S. Bettarini, F. Bosi, G. Casarosa, M. Ceccanti, F. Forti, M.A. Giorgi, A. Lusiani, P. Mammini, F. Morsani, B. Oberhof, E. Paoloni, A. Perez, G. Petragnani, A. Profeti, G. Rizzo, A. Soldani, J. Walsh, L. Gaioni, A. Manazza, E. Quartieri, L. Ratti, S. Zucca, G.-F. Dalla Betta, G. Fontana, L. Pancheri, M. Povoli, G. Verzellesi, L. Bosisio, L. Lanceri, I. Rashevskaya, C. Stella, L. Vitale, F., Giorgi, D., Comotti, M., Manghisoni, V., Re, G., Traversi, L., Fabbri, A., Gabrielli, G., Pellegrini, C., Sbarra, N., Semprini Cesari, S., Valentinetti, M., Villa, A., Zoccoli, A., Berra, D., Lietti, M., Prest, A., Bevan, F., Wilson, G., Beck, J., Morri, F., Ganaway, R., Cenci, L., Bombelli, M., Citterio, S., Coelli, C., Fiorini, V., Liberali, M., Monti, B., Nasri, N., Neri, F., Palombo, A., Stabile, G., Balestri, G., Batignani, A., Bernardelli, S., Bettarini, F., Bosi, G., Casarosa, M., Ceccanti, F., Forti, M. A., Giorgi, A., Lusiani, P., Mammini, F., Morsani, B., Oberhof, E., Paoloni, A., Perez, G., Petragnani, A., Profeti, G., Rizzo, A., Soldani, J., Walsh, L., Gaioni, A., Manazza, E., Quartieri, L., Ratti, S., Zucca, G. F., Dalla Betta, G., Fontana, L., Pancheri, M., Povoli, G., Verzellesi, Bosisio, Luciano, Lanceri, Livio, Rashevskaya, Irina, C., Stella, and Vitale, Lorenzo
Subjects: Nuclear and High Energy Physics, Physics::Instrumentation and Detectors, Tracker, Fast readout, HEP, front end electronics, Microstrip, ASIC, tracker, front end, strip, fast readout, VLSI, Settore ING-INF/01 - Elettronica, Particle detector, Front and back ends, Application-specific integrated circuit, Front end, Strip, Instrumentation, Electronic circuit, Physics, Very-large-scale integration, sezele, business.industry, Detector, Electrical engineering, Chip, Hit rate, business, HEP Tracker Front end Strip Fast readout ASIC VLSI
Abstract: The asymmetric e + e − collider SuperB is designed to deliver a high luminosity, greater than 10 36 cm − 2 s − 1 , with moderate beam currents and a reduced center of mass boost with respect to earlier B-Factories. The innermost detector is the Silicon Vertex Tracker which is made of 5 layers of double sided silicon strip sensors plus a layer 0, that can be equipped with short striplets detectors in a first phase of the experiment. In order to achieve an overall track reconstruction efficiency above 98% it is crucial to optimize both analog and digital readout circuits. The readout architecture being developed for the front-end chips will be able to cope with the very high rates expected in the first layer. The digital readout will be optimized to be fully efficient for hit rates up to 2 MHz/strip, including large margins on the maximum expected background rates, but can potentially accommodate higher rates with a proper tuning of the buffer depth. The readout is based on a triggered architecture where each of the 128 strip channel is provided with a dedicated digital buffer. Each buffer collects the digitized charge information by means of a 4-bit TOT, storing it in conjunction with the related time stamp. The depth of buffers was dimensioned considering the expected trigger latency and hit rate including suitable safety margins. Every buffer is connected to a highly parallelized circuit handling the trigger logic, rejecting expired data in the buffers and channeling the parallel stream of triggered hits to the common output of the chip. The presented architecture has been modeled by HDL language and investigated with a Monte Carlo hit generator emulating the analog front-end behavior. The simulations showed that even applying the highest stressing conditions, about 2 MHz per strip, the efficiency of the digital readout remained above 99.8%.
Published: 2013

17. Beam test results for the SuperB-SVT thin striplet detector

Author: G. A. Beck, R. Cenci, M. Ceccanti, L. Lanceri, S. Zambito, Eugenio Paoloni, A. Perez, S. Coelli, B. Oberhof, Luca Bombelli, Alberto Stabile, C. Stella, Luigi Gaioni, F. F. Wilson, G. Petragnani, Mauro Villa, M. Citterio, Alberto Lusiani, Antonio Zoccoli, M. Prest, A. Bernardelli, G. Batignani, Stefano Zucca, Laura Fabbri, G.-F. Dalla Betta, Adrian John Bevan, G. Balestri, Massimo Manghisoni, S. Bettarini, P. Cristaudo, Gianluca Traversi, B. Liberti, A. Profeti, B. Nasri, Valentino Liberali, G. Casarosa, G. Fontana, D. Lietti, J. J. Walsh, L. Bosisio, M. Povoli, Carla Sbarra, Irina Rashevskaya, Giovanni Verzellesi, F. Giorgi, A. Berra, Filippo Bosi, N. Semprini-Cesari, Daniele Comotti, G. Rizzo, Lodovico Ratti, F. Palombo, Lucio Pancheri, Nicola Neri, E. Quartieri, F. Ganaway, Valerio Re, D. Gamba, John Morris, P. Mammini, G. Pellegrini, M.A. Giorgi, M. Monti, Alessia Manazza, F. Forti, Fabio Morsani, Alessandro Gabrielli, G. Alampi, G. Cotto, A. Soldani, Carlo Fiorini, Sara Valentinetti, M. Bomben, L. Vitale, L. Fabbri, D. Comotti, M. Manghisoni, V. Re, G. Traversi, A. Gabrielli, F. Giorgi, G. Pellegrini, C. Sbarra, N. Semprini-Cesari, S. Valentinetti, M. Villa, A. Zoccoli, A. Berra, D. Lietti, M. Prest, A. Bevan, F. Wilson, G. Beck, J. Morri, F. Ganaway, R. Cenci, L. Bombelli, M. Citterio, S. Coelli, C. Fiorini, V. Liberali, M. Monti, B. Nasri, N. Neri, F. Palombo, A. Stabile, G. Balestri, G. Batignani, A. Bernardelli, S. Bettarini, F. Bosi, G. Casarosa, M. Ceccanti, F. Forti, M.A. Giorgi, A. Lusiani, P. Mammini, F. Morsani, B. Oberhof, E. Paoloni, A. Perez, G. Petragnani, A. Profeti, G. Rizzo, A. Soldani, J. Walsh, L. Gaioni, A. Manazza, E. Quartieri, L. Ratti, S. Zucca, G. Alampi, G. Cotto, D. Gamba, S. Zambito, G.-F. Dalla Betta, G. Fontana, L. Pancheri, M. Povoli, G. Verzellesi, M. Bomben, L. Bosisio, P. Cristaudo, L. Lanceri, B. Liberti, I. Rashevskaya, C. Stella, L. Vitale, L., Fabbri, D., Comotti, M., Manghisoni, V., Re, G., Traversi, A., Gabrielli, F., Giorgi, G., Pellegrini, C., Sbarra, N., Semprini Cesari, S., Valentinetti, M., Villa, A., Zoccoli, A., Berra, D., Lietti, M., Prest, A., Bevan, F., Wilson, G., Beck, J., Morri, F., Ganaway, R., Cenci, L., Bombelli, M., Citterio, S., Coelli, C., Fiorini, V., Liberali, M., Monti, B., Nasri, N., Neri, F., Palombo, A., Stabile, G., Balestri, G., Batignani, A., Bernardelli, S., Bettarini, F., Bosi, G., Casarosa, M., Ceccanti, F., Forti, M. A., Giorgi, A., Lusiani, P., Mammini, F., Morsani, B., Oberhof, E., Paoloni, A., Perez, G., Petragnani, A., Profeti, G., Rizzo, A., Soldani, J., Walsh, L., Gaioni, A., Manazza, E., Quartieri, L., Ratti, S., Zucca, G., Alampi, G., Cotto, D., Gamba, S., Zambito, G. F., Dalla Betta, G., Fontana, L., Pancheri, M., Povoli, G., Verzellesi, Bomben, Marco, Bosisio, Luciano, P., Cristaudo, Lanceri, Livio, B., Liberti, Rashevskaya, Irina, Stella, Carlo, and Vitale, Lorenzo
Subjects: Vertex detectors, strip sensors, striplets, Nuclear and High Energy Physics, Silicon, Physics::Instrumentation and Detectors, Instrumentation, chemistry.chemical_element, Strip sensors, Striplet detector, Striplets, STRIPS, Settore ING-INF/01 - Elettronica, Particle detector, law.invention, Optics, law, Vertex detector, Nuclear Experiment, Vertex detectors Strip sensors Striplets Striplet detector Silicon tracking Charged particle tracking, Physics, Large Hadron Collider, sezele, MICROSTRIP DETECTORS, business.industry, Detector, charged particle tracking, silicon tracking, Semiconductor detector, chemistry, Strip sensor, Physics::Accelerator Physics, striplet detector, High Energy Physics::Experiment, business, Beam (structure)
Abstract: The baseline detector option for the first layer of the SuperB Silicon Vertex Tracker (SVT) is a high resistivity double-sided silicon device with short strips (striplets) at 451 angle to the detector’s edge. A prototype was tested with a 120 GeV/c pion beam in September 2011 at the SPS-H6 test-beam line at CERN. In this paper studies on efficiency, resolution and cluster size are reported.
Published: 2013

18. Recent developments on CMOS MAPS for the SuperB Silicon Vertex Tracker

Author: D. Gamba, Sara Valentinetti, S. Zambito, N. Semprini-Cesari, Giovanni Verzellesi, Valentino Liberali, G. Balestri, M. Bomben, L. Vitale, D. Comott, S. Coelli, M. Chrzaszcz, Carlo Fiorini, G. Petragnani, Antonio Zoccoli, R. Cenci, G. Cotto, B. Liberti, Nicola Neri, Stefano Zucca, P. Mammini, Fabio Morsani, A. Perez, Alessandro Gabrielli, G. A. Beck, Alberto Stabile, B. Oberhof, Luca Bombelli, G. Alampi, Eugenio Paoloni, Filippo Bosi, Luigi Gaioni, D. Lietti, G. Fontana, L. Bosisio, Laura Fabbri, Massimo Manghisoni, S. Bettarini, M.A. Giorgi, L. Lanceri, G. Batignani, G. Casarosa, A. Profeti, M. Monti, Lucio Pancheri, A. Bernardelli, E. Quartieri, F. Forti, G.-F. Dalla Betta, F. F. Wilson, G. Rizzo, J. J. Walsh, Irina Rashevskaya, M. Povoli, M. Citterio, P. Cristaudo, Gianluca Traversi, Adrian John Bevan, M. Prest, B. Nasri, A. Soldani, M. Ceccanti, Mauro Villa, Alberto Lusiani, Alessia Manazza, Valerio Re, C. Stella, F. Giorgi, A. Berra, Lodovico Ratti, F. Palombo, John Morris, Fred Gannaway, G. Pellegrini, Carla Sbarra, G. Rizzo, D. Comott, M. Manghisoni, V. Re, G. Traversi, L. Fabbri, A. Gabrielli, F. Giorgi, G. Pellegrini, C. Sbarra, N. Semprini Cesari, S. Valentinetti, M. Villa, A. Zoccoli, A. Berra, D. Lietti, M. Prest, A. Bevan, F. Wilson, G. Beck, J. Morri, F. Gannaway, R. Cenci, L. Bombelli, M. Citterio, S. Coelli, C. Fiorini, V. Liberali, M. Monti, B. Nasri, N. Neri, F. Palombo, A. Stabile, G. Balestri, G. Batignani, A. Bernardelli, S. Bettarini, F. Bosi, G. Casarosa, M. Ceccanti, F. Forti, M.A. Giorgi, A. Lusiani, P. Mammini, F. Morsani, B. Oberhof, E. Paoloni, A. Perez, G. Petragnani, A. Profeti, A. Soldani, J. Walsh, M. Chrzaszcz, L. Gaioni, A. Manazza, E. Quartieri, L. Ratti, S. Zucca, G. Alampi, G. Cotto, D. Gamba, S. Zambito, G.-F. Dalla Betta, G. Fontana, L. Pancheri, M. Povoli, G. Verzellesi, M. Bomben, L. Bosisio, P. Cristaudo, L. Lanceri, B. Liberti, I. Rashevskaya, C. Stella, L. Vitale, G., Rizzo, D., Comott, M., Manghisoni, V., Re, G., Traversi, L., Fabbri, A., Gabrielli, F., Giorgi, G., Pellegrini, C., Sbarra, N., Semprini Cesari, S., Valentinetti, M., Villa, A., Zoccoli, A., Berra, D., Lietti, M., Prest, A., Bevan, F., Wilson, G., Beck, J., Morri, F., Gannaway, R., Cenci, L., Bombelli, M., Citterio, S., Coelli, C., Fiorini, V., Liberali, M., Monti, B., Nasri, N., Neri, F., Palombo, A., Stabile, G., Balestri, G., Batignani, A., Bernardelli, S., Bettarini, F., Bosi, G., Casarosa, M., Ceccanti, F., Forti, M. A., Giorgi, A., Lusiani, P., Mammini, F., Morsani, B., Oberhof, E., Paoloni, A., Perez, G., Petragnani, A., Profeti, A., Soldani, J., Walsh, M., Chrzaszcz, L., Gaioni, A., Manazza, E., Quartieri, L., Ratti, S., Zucca, G., Alampi, G., Cotto, D., Gamba, S., Zambito, G. F., Dalla Betta, G., Fontana, L., Pancheri, M., Povoli, G., Verzellesi, Bomben, Marco, Bosisio, Luciano, P., Cristaudo, Lanceri, Livio, B., Liberti, Rashevskaya, Irina, C., Stella, and Vitale, Lorenzo
Subjects: Nuclear and High Energy Physics, Vertex (computer graphics), CMOS MAPS pixel sensor, Nanotechnology, Settore ING-INF/01 - Elettronica, CMOS MAPS pixel sensors, law.invention, law, Vertex detector, Microelectronics, solid state detectors, Solid state detectors, vertex detectors, Collider, Instrumentation, Charged particle tracking, Physics, Luminosity (scattering theory), sezele, Pixel, Hybrid pixels, Vertex detectors, business.industry, hybrid pixels, charged particle tracking, Electrical engineering, Process (computing), CMOS MAPS, charge particle tracking, Solid state detectors, Vertex detectors, CMOS MAPS pixel sensors, Hybrid pixels, Charged particle tracking, CMOS, Hit rate, Solid state detector, business
Abstract: In the design of the Silicon Vertex Tracker for the high luminosity SuperB collider, very challenging requirements are set by physics and background conditions on its innermost Layer0: small radius (about 1.5 cm), resolution of View the MathML source10–15μm in both coordinates, low material budget
Published: 2013

19. Latest results of the R&D on CMOS MAPS for the Layer0 of the SuperB SVT

Author: G. Rizzo, P. Mammini, S. Coelli, Valentino Liberali, Laura Fabbri, Carla Sbarra, F. F. Wilson, B. Oberhof, Marco Villa, A. Profeti, Irina Rashevskaya, Eugenio Paoloni, A. Manazza, Luigi Gaioni, Antonio Zoccoli, Massimo Manghisoni, S. Bettarini, G. Batignani, M. Ceccanti, G. Fontana, L. Bosisio, Adrian John Bevan, M. Citterio, Carlo Fiorini, A. Perez, G. Casarosa, Lucio Pancheri, C. Stella, E. Quartieri, Alberto Stabile, J. J. Walsh, A. Soldani, Giovanni Verzellesi, M. Prest, M. Povoli, G. Petragnani, L. Vitale, F. Giorgi, Luca Bombelli, G.-F. Dalla Betta, R. Cenci, Nicola Neri, A. Berra, G. A. Beck, John Morris, Valerio Re, B. Nasri, Sara Valentinetti, L. Lanceri, D. Lietti, A. Bernardelli, N. Semprini-Cesari, Filippo Bosi, Fabio Morsani, Lodovico Ratti, Alessandro Gabrielli, Daniele Comotti, F. Palombo, Fred Gannaway, G. Pellegrini, M.A. Giorgi, S. Zucca, M. Monti, F. Forti, Gianluca Traversi, Alberto Lusiani, G. Balestri, G., Balestri, G., Batignani, G., Beck, A., Bernardelli, A., Berra, S., Bettarini, I. A., Bevan, L., Bombelli, F., Bosi, L., Bosisio, G., Casarosa, M., Ceccanti, R., Cenci, M., Citterio, S., Coelli, D., Comotti, G. . ., F., L., Fabbri, C., Fiorini, G., Fontana, F., Forti, A., Gabrielli, L., Gaioni, F., Gannaway, F., Giorgi, M. A., Giorgi, L., Lanceri, V., Liberali, D., Lietti, Lusiani, Alberto, P., Mammini, A., Manazza, M., Manghisoni, M., Monti, J., Morri, F., Morsani, B., Nasri, N., Neri, B., Oberhof, F., Palombo, L., Pancheri, E., Paoloni, G., Pellegrini, A., Perez, G., Petragnani, M., Prest, M., Povoli, A., Profeti, E., Quartieri, I., Rashevskaya, L., Ratti, V., Re, G., Rizzo, C., Sbarra, N., Semprini Cesari, A., Soldani, A., Stabile, C., Stella, G., Traversi, S., Valentinetti, G., Verzellesi, M., Villa, L., Vitale, J., Walsh, F., Wilson, A., Zoccoli, S., Zucca, Bevan, |. A., Bosisio, Luciano, G. F., Dalla Betta, Lanceri, Livio, A., Lusiani, Rashevskaya, Irina, Stella, Carlo, Vitale, Lorenzo, G. Balestri, G. Batignani, G. Beck, A. Bernardelli, A. Berra, S. Bettarini, A. Bevan, L. Bombelli, F. Bosi, L. Bosisio, G. Casarosa, M. Ceccanti, R. Cenci, M. Citterio, S. Coelli, D. Comotti, G.-F. Dalla Betta, L. Fabbri, C. Fiorini, G. Fontana, F. Forti, A. Gabrielli, L. Gaioni, F. Gannaway, F. Giorgi, M.A. Giorgi, L. Lanceri, V. Liberali, D. Lietti, A. Lusiani, P. Mammini, A. Manazza, M. Manghisoni, M. Monti, J. Morri, F. Morsani, B. Nasri, N. Neri, B. Oberhof, F. Palombo, L. Pancheri, E. Paoloni, G. Pellegrini, A. Perez, G. Petragnani, M. Prest, M. Povoli, A. Profeti, E. Quartieri, I. Rashevskaya, L. Ratti, V. Re, G. Rizzo, C. Sbarra, N. Semprini Cesari, A. Soldani, A. Stabile, C. Stella, G. Traversi, S. Valentinetti, G. Verzellesi, M. Villa, L. Vitale, J. Walsh, F. Wilson, A. Zoccoli, and S. Zucca
Subjects: Nuclear and High Energy Physics, Nanotechnology, Substrate (electronics), Settore ING-INF/01 - Elettronica, CMOS MAPS, DNW MAPS, INMAPS, Particle tracking, Instrumentation, Particle detector, law.invention, CMOS MAPS, DNW MAPS, INMAPS, Particle tracking, law, Charged particle tracking, Physics, Luminosity (scattering theory), Pixel, sezele, business.industry, tracking, Laser, Semiconductor detector, particle tracking, CMOS, Measuring instrument, Optoelectronics, business
Abstract: Physics and high background conditions set very challenging requirements on readout speed, material budget and resolution for the innermost layer of the SuperB Silicon Vertex Tracker operated at the full luminosity. Monolithic Active Pixel Sensors (MAPS) are very appealing in this application since the thin sensitive region allows grinding the substrate to tens of microns. Deep N-Well MAPS, developed in the ST 130 nm CMOS technology, achieved in-pixel sparsification and fast time stamping. Further improvements are being explored with an intense R&D program, including both vertical integration and 2D MAPS with the INMAPS quadruple well. We present the results of the characterization with IR laser, radioactive sources and beam of several chips produced with the 3D (Chartered/Tezzaron) process. We have also studied prototypes exploiting the features of the quadruple well and the high resistivity epitaxial layer of the INMAPS 180 nm process. Promising results from an irradiation campaign with neutrons on small matrices and other test-structures, as well as the response of the sensors to high energy charged tracks are presented.
Published: 2013

20. Advances in the development of pixel detector for the SuperB Silicon Vertex Tracker

Author: D. Lietti, Laura Fabbri, N. Semprini Cesari, Carla Sbarra, Filippo Bosi, L. Vitale, Daniele Comotti, Luca Bombelli, S. Coelli, Benjamin Jerome Andreas Oberhof, Irina Rashevskaya, Alberto Lusiani, Valentino Liberali, Antonio Zoccoli, Stefano Zucca, Eugenio Paoloni, G. Rizzo, Lucio Pancheri, E. Quartieri, A. Bernardelli, G. Batignani, Carlo Fiorini, John Morris, Mauro Villa, F. F. Wilson, Valerio Re, Sara Valentinetti, M. Monti, A. Perez, F. Forti, Alberto Stabile, Fred Gannaway, Fabio Morsani, Alessandro Gabrielli, P. Mammini, C. Stella, A. Berra, Lodovico Ratti, F. Palombo, A. Profeti, J. J. Walsh, M. Povoli, G. Balestri, R. Cenci, Massimo Manghisoni, S. Bettarini, G. Casarosa, Luigi Gaioni, G.-F. Dalla Betta, B. Nasri, M. Citterio, G. Fontana, L. Bosisio, M. Prest, G. Petragnani, Giovanni Verzellesi, F. M. Giorgi, Alessia Manazza, Marcello Giorgi, Nicola Neri, M. Ceccanti, A. Soldani, G. A. Beck, Adrian John Bevan, L. Lanceri, Gianluca Traversi, G. Pellegrini, E., Paoloni, D., Comotti, M., Manghisoni, V., Re, G., Traversi, L., Fabbri, A., Gabrielli, F., Giorgi, G., Pellegrini, C., Sbarra, N., Semprini Cesari, S., Valentinetti, M., Villa, A., Zoccoli, A., Berra, D., Lietti, M., Prest, A., Bevan, F., Wilson, G., Beck, J., Morri, F., Gannaway, R., Cenci, L., Bombelli, M., Citterio, S., Coelli, C., Fiorini, V., Liberali, M., Monti, B., Nasri, N., Neri, F., Palombo, A., Stabile, G., Balestri, G., Batignani, A., Bernardelli, S., Bettarini, F., Bosi, G., Casarosa, M., Ceccanti, F., Forti, M. A., Giorgi, Lusiani, Alberto, P., Mammini, F., Morsani, B., Oberhof, A., Perez, G., Petragnani, A., Profeti, G., Rizzo, A., Soldani, J., Walsh, L., Gaioni, A., Manazza, E., Quartieri, L., Ratti, S., Zucca, G. . ., F., G., Fontana, L., Pancheri, M., Povoli, G., Verzellesi, L., Bosisio, L., Lanceri, I., Rashevskaya, C., Stella, L., Vitale, A., Lusiani, G. F., Dalla Betta, Bosisio, Luciano, Lanceri, Livio, Rashevskaya, Irina, Vitale, Lorenzo, E. Paoloni, D. Comotti, M. Manghisoni, V. Re, G. Traversi, L. Fabbri, A. Gabrielli, F. Giorgi, G. Pellegrini, C. Sbarra, N. Semprini Cesari, S. Valentinetti, M. Villa, A. Zoccoli, A. Berra, D. Lietti, M. Prest, A. Bevan, F. Wilson, G. Beck, J. Morri, F. Gannaway, R. Cenci, L. Bombelli, M. Citterio, S. Coelli, C. Fiorini, V. Liberali, M. Monti, B. Nasri, N. Neri, F. Palombo, A. Stabile, G. Balestri, G. Batignani, A. Bernardelli, S. Bettarini, F. Bosi, G. Casarosa, M. Ceccanti, F. Forti, M.A. Giorgi, A. Lusiani, P. Mammini, F. Morsani, B. Oberhof, A. Perez, G. Petragnani, A. Profeti, G. Rizzo, A. Soldani, J. Walsh, L. Gaioni, A. Manazza, E. Quartieri, L. Ratti, S. Zucca, G.-F. Dalla Betta, G. Fontana, L. Pancheri, M. Povoli, G. Verzellesi, L. Bosisio, L. Lanceri, I. Rashevskaya, C. Stella, and L. Vitale
Subjects: Vertex (computer graphics), Nuclear and High Energy Physics, Nanotechnology, Vertex detectors, monolithic active pixels, charged particle tracking, Settore ING-INF/01 - Elettronica, Particle detector, law.invention, law, Monolithic active pixel sensors, charge particle tracking, Collider, Instrumentation, Charged particle tracking, Physics, Pixel, sezele, business.industry, Electrical engineering, Tracking system, Monolithic active pixels, Monolithic active pixel, Semiconductor detector, Upgrade, CMOS, Vertex detectors, Monolithic active pixels, Charged particle tracking, business
Abstract: The latest advances in the design and characterization of several pixel sensors developed to satisfy the very demanding requirements of the innermost layer of the SuperB Silicon Vertex Tracker will be presented in this paper. The SuperB machine is an electron positron collider operating at the ϒ(4S)ϒ(4S) peak to be built in the very near future by the Cabibbo Lab consortium. A pixel detector based on extremely thin, radiation hard devices able to cope with rate in the tens of MHz/cm^2 range will be the optimal solution for the upgrade of the inner layer of the SuperB tracking system. At present several options with different levels of maturity are being investigated to understand advantages and potential issues of the different technologies: thin hybrid pixels, Deep N-Well CMOS MAPS, INMAPS CMOS MAPS featuring a quadruple well and high resistivity substrates and CMOS MAPS realized with Vertical Integration technology. The newest results from beam test, the outcomes of the radiation damage studies and the laboratory characterization of the latest prototypes will be reported.
Published: 2013

21. Beam test results of different configurations of deep N-well MAPS matrices featuring in pixel full signal processing

Author: Roberto Spighi, D. Jugovaz, Filippo Bosi, Fabio Morsani, Alessandro Gabrielli, G. Venier, V. Speziali, Massimo Manghisoni, S. Bettarini, L. Sartori, Paola Giannetti, G. Giacomini, M. Bomben, L. Vitale, Mauro Villa, P. Cristaudo, F. Forti, C. Andreoli, G. Rizzo, Mauro Citterio, Marco Bruschi, Giovanni Soncini, J. J. Walsh, M. Ceccanti, G. Fontana, Benedetto Giacobbe, S. Gregucci, L. Lanceri, L. Bosisio, D. Gamba, Eugene Yurtsev, E. Paoloni, Mauro Dell'Orso, Sara Valentinetti, G. Giraudo, A. Profeti, G. Marchiori, A. Lusiani, F. M. Giorgi, Francesco Crescioli, Nicola Neri, Luigi Gaioni, Irina Rashevskaya, M. Piendibene, Giulia Casarosa, Carla Sbarra, Valerio Re, Alberto Cervelli, C. Avanzini, R. Di Sipio, G. Batignani, M. Massa, Gianluca Traversi, G. Pellegrini, N. Semprini, Valentino Liberali, P. Mammini, Antonio Zoccoli, Lodovico Ratti, F. Palombo, P. Mereu, G. Calderini, Mario Giorgi, R. Cenci, G.-F. Dalla Betta, E. Pozzati, E., Paoloni, C., Avanzini, G., Batignani, S., Bettarini, F., Bosi, G., Calderini, G., Casarosa, M., Ceccanti, R., Cenci, A., Cervelli, F., Crescioli, M., Dell’Orso, F., Forti, P., Giannetti, M. A., Giorgi, A., Lusiani, S., Gregucci, P., Mammini, G., Marchiori, M., Massa, F., Morsani, N., Neri, M., Piendibene, A., Profeti, G., Rizzo, L., Sartori, J., Walsh, E., Yurtsev, M., Manghisoni, V., Re, G., Traversi, M., Bruschi, R., Di Sipio, B., Giacobbe, A., Gabrielli, F., Giorgi, G., Pellegrini, C., Sbarra, N., Semprini, R., Spighi, S., Valentinetti, M., Villa, A., Zoccoli, M., Citterio, V., Liberali, F., Palombo, C., Andreoli, L., Gaioni, E., Pozzati, L., Ratti, V., Speziali, D., Gamba, G., Giraudo, P., Mereu, G. F., Dalla Betta, G., Soncini, G., Fontana, M., Bomben, Bosisio, Luciano, P., Cristaudo, Giacomini, Gabriele, D., Jugovaz, Lanceri, Livio, I., Rashevskaya, Vitale, Lorenzo, G., Venier, Paoloni, E, Avanzini, C, Batignani, G, Bettarini, S, Bosi, F, Calderini, G, Casarosa, G, Ceccanti, M, Cenci, R, Cervelli, A, Crescioli, F, Dell'Orso, M, Forti, F, Giannetti, P, Giorgi, Ma, Lusiani, Alberto, Gregucci, S, Mammini, P, Marchiori, G, Massa, M, Morsani, F, Neri, N, Piendibene, M, Profeti, A, Rizzo, G, Sartori, L, Walsh, J, Yurtsev, E, Manghisoni, M, Re, V, Traversi, G, Bruschi, M, Di Sipio, R, Giacobbe, B, Gabrielli, A, Giorgi, F, Pellegrini, G, Sbarra, C, Semprini, N, Spighi, R, Valentinetti, S, Villa, M, Zoccoli, A, Citterio, M, Liberali, V, Palombo, F, Andreoli, C, Gaioni, L, Pozzati, E, Ratti, L, Speziali, V, Gamba, D, Giraudo, G, Mereu, P, Dalla Betta, Gf, Soncini, G, Fontana, G, Bomben, M, Bosisio, L, Cristaudo, P, Giacomini, G, Jugovaz, D, Lanceri, L, Rashevskaya, I, Vitale, L, Venier, G., E. Paoloni, C. Avanzini, G. Batignani, S. Bettarini, F. Bosi, G. Calderini, G. Casarosa, M. Ceccanti, R. Cenci, A. Cervelli, F. Crescioli, M. Dell'Orso, F. Forti, P. Giannetti, M.A. Giorgi, A. Lusiani, S. Gregucci, P. Mammini, G. Marchiori, M. Massa, F. Morsani, N. Neri, M. Piendibene, A. Profeti, G. Rizzo, L. Sartori, J. Walsh, E. Yurtsev, M. Manghisoni, V. Re, G. Traversi, M. Bruschi, R. Di Sipio, B. Giacobbe, A. Gabrielli, F. Giorgi, G. Pellegrini, C. Sbarra, N. Semprini, R. Spighi, S. Valentinetti, M. Villa, A. Zoccoli, M. Citterio, V. Liberali, F. Palombo, C. Andreoli, L. Gaioni, E. Pozzati, L. Ratti, V. Speziali, D. Gamba, G. Giraudo, P. Mereu, G.F. Dalla Betta, G. Soncini, G. Fontana, M. Bomben, L. Bosisio, P. Cristaudo, G. Giacomini, D. Jugovaz, L. Lanceri, I. Rashevskaya, L. Vitale, and G. Venier
Subjects: Physics, Nuclear and High Energy Physics, Signal processing, CMOS sensor, Large Hadron Collider, Pixel, business.industry, digital signal processing, TRACKING DETECTORS, Monolithic active pixels sensors, Radiation, vertex detectors, Chip, Settore ING-INF/01 - Elettronica, Optics, CMOS, MAPS, business, Instrumentation, Beam (structure)
Abstract: We report on further developments of our proposed design approach for a full in-pixel signal processing chain of deep N-well monolithic active pixel sensor, by exploiting the triple well option of a CMOS 130 nm process. Two different geometries of the collecting electrode (namely "Apsel 3T(1) M(1)" and "Apsel 3T(1) M(2)") was implemented to compare their charge collection efficiency. The results of the characterization of the various versions of pixel matrices with a pion beam of 120 GeV/c at the SPS H6 CERN facility will be presented. The performances of an "Apsel 3T(1)" chip irradiated with a dose up to 10 Mrad (Co(60)) was also measured. Comparison will be presented among the irradiated and the new chip showing the impact of radiation damages on tracking efficiencies. (C) 2010 Elsevier B.V. All rights reserved. RI Forti, Francesco/H-3035-2011; Neri, Nicola/G-3991-2012; Gabrielli, Alessandro/H-4931-2012; Villa, Mauro/C-9883-2009; Dalla Betta, Gian-Franco/I-1783-2012; Ratti, Lodovico/I-8836-2012; Giorgi, Filippo Maria/I-7602-2012
Published: 2011

22. The superB silicon vertex tracker

Author: Marco Bruschi, Massimo Manghisoni, S. Bettarini, E. Pozzati, P. Cristaudo, Giuseppe Pellegrini, Alberto Lusiani, C. Andreoli, Giovanni Soncini, G. Venier, R. Cenci, V. Speziali, R. Spighi, Paola Giannetti, Fabio Morsani, Alessandro Gabrielli, R. Di Sipio, Mauro Villa, M. Dell'Orso, G. Fontana, G. Rizzo, F. Palombo, F. M. Giorgi, Carla Sbarra, D. Jugovaz, G. Calderini, G.-F. Dalla Betta, S. Gregucci, Eugenio Paoloni, G. Batignani, N. Semprini, Valentino Liberali, A. Profeti, Lodovico Ratti, Irina Rashevskaya, D. Gamba, Valerio Re, L. Lanceri, P. Mereu, Gianluca Traversi, F. Forti, M. Piendibene, M. Bomben, M. Massa, Mario Giorgi, B. Giacobbe, M. Citterio, G. Marchiori, G. Giacomini, J. J. Walsh, L. Vitale, Alberto Cervelli, Francesco Crescioli, C. Avanzini, Luigi Gaioni, Sara Valentinetti, G. Giraudo, Filippo Bosi, Nicola Neri, Luciano Bosisio, Antonio Zoccoli, Eugene Yurtsev, M. Ceccanti, P. Mammini, L. Sartori, G. Rizzo, C. Avanzini, G. Batignani, S. Bettarini, F. Bosi, G. Calderini, M. Ceccanti, R. Cenci, A. Cervelli, F. Crescioli, M. Dell'Orso, F. Forti, P. Giannetti, M.A. Giorgi, A. Lusiani, S. Gregucci, P. Mammini, G. Marchiori, M. Massa, F. Morsani, N. Neri, E. Paoloni, M. Piendibene, A. Profeti, L. Sartori, J. Walsh, E. Yurtsev, M. Manghisoni, V. Re, G. Traversi, M. Bruschi, R. Di Sipio, B. Giacobbe, A. Gabrielli, F. Giorgi, G. Pellegrini, C. Sbarra, N. Semprini, R. Spighi, S. Valentinetti, M. Villa, A. Zoccoli, M. Citterio, V. Liberali, F. Palombo, C. Andreoli, L. Gaioni, E. Pozzati, L. Ratti, V. Speziali, D. Gamba, G. Giraudo, P. Mereu, G.F. Dalla Betta, G. Soncini, G. Fontana, M. Bomben, L. Bosisio, P. Cristaudo, G. Giacomini, D. Jugovaz, L. Lanceri, I. Rashevskaya, L. Vitale, G. Venier, Forti, F, Avanzini, C, Batignani, G, Bettarini, S, Bosi, F, Calderini, G, Ceccanti, M, Cenci, R, Cervelli, A, Crescioli, F, Dell'Orso, M, Giannetti, P, Giorgi, Ma, Lusiani, Alberto, Gregucci, S, Mammini, P, Marchiori, G, Massa, M, Morsani, F, Neri, N, Paoloni, E, Piendibene, M, Profeti, A, Rizzo, G, Sartori, L, Walsh, J, Yurtsev, E, Manghisoni, M, Re, V, Traversi, G, Bruschi, M, Di Sipio, R, Giacobbe, B, Gabrielli, A, Giorgi, F, Pellegrini, G, Sbarra, C, Semprini, N, Spighi, R, Valentinetti, S, Villa, M, Zoccoli, A, Citterio, M, Liberali, V, Palombo, F, Andreoli, C, Gaioni, L, Pozzati, E, Ratti, L, Speziali, V, Gamba, D, Giraudo, G, Mereu, P, Betta, Gfd, Soncini, C, Fontana, G, Bomben, M, Bosisio, L, Cristaudo, P, Giacomini, G, Jugovaz, D, Lanceri, L, Rashevskaya, I, Vitale, L, Venier, G., Bomben, Marco, Bosisio, Luciano, Giacomini, Gabriele, Lanceri, Livio, I., Rachevskaia, Vitale, Lorenzo, SLIM5 Collaboration, et a. l., F., Forti, C., Avanzini, G., Batignani, S., Bettarini, F., Bosi, G., Calderini, M., Ceccanti, R., Cenci, A., Cervelli, F., Crescioli, M., Dell’Orso, P., Giannetti, M. A., Giorgi, A., Lusiani, S., Gregucci, P., Mammini, G., Marchiori, M., Massa, F., Morsani, N., Neri, E., Paoloni, M., Piendibene, A., Profeti, G., Rizzo, L., Sartori, J., Walsh, E., Yurtsev, M., Manghisoni, V., Re, G., Traversi, M., Bruschi, R., Di Sipio, B., Giacobbe, A., Gabrielli, F., Giorgi, G., Pellegrini, C., Sbarra, N., Semprini, R., Spighi, S., Valentinetti, M., Villa, A., Zoccoli, M., Citterio, V., Liberali, F., Palombo, C., Andreoli, L., Gaioni, E., Pozzati, L., Ratti, V., Speziali, D., Gamba, G., Giraudo, P., Mereu, G. F., Dalla Betta, G., Soncini, G., Fontana, P., Cristaudo, D., Jugovaz, Rashevskaya, Irina, and G., Venier
Subjects: Nuclear and High Energy Physics, Vertex (computer graphics), Silicon, chemistry.chemical_element, HYBRID PIXELS, Settore ING-INF/01 - Elettronica, law.invention, Combinatorics, B factory, Silicon tracking detectors, MAPS, Microstrip detectors, Optics, law, SILICON TRACKING, Collider, Instrumentation, Silicon tracking detector, Physics, Luminosity (scattering theory), Interaction point, business.industry, Detector, Vertex detectors, Hybrid Pixels, CMOS MAPS pixel sensors, Charged particle tracking, VERTEX DETECTORS, CMOS MAPS PIXEL SENSORS, CHARGED PARTICLE TRACKING, B-factory, chemistry, SuperB silicon vertex tracker, business, Beam (structure)
Abstract: The SUPERB asymmetric e(+)e(-) collider, to be built near the INFN National Frascati Laboratory in Italy, has been designed to deliver a luminosity greater than 10(36) cm(-2) s(-1) with moderate beam currents, allowing precision measurements in the flavour sector sensitive to New Physics. The conceptual design of the Silicon Vertex Tracker for the SUPERB Detector is presented, based on double-sided silicon strip detectors for the outer layers, with the addition of an innermost Layer 0 close to the interaction point, with low material budget and capable of sustaining a background rate of several MHz/cm(2). (C) 2010 Elsevier B.V. All rights reserved.
Published: 2010

23. The SLIM5 low mass silicon tracker demonstrator

Author: Marco Bruschi, Laura Fabbri, A. Profeti, R. Spighi, M. Piendibene, Alberto Lusiani, D. Jugovaz, D. Gamba, Valerio Re, Eugenio Paoloni, Alberto Cervelli, C. Avanzini, G. Pellegrini, Irina Rashevskaya, G. Marchiori, G.-F. Dalla Betta, Lodovico Ratti, G. Rizzo, Mario Giorgi, B. Giacobbe, G. Fontana, Gianluca Traversi, Filippo Bosi, M. Bomben, G. Batignani, J. J. Walsh, L. Vitale, P. Mereu, M. Dell'Orso, S. Gregucci, Filippo Maria Giorgi, F. Forti, Eugene Yurtsev, R. Cenci, Fabio Morsani, G. Giraudo, Nicola Neri, Alessandro Gabrielli, N. Semprini, Paola Giannetti, V. Speziali, G. Venier, Mauro Villa, G. Giacomini, Francesco Crescioli, Sara Valentinetti, M. Ceccanti, L. Sartori, Carla Sbarra, M. Massa, Luciano Bosisio, Antonio Zoccoli, P. Mammini, L. Lanceri, R. Di Sipio, P. Cristaudo, Giovanni Soncini, Massimo Manghisoni, S. Bettarini, Luigi Gaioni, Bomben, Marco, Bosisio, Luciano, Giacomini, Gabriele, Lanceri, Livio, I., Rachevskaia, Vitale, Lorenzo, SLIM5 Collaboration, et a. l., S. Bettarini, L. Ratti, G. Rizzo, M. Villa, L. Vitale, J. Walsh, C. Avanzini, G. Batignani, F. Bosi, M. Ceccanti, R. Cenci, A. Cervelli, F. Crescioli, M. Dell'Orso, F. Forti, P. Giannetti, M.A. Giorgi, A. Lusiani, S. Gregucci, P. Mammini, G. Marchiori, M. Massa, F. Morsani, N. Neri, E. Paoloni, M. Piendibene, A. Profeti, L. Sartori, E. Yurtsev, L. Gaioni, V. Speziali, M. Bruschi, R. Di Sipio, L. Fabbri, B. Giacobbe, A. Gabrielli, F. Giorgi, G. Pellegrini, C. Sbarra, N. Semprini, R. Spighi, S. Valentinetti, A. Zoccoli, M. Bomben, L. Bosisio, P. Cristaudo, G. Giacomini, D. Jugovaz, L. Lanceri, I. Rashevskaya, G. Venier, M. Manghisoni, V. Re, G. Traversi, D. Gamba, G. Giraudo, P. Mereu, G.F. Dalla Betta, G. Soncini, and G. Fontana
Subjects: Nuclear and High Energy Physics, Physics::Instrumentation and Detectors, Integrated circuit, STRIPS, Settore ING-INF/01 - Elettronica, law.invention, Telescope, Data acquisition, Optics, law, MAPS, Instrumentation, Image resolution, CMOS pixel, Charged particle tracking, Physics, Monolithic active pixel sensor, business.industry, Monolithic active pixel sensors, CMOS pixels, Striplets, Striplet detector, Striplet, Detector, Chip, CMOS, Optoelectronics, business
Abstract: A low material budget silicon demonstrator has been tested by the SLIM5 collaboration with 12 GeV/ c protons at the PS-T9 beam line at CERN. Two devices were placed inside a reference telescope and their characteristics were measured. The first was a 4k-Pixel Matrix of Deep N Well MAPS, developed in a 130 nm CMOS technology, providing digital sparsified readout. The other one was a high resistivity double-sided silicon detector, with short strips at a 45 ∘ angle to the detector's edge, read out by the FSSR2 chip. In this paper we describe the main features of both sensors. The primary goal of the test was to measure the efficiency and the resolution of the DUTs under different conditions of threshold setting and incident angle of the impinging particles. The data-driven approach of the readout chips has been fully exploited by the DAQ system to take data with a track-based level-1 trigger provided by a pattern matching algorithm with very low latency.
Published: 2010
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24. A quadruple well CMOS MAPS prototype for the Layer0 of the SuperB SVT

Author: Filippo Maria Giorgi, Lodovico Ratti, Fabio Morsani, Alessandro Gabrielli, Gianluca Traversi, Stefano Zucca, S. Zucca, L. Ratti, G. Traversi, F. Morsani, A. Gabrielli, and F. Giorgi
Subjects: Physics, Nuclear and High Energy Physics, Vertex (computer graphics), Pixel, CMOS, Transistor, CMOS MAPS, quadruple well process, low noise design, particle tracking, device simulations, Chip, Settore ING-INF/01 - Elettronica, law.invention, Quadruple Well Proce, Upgrade, law, MAPS, Electronic engineering, Layer (object-oriented design), Instrumentation, Communication channel
Abstract: The chip prototype Apsel4well, including monolithic active pixel sensors (MAPS), is meant as an upgrade solution for the Layer0 of the SuperB silicon vertex tracker. The design is based on a 180 nm CMOS process with quadruple well called INMAPS. This technology makes it possible to overcome the main drawbacks of three transistor MAPS. Moreover, the presence of a high resistivity epitaxial layer is expected to lead to a further improvement in terms of charge collection performance and radiation resistance. This work introduces the channel readout design features of the chip Apsel4well developed with the mentioned approach and shows results of device simulations of a 3×3 pixel matrix.
Published: 2013
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25. SuperB Technical Design Report

Author: Superb, Collaboration, Baszczyk, M., Dorosz, P., Kolodziej, J., Kucewicz, W., Sapor, M., Jeremie, A., Grauges Pous, E., Bruno, G. E., De Robertis, G., Diacono, D., Donvito, G., Fusco, P., Gargano, F., Giordano, F., Loddo, F., Loparco, F., Maggi, G. P., Manzari, V., Mazziotta, M. N., Nappi, E., Palano, A., Santeramo, B., Sgura, I., Silvestris, L., Spinoso, V., Eigen, G., Zalieckas, J., Zhuo, Z., Jenkovszky, L., Balbi, G., Boldini, M., Bonacorsi, D., Cafaro, V., D'Antone, I., Dallavalle, G. M., Di Sipio, R., Fabbri, F., Fabbri, L., Gabrielli, A., Galli, D., Giacomelli, P., Giordano, V., Giorgi, F. M., Grandi, C., Lax, I., Lo Meo, S., Marconi, U., Montanari, A., Pellegrini, G., Piccinini, M., Rovelli, T., Semprini Cesari, N., Torromeo, G., Tosi, N., Travaglini, R., Vagnoni, V. M., Valentinetti, S., Villa, M., Zoccoli, A., Caron, J. F., Hearty, C., P. F. T., Lu, Mattison, T. S., Mckenna, J. A., R. Y. C., So, Yu Barnyakov, M. Y. u. Barnyakov, Blinov, V. E., Botov, A. A., Druzhinin, V. P., Golubev, V. B., Kononov, S. A., Kravchenko, E. A., Levichev, E. B., Onuchin, A. P., Serednyakov, S. I., Shtol, D. A., Skovpen, Y. I., Solodov, E. P., Cardini, A., Carpinelli, M., Chao, D. S. T., Cheng, C. H., Doll, D. A., Echenard, B., Flood, K., Hanson, J., Hitlin, D. G., Ongmongkolkul, P., Porter, F. C., Zhu, R. Y., Randazzo, N., De La Cruz Burelo, E., Zheng, Y., Campos, P., De Silva, M., Kathirgamaraju, A., Meadows, B., Pushpawela, B., Shi, Y., Sokoloff, M., Lopez Castro, G., Ciaschini, V., Franchini, P., Giacomini, F., Paolini, A., Calderon Polania, G. A., Laczek, S., Romanowicz, P., Szybinski, B., Czuchry, M., Flis, L., Harezlak, D., Kocot, J., Radecki, M., Sterzel, M., Szepieniec, T., Szymocha, T., Wójcik, P., Andreotti, M., Baldini, W., Calabrese, R., Carassiti, V., Cibinetto, G., Cotta Ramusino, A., Evangelisti, F., Gianoli, A., Luppi, E., Malaguti, R., Manzali, M., Melchiorri, M., Munerato, M., Padoan, C., Santoro, V., Tomassetti, L., Beretta, M. M., Biagini, M., Boscolo, M., Capitolo, E., de Sangro, R., Esposito, M., Felici, G., Finocchiaro, G., Gatta, M., Gatti, C., Guiducci, S., Lauciani, S., Patteri, P., Peruzzi, I., Piccolo, M., Raimondi, P., Rama, Matteo, Sanelli, C., Tomassini, S., Fabbricatore, P., Delepine, D., Reyes Santos, M. A., Chrzaszcz, M., Grzymkowski, R., Knap, P., Kotula, J., Lesiak, T., Ludwin, J., Michalowski, J., Pawlik, B., Rachwal, B., Stodulski, M., Wiechczynski, J., Witek, M., Zawiejski, L., Zdybal, M., Aushev, V. Y., Ustynov, A., Arnaud, N., Bambade, P., Beigbeder, C., Bogard, F., Borsato, M., Breton, D., Brossard, J., Burmistrov, L., Charlet, D., Chaumat, V., Dadoun, O., El Berni, M., Maalmi, J., Puill, V., Rimbault, C., Stocchi, A., Tocut, V., Variola, A., Wallon, S., Wormser, G., Grancagnolo, F., Ben Haim, E., Sitt, S., Baylac, M., Bourrion, O., Deconto, J. M., Gomez Martinez, Y., Monseu, N., Muraz, J. F., Real, J. S., Vescovi, C., Cenci, R., Jawahery, A., Roberts, D., Twedt, E. W., Cheaib, R., Lindemann, D., Nderitu, S., Patel, P., Robertson, S. H., Swersky, D., Warburton, A., Cuautle Flores, E., Toledo Sanchez, G., Biassoni, P., Bombelli, L., Citterio, M., Coelli, S., Fiorini, C., Liberali, V., Monti, M., Nasri, B., Neri, N., Palombo, F., Sabatini, F., Stabile, A., Berra, A., Giachero, A., Gotti, C., Lietti, D., Maino, M., Pessina, G., Prest, M., Martin, J. P., Simard, M., Starinski, N., Taras, P., Drutskoy, A., Makarychev, S., Nefediev, A. V., Aloisio, A., Cavaliere, S., De Nardo, G., Della Pietra, M., Doria, A., Giordano, R., Ordine, A., Pardi, S., Russo, G., Sciacca, C., Bigi, I. I., Jessop, C. P., Wang, W., Bellato, M., Benettoni, M., Corvo, M., Crescente, A., Dal Corso, F., Dosselli, U., Fanin, C., Gianelle, A., Longo, S., Michelotto, M., Montecassiano, F., Morandin, M., Pengo, R., Posocco, M., Rotondo, M., Simi, G., Stroili, R., Gaioni, L., Manazza, A., Manghisoni, M., Ratti, L., Re, V., Traversi, G., Zucca, S., Bizzaglia, S., Bizzarri, M., Cecchi, C., Germani, S., Lebeau, M., Lubrano, P., Manoni, E., Papi, A., Rossi, A., Scolieri, G., Batignani, Giovanni, Bettarini, Stefano, Casarosa, Giulia, Cervelli, A., Fella, A., Forti, Francesco, Giorgi, Marcello, Lilli, L., Lusiani, A., Oberhof, BENJAMIN JEROME ANDREAS, Paladino, Antonio, Pantaleo, F., Paoloni, Eugenio, Perez Perez, A. L., Rizzo, Giuliana, Walsh, J., Fernández Téllez, A., Beck, G., Berman, M., Bevan, A., Gannaway, F., Inguglia, G., Martin, A. J., Morris, J., Bocci, V., Capodiferro, M., Chiodi, G., Dafinei, I., Drenska, N. V., Faccini, R., Ferroni, F., Gargiulo, C., Gauzzi, P., Luci, C., Lunadei, R., Martellotti, G., Pellegrino, F., Pettinacci, V., Pinci, D., Recchia, L., Ruggeri, D., Zullo, A., Camarri, P., Cardarelli, R., De Santis, C., Di Ciaccio, A., Di Felice, V., Di Palma, F., Di Simone, A., Marcelli, L., Messi, R., Moricciani, D., Sparvoli, R., Tammaro, S., Branchini, P., Budano, A., Bussino, S., Ciuchini, M., Nguyen, F., Passeri, A., Ruggieri, F., Spiriti, E., Wilson, F., Leon Monzon, I., Millan Almaraz, J. R., Podesta Lerma, P. L. M., Aston, D., Dey, B., Fisher, A., Jackson, P. D., Leith, D. W. G. S., Luitz, S., Macfarlane, D., Mcculloch, M., Metcalfe, S., Novokhatski, A., Osier, S., Prepost, R., Ratcliff, B., Seeman, J., Sullivan, M., Va'Vra, J., Wienands, U., Wisniewski, W., Altschul, B. D., Purohit, M. V., Baudot, J., Ripp Baudot, I., Cirrone, G. A. P., Cuttone, G., Bezshyyko, O., Dolinska, G., Soffer, A., Bianchi, F., De Mori, F., Filippi, A., Gamba, D., Marcello, S., Bomben, M., Bosisio, L., Cristaudo, P., Lanceri, L., Liberti, B., Rashevskaya, I., Stella, C., Vallazza, E. S., Vitale, L., Auriemma, G., Satriano, C., Martinez Vidal, F., Mazorra de Cos, J., Oyanguren, A., Ruiz Valls, P., Beaulieu, A., Dejong, S., Franta, J., Lewczuk, M. J., Roney, M., Sobie, R., M., Baszczyk, P., Dorosz, J., Kolodziej, W., Kucewicz, M., Sapor, A., Jeremie, E., Grauges Pou, G. E., Bruno, G., De Roberti, D., Diacono, G., Donvito, P., Fusco, F., Gargano, F., Giordano, F., Loddo, F., Loparco, G. P., Maggi, V., Manzari, M. N., Mazziotta, E., Nappi, A., Palano, B., Santeramo, I., Sgura, L., Silvestri, V., Spinoso, G., Eigen, J., Zaliecka, Z., Zhu, L., Jenkovszky, G., Balbi, M., Boldini, D., Bonacorsi, V., Cafaro, I., D'Antone, G. M., Dallavalle, R., Di Sipio, F., Fabbri, L., Fabbri, A., Gabrielli, D., Galli, P., Giacomelli, V., Giordano, F. M., Giorgi, C., Grandi, I., Lax, S., Lo Meo, U., Marconi, A., Montanari, G., Pellegrini, M., Piccinini, T., Rovelli, N., Semprini Cesari, G., Torromeo, N., Tosi, R., Travaglini, V. M., Vagnoni, S., Valentinetti, M., Villa, A., Zoccoli, J. F., Caron, C., Hearty, P. F. T., Lu, T. S., Mattison, J. A., Mckenna, R. Y. C., So, Barnyakov, M. Y. u., V. E., Blinov, A. A., Botov, V. P., Druzhinin, V. B., Golubev, S. A., Kononov, E. A., Kravchenko, E. B., Levichev, A. P., Onuchin, S. I., Serednyakov, D. A., Shtol, Y. I., Skovpen, E. P., Solodov, A., Cardini, M., Carpinelli, D. S. T., Chao, C. H., Cheng, D. A., Doll, B., Echenard, K., Flood, J., Hanson, D. G., Hitlin, P., Ongmongkolkul, F. C., Porter, R. Y., Zhu, N., Randazzo, E., De La Cruz Burelo, Y., Zheng, P., Campo, M., De Silva, A., Kathirgamaraju, B., Meadow, B., Pushpawela, Y., Shi, M., Sokoloff, G., Lopez Castro, V., Ciaschini, P., Franchini, F., Giacomini, A., Paolini, G. A., Calderon Polania, S., Laczek, P., Romanowicz, B., Szybinski, M., Czuchry, L., Fli, D., Harezlak, J., Kocot, M., Radecki, M., Sterzel, T., Szepieniec, T., Szymocha, P., Wójcik, M., Andreotti, W., Baldini, R., Calabrese, V., Carassiti, G., Cibinetto, A., Cotta Ramusino, F., Evangelisti, A., Gianoli, E., Luppi, R., Malaguti, M., Manzali, M., Melchiorri, M., Munerato, C., Padoan, V., Santoro, L., Tomassetti, M. M., Beretta, M., Biagini, M., Boscolo, E., Capitolo, R., de Sangro, M., Esposito, G., Felici, G., Finocchiaro, M., Gatta, C., Gatti, S., Guiducci, S., Lauciani, P., Patteri, I., Peruzzi, M., Piccolo, P., Raimondi, M., Rama, C., Sanelli, S., Tomassini, P., Fabbricatore, D., Delepine, M. A., Reyes Santo, M., Chrzaszcz, R., Grzymkowski, P., Knap, J., Kotula, T., Lesiak, J., Ludwin, J., Michalowski, B., Pawlik, B., Rachwal, M., Stodulski, J., Wiechczynski, M., Witek, L., Zawiejski, M., Zdybal, V. Y., Aushev, A., Ustynov, N., Arnaud, P., Bambade, C., Beigbeder, F., Bogard, M., Borsato, D., Breton, J., Brossard, L., Burmistrov, D., Charlet, V., Chaumat, O., Dadoun, M., El Berni, J., Maalmi, V., Puill, C., Rimbault, A., Stocchi, V., Tocut, A., Variola, S., Wallon, G., Wormser, F., Grancagnolo, E., Ben Haim, S., Sitt, M., Baylac, O., Bourrion, J. M., Deconto, Y., Gomez Martinez, N., Monseu, J. F., Muraz, J. S., Real, C., Vescovi, R., Cenci, A., Jawahery, D., Robert, E. W., Twedt, R., Cheaib, D., Lindemann, S., Nderitu, P., Patel, S. H., Robertson, D., Swersky, A., Warburton, E., Cuautle Flore, G., Toledo Sanchez, P., Biassoni, L., Bombelli, M., Citterio, S., Coelli, C., Fiorini, V., Liberali, M., Monti, B., Nasri, N., Neri, F., Palombo, F., Sabatini, A., Stabile, A., Berra, A., Giachero, C., Gotti, D., Lietti, M., Maino, G., Pessina, M., Prest, J. P., Martin, M., Simard, N., Starinski, P., Tara, A., Drutskoy, S., Makarychev, A. V., Nefediev, A., Aloisio, Cavaliere, Sergio, G., De Nard, DELLA PIETRA, Massimo, A., Doria, Giordano, Raffaele, A., Ordine, S., Pardi, Russo, Guido, C., Sciacca, I. I., Bigi, C. P., Jessop, W., Wang, M., Bellato, M., Benettoni, M., Corvo, A., Crescente, F., Dal Corso, U., Dosselli, C., Fanin, A., Gianelle, S., Longo, M., Michelotto, F., Montecassiano, M., Morandin, R., Pengo, M., Posocco, M., Rotondo, G., Simi, R., Stroili, L., Gaioni, A., Manazza, M., Manghisoni, L., Ratti, V., Re, G., Traversi, S., Zucca, S., Bizzaglia, M., Bizzarri, C., Cecchi, S., Germani, M., Lebeau, P., Lubrano, E., Manoni, A., Papi, A., Rossi, G., Scolieri, G., Batignani, S., Bettarini, G., Casarosa, A., Cervelli, A., Fella, F., Forti, M., Giorgi, L., Lilli, A., Lusiani, B., Oberhof, A., Paladino, F., Pantaleo, E., Paoloni, A. L., Perez Perez, G., Rizzo, J., Walsh, A., Fernández Téllez, G., Beck, M., Berman, A., Bevan, F., Gannaway, G., Inguglia, A. J., Martin, J., Morri, V., Bocci, M., Capodiferro, G., Chiodi, I., Dafinei, N. V., Drenska, R., Faccini, F., Ferroni, C., Gargiulo, P., Gauzzi, C., Luci, R., Lunadei, G., Martellotti, F., Pellegrino, V., Pettinacci, D., Pinci, L., Recchia, D., Ruggeri, A., Zullo, P., Camarri, R., Cardarelli, C., De Santi, A., Di Ciaccio, V., Di Felice, F., Di Palma, A., Di Simone, L., Marcelli, R., Messi, D., Moricciani, R., Sparvoli, S., Tammaro, P., Branchini, A., Budano, S., Bussino, M., Ciuchini, F., Nguyen, A., Passeri, F., Ruggieri, E., Spiriti, F., Wilson, I., Leon Monzon, J. R., Millan Almaraz, P. L. M., Podesta Lerma, D., Aston, B., Dey, A., Fisher, P. D., Jackson, D. W. G. S., Leith, S., Luitz, D., Macfarlane, M., Mcculloch, S., Metcalfe, A., Novokhatski, S., Osier, R., Prepost, B., Ratcliff, J., Seeman, M., Sullivan, J., Va'Vra, U., Wienand, W., Wisniewski, B. D., Altschul, M. V., Purohit, J., Baudot, I., Ripp Baudot, G. A. P., Cirrone, G., Cuttone, O., Bezshyyko, G., Dolinska, A., Soffer, F., Bianchi, F., De Mori, A., Filippi, D., Gamba, S., Marcello, M., Bomben, L., Bosisio, P., Cristaudo, L., Lanceri, B., Liberti, I., Rashevskaya, C., Stella, E. S., Vallazza, L., Vitale, G., Auriemma, C., Satriano, F., Martinez Vidal, J., Mazorra de Co, A., Oyanguren, P., Ruiz Vall, A., Beaulieu, S., Dejong, J., Franta, M. J., Lewczuk, M., Roney, and R., Sobie
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: In this Technical Design Report (TDR) we describe the SuperB detector that was to be installed on the SuperB e+e- high luminosity collider. The SuperB asymmetric collider, which was to be constructed on the Tor Vergata campus near the INFN Frascati National Laboratory, was designed to operate both at the Upsilon(4S) center-of-mass energy with a luminosity of 10^{36} cm^{-2}s^{-1} and at the tau/charm production threshold with a luminosity of 10^{35} cm^{-2}s^{-1}. This high luminosity, producing a data sample about a factor 100 larger than present B Factories, would allow investigation of new physics effects in rare decays, CP Violation and Lepton Flavour Violation. This document details the detector design presented in the Conceptual Design Report (CDR) in 2007. The R&D and engineering studies performed to arrive at the full detector design are described, and an updated cost estimate is presented. A combination of a more realistic cost estimates and the unavailability of funds due of the global economic climate led to a formal cancelation of the project on Nov 27, 2012.
Published: 2013

26. Characterization of Bulk Damage in CMOS MAPS With Deep N-Well Collecting Electrode

Author: Irina Rashevskaya, Gianluca Traversi, Vladimir Cindro, Luciano Bosisio, Fabio Morsani, Lodovico Ratti, S. Bettarini, Stefano Zucca, G. Rizzo, S., Zucca, L., Ratti, G., Traversi, S., Bettarini, F., Morsani, G., Rizzo, Bosisio, Luciano, I., Rashevskaya, and V., Cindro
Subjects: Nuclear and High Energy Physics, Materials science, business.industry, charge collection efficiency, Laser, CMOS MAPS, Fluence, Settore ING-INF/01 - Elettronica, Charged particle, law.invention, Nuclear Energy and Engineering, Bulk damage, deep N-well sensor, law, Electrode, Optoelectronics, Neutron, Irradiation, Sensitivity (control systems), Electrical and Electronic Engineering, business, Diode
Abstract: Monolithic active pixel sensors in CMOS technology, featuring a deep N-well as the collecting electrode (so called DNW MAPS), have been exposed to neutrons from a nuclear reactor, up to a total 1 MeV neutron equivalent fluence of about $3.7\times 10^{13}~{\hbox {cm}}^{-2}$ . The irradiation campaign was aimed at studying the effects of radiation induced displacement damage on the charge collection properties of the device, which was conceived for applications to charged particle tracking in high energy physics experiments. A number of different techniques, including electrical characterization of the front-end electronics and of DNW diodes, laser stimulation of the sensors and tests with $^{55}{\hbox {Fe}}$ and $^{90}{\hbox {Sr}}$ radioactive sources, has been employed for evaluating the device operation before and after irradiation. This paper discusses the measurement results and their relation with the bulk damage mechanisms underlying performance degradation in DNW MAPS.
Published: 2012

27. Thin pixel development for the SuperB silicon vertex tracker

Author: M. Ceccanti, M. Dell'Orso, L. Sartori, Alberto Lusiani, D. Jugovaz, C. Avanzini, Luciano Bosisio, Mario Giorgi, Antonio Zoccoli, B. Giacobbe, J. J. Walsh, Eugenio Paoloni, Stefano Zucca, Carla Sbarra, S. Gregucci, M. Massa, G. Batignani, Francesco Crescioli, Sara Valentinetti, Filippo Maria Giorgi, P. Mammini, G. Rizzo, Eugene Yurtsev, Nicola Neri, R. Cenci, L. Lanceri, Paola Giannetti, G.-F. Dalla Betta, Valerio Re, M. Piendibene, G. Fontana, Lodovico Ratti, Alberto Stabile, R. Di Sipio, N. Semprini, Valentino Liberali, Marco Bruschi, Alberto Cervelli, F. Palombo, Mauro Citterio, Irina Rashevskaya, Luigi Gaioni, Massimo Manghisoni, S. Bettarini, R. Spighi, G. Marchiori, G. Pellegrini, G. Venier, Filippo Bosi, Gianluca Traversi, A. Profeti, Lorenzo Vitale, M. Bomben, V. Speziali, Fabio Morsani, Mauro Villa, Alessandro Gabrielli, F. Forti, Alessia Manazza, P. Cristaudo, Giovanni Soncini, Rizzo G., Avanzini C., Batignani G., Bettarini. S., Bosi F., Ceccanti M., Cenci R., Cervelli A., Crescioli F., Dell'Orso M., Forti F., Giannetti P., Giorgi M.A., Lusiani A., Gregucci S., Mammini P., Marchiori G., Massa M., Morsani F., Neri N., Paoloni E., Piendibene M., Profeti A., Sartori L., Walsh J., Yurtsev E., Manghisoni M., Re V., Traversi G., Bruschi M., Di Sipio R., Giacobbe B., Gabrielli A., Giorgi F., Pellegrini G., Sbarra C., Semprini N., Spighi R., Valentinetti S., Villa M., Zoccoli A., Citterio M., Liberali V., Stabile A., Palombo F., Gaioni L., Manazza A., Ratti L., Speziali V., Zucca S., Dalla Betta G.F., Soncini G., Fontana G., Bomben M., Bosisio L., Cristaudo P., Jugovaz D., Lanceri L., Rashevskaya I., Vitale L., Venier G., G., Rizzo, C., Avanzini, G., Batignani, S., Bettarini, F., Bosi, M., Ceccanti, R., Cenci, A., Cervelli, F., Crescioli, M., Dell’Orso, F., Forti, P., Giannetti, M. A., Giorgi, A., Lusiani, S., Gregucci, P., Mammini, G., Marchiori, M., Massa, F., Morsani, N., Neri, E., Paoloni, M., Piendibene, A., Profeti, L., Sartori, J., Walsh, E., Yurtsev, M., Manghisoni, V., Re, G., Traversi, M., Bruschi, R., Di Sipio, B., Giacobbe, A., Gabrielli, F., Giorgi, G., Pellegrini, C., Sbarra, N., Semprini, R., Spighi, S., Valentinetti, M., Villa, A., Zoccoli, M., Citterio, V., Liberali, A., Stabile, F., Palombo, L., Gaioni, A., Manazza, L., Ratti, V., Speziali, S., Zucca, G. F., Dalla Betta, G., Soncini, G., Fontana, Bomben, Marco, Bosisio, Luciano, P., Cristaudo, D., Jugovaz, Lanceri, Livio, Rashevskaya, Irina, Vitale, Lorenzo, and G., Venier
Subjects: Physics, Nuclear and High Energy Physics, Pixel, Silicon, business.industry, chemistry.chemical_element, CMOS MAPS PIXEL SENSORS, VERTEX DETECTORS, CHARGED PARTICLE TRACKING, HYBRID PIXELS, Settore ING-INF/01 - Elettronica, Vertex (geometry), Vertex detectors, hybrid pixels, CMOS MAPS pixel sensors, charged particle tracking, Optics, CMOS, chemistry, Vertex detector, SuperB silicon vertex tracker, business, Instrumentation
Abstract: The high luminosity SuperB asymmetric e + e − collider, to be built near the INFN National Frascati Laboratory in Italy, has been designed to deliver a luminosity greater than 10 36 cm −2 s −1 with moderate beam currents and a reduced center of mass boost with respect to earlier B-Factories. An improved vertex resolution is required for precise time-dependent measurements and the SuperB Silicon Vertex Tracker will be equipped with an innermost layer of small radius (about 1.5 cm), resolution of 10 – 15 μ m in both coordinates, low material budget ( 1 % X0), and able to withstand a background rate of several tens of MHz/cm 2 . The ambitious goal of designing a thin pixel device with these stringent requirements is being pursued with specific R&D programs on different technologies: hybrid pixels, CMOS MAPS and pixel sensors developed with vertical integration technology. The latest results on the various pixel options for the SuperB SVT will be presented.
Published: 2011

28. Deep n-well MAPS in a 130 nm CMOS technology: Beam test results

Author: Laura Fabbri, A. Profeti, Paola Giannetti, M. Piendibene, L. Lanceri, Massimo Manghisoni, Irina Rashevskaya, Roberto Spighi, Filippo Bosi, G. Giacomini, D. Gamba, Marco Bruschi, G. Marchiori, G. Giraudo, Gianluca Traversi, Nicola Neri, P. Mammini, D. Iugovaz, Sara Valentinetti, G.-F. Dalla Betta, E. Paoloni, F. Forti, M. Bomben, N. Semprini, F. M. Giorgi, M. Ceccanti, J. J. Walsh, L. Vitale, Antonio Zoccoli, Fabio Morsani, V. Speziali, Alessandro Gabrielli, A. Lusiani, Francesco Crescioli, G. Pellegrini, Mauro Villa, C. Avanzini, Mario Giorgi, C. Andreoli, G. Rizzo, G. Venier, G. Batignani, Luigi Gaioni, E. Pozzati, L. Sartori, G. Fontana, L. Bosisio, P. Cristaudo, Valerio Re, Giovanni Soncini, R. Cenci, Benedetto Giacobbe, Alberto Cervelli, Eugene Yurtsev, Mauro Dell'Orso, Lodovico Ratti, S. Gregucci, P. Mereu, S. Bettarini, Carla Sbarra, M. Massa, R. Di Sipio, N. Neri, C. Avanzini, G. Batignani, S. Bettarini, F. Bosi, M. Ceccanti, R. Cenci, A. Cervelli, F. Crescioli, M. Dell'Orso, F. Forti, P. Giannetti, M.A. Giorgi, S. Gregucci, P. Mammini, G. Marchiori, M. Massa, F. Morsani, E. Paoloni, M. Piendibene, A. Profeti, G. Rizzo, L. Sartori, J. Walsh, E. Yurtsev, A. Lusiani, M. Manghisoni, V. Re, G. Traversi, M. Bruschi, R. Di Sipio, L. Fabbri, B. Giacobbe, A. Gabrielli, F. Giorgi, G. Pellegrini, C. Sbarra, N. Semprini, R. Spighi, S. Valentinetti, M. Villa, A. Zoccoli, C. Andreoli, L. Gaioni, E. Pozzati, L. Ratti, V. Speziali, D. Gamba, G. Giraudo, P. Mereu, G.F. Dalla Betta, G. Soncini, G. Fontana, M. Bomben, L. Bosisio, P. Cristaudo, G. Giacomini, D. Iugovaz, L. Lanceri, I. Rashevskaya, L. Vitale, G. Venier, Bomben, Marco, Bosisio, Luciano, Giacomini, Gabriele, Lanceri, Livio, Rashevskaya, Irina, Vitale, Lorenzo, et al SLIM5, Collaboration, Neri, N, Avanzini, C, Batignani, G, Bettarini, S, Bosi, F, Ceccanti, M, Cenci, R, Cervelli, A, Crescioli, F, Dell'Orso, M, Forti, F, Giannetti, P, Giorgi, Ma, Gregucci, S, Mammini, P, Marchiori, G, Massa, M, Morsani, F, Paoloni, E, Piendibene, M, Profeti, A, Rizzo, G, Sartori, L, Walsh, J, Yurtsev, E, Lusiani, Alberto, Manghisoni, M, Re, V, Traversi, G, Bruschi, M, Di Sipio, R, Fabbri, L, Giacobbe, B, Gabrielli, A, Giorgi, F, Pellegrini, G, Sbarra, C, Semprini, N, Spighi, R, Valentinetti, S, Villa, M, Zoccoli, A, Andreoli, C, Gaioni, L, Pozzati, E, Ratti, L, Speziali, V, Gamba, D, Giraudo, G, Mereu, P, Dalla Betta, Gf, Soncini, G, Fontana, G, Bomben, M, Bosisio, L, Cristaudo, P, Giacomini, G, Iugovaz, D, Lanceri, L, Rashevskaya, I, Vitale, L, and Venier, G.
Subjects: Physics, Nuclear and High Energy Physics, Signal processing, Silicon pixel sensors, MAPS, Beam test, Deep n-well, Charged particle tracker, Pixel, business.industry, Physics::Instrumentation and Detectors, Detector, Chip, Settore ING-INF/01 - Elettronica, Silicon pixel sensor, Optics, CMOS, Device under test, business, Instrumentation, Beam (structure), Test data
Abstract: We report on recent beam test results for the APSEL4D chip, a new deep n-well MAPS prototype with a full in-pixel signal processing chain obtained by exploiting the triple well option of the CMOS 0.13 mu m process. The APSEL4D chip consists of a 4096 pixel matrix (32 rows and 128 columns) with 50 x 50 mu m(2) pixel cell area, with custom readout architecture capable of performing data sparsification at pixel level. APSEL4D has been characterized in terms of charge collection efficiency and intrinsic spatial resolution under different conditions of discriminator threshold settings using a 12 GeV/c proton beam in the T9 area of the CERN PS. We observe a maximum hit efficiency of 92% and we estimate an intrinsic resolution of about 14 mu m. The data driven approach of the tracking detector readout chips has been successfully used to demonstrate the possibility to build a Level 1 trigger system based on associative memories. The analysis of the beam test data is critically reviewed along with the characterization of the device under test. (C) 2010 Elsevier B.V. All rights reserved. RI Forti, Francesco/H-3035-2011; Neri, Nicola/G-3991-2012; Fabbri, Laura/H-3442-2012; Gabrielli, Alessandro/H-4931-2012; Villa, Mauro/C-9883-2009; Dalla Betta, Gian-Franco/I-1783-2012; Ratti, Lodovico/I-8836-2012; Giorgi, Filippo Maria/I-7602-2012
Published: 2010

29. On-Chip Fast Data Sparsification for a Monolithic 4096-Pixel Device

Author: Lucio Pancheri, Gianluca Traversi, Sara Valentinetti, V. Speziali, Carla Sbarra, L. Vitale, Marco Bomben, F. Forti, Mauro Dell'Orso, Massimo Manghisoni, R. Di Sipio, Mauro Villa, Paola Giannetti, C. Andreoli, R. Spighi, G. Batignani, Valerio Re, D. Gamba, Giovanni Soncini, I. Rachevskaia, G. Fontana, Marco Bruschi, L. Bosisio, S. Bettarini, L. Lanceri, Fabio Morsani, G. Rizzo, E. Paoloni, Alessandro Gabrielli, J. J. Walsh, N. Semprini, Giuseppe Giraudo, G. Marchiori, Filippo Bosi, Mario Giorgi, B. Giacobbe, F. Giorgi, A. Lusiani, R. Cenci, Lodovico Ratti, Gabriele Giacomini, P. Mereu, G. Calderini, Antonio Zoccoli, Giovanni Verzellesi, Nicola Neri, Luigi Gaioni, E. Pozzati, G.-F. Dalla Betta, Bomben, Marco, Bosisio, Luciano, Giacomini, Gabriele, Lanceri, Livio, I., Rachevskaia, Vitale, Lorenzo, SLIM5 Collaboration, et a. l., A. Gabrielli, G. Batignani, S. Bettarini, F. Bosi, G. Calderini, R. Cenci, M. Dell'Orso, F. Forti, P. Giannetti, M.A. Giorgi, A.Lusiani, G. Marchiori, F. Morsani, N. Neri, E. Paoloni, G. Rizzo, J. Walsh, C. Andreoli, L. Gaioni, E. Pozzati, L. Ratti, V. Speziali, M. Manghisoni, V. Re, G. Traversi, M. Bomben, L. Bosisio, G. Giacomini, L. Lanceri, I. Rachevskaia, L. Vital, G.F. Dalla Betta, G. Soncini, G. Fontana, L. Pancheri, G. Verzellesi, D. Gamba, G. Giraudo, P. Mereu, R. Di Sipio, M. Bruschi, B. Giacobbe, F. Giorgi, N. Semprini, C. Sbarra, R. Spighi, S. Valentinetti, M. Villa, A. Zoccoli, Gabrielli, A, Batignani, G, Bettarini, S, Bosi, F, Calderini, G, Cenci, R, Dell'Orso, M, Forti, F, Giannetti, P, Giorgi, Ma, Lusiani, Alberto, Marchiori, G, Morsani, F, Neri, N, Paoloni, E, Rizzo, G, Walsh, J, Andreoli, C, Gaioni, L, Pozzati, E, Ratti, L, Speziali, V, Manghisoni, M, Re, V, Traversi, G, Bomben, M, Bosisio, L, Giacomini, G, Lanceri, L, Rachevskaia, I, Vitale, L, Betta, Gfd, Soncini, G, Fontana, G, Pancheri, L, Verzellesi, G, Gamba, D, Giraudo, G, Mereu, P, Di Sipio, R, Bruschi, M, Giacobbe, B, Giorgi, F, Semprini, N, Sbarra, C, Spighi, R, Valentinetti, S, Villa, M, and Zoccoli, A.
Subjects: Nuclear and High Energy Physics, EFFICIENCY, sparsification, Physics::Instrumentation and Detectors, Digital readout, PIXEL, Active pixel detectors, Settore ING-INF/01 - Elettronica, Computer Science::Hardware Architecture, Application-specific integrated circuit, MAPS, pixel detector, Nuclear electronics, Electronic engineering, System on a chip, Electrical and Electronic Engineering, Physics, sparsiﬁcation, Pixel, Detector, Chip, READOUT, Nuclear Energy and Engineering, CMOS, Sparsification, Master clock
Abstract: The paper describes a mixed-mode ASIC composed of a fast readout architecture that interfaces with a matrix of 4096 Monolithic Active Pixel Sensors (MAPS). The matrix has 128 columns and 32 rows of pixels and is divided into 256 regions of 4 x 4 pixels, named macro-pixels (MPs). The chip is an upgrade of a smaller version having 256 pixels that was designed and tested. The two chips were designed via STM 130 nm CMOS technology. The pixel dimension is 50 by 50 mu m(2). The work is aimed at improving the design of MAPS detectors with an on-chip fast sparsification system, for particle tracking, to match the requirements of future high-energy physics experiments. The readout architecture implemented is data driven to extend the flexibility of the system, to be also used in first level triggers on tracks in vertex detectors. Simulations indicate that the readout system can cope with an average hit rate up to 100 MHz/cm(2) if a master clock of 80 MHz is used, while maintaining an overall efficiency over 99%. RI Gabrielli, Alessandro/H-4931-2012; Villa, Mauro/C-9883-2009; Dalla Betta, Gian-Franco/I-1783-2012; Forti, Francesco/H-3035-2011; Ratti, Lodovico/I-8836-2012; Giorgi, Filippo Maria/I-7602-2012
Published: 2009

30. A 4096-pixel MAPS device with on-chip data sparsification

Author: R. Spighi, Giovanni Verzellesi, Marco Bruschi, L. Lanceri, R. Cenci, G. Giraudo, Nicola Neri, E. Paoloni, G. Batignani, Filippo Bosi, G.-F. Dalla Betta, F. Forti, Valerio Re, Carla Sbarra, Giovanni Soncini, I. Rachevskaia, Luigi Gaioni, Paola Giannetti, Massimo Manghisoni, Federico M. Giorgi, Gianluca Traversi, Sara Valentinetti, D. Gamba, G. Marchiori, Mario Giorgi, N. Semprini, B. Giacobbe, V. Speziali, G. Giacomini, Lucio Pancheri, Mauro Villa, G. Rizzo, Alberto Lusiani, M. Bomben, L. Vitale, E. Pozzati, Mauro Dell'Orso, Fabio Morsani, Alessandro Gabrielli, R. Di Sipio, C. Andreoli, G. Calderini, G. Fontana, L. Bosisio, Lodovico Ratti, P. Mereu, J. J. Walsh, S. Bettarini, Antonio Zoccoli, A. Gabrielli, G. Batignani, S. Bettarini, F. Bosi, G. Calderini, R. Cenci, M. Dell’Orso, F. Forti, P. Giannetti, M.A. Giorgi, A. Lusiani, G. Marchiori, F. Morsani, N. Neri, E. Paoloni, G. Rizzo, J. Walsh, C. Andreoli, L. Gaioni, E. Pozzati, L. Ratti, V. Speziali, M. Manghisoni, V. Re, G. Traversi, M. Bomben, L. Bosisio, G. Giacomini, L. Lanceri, I. Rachevskaia, L. Vitale, G.F. Dalla Betta, G. Soncini, G. Fontana, L. Pancheri, G. Verzellesi, D. Gamba, G. Giraudo, P. Mereu, R. Di Sipio, M. Bruschi, B. Giacobbe, F. Giorgi, C. Sbarra, N. Semprini, R. Spighi, S. Valentinetti, M. Villa, A. Zoccoli, Bomben, Marco, Bosisio, Luciano, Giacomini, Gabriele, Lanceri, Livio, I., Rachevskaia, Vitale, Lorenzo, SLIM5 Collaboration, et a. l., Gabrielli, A, Batignani, G, Bettarini, S, Bosi, F, Calderini, G, Cenci, R, Dell'Orso, M, Forti, F, Giannetti, P, Giorgi, Ma, Lusiani, Alberto, Marchiori, G, Morsan, F, Neri, N, Paoloni, E, Rizzo, G, Walsh, J, Andreoli, C, Gaioni, L, Pozzati, E, Ratti, L, Speziali, V, Manghisoni, M, Re, V, Traversi, G, Bomben, M, Bosisio, L, Giacomini, G, Lanceri, L, Rachevskaia, I, Vitale, L, Dalla Betta, Gf, Soncini, G, Fontana, G, Pancheri, L, Verzellesi, G, Gamba, D, Giraudo, G, Mereu, P, Di Sipio, R, Bruschi, M, Giacobbe, B, Giorgi, F, Sbarra, C, Semprini, N, Spighi, R, Valentinetti, S, Villa, M, and Zoccoli, A.
Subjects: Physics, Nuclear and High Energy Physics, CMOS sensor, Pixel, Physics::Instrumentation and Detectors, business.industry, Sparsification, Detector, HEPE, Chip, Settore ING-INF/01 - Elettronica, Matrix (mathematics), CMOS, Application-specific integrated circuit, MAPS, Master clock, business, Instrumentation, Computer hardware
Abstract: A prototype of a mixed-mode ASIC composed of a fast readout architecture that interfaces with a matrix of 4096 Monolithic Active Pixel Sensor (MAPS) was fabricated via STM 130 nm CMOS technology. Groups of 4 x 4 pixels form a macro-pixel (MP). The readout architecture is parallel and could overcome the readout speed limit of big matrices. As the output port can only accept one-hit information at a time, an internal queuing system has been provided to face high hit-rate conditions. The ASIC can work in two different manners as it can be connected to an actual full-custom matrix of MAPS or to a digital matrix emulator composed of standard cells, for testing facilities. For both operating modes a slow-control phase is required to load the chip configuration. Previous versions of similar ASICs were designed and tested. The work is aimed at improving the design of MAPS detectors with an on-chip fast sparsification system, for particle tracking, to match the requirements of future high-energy physics experiments. The readout architecture implemented is data driven extending the flexibility of the system to be also used in first level triggers on tracks in vertex detectors. Preliminary simulations and tests indicate that the readout system can cope with an average hit-rate up to 100 MHz/cm(2) if a master clock of 80 MHz is used, while maintaining an overall efficiency over 99%. (c) 2009 Elsevier B.V. All rights reserved.
Published: 2009

31. Development of deep N-well MAPS in a 130 nm CMOS technology and beam test results on a 4k-Pixel matrix with digital sparsified readout

Author: Rizzo, G., Avanzini, C., Batignani, G., Bettarini, S., Bosi, F., Calderini, G., Ceccanti, M., Cenci, R., Cervelli, A., Crescioli, F., Orso, M., Francesco Forti, Giannetti, P., Giorgi, M. A., Lusiani, A., Gregucci, S., Mammini, P., Marchiori, G., Massa, M., Morsani, F., Neri, N., Paoloni, E., Piendibene, M., Sartori, L., Walsh, J., Yurtsev, E., Manghisoni, M., Re, V., Traversi, G., Bruschi, M., Di Sipio, R., Giacobbe, B., Gabrielli, A., Giorgi, F., Pellegrini, G., Sbarra, C., Semprini, N., Spighi, R., Valentinetti, S., Villa, M., Zoccoli, A., Andreoli, C., Gaioni, L., Pozzati, E., Ratti, L., Speziali, V., Gamba, D., Giraudo, G., Mereu, P., Betta, G. F. D., Soncini, G., Fontana, G., Bomben, M., Bosisio, L., Cristaudo, P., Giacomini, G., Jugovaz, D., Lanceri, L., Rashevskaya, I., Vitale, L., Venier, G., Ieee, PAUL SELLIN, G. Rizzo, C. Avanzini, G. Batignani, S. Bettarini, F. Bosi, G. Calderini, M. Ceccanti, R. Cenci, A. Cervelli, F. Crescioli, M. Dell’Orso, F. Forti, P. Giannetti, M.A. Giorgi, A.Lusiani, S. Gregucci, P. Mammini, G. Marchiori, M. Massa, F. Morsani, N. Neri, E. Paoloni, M. Piendibene, A. Profeti, L. Sartori, J. Walsh, E. Yurtsev, M. Manghisoni, V. Re, G. Traversi, M. Bruschi, R. Di Sipio, B. Giacobbe, A. Gabrielli, F. Giorgi, G. Pellegrini, C. Sbarra, N. Semprini, R. Spighi, S. Valentinetti, M. Villa, A. Zoccoli, C. Andreoli, L. Gaioni, E. Pozzati, L. Ratti, V. Speziali, D. Gamba, G. Giraudo, P. Mereu, G.F. Dalla Betta, G. Soncini, G. Fontana, M. Bomben, L. Bosisio, P. Cristaudo, G. Giacomini, D. Jugovaz, L. Lanceri, I. Rashevskaya, L. Vitale, and G. Venier.
Subjects: Nuclear and High Energy Physics, Physics::Instrumentation and Detectors, Computer science, Settore ING-INF/01 - Elettronica, Signal-to-noise ratio, Nuclear Medicine and Imaging, MAPS, Charged particle tracking, CMOS pixels, Monolithic active pixel sensors, Radiation, Radiology, Nuclear Medicine and Imaging, Signal processing, Pixel, business.industry, Noise (signal processing), Electrical engineering, Content-addressable memory, Chip, CMOS, Scalability, ASSOCIATIVE MEMORY, PIXEL SENSORS, business, Radiology, Computer hardware
Abstract: We report on further developments of our recently proposed design approach for a full in-pixel signal processing chain of deep n-well (DNW) MAPS sensors, by exploiting the triple well option of a CMOS 0.13 µm process. The optimization of the collecting electrode geometry and the redesign of the analog circuit to decrease power consumption have been implemented in two versions of the APSEL chip series, namely “APSEL3T1” and “APSEL3T2”. The results of the characterization of 3x3 pixel matrices with full analog output with photons from55Fe and electrons from90Sr are described. Pixel equivalent noise charge (ENC) of 46 e- and 36 e- have been measured for the two versions of the front-end implemented toghether with signal-to-noise ratios between 20 and 30 for Minimum Ionizing Particles. In order to fully exploit the readout capabilities of our MAPS, a dedicated fast readout architecture performing on-chip data sparsiﬁcation and providing the timing information for the hits has been implemented in the prototype chip “APSEL4D”, having 4096 pixels. The criteria followed in the design of the readout architecture are reviewed. The implemented readout architecture is data-driven and scalable to chips larger than the current one, which has 32 rows and 128 columns. Tests concerning the functional characterization of the chip and response to radioactive sources have shown encouraging preliminary results. A successful beam test took place in September 2008. Preliminary measurements of the APSEL4D charge collection efﬁciency and resolution conﬁrmed the DNW device is working well. Moreover the data driven approach of the readout chips has been successfully used to demonstrate the possibility to build a Level 1 trigger system based on Associative Memories.
Published: 2009

32. Development of deep N-well monolithic active pixel sensors in a 0.13 um CMOS technology

Author: Bettarini, S., Bardi, A., Batignani, G., Bosi, F., Calderini, G., Cenci, R., Dell’Orso, M., Forti, F., Giannetti, P., Giorgi, M. A., Lusiani, A., Marchiori, G., Morsani, F., Neri, N., Paoloni, E., Rizzo, G., Walsh, J., Andreoli, C., Pozzati, E., Ratti, L., Speziali, V., Manghisoni, M., Re, V., Traversi, G., Bosisio, L., Giacomini, G., Lanceri, L., Rachevskaia, I., Vitale, L., Bruschi, M., Giacobbe, B., Semprini, N., Spighi, R., Villa, M., Zoccoli, A., Gamba, D., Giraudo, G., Mereu, P., Dalla Betta, G. F., Soncini, G., Fontana, G., Pancheri, L., Verzellesi, Giovanni, FRANCO CERVELLI, FRANCESCO FORTI, RICCARDO PAOLETTI, ANGELO SCRIBANO, S. Bettarini, A. Bardi, G. Batignani, F. Bosi, G. Calderini, R. Cenci, M. Dell’Orso, F. Forti, P. Giannetti, M.A. Giorgi, A. Lusiani, G. Marchiori, F. Morsani, N. Neri, E. Paoloni, G. Rizzo, J. Walsh, C. Andreoli, E. Pozzati, L. Ratti, V. Speziali, M. Manghisoni, V. Re, G. Traversi, L. Bosisio, G. Giacomini, L. Lanceri, I. Rachevskai, L. Vitale, M. Bruschi, B. Giacobbe, N. Semprini, R. Spighi, M. Villa, A. Zoccoli, D. Gamba, G. Giraudo, P. Mereu, G.F. Dalla Betta, G. Soncini, G. Fontana, L. Pancheri, and G. Verzellesi
Subjects: Physics::Instrumentation and Detectors, MONOLITHIC ACTIVE PIXEL SENSORS, MAPS, CMOS PIXELS, Monolithic active pixel sensors, CMOS pixels, Charged particle detectors, CHARGED PARTICLE TRACKING
Abstract: By exploiting the triple-well option available in a deep-submicron CMOS process, we developed monolithic active pixel sensors (MAPS) with the unique features of full analog signal processing and digital functionality implemented at the pixel level. After briefly reviewing the results achieved with the first prototype chip, we report on the extensive measurements on the second prototype, containing both single-channel sensors, with an improved noise figure, and an 8×8 pixel array. For the pixel having a collecting electrode area of Click to view the MathML source we measured an equivalent noise charge of about 40 electrons. Using the Click to view the MathML source 5.9 keV line, we obtained a Signal-to-noise (S/N) ratio of about 30. The pixel matrix Click to view the MathML source has been successfully readout up to 30 MHz. Through noise scans, an expected significant threshold dispersion has been measured. The measurements presented in this paper confirm the capability of our MAPS, based on the deep n-well concept, to be operated as ionizing radiation detectors and suggest a series of improvements we are already implementing in the design of the next prototype chip.
Published: 2007

33. Development of 130nm CMOS Monolithic Active Pixels with In-pixel Signal Processing

Author: R. Cenci, G.-F. Dalla Betta, G. Batignani, D. Gamba, Paola Giannetti, Mario Giorgi, B. Giacobbe, C. Andreoli, E. Paoloni, G. Rizzo, G. Fontana, G. Marchiori, L. Bosisio, G. Giacomini, Lucio Pancheri, Valerio Re, Marco Bruschi, R. Spighi, J. J. Walsh, N. Semprini, Massimo Manghisoni, F. Forti, L. Vitale, G. Calderini, V. Speziali, Gianluca Traversi, Giovanni Verzellesi, Mauro Villa, Mauro Dell'Orso, Fabio Morsani, S. Bettarini, Alessandro Gabrielli, G. Giraudo, Filippo Bosi, Nicola Neri, Lodovico Ratti, P. Mereu, L. Lanceri, Giovanni Soncini, I. Rachevskaia, E. Pozzati, A. Lusiani, Antonio Zoccoli, BERNARD PHLIPS, F. Forti, C. Andreoli, G. Batignani, S. Bettarini, F. Bosi, L. Bosisio, M. Bruschi, G. Calderini, R. Cenci, G.F. Dalla Betta, M. Dell’Orso, G. Fontana, A. Gabrielli, D. Gamba, B. Giacobbe, G. Giacomini, P. Giannetti, M.A. Giorgi, G. Giraudo, L. Lanceri, A. Lusiani, M. Manghisoni, G. Marchiori, P. Mereu, F. Morsani, N. Neri, L. Pancheri, E. Paoloni, E. Pozzati, I. Rachevskaia, L. Ratti, V. Re, G. Rizzo, N. Semprini, G. Soncini, R. Spighi, V. Speziali, G. Traversi, J. Walsh, G. Verzellesi, L. Vitale, M. Villa, and A. Zoccoli
Subjects: Physics, Signal processing, RIVELATORI A PIXEL ATTIVI, MAPS, CMOS, Charged particle tracking, Pixel, business.industry, Preamplifier, Physics::Instrumentation and Detectors, Detector, Electrical engineering, Analog signal processing, Chip, Optoelectronics, business, Digital signal processing
Abstract: We developed monolithic active pixel detectors that exploit the triple well option of CMOS 130nm technology to implement analog and digital signal processing at the pixel level. The charge collecting element is realized using the deep N-well (DNW) and partially overlaps the analog circuit. With this scheme we were able to implement a full in-pixel signal processing chain, composed of a charge preamplifier, shaper, discriminator, and latch. This approach has been validated by a first prototype (APSEL0), and we report here on the extensive measurements performed on the second prototype (APSEL1), containing various single pixel structures with analog readout and an 8×8 matrix of 50 × 50 μm2 pixels with sequential digital readout. For 900 μm2 pixels the equivalent noise charge has been measured to be 40 e−, with a S/N ratio of about 30 for the 55Fe 5.9 keV signal. The matrix readout has been tested up to 30 MHz and the crosstalk between pixels characterized. The threshold dispersion and the noise of the pixels in the matrix have been measured through noise scans. These measurements confirm the viability of the triple well process for MAPS fabrication, and indicate the design improvements for the next prototype chip (APSEL2).
Published: 2006

34. The SuperB silicon vertex tracker

Author: Bettarini, S., Avanzini, C., Batignani, G., Bosi, F., Ceccanti, M., Cenci, R., Cervelli, A., Crescioli, F., Orso, M., Forti, F., Giannetti, P., Giorgi, M. A., Gregucci, S., Mammini, P., Marchiori, G., Massa, M., Morsani, F., Nicola Neri, Paoloni, E., Piendibene, M., Profeti, A., Rizzo, G., Sartori, L., Walsh, J., Yurtsev, E., Lusiani, A., Manghisoni, M., Re, V., Traversi, G., Bruschi, M., Di Sipio, R., Giacobbe, B., Gabrielli, A., Giorgi, F., Pellegrini, G., Sbarra, C., Semprini, N., Spighi, R., Valentinetti, S., Villa, M., Zoccoli, A., Citterio, M., Liberali, V., Palombo, F., Andreoli, C., Gaioni, L., Pozzati, E., Ratti, L., Speziali, V., Gamba, D., Giraudo, G., Mereu, P., Dalla Betta, G. F., Soncini, G., Fontana, G., Bomben, M., Bosisio, L., Cristaudo, P., Giacomini, G., Jugovaz, D., Lanceri, L., Rashevskaya, I., Vitale, L., Venier, G., S. Bettarini, C. Avanzini, G. Batignani, F. Bosi, M. Ceccanti, R. Cenci, A. Cervelli, F. Crescioli, M. Dell'Orso, F. Forti, P. Giannetti, M.A. Giorgi, S. Gregucci, P. Mammini, G. Marchiori, M. Massa, F. Morsani, N. Neri, E. Paoloni, M. Piendibene, A. Profeti, G. Rizzo, L. Sartori, J. Walsh, E. Yurtsev, A.Lusiani, M. Manghisoni, V. Re, G. Traversi, M. Bruschi, R. Di Sipio, B. Giacobbe, A. Gabrielli, F. Giorgi, G. Pellegrini, C. Sbarra, N. Semprini, R. Spighi, S. Valentinetti, M. Villa, A. Zoccoli, M. Citterio, V. Liberali, F. Palombo, C. Andreoli, L. Gaioni, E. Pozzati, L. Ratti, V. Speziali, D. Gamba, G. Giraudo, P. Mereu, G.F. Dalla Betta, G. Soncini, G. Fontana, M. Bomben, L. Bosisio, P. Cristaudo, G. Giacomini, D. Jugovaz, L. Lanceri, I. Rashevskaya, L. Vitale, and G. Venier
Subjects: Physics::Instrumentation and Detectors, TRACKING DETECTORS, High Energy Physics::Experiment, SUPERB
Abstract: In the current design of the high luminosity SuperB asymmetric e+-e- collider, the center of mass boost is reduced with respect to BaBar and to efficiently perform the time-dependent measurements an improved vertex resolution is required. A vertex tracker based on the layout of the BaBar Silicon Vertex Tracker (SVT) with an additional innermost layer (Layer0) is a design that achieves such a tracking resolution, provided that the extra layer is placed at radius of 1.5 cm from the interaction point, its thickness is less than 1% X0 and it is able to withstand a background rate of several MHz/cm2. The different options for the Layer0 are reviewed, starting from the most technologically mature solution, a high resistivity short strip detector, describing then a smallpitch hybrid pixel detector and finally presenting the most challenging proposal, based on CMOS MAPS.

35. Vertex detector for the SuperB factory

Author: Rizzo, G., Batignani, G., Bettarini, S., Bosi, F., Calderini, G., Cenci, R., Cervelli, A., Orso, M., Forti, F., Giannetti, P., Giorgi, M. A., Lusiani, A., Marchiori, G., Massa, M., Morsani, F., Neri, N., Paoloni, E., Piendibene, M., Raffaelli, F., Walsh, J., Andreoli, C., Gaioni, L., Pozzati, E., Ratti, L., Speziali, V., Manghisoni, M., Re, V., Traversi, G., Bomben, M., Bosisio, L., Giacomini, G., Lanceri, L., Rachevskaia, I., Vitale, L., Verzellesi, G., Gamba, D., Giraudo, G., Mereu, P., Bruschi, M., Gabrielli, A., benedetto giacobbe, Semprini, N., Spighi, R., Villa, M., Zoccoli, A., G. Rizzo, G. Batignani, S. Bettarini, F. Bosi, G. Calderini, R. Cenci, A. Cervelli, M. Dell'Orso, F. Forti, P. Giannetti, M.A. Giorgi, A.Lusiani, G. Marchiori, M. Massa, F. Morsani, N. Neri, E. Paoloni, M. Piendibene, F. Raffaelli, J. Walsh, C. Andreoli, L. Gaioni, E. Pozzati, L. Ratti, V. Speziali, M. Manghisoni, V. R, G. Traversi, M. Bomben, L. Bosisio, G. Giacobini, L. Lanceri, I. Rachevskai, L. Vitale, G. Verzellesi, D. Gamba, G. Giraudo, P. Mereu, M. Bruschi, A. Gabrielli, B. Giacobbe, N. Semprini, R. Spighi, M. Villa, and A. Zoccoli
Subjects: Multidisciplinary, PIXEL, MAPS, SPARSIFICATION, VERTEX DETECTOR
Abstract: A new concept for a high-luminosity B-Factory (SuperB) has been recently proposed to deliver a luminosity greater than 10^36cm^-2s^-1 with moderate beam currents. Comparing to current B Factories, the reduced center of mass boost of the SuperB machine requires improved vertex resolution for optimal time dependent measurements, which form the basis of the SuperB scientific program. Design studies indicate that such improved resolution is achievable with a vertex detector based on the BABAR silicon vertex tracker layout with the addition of an innermost Layer 0 at radius of about 1.5 cm, with a material budget of about 0.5% X0 and capable to sustain a background rate of about 5MHz/cm2. Several options for the Layer 0 design are reviewed in this paper. CMOS Monolithic Active Pixels (MAPS) is the most promising technology but extensive R&D is needed to meet all the requirements. The most recent developments on a new CMOS MAPS sensor, based on Deep NWell (DNW), are discussed. The design of DNW CMOS MAPS has been recently proposed by the SLIM5 Collaboration to develop a thin pixel system with sparsified readout suitable for application in the SuperB Layer0. Several prototype chips, realized with the STMicroelectronics 130 nm triple well process, have demonstrated that the design is viable with good sensitivity to electrons from 90Sr. Based on the new DNW MAPS design,a dedicated fast readout architecture to perform on-chip data sparsification is currently under development.

36. The Brain-Heart Axis: An Umbrella Review on Impact of Psychiatric Disease on Incidence, Management, and Outlook of Cardiovascular Disease.

Author: Mazza M, Biondi-Zoccai G, Lisci FM, Brisi C, Sfratta G, Rossi S, Traversi G, Gaetani E, Pola R, Morini S, Romagnoli E, Simeoni B, Covino M, and Marano G
Abstract: Psychiatric conditions, such as depression, anxiety, bipolar disorder, and schizophrenia, are increasingly recognized as significant risk factors for cardiovascular disease (CVD). This review systematically analyzes evidence from various databases to provide a comprehensive understanding of the impact of psychiatric illnesses on the incidence, management, and prognosis of CVD. Key findings suggest a bidirectional relationship between psychiatric disorders and CVD, indicating that mental health conditions can predispose individuals to CVD, while CVD can exacerbate or trigger psychiatric symptoms. The review explores the underlying mechanisms of these associations, including behavioral factors, stress responses, and medication side effects. It also examines the challenges in managing CVD patients with comorbid psychiatric conditions, emphasizing the importance for integrated care approaches. This review underscores the necessity of considering mental health as an integral component of cardiovascular care and calls for further research to develop tailored management strategies for these complex conditions, ultimately aiming to improve patient outcomes and quality of life. This comprehensive analysis provides valuable insights for future investigations and guides clinicians in optimizing care for patients with both psychiatric and cardiovascular conditions.
Published: 2024
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37. Gut microbiota in women: The secret of psychological and physical well-being.

Author: Marano G, Traversi G, Gaetani E, Gasbarrini A, and Mazza M
Subjects: Female, Humans, Brain, Central Nervous System, Gastrointestinal Microbiome physiology, Microbiota
Abstract: The gut microbiota works in unison with the host, promoting its health. In particular, it has been shown to exert protective, metabolic and structural functions. Recent evidence has revealed the influence of the gut microbiota on other organs such as the central nervous system, cardiovascular and the endocrine-metabolic systems and the digestive system. The study of the gut microbiota is outlining new and broader frontiers every day and holds enormous innovation potential for the medical and pharmaceutical fields. Prevention and treatment of specific women's diseases involves the need to deepen the function of the gut as a junction organ where certain positive bacteria can be very beneficial to health. The gut microbiota is unique and dynamic at the same time, subject to external factors that can change it, and is capable of modulating itself at different stages of a woman's life, playing an important role that arises from the intertwining of biological mechanisms between the microbiota and the female genital system. The gut microbiota could play a key role in personalized medicine., Competing Interests: Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article., (©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.)
Published: 2023
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38. The Microbiota-Gut-Brain Axis: Psychoneuroimmunological Insights.

Author: Marano G, Mazza M, Lisci FM, Ciliberto M, Traversi G, Kotzalidis GD, De Berardis D, Laterza L, Sani G, Gasbarrini A, and Gaetani E
Subjects: Humans, Pituitary-Adrenal System, Brain physiology, Central Nervous System, Brain-Gut Axis, Hypothalamo-Hypophyseal System
Abstract: There is growing interest in the role that the intestinal microbiota and the related autoimmune processes may have in the genesis and presentation of some psychiatric diseases. An alteration in the communication of the microbiota-gut-brain axis, which constitutes a communicative model between the central nervous system (CNS) and the gastro-enteric tract, has been identified as one of the possible causes of some psychiatric diseases. The purpose of this narrative review is to describe evidence supporting a role of the gut microbiota in psychiatric diseases and the impact of diet on microbiota and mental health. Change in the composition of the gut microbiota could determine an increase in the permeability of the intestinal barrier, leading to a cytokine storm. This could trigger a systemic inflammatory activation and immune response: this series of events could have repercussions on the release of some neurotransmitters, altering the activity of the hypothalamic-pituitary-adrenal axis, and reducing the presence of trophic brain factors. Although gut microbiota and psychiatric disorders seem to be connected, more effort is needed to understand the potential causative mechanisms underlying the interactions between these systems.
Published: 2023
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39. Alcohol use disorder and liver injury related to the COVID-19 pandemic.

Author: Marano G, Traversi G, Gaetani E, Pola R, Claro AE, and Mazza M
Abstract: Alcohol use disorder is a complex and heterogeneous phenomenon that can be studied from several points of view by focusing on its different components. Alcohol is a hepatotoxin whose metabolism creates profound alterations within the hepatocyte. The liver is the central organ in the metabolism of alcohol, a process that also involves other organs and tissues such as the brain, heart and muscles, but the most relevant organ is the liver. The anatomopathological alterations in the liver associated with the prolonged use of alcohol range from the simple accumulation of neutral fats in the hepatocytes, to cirrhosis and hepatocellular carcinoma. Alcohol abuse frequently leads to liver disease such as steatosis, steatohepatitis, fibrosis, cirrhosis, and tumors. Following the spread of coronavirus disease 2019 (COVID-19), there was an increase in alcohol consumption, probably linked to the months of lockdown and smart working. It is known that social isolation leads to a considerable increase in stress, and it is also recognized that high levels of stress can result in an increase in alcohol intake. Cirrhotic patients or subjects with liver cancer are immunocompromised, so they may be more exposed to COVID-19 infection with a worse prognosis. This review focuses on the fact that the COVID-19 pandemic has made the emergence of alcohol-induced liver damage a major medical and social problem., Competing Interests: Conflict-of-interest statement: Authors declare no conflict of interests for this article., (©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.)
Published: 2022
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40. Taking Care of Intellectual Disabilities in the Era of COVID-19: Biological Substrates, Personalized Medicine and Counseling.

Author: Marano G, Traversi G, Gaetani E, Pecora RD, Paris A, Mazza S, and Mazza M
Subjects: Counseling, Humans, Precision Medicine, Surveys and Questionnaires, COVID-19, Intellectual Disability epidemiology, Intellectual Disability therapy
Published: 2022

41. Web-mediated Counseling Relationship in Support of the New Sexuality and Affectivity During the COVID-19 Epidemic: A Continuum Between Desire and Fear.

Author: Marano G, Traversi G, and Mazza M
Subjects: Epidemics, Female, Humans, Male, SARS-CoV-2, Sexuality, COVID-19 psychology, Counseling, Fear, Internet, Sexual Behavior psychology
Published: 2021
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42. Mental Health and Coaching Challenges Facing the COVID-19 Outbreak.

Author: Marano G, Traversi G, Gesualdi A, Biffi A, Gaetani E, Sani G, and Mazza M
Subjects: Disease Outbreaks, Humans, Mental Health, SARS-CoV-2, COVID-19, Mentoring
Published: 2021

43. Effect of p53 activation through targeting MDM2/MDM4 heterodimer on T regulatory and effector cells in the peripheral blood of Type 1 diabetes patients.

Author: Pellegrino M, Traversi G, Arena A, Cappa M, Rosado MM, Andreani M, Delfino DV, Moretti F, and Fierabracci A
Subjects: Adult, CD8-Positive T-Lymphocytes metabolism, Case-Control Studies, Cell Cycle Proteins metabolism, Diabetes Mellitus, Type 1 genetics, Female, Humans, Leukocytes, Mononuclear immunology, Male, Polymorphism, Genetic, Proto-Oncogene Proteins metabolism, Proto-Oncogene Proteins c-mdm2 metabolism, Tumor Suppressor Protein p53 antagonists & inhibitors, Tumor Suppressor Protein p53 genetics, Young Adult, Diabetes Mellitus, Type 1 immunology, Imidazoles pharmacology, Leukocytes, Mononuclear drug effects, Multiprotein Complexes antagonists & inhibitors, Peptides pharmacology, Piperazines pharmacology, T-Lymphocytes, Regulatory metabolism
Abstract: Various immunotherapies for the treatment of type 1 diabetes are currently under investigation. Some of these aim to rescue the remaining beta cells from autoimmune attack caused by the disease. Among the strategies employed, p53 has been envisaged as a possible target for immunomodulation. We studied the possible effect of p53 activation on Treg subsets and Treg/Teff balance in type 1 diabetes patients' PBMC. Upon p53 activation, we observed an increase in CD8+ Treg and activated CD8+ Teff whilst CD8+ Teff cells significantly decreased in healthy PBMC when stimulated with anti-CD3/CD28. No effect was detected on percentages of CD4+ Treg, while a reduction was seen in CD4+ Teff cells and an increase in activated CD4+ Teff cells. In patients' PBMC, upon p53 activation followed by 6 days of anti-CD3/CD28 stimulation, CD8+ Treg and activated CD8+ Teff were increased while CD8+ Teff were decreased. No differences were detected in the CD4+ counterparts. CD8+ Teff PD1+, CD8+ Teff PD1low were increased upon p53 activation in type 1 diabetics compared to controls while CD8+ Teff PD1high were increased in both groups. The same increased percentages were detected for CD4+ counterparts. CD4+ Treg PD1high cells were decreased in diabetics upon p53 activation at day 6 of anti-CD3/CD28 stimulation. In conclusion, a Teff dysregulation is observed upon p53 activation suggesting that molecules promoting p53 cannot be used for therapy in type 1 diabetics., Competing Interests: The authors have declared that no competing interests exist.
Published: 2020
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44. Evidence on the New Drug Lumateperone (ITI-007) for Psychiatric and Neurological Disorders.

Author: Mazza M, Marano G, Traversi G, Sani G, and Janiri L
Subjects: Alzheimer Disease psychology, Bipolar Disorder drug therapy, Dementia drug therapy, Dementia psychology, Dopamine D2 Receptor Antagonists pharmacology, Drug Partial Agonism, Heterocyclic Compounds, 4 or More Rings pharmacology, Humans, Receptor, Serotonin, 5-HT2A drug effects, Receptors, Dopamine D1 drug effects, Receptors, Dopamine D2 drug effects, Serotonin 5-HT2 Receptor Antagonists pharmacology, Serotonin Plasma Membrane Transport Proteins drug effects, Alzheimer Disease drug therapy, Dopamine D2 Receptor Antagonists therapeutic use, Heterocyclic Compounds, 4 or More Rings therapeutic use, Schizophrenia drug therapy, Serotonin 5-HT2 Receptor Antagonists therapeutic use, Sleep Wake Disorders drug therapy
Abstract: Lumateperone (ITI-007) is a tosylate salt with binding affinities to receptors implicated in the therapeutic actions of antipsychotic medications, including the serotonin 5HT2A receptors, dopamine D2 and D1 receptors and the serotonin transporter. It has a unique mechanism of action because it simultaneously modulates serotonin, dopamine, and glutamate neurotransmission, implicated in serious mental illness. It can be considered a multi-target-directed ligand and a multifunctional modulator of serotoninergic system with possible precognitive, antipsychotic, antidepressant and anxiolytic properties. Lumateperone has been investigated as a novel agent for the treatment of schizophrenia, but it represents a new potential option for other psychiatric and neurological diseases, such as behavioural symptoms of dementia or Alzheimer's disease, sleep disturbances, bipolar depression. Besides, it has demonstrated a favourable safety profile without significant extrapyramidal side effects, hyperprolactinemia or changes in cardiometabolic or endocrine factors versus placebo. Additional studies are warranted to confirm and examine the benefit of lumateperone and possible therapeutic targets. This paper is a comprehensive and thorough summary of the most important findings and potential future role of this particular compound in personalized treatments., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Published: 2020
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45. HIPK2 role in the tumor-host interaction: Impact on fibroblasts transdifferentiation CAF-like.

Author: Garufi A, Traversi G, Cirone M, and D'Orazi G
Subjects: Cancer-Associated Fibroblasts pathology, Cancer-Associated Fibroblasts physiology, Carrier Proteins genetics, Cells, Cultured, Colonic Neoplasms genetics, Colonic Neoplasms pathology, Culture Media, Conditioned pharmacology, Fibroblasts drug effects, Fibroblasts physiology, Humans, Protein Serine-Threonine Kinases genetics, Carrier Proteins metabolism, Cell Transdifferentiation, Fibroblasts pathology, Protein Serine-Threonine Kinases metabolism, Tumor Microenvironment physiology
Abstract: The dialogue between cancer cells and the surrounding fibroblasts, tumor-associated macrophages (TAM), and immune cells can create a tumor microenvironment (TME) able to promote tumor progression and metastasis and induce resistance to anticancer therapies. Cancer cells, by producing growth factors and cytokines, can recruit and activate fibroblasts in the TME inducing their transdifferention in cancer-associated fibroblasts (CAFs). Then, CAFs, in a reciprocal cross-talk with cancer cells, sustain cancer growth and survival and support malignancy and tumor resistance to therapies. Therefore, the identification of the molecular mechanisms regulating the interplay between cancer cells and fibroblasts can offer an intriguing opportunity for novel diagnostic and therapeutic anticancer purpose. HIPK2 is a multifunctional tumor suppressor protein that modulates cancer cell growth and apoptosis in response to anticancer drugs and negatively regulates pathways involved in tumor progression and chemoresistance. HIPK2 protein downregulation is induced by hypoxia and hyperglycemia and HIPK2 knockdown favors tumor progression and resistance to therapy other than a pseudohypoxic, inflammatory, and angiogenic cancer phenotype. Therefore, we hypothesized that HIPK2 modulation in cancer cells could contribute to modify the tumor-host interaction. In support of our hypothesis, here we provide evidence that culturing human fibroblasts (hFB) with conditioned media derived from cancer cells undergoing HIPK2 knockdown (CM siHIPK2 ) triggered their transdifferentiation CAF-like, compared to hFB cultured with CM-derived from HIPK2-carrying control cancer cells. CAF transdifferentiation was identified by expression of several markers including α-smooth muscle actin (α-SMA) and collagen I and correlated with autophagy-mediated caveolin-1 degradation. Although the molecular mechanisms dictating CAF-transdifferentiation need to be elucidated, these results open the way to further study the role of HIPK2 in TME remodeling for prognostic and therapeutic purpose., (© 2019 The Authors. IUBMB Life published by Wiley Periodicals, Inc. on behalf of International Union of Biochemistry and Molecular Biology.)
Published: 2019
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46. Reduced chemotherapeutic sensitivity in high glucose condition: implication of antioxidant response.

Author: Garufi A, Traversi G, Gilardini Montani MS, D'Orazi V, Pistritto G, Cirone M, and D'Orazi G
Abstract: Resistance to chemotherapy represents a major obstacle to successful treatment. The generation of reactive oxygen species (ROS) has been directly linked to the cytotoxic effects of several antitumor agents, including Adriamycin (ADR), and modulation of the oxidative balance has been implicated in the development and/or regulation of resistance to chemotherapeutic drugs. We recently showed that high glucose (HG) markedly diminished the cancer cell death induced by anticancer agents such as ADR. In the present study we attempted to evaluate the mechanism that impaired the cytotoxic effect of ADR in HG. We found that, in colon cancer cells, HG attenuated ADR-induced ROS production that consequently diminished ADR-induced H2AX phosphorylation and micronuclei (MN) formation. Mechanistically, HG attenuation of ADR-induced ROS production correlated with increased antioxidant response promoted by NRF2 activity. Thus, pharmacologic inhibition of NRF2 pathway by brusatol re-established the ADR cytotoxic effect impaired by HG. Together, the data provide new insights into chemotherapeutic-resistance mechanisms in HG condition dictated by increased NRF2-induced antioxidant response and how they may be overcome in order to restore chemosensitivity and ADR-induced cell death., Competing Interests: CONFLICTS OF INTEREST None.
Published: 2019
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47. A novel resveratrol derivative induces mitotic arrest, centrosome fragmentation and cancer cell death by inhibiting γ-tubulin.

Author: Traversi G, Staid DS, Fiore M, Percario Z, Trisciuoglio D, Antonioletti R, Morea V, Degrassi F, and Cozzi R
Abstract: Background: Resveratrol and its natural stilbene-containing derivatives have been extensively investigated as potential chemotherapeutic agents. The synthetic manipulation of the stilbene scaffold has led to the generation of new analogues with improved anticancer activity and better bioavailability. In the present study we investigated the anticancer activity of a novel trimethoxystilbene derivative (3,4,4'-trimethoxylstilbene), where two methoxyl groups are adjacent on the benzene ring (ortho configuration), and compared its activity to 3,5,4'-trimethoxylstilbene, whose methoxyl groups are in meta configuration., Results: We provide evidence that the presence of the two methoxyl groups in ortho configuration renders 3,4,4'-trimethoxystilbene more efficient than the meta isomer in inhibiting cell proliferation and producing apoptotic death in colorectal cancer cells. Confocal microscopy of α- and γ-tubulin staining shows that the novel compound strongly depolymerizes the mitotic spindle and produces fragmentation of the pericentrosomal material. Computer assisted docking studies indicate that both molecules potentially interact with γ-tubulin, and that 3,4,4'-trimethoxystilbene is likely to establish stronger interactions with the protein., Conclusions: These findings demonstrate the ortho configuration confers higher specificity for γ-tubulin with respect to α-tubulin on 3,4,4' trimethoxystilbene, allowing it to be defined as a new γ-tubulin inhibitor. A strong interaction with γ-tubulin might be a defining feature of molecules with high anticancer activity, as shown for the 3,4,4' isomer., Competing Interests: The authors declare that they have no competing interests.
Published: 2019
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48. Cariprazine in Bipolar Depression and Mania: State of the Art.

Author: Mazza M, Marano G, Traversi G, Carocci V, Romano B, and Janiri L
Subjects: Humans, Antipsychotic Agents therapeutic use, Bipolar Disorder drug therapy, Piperazines therapeutic use
Abstract: Background & Objective: Cariprazine is a piprazine derivative approved by the FDA in 2015 for the treatment of schizophrenia and bipolar manic or mixed episodes in adults. High affinity for D3 dopamine receptors and observed actions on 5HT1A, 5HT2A and alpha 1B receptors differentiate it pharmacologically from other antipsychotics. This review is a comprehensive and thorough summary of the most important findings on cariprazine use in bipolar mania and depression. Pharmacokinetics, pharmacogenetics, tolerability and safety adverse effects are discussed in this paper., Results & Conclusion: Moreover, the results from pivotal clinical trials are presented. Cariprazine represents an additional option for clinicians to treat patients with bipolar disorder. It shows a unique pharmacological profile and has demonstrated in randomized clinical trials efficacy and general tolerability compared to placebo in bipolar mania and seem to be a promising therapeutic option for bipolar depression., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
Published: 2018
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49. The resveratrol analogue trimethoxystilbene inhibits cancer cell growth by inducing multipolar cell mitosis.

Author: Traversi G, Fiore M, Percario Z, Degrassi F, and Cozzi R
Subjects: Animals, CHO Cells, Cell Cycle drug effects, Cell Proliferation drug effects, Cell Survival drug effects, Cricetulus, HeLa Cells, Humans, Neoplasms drug therapy, Neoplasms metabolism, Resveratrol, Stilbenes chemistry, Tubulin drug effects, Mitosis drug effects, Neoplasms genetics, Stilbenes pharmacology, Tubulin metabolism
Abstract: Natural compounds are extensively studied for their potential use in traditional and non-traditional medicine. Several natural and synthetic Resveratrol analogues have shown interesting biological activities in the field of cancer chemoprevention. In the present study, we have focused on the ability of Resveratrol and two methoxylated derivatives (Trimethoxystilbene and Pterostilbene) to inhibit human cancer cell growth particularly analyzing their ability to interfere with tubulin dynamics at mitosis. We show that Trimethoxystilbene, differently from Resveratrol and Pterostilbene, alters microtubule polymerization dynamics in HeLa cells specifically inducing multipolar spindles and mitotic arrest coupled to a reduction of cell growth and an increase in apoptotic death by mitotic catastrophe. This work demonstrates that the structural modification of Rsv causes substantial changes in the mechanism of action of the derivatives. The presence of three extra methyl groups renders Trimethoxy very efficient in impairing cell proliferation by inducing mitotic catastrophe in cancer cells. © 2016 Wiley Periodicals, Inc., (© 2016 Wiley Periodicals, Inc.)
Published: 2017
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50. Resveratrol affects DNA damage induced by ionizing radiation in human lymphocytes in vitro.

Author: Basso E, Regazzo G, Fiore M, Palma V, Traversi G, Testa A, Degrassi F, and Cozzi R
Subjects: Apoptosis drug effects, Apoptosis radiation effects, Cell Cycle drug effects, Cell Cycle radiation effects, DNA Damage drug effects, DNA Damage radiation effects, Flow Cytometry, Humans, Lymphocytes drug effects, Lymphocytes radiation effects, Resveratrol, Radiation, Ionizing, Stilbenes pharmacology
Abstract: Resveratrol (3,4',5-trihydroxystilbene; RSV) acts on cancer cells in several ways, inducing cell cycle delay and apoptotic death, and enhancing ionizing radiation (IR)-mediated responses. However, fewer studies have examined RSV effects on normal cells. We have treated human lymphocytes in vitro with RSV, either alone or combined with IR, to evaluate its potential use as a radioprotector. We measured the effects of RSV on induction of DNA damage, repair kinetics, and modulation of histone deacetylase activity., (Copyright © 2016 Elsevier B.V. All rights reserved.)
Published: 2016
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