73 results on '"Kolarova, M."'
Search Results
2. Fear of infection or fear of protection – driving factors of COVID-19 vaccine uptake in Bulgaria
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Rohova, M, primary, Pancheva, R, additional, Mihaylov, NL, additional, Radeva, N, additional, Ivanova, E, additional, Chamova, R, additional, Paunov, Ts, additional, Kolarova, M, additional, and Hadzhieva, S, additional
- Published
- 2022
- Full Text
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3. Attitudes towards mandatory vaccinations during the COVID-19 pandemic in Bulgaria
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Hadzhieva, S, primary, Chamova, R, additional, Ivanova, E, additional, Radeva, N, additional, Rohova, M, additional, Mihaylov, NL, additional, Paunov, Ts, additional, Kolarova, M, additional, and Pancheva, R, additional
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- 2022
- Full Text
- View/download PDF
4. In vitro cytotoxicity analysis of doxorubicin-loaded/superparamagnetic iron oxide colloidal nanoassemblies on MCF7 and NIH3T3 cell lines
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Tomankova K, Polakova K, Pizova K, Binder S, Havrdova M, Kolarova M, Kriegova E, Zapletalova J, Malina L, Horakova J, Malohlava J, Kolokithas-Ntoukas A, Bakandritsos A, Kolarova H, and Zboril R
- Subjects
Medicine (General) ,R5-920 - Abstract
Katerina Tomankova,1 Katerina Polakova,2 Klara Pizova,1 Svatopluk Binder,1 Marketa Havrdova,2 Mary Kolarova,2 Eva Kriegova,3 Jana Zapletalova,1 Lukas Malina,1 Jana Horakova,1 Jakub Malohlava,1 Argiris Kolokithas-Ntoukas,4 Aristides Bakandritsos,4 Hana Kolarova,1 Radek Zboril2 1Department of Medical Biophysics, Institute of Translation Medicine, Faculty of Medicine and Dentistry, 2Regional Centre of Advanced Technologies and Materials, Departments of Physical Chemistry and Experimental Physics, Faculty of Science, 3Department of Immunology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic; 4Department of Materials Science, University of Patras, Patras, Greece Abstract: One of the promising strategies for improvement of cancer treatment is based on magnetic drug delivery systems, thus avoiding side effects of standard chemotherapies. Superparamagnetic iron oxide (SPIO) nanoparticles have ideal properties to become a targeted magnetic drug delivery contrast probes, named theranostics. We worked with SPIO condensed colloidal nanocrystal clusters (MagAlg) prepared through a new soft biomineralization route in the presence of alginate as the polymeric shell and loaded with doxorubicin (DOX). The aim of this work was to study the in vitro cytotoxicity of these new MagAlg–DOX systems on mouse fibroblast and breast carcinoma cell lines. For proper analysis and understanding of cell behavior after administration of MagAlg–DOX compared with free DOX, a complex set of in vitro tests, including production of reactive oxygen species, comet assay, cell cycle determination, gene expression, and cellular uptake, were utilized. It was found that the cytotoxic effect of MagAlg–DOX system is delayed compared to free DOX in both cell lines. This was attributed to the different mechanism of internalization of DOX and MagAlg–DOX into the cells, together with the fact that the drug is strongly bound on the drug nanocarriers. We discovered that nanoparticles can attenuate or even inhibit the effect of DOX, particularly in the tumor MCF7 cell line. This is a first comprehensive study on the cytotoxic effect of DOX-loaded SPIO compared with free DOX on healthy and cancer cell lines, as well as on the induced changes in gene expression. Keywords: DOX/SPIO nanocarriers, superparamagnetic iron oxide nanoparticles, doxorubicin, in vitro cytotoxicity
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- 2015
5. On the Absolute Maximal Concentrations of Polydispersive Particles from a Gaussian Plume Model Under Unstable Conditions
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Yordanov, D. L., Ganev, K. G., Kolarova, M. P., Melas, Dimitrios, editor, and Syrakov, Dimiter, editor
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- 2003
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6. Parameterization of PBL from the Surface Wind and Stability Classes Data
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Yordanov, D. L., Syrakov, D. E., Kolarova, M. P., Melas, Dimitrios, editor, and Syrakov, Dimiter, editor
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- 2003
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7. Model of Long-Range Pollutants Transport and Acidity of Precipitation for Baltic Region
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Syrakov, D., Kolarova, M., Perkauskas, D., Senuta, K., Mikelinskene, A., Gryning, Sven-Erik, editor, and Millán, Millán M., editor
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- 1994
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8. Variation of short-lived beta radionuclide (radon progeny) concentrations and the mixing processes in the atmospheric boundary layer
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Veleva, B., Valkov, N., Batchvarova, E., and Kolarova, M.
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- 2010
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9. The Bulgarian Emergency Response System for dose assessment in the early stage of accidental releases to the atmosphere
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Syrakov, D., Veleva, B., Prodanova, M., Popova, T., and Kolarova, M.
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- 2009
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10. Effect of probiotics on the viability of porcine and human neutrophils in vitro
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Sustrova, T., primary, Ondrackova, P., additional, Leva, L., additional, Kolarova, M., additional, Kulich, P., additional, and Sladek, Z., additional
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- 2017
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11. Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study
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Keth, Th, Azoulay, E, Echeverria, Pm, Vincent, Jl, Collaboratorsmargarit, A, Valentini, R, Alan Javier, Z, Bevilacqua, C, Curone, M, Rabuffetti, R, Comignani, P, Torres Boden, M, Chertcoff, F, Cardonatti, G, Adén, F, Marcos, L, Dónofrio, M, Fernández, R, Lamberghini, R, Balasini, S, Teves, J, Las Heras, M, Sinner, J, Ceraso, D, Curcio, D, Aguilar, L, Weller, C, Cardonnet, L, Santa Cruz, R, Manrique, E, Bernardez, D, Iolster, T, Chiappero, G, Ramos, P, Vergara, J, Moine, I, Ilutovich, S, Jannello, G, Waschbusch, M, Rios Picaza, G, Raimondi, A, Miriam, M, Lovesio, C, Caridi, M, Leong, T, Orford, N, Reece, G, Ernest, D, Hawker, F, Tan, J, Giannellis, C, Ihle, B, Bersten, A, Mcinnes, J, Tallott, M, Mcfadyen, B, Vibert, J, Parr, M, Tran, K, Sutton, J, Webb, S, Groves, N, Cole, L, Long, D, Bass, F, Erickson, S, Lipman, J, Delzoppo, C, Thomas, J, Dobb, G, Daley, M, Roberts, B, Santamaria, J, Young, J, Festa, M, Holland, R, Mullany, D, Williams, P, Corkeron, M, Gales, M, Banerjee, A, Yung, M, Mutz, N, Hiesmayr, M, Faybik, P, Fitzgerald, R, Firlinger, F, Zasmeta, G, Zink, M, Sieber, W, Hildegard, J, Bakondy, R, Schlieber, J, Filzwieser, G, Beer, R, Joannidis, M, Schuster, R, Scherzer, W, Smolle, K, Fitzal, S, Manzoor, R, Brunain, J, D'Hondt, A, Huylenbroeck, G, Van der Schueren, M, 't Kindt, H, Slock, E, Rijckaert, D, Raemaekers, J, Bourgeois, M, Van Cotthem, I, Nackaerts, G, Gusu, D, Gadisseux, P, Vancollie, O, Lignian, H, Michel, P, Fraipont, V, Vander Stappen, M, Forêt, F, De Bels, D, Devriendt, J, Massaut, J, Biston, P, Roman, A, Lambermont, B, De Meulder, A, Frederic, V, Sottiaux, T, Ruyffelaere, P, Collin, V, Anane, S, Kleiren, P, Simon, M, Machayekhi, S, Frans, E, Leroy, G, Berghmans, T, Joseph, R, Eerens, J, Laterre, P, Lagrou, B, Rutsaert, R, Pisarek, W, Dive, A, De Waele, J, Spapen, H, Damas, P, Malbrain, M, Hidalgo, J, Baptista, M, Salgado, D, Braga, M, Avila, C, Westphal, G, Caser, E, Alves, A, Friedman, G, Luz, M, Assuncao, M, Reis, H, Gomes, A, Silva, U, Nogueira Fh, W, El Dash, S, Valiatti, J, Barbosa, A, Coelho, C, Knibel, M, Minelli, C, Caovilla, J, Teixeira, G, Hovnanian, A, Rea Neto, A, Lobo, S, Lugarinho, M, Souza, P, Ferreira, D, Duarte, P, Oliveira, M, Marques, J, Machado, R, Rehder, P, Mataloun, S, Grilo, M, Quesado, P, Moock, M, Ferreira, F, Teles, J, Silva, E, Morais, A, Bruzzi de Carvalho, F, Wanderley, M, Velasco, M, Brandão da Silva, N, Feijó, J, Souza Dantas, V, Costa Filho, R, Japiassú, A, Villela, D, Santos, C, Passos, R, Alheira Rocha, R, Silva, R, Houly, J, Aldrighi, J, Hatum, R, Suparregui Dias, F, Ferreira, L, Ferro, L, Gomez, J, Fleury, R, David, C, Resener, T, Mendes, C, Germano, A, De Marco, F, Lage, S, Salluh, J, Torelly, A, Sad, R, Oliveira, G, Lima, R, Paranhos, J, Rocha, M, Bitencourt, W, Grion, C, Forte, D, Guimarães, H, Piras, C, Stephanova, L, Lyubenov, L, Tsarianski, G, Dimov, G, Green, R, Levasseur, J, Ward, R, Lesur, O, Poirier, G, Wax, R, Wood, G, Cook, D, Marshall, J, Herridge, M, Ferguson, N, Espinoza, M, Valdés jimenez, S, Bruhn, A, Micolich, J, Fricke, G, Galvez, S, Escamilla Leon, I, Zhan, Q, Xu, Y, Zhao, Y, Zhang, L, Qin, T, Du, B, Li, M, Wang, X, Jing, Y, Zhang, Z, Xianyao, W, Li, F, Congshan, Y, Rebolledo, C, Diaz, D, Murillo Arboleda, R, Arias Antun, A, Montenegro, G, Granados, M, Dueñas, C, Perez, N, Libreros Duque, G, Coral, M, Ortiz, G, Rodriguez, D, Barsic, B, Cubrilo Turek, M, Gornik, I, Grljusic, M, Caballero lopez, A, Iraola Ferrer, M, Pavlik, P, Manak, J, Radej, J, Belohlavek, J, Sevcik, P, Blahut, L, Tyl, D, Steinbach, J, Herold, I, Zykova, I, Prchal, D, Bartosik, T, Kolarova, M, Hájek, R, Kohoutová, J, Marek, O, Hon, P, Chytra, I, Betsch, H, Fogh, B, Espersen, K, Jacobsen, K, Berezowicz, P, Andrade, C, Guerrero, F, Salgado, E, Barahona, D, Del Pozo Sanchez, H, Jibaja, M, Alansary, A, Reintam, A, Starkopf, J, Harjola, V, Tual, L, Leone, M, Serge, M, Leroy, O, Mallet, L, Marc, B, Dormoy, D, Pascal, H, Tronchon, L, Garrigues, B, Santré, C, Dupont, H, Duranteau, J, Leon, A, Henry, L, Canevet, C, Dube, L, Julien, H, Nadia, A, Francois, B, Gérard, J, Freysz, M, Remy, G, Blanloeil, Y, Squara, P, Korach, Jm, Durand, M, Gabriel, C, Eric, P, Jacobs, F, Bronchard, R, Kipnis, E, Moussa, M, Launoy, A, Guérin, C, Vanhems, P, Wynckel, A, Clair, B, Fulgencio, J, Gottwalles, Y, Krummel, T, Lepape, A, Lesieur, O, Payen, D, Hérvé, O, Farkas, J, Cougot, P, Mallédant, Y, Joannes Boyau, O, Standl, T, Sierig, U, Geiseler, J, Hopf, H, Conrad Opel, E, Hermann, C, Ventzke, M, Henneberg, T, Esposito, F, Loeser, H, Spies, C, Zuckermann Becker, H, Voegeler, S, Scherer, R, Pauer, A, Kljucar, S, Delfs, K, Blank, E, Busch, J, Wendt, K, Lessmann, J, Bach, F, Sakr, Y, Berlet, T, Kernchen, A, Quintel, M, Holst, D, Kilger, E, Holubarsch, T, Raufhake, C, Stolt, C, Lubasch, A, Meier Hellmann, A, Woebker, G, Scharnofske, C, Breyer, M, Risch, T, Manhold, C, Goethe, Jw, Meininger, D, Greive, C, Rau, J, Seibel, A, Henn beilharz, A, Wolbert, R, Scherke, T, Martin, J, Rudolph, M, Gleissner, J, Wolf, M, Schleibach, F, Jaschinski, U, Lunkeit, A, Welte, M, Bingold, T, Kogelmann, K, Fischer, F, Fischer, B, Schmid, M, Klein, M, Bechtold, A, Bodmann, K, Klasen, J, Meyrl, H, Goetz, J, Geldner, G, Helmes, T, Jensen, N, Eickmeyer, H, Lengfelder, W, Langenstein, B, Bogdanski, R, Jelen Esselborn, S, Umgelter, A, Dörr, F, Lüttje, K, Heinemeyer, D, Uhl, M, Schirle, P, Benad, H, Glaser, M, Panzer, W, Huettemann, E, Stierwaldt, R, Schappacher, M, Müller, E, Stadlmeyer, W, Fantini, M, Dummer, B, Thörner, M, Jost, V, Loerbroks, T, Glück, T, Zimmermann, R, Clement, R, Hering, R, Klinger, T, Mehl, J, Polozek, H, Rothhammer, A, Seidler, R, Lorenz, P, Mueritz, W, Lutze, M, Euler, M, Heintz, M, Winkler, M, Angstwurm, M, Krohe, K, Treu, T, Steiner, T, Locher, S, Walz, A, Zahn, P, Brandt, W, Marks, M, Henning, F, Janssens, U, Luethgens, M, Theelen, W, Sydow, M, Weber, M, Meiser, A, Deutschmann, C, Buttner, C, Jokiel, M, Bozzetti, C, Jürgen, B, Fiedler, F, Wresch, K, Kremer, A, Bleier, H, Rueckert, M, Ditter, H, Peckelsen, C, Friederich, P, Weber, K, Krueger, W, Lowack, R, Michalsen, A, Ragaller, M, Groeschel, A, Friedrich, T, Hinz, M, Christel, A, Hartwig, T, Kaisers, U, Schmitt, D, Vögeler, S, Weiss, M, Reiter, K, Schwab, T, Trieschmann, U, Kindgen milles, D, Engel, J, Sedemund adib, B, Lauterbach, M, Max, M, Volkert, T, Waydhas, C, Hien, S, Briegel, J, Guralnik, V, Zoremba, N, Riessen, R, Müllges, W, Nierhaus, A, Strauss, R, Utzolino, S, Thul, J, Abel, P, Gründling, M, Kessler, W, Scheuren, K, Vagts, D, Rensing, H, Schoch, B, Kopp, K, Gerlach, H, Corea, M, Uhrig, A, Schroeder, S, Jordan, F, Huber, T, Bittinger, M, Sofianos, E, Armaganidis, A, Routsi, C, Bitzani, M, Chalkiadaki, A, Michalopoulos, A, Mouloudi, E, Ioannidou, E, Myrianthefs, P, Koulenti, D, Karampela, I, Kyriazopoulos, G, Mandragos, K, Clouva molyvdas, P, Moraiti, A, Pneumatikos, I, Filos, K, Zakynthinos, E, Kotanidou, A, Vakalos, A, Cheng, A, Buckley, T, Gomersall, C, Kiss, K, Tamási, P, Sarkany, A, Csomos, A, Zöllei, É, Todi, S, Udwadia, F, Shah, R, Amin, P, Samavedam, S, Mathai, A, Patil, M, Jog, S, Gurjar, M, Vats, M, Varma, A, Gopal, P, Kapadia, F, Chawla, R, Iyer, S, Sahu, S, Bakshi, C, Ambike, D, Govil, D, Karipparambath, V, Chacko, J, Sathe, P, Rungta, N, Jani, C, Bhome, A, Prayag, S, Ray, S, Rajagopalan, R, Divatia, J, Da costa, R, Shyam Sunder, T, Wibowo, P, Maskoen, T, Sugiman, T, Nowruzinia, S, Lotfi, A, Mahmoodpoor, A, Donnelly, M, Breen, D, Ng, S, Bates, J, Sprung, C, Lev, A, Kishinevsky, E, Cohen, J, Sofer, S, Vesconi, S, Greco, S, Borelli, M, Cecilia, P, Sapuppo, M, Lazzero, A, Mangani, V, Petrucci, N, Minerva, M, Rummo, G, De blasio, E, Marzorati, S, Rosi, R, Giarratano, A, Margarit, O, Guberti, A, Scolz, S, Stelian, E, Emmi, V, Caspani, M, Rosano, A, Abbruzzese, C, Colonna, S, Ceriani, R, De Blasi, R, Panella, L, Borrelli, F, Lorella, P, Ruatti, H, Munch, C, Sorbara, C, Fiore, G, Chieregato, A, Conti, V, Guadagnucci, A, Pizzamiglio, M, Locicero, Mt, Marri, I, Sicignano, A, Conte, V, Oggioni, R, De Gasperi, A, De negri, P, Santagostino, G, Roberto, F, Marino, G, Castiglione, G, Sforza, D, Camillo, S, Giuseppe, N, Bassetti, Matteo, Napoli, D, Ferraro, F, Clementi, S, Di Filippo, A, Cotogni, P, Ranieri, Mv, Antonelli, M, Martinelli, L, Gianesello, L, Gullo, A, Morelli, A, Biancofiore, G, DELLA ROCCA, Giorgio, Hashimoto, S, Onodera, M, Kobayashi, A, Shinozuka, T, Imanaka, H, Ikeda, T, Yaguchi, A, Misane, I, Piebalga, A, Moughaghab, A, Pilvinis, V, Vosylius, S, Balciunas, M, Kekstas, G, Margaret, H, Klop, M, Grozdanovski, K, Eftimova, B, Wafa, S, Lim, C, Mat nor, M, Tai, L, Syed Mohd Tahir, S, Idris, N, Tan, C, Borg, M, Manzo, E, Gutierrez Morales, H, Miguel, P, Villagomez, A, Bassols, A, Aguirre, G, Cerón, U, Lopez ramos, J, Monjardín, J, Bermudez Aceves, E, Gonzalez Salazar, F, Rodriguez Gonzalez, D, Poblano Morales, M, Ramirez, F, Cetina, M, Navarro, J, Villagomez Ortiz, A, Sanchez, V, Chavarria, U, Fernandez Ponce, O, Serna secundino, H, Leonardo, O, Diego Manuel, R, Mijangos, J, Vazquez de Anda, G, Martin, E, Gutierrez, P, López Islas, I, Soberanes, L, Pejakov, L, Sbihi, A, Ouahid, B, Naoufel, M, De Pont, A, Rosseel, P, Ten Cate, J, Van Berkel, G, Corsten, S, Bakker, J, Vogelaar, J, Blom, H, Kieft, H, Kuiper, M, Gille, A, Pickkers, P, Vet, J, Ammann, J, Den Boer, S, Wesselink, R, Speelberg, B, Pham, C, Rodgers, M, Bergmans, D, Groeneveld, J, Mcarthur, C, Parke, R, Mehrtens, J, Celi, L, Freebairn, R, Rankin, N, Heffernan, C, Mchugh, G, Beca, J, Van haren, F, Barry, B, Kalkoff, M, Loevstad, R, Klepstad, P, Erno, P, Junker, A, Naqvi, S, Javed, I, Sinclair, J, Rivera, R, Chavez, C, Donayre Taber, Z, Quispe Sierra, R, Muñoz, J, Galvez Ruiz, J, Fang Li, J, Candiotti Herrera, M, Arroyo, A, Becerra, R, Meza, J, Mayorga, M, Garba, P, Kot, J, Gaszynski, T, Piechota, M, Renata, S, Müller, P, Stepinska, J, Jacek, K, Cieniawa, T, Mikstacki, A, Tamowicz, B, Bartkowska Sniatkowska, A, Karpel, E, Kusza, K, Smuszkiewicz, P, Mikaszewska Sokolewicz, M, Goraj, R, Kubler, A, Bártolo, A, Castelo Branco Sousa, M, Esteves, F, Martins, A, João, Hs, Oliveira, T, Ponce, P, Mourão, L, Febra, C, Carmo, E, Lopes, V, Póvoa, P, Rezende, A, Costa, H, Moreira, P, Pádua, F, Leite, A, Almeida, E, Alves, M, Sousa, A, Telo, L, João, S, Dias, C, Paiva, J, Ribeiro, R, Amaro, P, Carneiro, A, Moreno, R, Matos, R, Afonso, S, Bouw, M, França, C, Ibrahim, A, Tabacaru, R, Ionita, V, Tulbure, D, Filipescu, D, Pascanu, S, Grigoras, I, Copotoiu, S, Popov, D, Lebedev, E, Olga, I, Yaroshetskiy, A, Lugovkina, T, Dmitry, B, Malinin, O, Lekmanov, A, Abulmagd, M, Arabi, Y, Alhashemi, J, Ali, A, Maghrabi, K, Debek, A, Malik, M, Jankovic, R, Palibrk, I, Maravic stojkovic, V, Malenkovic, V, Surbatovic, M, Bumbasirevic, V, Lim, N, Loh, T, Tan, H, Sekeresova, H, Koutun, J, Firment, J, Malik, P, Trenkler, S, Muzlovic, I, Kosec, L, Ozek, B, Kasnik, D, Tomic, V, Knafelj, R, Svigelj, V, Du Plessis, H, Raine, R, Bhagwanjee, S, Richards, G, Goosen, J, De Jager, J, Schleicher, G, Rubio, O, Mañez, R, Burgueño Campiñez, M, Alvarez, M, Jorda, R, Naveira Abeigón, E, Monedero, P, Alemparte Pardavila, E, Garcia del Valle, S, Perez Calvo, C, Palomar, M, Caballero Zirena, A, Arribas, M, Bustamante Munguira, E, Ruiz, J, Blanco Vicente, A, Zavala, E, Valencia, M, Blesa Malpica, A, Martinez Sagasti, F, Nieto, M, Aguilar, G, Martinon Torres, F, Lorente, C, Insausti, J, Vegas Pinto, R, Santos, I, Escriba, A, Olaechea, P, Muñoz, E, Antón Caraballo, E, Galdos Anuncibay, P, Lopez Camps, V, Esteban Reboll, F, Estella, A, Bocero, L, Ibañez, A, Yagüe, G, Pueyo, L, María Jesús, L, Iglesias Fraile, L, Silva, J, Garro, P, Palma, L, Ramos gómez, L, Rovira, A, Martin Delgado, M, Monton Dito, J, Garcia, F, Latour Perez, J, Albaya, A, Bustinza, A, Sole violán, J, Ugarte Peña, P, Yuste, I, De Rojas Román, J, Vallés, J, Esteban, E, Quintana Tort Martorell, E, Moreno, M, López Ciudad, V, Manzano Ramirez, A, Sánchez Olmedo, J, Borges, M, Amador Amerigo, J, Guerrero Gomez, F, Montejo González, J, Sirvent, J, Pujol, I, Mesalles Sanjuan, E, Barcenilla Gaite, F, Serrano, N, Cerdá, E, Lesmes Serrano, A, Garcia Fuentes, C, Macias Pingarrón, J, Espinosa, E, Sanchez Garcia, M, Felices, F, de la Torre Prados, M, Maria Jesus, H, Luis, V, Jara, R, Briones Lopez, M, Posada, P, Galvan, B, Mariscal, F, Rello, J, Gil, B, Sierra, R, Rico Feijoo, J, Izura, J, González, J, Soto Ibáñez, J, Agabani, H, Petersen, P, Johansson, L, Blomqvist, H, Peterzén, B, Wyon, N, Lindström, I, Paulsson, A, Agvald Ohman, C, Petersson, J, Friberg, H, Einar, V, Hammarskjöld, F, Schindele, M, Arvidsson, S, Sellgren, S, Hulting, J, Häggqvist, J, Rudenstam, J, Lind, D, Kokinsky, E, Owall, A, Jacobson, S, Stiernstrom, H, Nydahl, A, Eggimann, P, Stocker, R, Loderer, G, Loetscher, R, Heer, K, Zender, H, Cottini, S, Pagnamenta, A, Eich, G, Felleiter, P, Marco, M, Pugin, J, Shu Hui, W, Hsieh, K, Toomtong, P, Khwannimit, B, Kietdumrongwong, P, Khaldi, A, Messadi, A, Labbene, I, Frikha, N, Atalan, K, Ates, C, Kahveci, A, Ozgencil, E, Kizilkaya, M, Bosnak, M, Bodur, H, Akan, M, Guven, M, Turkoglu, M, Topeli, A, Togal, T, Uzel, N, Akinci, I, Cakar, N, Tugrul, S, Demirkiran, O, Adanir, T, Dogruer, K, Turkmen, A, Guven, H, Ulger, F, Kocak, S, Nalapko, Y, Rady, S, Alsabbah, A, Elahi, N, Al rahma, H, Rahman, M, Kashef, S, Cuthbertson, B, Gunning, K, Myint, Y, Bewley, J, Burnstein, R, Haji Michael, P, Wrathall, D, Folan, L, Nesbitt, I, Ratnaparkhi, A, Pambakian, S, Booth, M, Watters, M, Sherry, T, Buehner, U, Barrera Groba, C, Bothma, P, George, N, Frater, J, Hollos, L, Mclellan, S, Hunter, J, Garrioch, M, O'Keeffe, N, Divekar, N, Eggert, S, Smith, S, Vincent, A, Withington, P, Macmillan, C, Webster, R, Vuylsteke, A, Appadu, B, Barrera groba, C, Mcquillan, P, Blunt, M, Parekh, N, William, D, Jones, C, Krige, A, Schuster Bruce, M, Boyden, J, Boulanger, C, Swann, D, Walker, J, Wigmore, T, Law, R, Baldwin, F, Muench, C, Robinson, S, Crerar Gilbert, A, Rhodes, A, Mahambrey, T, Cameron, L, Thornton, J, Stotz, M, Russell, M, Longmate, A, Kitson, R, Browne, B, Thorniley, A, Gonzalez, I, Swart, M, Singer, M, Gautam, N, Prasad, V, Watson, D, Szakmany, T, Cardy, J, Binning, A, Loveland, R, Gannon, J, Martinelli, G, Nightingale, P, Howes, J, Steingrub, J, Ammons, L, Fisher, M, Gandhi, N, Martin, G, Deutschman, C, Dean, N, Michetti, C, Belzberg, H, Hutchinson, K, Van der kloot, T, Afessa, B, Kaufman, D, Iqbal, J, Ost, D, Afifi, S, West, M, Wunderink, R, Stein, S, Hagg, D, Jimenez, E, Blosser, S, Chhangani, S, Kleinpell, R, Reich, H, Fields, E, Willms, D, Castellanos Mateus, P, Melnik, L, Oud, L, Chi, E, Halfon, R, Badr, A, Restrepo, M, Pohlman, A, Branson, R, Simpson, S, Kett, D, Jacobs, T, Park, P, Wahl, W, Patricia, C, Hammersley, J, Papadimos, T, Sawyer, R, Freire, A, Rodriguez, W, Ryan, A, Margolis, B, Groth, M, Escanda, H, Baraibar, J, Paciel, D, Bagnulo, H, Hitta, F, Nadales, P, Albornoz, H, Salmen, Z, Pacheco, C, Bui, T, Potie, F, and Nguyen Huu, C.
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- 2011
12. Evaluation of wind and turbulent parameterisations for short range air pollution modeling
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YORDANOV D. (1), KOLAROVA M. (1), RIZZA U. (2), MANGIA C. (2), and TIRABASSI T. (3) e SYRACOV D. (1)
- Abstract
Most of the air quality dispersion models used for regulatory applications are based on K-diffusion formulations. In this paper, two turbulent parameterisations for dispersion models in the atmospheric boundary layer are evaluated with experimental data. The first scheme is based on a similarity approach and provides wind and eddy diffusivity profiles on the basis of a diagnostic PBL model. The second one provides an eddy diffusivity profile based on the Taylor statistical diffusion theory and on the spectral properties of turbulence. The two parameterisations have been included in a numerical grid model and tested with the Copenhagen data set. Results show tha: i) the dispersion model with both turbulent schemes, produces a good fitting of the measured ground-level concentration data for all the experimental conditions considered; ii) there are no significant differences between the two schemes in the range of experimental data - the profiles are close to each other in the lower layers while they show larger differences in the layer above the surface layer. Therefore, both parameterisations give a realistic description of the dispersion processes in the lower PBL, and can be used for short range air pollution models and ground level concentrations.
- Published
- 2006
13. ID 363 – Development of novel paradigms for social neuroscience – Ongoing bilateral project
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Kašpárek, T., Krpoun, Z., Landa, L., and Kolářová, M.
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- 2016
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14. Nosocomial infections – 5 years of prevalence studies in the Czech Republic
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Cecetkova, B., primary, Schreinerova, M. Girod, additional, Kolarova, M., additional, Kancelova, Z., additional, Chlibek, R., additional, Jirous, J., additional, Kapek, J., additional, Kohoutova, J., additional, Kratochvilova, J., additional, Kurkova, V., additional, Mickova, E., additional, Podzimkova, M., additional, Ryantova, V., additional, Sipova, I., additional, and Totusek, P., additional
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- 2010
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15. Structural Elucidation of a Bioactive Metabolites Produced byStreptomyces AvidiniiSB9 Strain, Isolated from Permafrost Soil in Spitsbergen, Arctic
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Ivanova, V., primary, Lyutskanova, D., additional, Kolarova, M., additional, Aleksieva, K., additional, Raykovska, V., additional, and Stoilova-Disheva, M., additional
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- 2010
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16. Isolation, Characterization and Screening for Antimicrobial Activities of PsychrotolerantStreptomycetesIsolated from Polar Permafrost Soil
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Lyutskanova, D., primary, Ivanova, V., additional, Stoilova-Disheva, M., additional, Kolarova, M., additional, Aleksieva, K., additional, Raykovska, V., additional, and Peltekova, V., additional
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- 2009
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17. Isolation and Characterization of a PsychrotolerantStreptomycesStrain from Permafrost Soil in Spitsbergen, Producing Phthalic Acid Ester
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Lyutskanova, D., primary, Ivanova, V., additional, Stoilova-Disheva, M., additional, Kolarova, M., additional, Aleksieva, K., additional, and Peltekova, V., additional
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- 2009
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18. Usnic Acid, Metabolite from Neuropogon Sp., An Antarctic Lichen Isolation, Structure Elucidation and Biological Activity
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Ivanova, V., primary, Graefe, U., additional, Schlegel, B., additional, Kolarova, M., additional, Aleksieva, K., additional, Najdenski, H., additional, Tzvetkova, I., additional, and Chipeva, V., additional
- Published
- 2004
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19. Taxonomic Investigations of the Antarctic Mesophilic Strain 2BG, Producer of Secondary Metabolites
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Gusterova, A., primary, Ivanova, V., additional, Aleksieva, K., additional, Kolarova, M., additional, Schlegel, B., additional, and Graefe, U., additional
- Published
- 2004
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20. Isolation and Structure Elucidation of Tyramine and Indole Alkaloids from Antarctic StrainMicrobispora AerataIMBAS-11A
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Ivanova, V., primary, Graefe, U., additional, Schlegel, R., additional, Schlegel, B., additional, Gusterova, A., additional, Kolarova, M., additional, and Aleksieva, K., additional
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- 2003
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21. ChemInform Abstract: Neuropogonines A, B, and C, New Depsidon‐Type Metabolites from Neuropogon sp., an Antarctic Lichen.
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Ivanova, V., primary, Aleksieva, K., additional, Kolarova, M., additional, Chipeva, V., additional, Schlegel, R., additional, Schlegel, B., additional, and Graefe, U., additional
- Published
- 2002
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22. Isolation of a Polysaccharide with Antiviral Effect from Ulva Lactuca
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Ivanova, V., primary, Rouseva, R., additional, Kolarova, M., additional, Serkedjieva, J., additional, Rachev, R., additional, and Manolova, N., additional
- Published
- 1994
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23. Structural Elucidation of a Bioactive Metabolites Produced by Streptomyces AvidiniiSB9 Strain, Isolated from Permafrost Soil in Spitsbergen, Arctic
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Ivanova, V., Lyutskanova, D., Kolarova, M., Aleksieva, K., Raykovska, V., and Stoilova-Disheva, M.
- Abstract
ABSTRACTStreptomyces avidinii strain SB9 was isolated from permafrost soil samples in Spitsbergen, Arctic Ocean. The strain is psychrotolerant with optimal growth temperature between 20°C and 28°C. During our continuous search for unique secondary metabolites, we have investigated an arctic isolate of Streptomyces avidinii SB9 and we found for the first time, that Sreptomyces avidinii strain SB9 produces 2-amino-3-dodecanol [1], norophthalmic acid (2S)-2-amino-4-[[(1S)-1-(carboxymethylcarbamoyl) ethyl]carbamoyl] butanoic acid [2] and phthalic acid ester [3]. The compounds were purified by solvent extraction, silica gel column chromatography and preparative TLC consecutively. The structures of the compounds were elucidated by NMR experiments and mass spectrometric investigations. These compounds showed antimicrobial activity against important Gram-positive bacteria and fungi. Our studies are motivated by an interest in the functional role played by natural products in the ecological interactions of the strain with other members of the microbial community.
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- 2010
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24. Isolation and Characterization of a Psychrotolerant StreptomycesStrain from Permafrost Soil in Spitsbergen, Producing Phthalic Acid Ester
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Lyutskanova, D., Ivanova, V., Stoilova-Disheva, M., Kolarova, M., Aleksieva, K., and Peltekova, V.
- Abstract
ABSTRACTAn actinomycete, strain SB9, was isolated from a soil sample collected from permafrost in Spitsbergen, Arctic Ocean. The strain is psychrotolerant with growth at temperatures between 4°C and 30°C and optimal growth temperature between 20°C and 28°C. Phylogenetic analysis of the 16S rRNA gene sequence of the strain SB9 indicated a high level of sequence similarity (99%) to Streptomyces avidinii. The 16S rRNA gene sequence data of strain SB9 have been deposited in the GenBank databases under the accession number EU878377. The strain produces di-(2-ethylhexyl) phthalate (DEHP). The identification of (DEHP) was settled on the basis of electrospray mass spectrometry (ESI-MS), 1D NMR spectroscopy, and comparison with standards. Isolated compound showed antimicrobial activity against various microorganisms.
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- 2009
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25. Isolation, Characterization and Screening for Antimicrobial Activities of Psychrotolerant StreptomycetesIsolated from Polar Permafrost Soil
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Lyutskanova, D., Ivanova, V., Stoilova-Disheva, M., Kolarova, M., Aleksieva, K., Raykovska, V., and Peltekova, V.
- Abstract
ABSTRACTNinety one streptomycetes strains were isolated from permafrost soil in Spitsbergen, Arctic Ocean. Five of them showed antimicrobial activity against Gram-positive, Gram-negative bacteria, yeasts and fungi. The strains were psychrotolerant with growth at temperatures between 4°C and 28°C. Morphological, physiological and biochemical characterizations were investigated and the starins could be affiliated to the same genus. Antibiotic production of the strains was investigated at 4°C and the active compouds were isolated from the culture filtrate. Strong activity of the isolated compounds against bacteria, yeast and fungi was detected.
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- 2009
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26. Isolation and Structure Elucidation of Tyramine and Indole Alkaloids from Antarctic Strain Microbispora AerataIMBAS-11A
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Ivanova, V., Graefe, U., Schlegel, R., Schlegel, B., Gusterova, A., Kolarova, M., and Aleksieva, K.
- Abstract
ABSTRACTThe tyramine alkaloids as a N-acetyltyramine (C10H13NO2, MW.179), N-acetyl-3-(phydroxyphenyl)-propylamine (C11H15NO2, MW.193) and the indole alkaloid L, L-cyclo(tryptophanylprolyl) (C16H17N3O2, MW.283) were isolated from the culture broth of Microbispora aerata subsp.nov.IMBAS-11A. The strain was isolated from penguin excrements collected on the Antarctic Livingstone Island. The structures of the metabolites were settled on the basis of mass spectrometry, 1D and 2D NMR spectroscopy.
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- 2003
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27. Meteorology and air pollution at a coastal site - Experiment and modeling
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Batchvarova, E., Barantiev, D., Kirova, H., Kolarova, M., Hristova, E., Syrakov, D., Prodanova, M., Claudia Roberta Calidonna, Ammoscato, I., Avolio, E., Gulli, D., Feudo, T. L., Torcasio, C. R., Chianese, E., and Riccio, A.
- Subjects
Aerosols ,Atmospheric Science ,Modeling and Simulation ,Air pollution ,Coastal studies ,HYSPLIT ,Sodar measurements ,Wet-deposition chemical analysis ,Pollution - Abstract
Here we presents results of an experimental campaign performed in October 2016 in Ahtopol (Bulgaria) in the context of Exchange program between ISAC-CNR and NIHM-BAS research centers. The aim of the campaign is to collect aerosols in the coastal area, together with physical parameters; to consider air-masses circulation from meteorological output and to demonstrate that for some period Ahtopol and Lamezia Terme sites are in the same system. Evidence of aerosols circulation is also given by using HYSPLIT model for a better understanding of pollution sources also by chemical analysis form wet and dry deposition and filters from impactor.
28. Meteorology and aerosol studies at a Black Sea coastal site
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Batchvarova, E., Calidonna, C., Kolarova, M., Ammoscato, I., Barantiev, D., Elena Hristova, Kirova, H., Georgieva, E., Syrakov, D., Prodanova, M., Torcasio, C. R., Avolio, E., Gulli, D., Feudo, T. L., Chianese, E., Riccio, A., Savov, P., Kolev, N., and Neykova, R.
- Subjects
Aerosol concentrations ,Aerosol chemical composition ,Coastal meteorology ,HYSPLIT ,Trajectory modelling - Abstract
Coastal meteorology is characterised with complex physical and chemical processes related to aerosols exchange and transport. Aerosol measurements in Bulgaria are rare in areas outside big cities which makes extremely valuable the 3-year effort of a bilateral project between BAS and CNR to perform experimental campaigns at a rural Black Sea coastal site. Not only the concentration of different fractions of PM, but also the chemical composition of aerosols was studied during three short experimental studies in 2016, 2017 and 2018.
29. RUMOURS, CONSPIRACY BELIEFS AND COVID-19 VACCINATION ATTITUDES IN BULGARIA: A CROSS-SECTIONAL STUDY.
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Rohova, M., Mihaylov, N. L., Ivanova, E., Pancheva, R., Chamova, R., Hadzhieva, S., Kolarova, M., Paunov, T., and Radeva, N.
- Subjects
- *
CONSPIRACY theories , *HEALTH attitudes , *COVID-19 vaccines , *RUMOR , *CROSS-sectional method , *RISK perception - Abstract
Aim. This study aims to examine, in the Bulgarian context, the relationships between vaccination attitudes and acceptance on the one hand, and use of communication channels, trust in medical authorities, and belief in misleading information on the other. Materials and methods. A cross-sectional study of Bulgarian respondents was conducted between April and May 2022 using a self-administered online survey with 1,200 participants. Logistic regression models were implemented to examine first, the association between conspiracy beliefs and COVID-19 vaccination uptake and second, between susceptibility to misinformation, sociodemographic variables, trust in medical authorities, and the use of information sources. Results. People who agreed with at least one of the conspiratorial statements were 8.56 times more likely to decline immunization. Belief in rumours and conspiracy theories was associated with a higher perceived risk of adverse events and lower perceived benefits of vaccination. In the logistic regression models, age, residence, and mistrust were associated with believing in rumours and conspiracy theories. Sourcing information from health authorities was negatively associated with belief in rumours while getting information from relatives and friends had the opposite effect. Conclusions. Misinformation had a significant impact on vaccine uptake. More efforts are needed to dispel myths and rumours surrounding vaccination. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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30. Racial and ethnic disparities in genomic testing among lung cancer patients: a systematic review.
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Meernik C, Raveendran Y, Kolarova M, Rahman F, Olunuga E, Hammond E, Shivaramakrishnan A, Hendren S, Bosworth HB, Check DK, Green M, Strickler JH, and Akinyemiju T
- Subjects
- Humans, United States epidemiology, Ethnicity statistics & numerical data, Ethnicity genetics, Carcinoma, Non-Small-Cell Lung genetics, Carcinoma, Non-Small-Cell Lung ethnology, Genomics, Lung Neoplasms genetics, Lung Neoplasms ethnology, Lung Neoplasms diagnosis, Healthcare Disparities ethnology, Healthcare Disparities statistics & numerical data, Genetic Testing statistics & numerical data
- Abstract
Background: Racial and ethnic disparities in genomic testing could exacerbate disparities in access to precision cancer therapies and survival-particularly in the context of lung cancer where genomic testing has been recommended for the past decade. However, prior studies assessing disparities in genomic testing have yielded mixed results., Methods: We conducted a systemic review to examine racial and ethnic disparities in the use of genomic testing among lung cancer patients in the United States. Two comprehensive searches in PubMed, Embase, and Scopus were conducted (September 2022, May 2023). Original studies that assessed rates of genomic testing by race or ethnicity were included. Findings were narratively synthesized by outcome., Results: The search yielded 2739 unique records, resulting in 18 included studies. All but 1 study were limited to patients diagnosed with non-small cell lung cancer. Diagnosis years ranged from 2007 to 2022. Of the 18 studies, 11 found statistically significant differences in the likelihood of genomic testing by race or ethnicity; in 7 of these studies, testing was lower among Black patients compared with White or Asian patients. However, many studies lacked adjustment for key covariates and included patients with unclear eligibility for testing., Conclusions: A majority of studies, though not all, observed racial and ethnic disparities in the use of genomic testing among patients with lung cancer. Heterogeneity of study results throughout a period of changing clinical guidelines suggests that minoritized populations-Black patients in particular-have faced additional barriers to genomic testing, even if not universally observed at all institutions., (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2024
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31. A Total of 207 Days of Veno-Venous Extracorporeal Membrane Oxygenation Support for Severe COVID-19 Prior to Successful Lung Transplantation: A Case Report.
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Naar J, Kruger A, Vondrakova D, Janotka M, Kubele J, Lischke R, Kolarova M, Neuzil P, and Ostadal P
- Abstract
Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a life-saving treatment for respiratory failure that may serve as a bridge to patient recovery or lung transplantation. In COVID-19, recovery is somewhat unpredictable and occasionally occurs after >100 days on VV-ECMO support. Thus, determining therapy cessation may be difficult. We report the case of a 59-year-old male without specific risk factors admitted to a tertiary center for rapidly progressive respiratory failure due to severe COVID-19, despite aggressive mechanical ventilatory support. Immediate insertion of VV-ECMO was associated with prompt resolution of hypoxemia and hypercapnia; however, all therapeutic efforts to wean the patient from VV-ECMO failed. During the prolonged hospitalization on VV-ECMO, sepsis was the most life-threatening complication. The patient overcame roughly 40 superinfections, predominantly affecting the respiratory tract, and spent 183 days on antimicrobial treatment. Although the function of other organ systems was generally stable, gradually progressive right ventricular dysfunction due to precapillary pulmonary hypertension required increasing doses of inotropes. A successful lung transplantation was performed after 207 days of VV-ECMO support. The present case provides evidence for prolonged VV-ECMO therapy as a bridge to lung transplantation in severe COVID-19 despite numerous, predominantly infectious complications.
- Published
- 2022
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32. Magnesium Phthalocyanines and Tetrapyrazinoporphyrazines: The Influence of a Solvent and a Delivery System on a Dissociation of Central Metal in Acidic Media.
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Kolarova M, Mulaku A, Miletin M, Novakova V, and Zimcik P
- Abstract
Magnesium complexes of phthalocyanines (Pcs) and their aza-analogues have a great potential in medical applications or fluorescence detection. They are known to demetallate to metal-free ligands in acidic environments, however, detailed investigation of this process and its possible prevention is lacking. In this work, a conversion of lipophilic and water-soluble magnesium complexes of Pcs and tetrapyrazinoporphyrazines (TPyzPzs) to metal-free ligands was studied in relation to the acidity of the environment (organic solvent, water) including the investigation of the role of delivery systems (microemulsion or liposomes) in improvement in their acido-stability. The mechanism of the demetallation in organic solvents was based on an acidoprotolytic mechanism with the protonation of the azomethine nitrogen as the first step and a subsequent conversion to non-protonated metal-free ligands. In water, the mechanism seemed to be solvoprotolytic without any protonated intermediate. The water-soluble magnesium complexes were stable in a buffer with a physiological pH 7.4 while a time-dependent demetallation was observed in acidic pH. The demetallation was immediate at pH < 2 while the full conversion to metal-free ligand was done within 10 min and 45 min for TPyzPzs at pH 3 and pH 4, respectively. Incorporation of lipophilic magnesium complexes into microemulsion or liposomes substantially decreased the rate of the demetallation with the latter delivery system being much more efficient in the protection from the acidic environment. A comparison of two different macrocyclic cores revealed significantly higher kinetic inertness of magnesium TPyzPz complexes than their Pc analogues.
- Published
- 2022
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33. Evaluation of the effect of Lepidium meyenii Walpers in infertile patients: A randomized, double-blind, placebo-controlled trial.
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Melnikovova I, Russo D, Fait T, Kolarova M, Tauchen J, Kushniruk N, Falabella R, Milella L, and Fernández Cusimamani E
- Subjects
- Adult, Animals, Humans, Plant Extracts pharmacology, Plant Extracts therapeutic use, Semen Analysis, Sperm Count, Testosterone, Infertility, Male drug therapy, Lepidium
- Abstract
Male infertility refers to the inability to conceive a natural pregnancy in a fertile female, and approximately 15% of reproductive-aged couples worldwide face this problem. Several plants were used to treat fertility disorders and, among them, Lepidium meyenii, a folk medicament of Andean regions, is still used to enhance vitality and treat sterility in humans and domestic animals. The aim of the study was to evaluate the effects of L. meyenii Walpers on infertile patients by a randomized, double-blind, placebo-controlled trial. Fifty patients suffering from various reproductive-related problems were enrolled for 16 weeks to evaluate the effect of yellow maca on semen quality and serum hormone levels. Treatment with maca improved the percentage of sperm concentration by 40%, whereas the placebo improved by 76% after 8 and 16 weeks of treatment, but the results were statistically non-significant. No statistically significant change in hormone levels was reported by using maca, except a decrease in the level of free testosterone. Results are not sufficient to assess the efficacy of maca on male fertility. Further investigation and trials are required to obtain conclusive results., (© 2021 The Authors. Phytotherapy Research published by John Wiley & Sons Ltd.)
- Published
- 2021
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34. Cognitive and motor function in adults with spina bifida myelomeningocele: a pilot study.
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Jasien JM, Mikati MA, Kolarova M, Smith B, Thera S, and Lee P
- Subjects
- Adult, Cognition, Humans, Middle Aged, Neuropsychological Tests, Pilot Projects, Prospective Studies, Young Adult, Meningomyelocele complications, Spinal Dysraphism
- Abstract
Purpose: Determine the feasibility and utility of using a battery of tests utilized, so far, to assess neurological-cognitive functions in the typical adult population and identify the spectrum of these functions in adult SBM patients., Methods: Prospective study in which 15 participants (mean age = 28.7 ± 8.7 years, range = 19-45 years) completed the targeted battery of tests (n = 5-15/test) previously standardized to the general population. Results were compared with normative data., Results: Statistically significant differences with normative means were noted in the following tests: Montreal Cognitive Assessment (MoCA), Functional Activities Questionnaire (FAQ), and NIH Toolbox Fine Motor (Dexterity and Grip Strength) tests. Cohort means for NIH Toolbox Fluid, Crystallized, and Cognitive Composite Scores and Timed Up and GO (TUG) were not different from normative means., Conclusion: All tests were successfully completed by cohort. Whereas many aspects of cognition were normal, tests assessing visual-constructural, calculation, motor, and fluency functions did show differences from population means. Numerous tests assessing multiple domains are needed and can be used in future aging studies to appreciate the spectrum of cognitive and motor abilities in adults with SBM.
- Published
- 2021
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35. Analysis of body segments and postural state in school children.
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Kolarova M, Kutiš P, Rusnak R, Hrčková Z, Hudáková Z, Lysá Ľ, Luliak M, and Babeľa R
- Abstract
Objective: Aim of our study was to identify the number of existing posture disorders in children in primary schools and to identify the most prevalent position of body segments that cause postural disorders., Methods: The occurrence of postural disorders was analysed in the school year 2016/2017. The sample consisted of 311 pupils age 6-8 from the 16 districts of the Slovak republic. We used Klein, Thomas and Mayer method to evaluate the posture. Flat feet were evaluated according to Napoleon Wolanski scale. The results were verified by using a base rate quantity test. We determined the level of statistical significance at p = 0.05., Results: We observed statistically significant postural disorders in children. Poor posture occurs in more than 50% of the population under the study. The most critical body segments which were subjected to pathology were shoulder blades and shoulders. Pathology in these segments exceeds 80%. Flat feet occurrence was in 65% children. Adverse results were also seen in pathologic position of: pelvis anteversion (46 %), head protruding (42%) and spinal curvature deformities in the sagittal plane (30%). In the frontal plane deformities of spinae reached 13%., Conclusion: Health status of the children's locomotor system, especially postural system is poor. High prevalence of postural disorders in children requires preventive programs such as introducing corrective exercises into physical education and engaging children in sports. Knowledge of the most frequent body segments defects in children can be helpful for professionals in creating adequate corrective programs for children.
- Published
- 2019
36. Tau Oligomers in Sera of Patients with Alzheimer's Disease and Aged Controls.
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Kolarova M, Sengupta U, Bartos A, Ricny J, and Kayed R
- Subjects
- Aged, Aged, 80 and over, Alzheimer Disease cerebrospinal fluid, Alzheimer Disease complications, Amyloid beta-Peptides blood, Amyloid beta-Peptides cerebrospinal fluid, Cognitive Dysfunction blood, Cognitive Dysfunction etiology, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Mental Status Schedule, Middle Aged, Peptide Fragments blood, tau Proteins cerebrospinal fluid, tau Proteins chemistry, Aging blood, Alzheimer Disease blood, tau Proteins blood
- Abstract
Although tau protein was long regarded as an intracellular protein with several functions inside the cell, new evidence has shown tau secretion into the extracellular space. The active secretion of tau could be a physiological response of neurons to increased intracellular amounts of tau during the progression of tau pathology. We looked for potential differences in the serum levels of toxic tau oligomers in regards to cognitive impairment of subjects. We detected tau oligomers in the serum of Alzheimer's disease (AD) patients, but they were also present to some extent in the serum of healthy older subjects where the levels positively correlated with aging (Spearman r = 0.26, p = 0.016). On the contrary, we found lower levels of tau oligomers in the serum of mild cognitive impairment (MCI) (p = 0.033) and MCI-AD (p = 0.006) patients. These results could suggest that clearance of extracellular tau proteins takes place, in part, in the periphery. In the case of MCI patients, the lower levels of tau oligomers could be the result of impaired clearance of tau protein from interstitium to blood and consequent accumulation of tau aggregates in the brain.
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- 2017
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37. Identification and characterization of natural antibodies against tau protein in an intravenous immunoglobulin product.
- Author
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Hromadkova L, Kolarova M, Jankovicova B, Bartos A, Ricny J, Bilkova Z, and Ripova D
- Subjects
- Epitopes chemistry, Humans, Immunoglobulin G immunology, Immunoglobulins, Intravenous immunology, Immunosorbent Techniques, Molecular Weight, Peptides immunology, Protein Binding immunology, Protein Structure, Tertiary, Immunoglobulin G isolation & purification, Immunoglobulins, Intravenous chemistry, tau Proteins immunology
- Abstract
The latest therapeutic approaches to Alzheimer disease are using intravenous immunoglobulin (IVIG) products. Therefore, the detailed characterization of target-specific antibodies naturally occurring in IVIG products is beneficial. We have focused on characterization of antibodies isolated against tau protein, a biomarker of Alzheimer's disease, from Flebogamma IVIG product. The analysis of IgG subclass distribution indicated skewing toward IgG3 in anti-tau-enriched IgG fraction. The evaluation of their reactivity and avidity with several recombinant tau forms was performed by ELISA and blotting techniques. Truncated non-phosphorylated tau protein (amino acids 155-421) demonstrated the highest reactivity and avidity index. We provide the first detailed insight into the reactivity of isolated natural antibodies against tau protein., (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
38. Effect of Lepidium meyenii Walp. on Semen Parameters and Serum Hormone Levels in Healthy Adult Men: A Double-Blind, Randomized, Placebo-Controlled Pilot Study.
- Author
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Melnikovova I, Fait T, Kolarova M, Fernandez EC, and Milella L
- Abstract
Background/Aims. Products of Lepidium meyenii Walp. (maca) are touted worldwide as an alimentary supplement to enhance fertility and restore hormonal balance. Enhancing properties of maca on semen parameters in animals were previously reported by various authors, but we present to the best of our knowledge the first double-blind, randomized, placebo-controlled pilot trial in men. The aim of this study was to evaluate the effects of maca on semen parameters and serum hormone levels in healthy adult men. Methods. A group of 20 volunteers aged 20-40 years was supplied by milled hypocotyl of maca or placebo (1.75 g/day) for 12 weeks. Negative controls of semen were compared to the samples after 6 and 12 weeks of maca administration; negative blood controls were compared to the samples after 12 weeks of treatment. Results. Sperm concentration and motility showed rising trends compared to placebo even though levels of hormones did not change significantly after 12 weeks of trial. Conclusion. Our results indicate that maca possesses fertility enhancing properties in men. As long as men prefer to use alimentary supplement to enhance fertility rather than prescribed medication or any medical intervention, it is worth continuing to assess its possible benefits.
- Published
- 2015
- Full Text
- View/download PDF
39. Interactions between amyloid-β and tau in cerebrospinal fluid of people with mild cognitive impairment and Alzheimer's disease.
- Author
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Kristofikova Z, Ricny J, Kolarova M, Vyhnalek M, Hort J, Laczo J, Sirova J, and Ripova D
- Subjects
- Aged, Aged, 80 and over, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Mental Status Schedule, Middle Aged, Neuropsychological Tests, Sensitivity and Specificity, Statistics, Nonparametric, Alzheimer Disease cerebrospinal fluid, Amyloid beta-Peptides cerebrospinal fluid, Cognitive Dysfunction cerebrospinal fluid, Peptide Fragments cerebrospinal fluid, tau Proteins cerebrospinal fluid
- Abstract
Background: Despite the physiological sequestration of amyloid-β (Aβ) peptides by various carriers, interactions between peptides and protein tau appear to be pathological and involved in the development of Alzheimer's disease (AD). A recent study reported increased Aβ-tau interactions in the neurons of AD patients., Objective: We investigated the possibility that levels of Aβ-tau complexes in cerebrospinal fluid could be a prospective biomarker of AD, with greater sensitivity and specificity than Aβ1-42, tau, or phospho-tau individually., Methods: By means of ELISA, we estimated levels of the complexes in 161 people (non-demented controls, people with mild cognitive impairment (MCI), probable AD or other types of dementia)., Results: We found significant reductions in levels in people with MCI due to AD (down to 84.5%) or with AD (down to 80.5%) but not in other types of dementia. The sensitivity of the new biomarker to AD was 68.6%, the specificity 73.3% (compared to controls) or 59.1-66.1% (compared to other types of dementia). No significant correlations were observed between the complexes and the remaining biomarkers or between those and Mini-Mental State Examination score., Conclusion: We suppose that attenuated levels of complexes in cerebrospinal fluid reflect the accumulation of Aβ bound to tau in AD neurons and that changes start many years before symptom onset, analogously to those in Aβ1-42, tau, or phospho-tau. Unfortunately, these complexes are not a significantly better biomarker of AD than current biomarkers.
- Published
- 2014
- Full Text
- View/download PDF
40. Structure elucidation of a new natural diketopiperazine from a Microbispora aerata strain isolated from Livingston Island, Antarctica.
- Author
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Ivanova V, Laatsch H, Kolarova M, and Aleksieva K
- Subjects
- Amino Acids analysis, Animals, Antarctic Regions, Cell Proliferation drug effects, Chromatography, Chromatography, High Pressure Liquid, Diketopiperazines isolation & purification, Diketopiperazines pharmacology, Fibroblasts, HeLa Cells, Humans, Magnetic Resonance Spectroscopy, Mass Spectrometry, Mice, Microbial Sensitivity Tests, Molecular Structure, Spheniscidae, Actinomycetales chemistry, Diketopiperazines analysis, Feces microbiology
- Abstract
A new natural diketopiperazine (1) was obtained from the culture broth of Microbispora aerata strain imbas-11A, isolated from penguin excrements collected on the Antarctic Livingston Island. Compound 1 was purified consecutively by solvent extraction, silica gel column chromatography and preparative HPLC. The structure of the compound was elucidated by 1D and 2D NMR experiments and mass spectrometric investigations. The absolute configuration of compound 1 was determined by amino acid analysis and NOESY correlations. A low antiproliferative and cytotoxic effect of trans-cyclo-(D-tryptophanyl-L-tyrosyl) (1) was determined with L-929 mouse fibroblast cells, K-562 human leukemia cells and HeLa human cervix carcinoma. Trans-cyclo-(D-tryptophanyl-L-tyrosyl) (1) did not show antimicrobial activity at a concentration of 50 µg per disc against Bacillus subtilis, Staphylococcus aureus, Streptomyces viridochromogenes, Escherichia coli, Candida albicans and Mucor miehei.
- Published
- 2013
- Full Text
- View/download PDF
41. Structure and pathology of tau protein in Alzheimer disease.
- Author
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Kolarova M, García-Sierra F, Bartos A, Ricny J, and Ripova D
- Abstract
Alzheimer's disease (AD) is the most common type of dementia. In connection with the global trend of prolonging human life and the increasing number of elderly in the population, the AD becomes one of the most serious health and socioeconomic problems of the present. Tau protein promotes assembly and stabilizes microtubules, which contributes to the proper function of neuron. Alterations in the amount or the structure of tau protein can affect its role as a stabilizer of microtubules as well as some of the processes in which it is implicated. The molecular mechanisms governing tau aggregation are mainly represented by several posttranslational modifications that alter its structure and conformational state. Hence, abnormal phosphorylation and truncation of tau protein have gained attention as key mechanisms that become tau protein in a pathological entity. Evidences about the clinicopathological significance of phosphorylated and truncated tau have been documented during the progression of AD as well as their capacity to exert cytotoxicity when expressed in cell and animal models. This paper describes the normal structure and function of tau protein and its major alterations during its pathological aggregation in AD.
- Published
- 2012
- Full Text
- View/download PDF
42. Isolation and identification of alpha,alpha-trehalose and glycerol from an arctic psychrotolerant Streptomyces sp. SB9 and their possible role in the strain's survival.
- Author
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Ivanova V, Lyutskanova D, Stoilova-Disheva M, Kolarova M, Aleksieva K, Raykovska V, Peltekova V, and Laatsch H
- Subjects
- Arctic Regions, Cell Survival, Species Specificity, Glycerol isolation & purification, Glycerol metabolism, Soil Microbiology, Streptomyces classification, Streptomyces metabolism, Trehalose isolation & purification, Trehalose metabolism
- Abstract
Streptomyces sp. strain SB9 was isolated from perm frost soil samples in Spitsbergen, Arctic Ocean; it grows in a temperature range between 4 degrees C and 28 degrees C. During the survey of biologically active metabolites biosynthesized by this strain, significant amounts of alpha,alpha-trehalose (1) and glycerol (2) were detected. The compounds were isolated from the mycelium, were chromatographically separated, and the structures were elucidated on the basis of MS and NMR measurements. A possible role of trehalose in cold adaptation of the strain was examined. It was determined that the mycelium of the strain cultivated at 4 degrees C accumulated 5-fold higher amounts of trehalose in comparison with the cells cultivated at 28 degrees C. The mesofilic reference strains, Streptomyces spectabilis NRRL 2494 and Streptomyces lividans TK64, accumulated 100-fold less trahalose than the psychrotolerant Streptomyces sp. SB9. High amounts of trehalose in the cells could be a reason for adaptation of the strain to life at Arctic conditions.
- Published
- 2009
- Full Text
- View/download PDF
43. Diphenylether and macrotriolides occurring in a fungal isolate from the antarctic lichen Neuropogon.
- Author
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Ivanova V, Kolarova M, Aleksieva K, Graefe U, and Schlegel B
- Subjects
- Lichens chemistry, Macrolides metabolism, Phenyl Ethers metabolism, Lichens growth & development, Macrolides chemistry, Phenyl Ethers chemistry
- Abstract
The fungus, Tritirachium sp. HKI 0317, was isolated from the Antarctic lichen Neuropogon sp. Fermentation of this strain, extraction of the culture broth, and preparative separation of produced compounds furnished 4-carboxy-5,5'-dihydroxy-3,3'-dimethyldiphenylether (1), macrosphelide A (2), and macrosphelide J (3). The structures were elucidated on the basis of MS and NMR measurements, and the previously published data for this compounds.
- Published
- 2007
- Full Text
- View/download PDF
44. Sanionins: anti-inflammatory and antibacterial agents with weak cytotoxicity from the Antarctic moss Sanionia georgico-uncinata.
- Author
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Ivanova V, Kolarova M, Aleksieva K, Dornberger KJ, Haertl A, Moellmann U, Dahse HM, and Chipev N
- Subjects
- Animals, Antarctic Regions, Anti-Bacterial Agents isolation & purification, Anti-Inflammatory Agents isolation & purification, Bibenzyls isolation & purification, Cell Proliferation drug effects, Chromatography, Gel, Chromatography, High Pressure Liquid, Epithelial Cells drug effects, Fibroblasts drug effects, Gram-Positive Bacteria drug effects, HeLa Cells, Humans, K562 Cells, L Cells, Leukemia, Erythroblastic, Acute drug therapy, Mass Spectrometry, Mice, Microbial Sensitivity Tests, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Solubility, Solvents chemistry, Spectrometry, Mass, Electrospray Ionization, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents toxicity, Anti-Inflammatory Agents pharmacology, Anti-Inflammatory Agents toxicity, Bibenzyls pharmacology, Bibenzyls toxicity, Bryophyta chemistry, Plants, Medicinal chemistry
- Abstract
Sanionins A (1) and B (2) were isolated from the moss Sanionia georgico-uncinata, collected on the Antarctic Livingston Island. The compounds 1 and 2 were purified by solvent extraction, silica gel column chromatography, and preparative HPLC, consecutively. The structures of the both compounds were elucidated by 1D and 2D NMR experiments and mass spectrometric investigations. These compounds showed activity against important Gram-positive pathogens, such as mycobacteria, multiresistant staphylococci, and vancomycin resistant enterococci. This activity is combined with antiinflammatoric activity and low cytotoxicity.
- Published
- 2007
- Full Text
- View/download PDF
45. Microbiaeratin, a new natural indole alkaloid from a Microbispora aerata strain, isolated from Livingston Island, Antarctica.
- Author
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Ivanova V, Kolarova M, Aleksieva K, Gräfe U, Dahse HM, and Laatsch H
- Subjects
- Actinomycetales genetics, Actinomycetales physiology, Animals, Antarctic Regions, Bacteria growth & development, Cell Line, Tumor drug effects, Chromatography, High Pressure Liquid, Feces chemistry, Feces microbiology, Fibroblasts cytology, Humans, Indole Alkaloids chemistry, Mice, Molecular Structure, Spectrum Analysis, Spheniscidae, Sulfur chemistry, Actinomycetales chemistry, Bacteria drug effects, Fibroblasts drug effects, Indole Alkaloids isolation & purification, Indole Alkaloids pharmacology
- Abstract
A new sulphur-containing natural alkaloid named microbiaeratin (1a) was isolated, together with the known microbiaeratinin (2, bacillamide) from the culture filtrate of Microbispora aerata strain IMBAS-11A. The organism was isolated from penguin excrements collected on the Antarctic Livingston Island. The structure was elucidated by one- and two-dimensional NMR experiments and mass spectrometric investigations.
- Published
- 2007
- Full Text
- View/download PDF
46. Neuropogonines A, B and C, new depsidon-type metabolites from Neuropogon sp., an Antarctic lichen.
- Author
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Ivanova V, Aleksieva K, Kolarova M, Chipeva V, Schlegel R, Schlegel B, and Gräfe U
- Subjects
- Antarctic Regions, Depsides, Mass Spectrometry, Models, Molecular, Heterocyclic Compounds, 3-Ring chemistry, Lactones chemistry, Lichens chemistry
- Published
- 2002
47. Dihydroniphimycin: new polyol macrolide antibiotic produced by Streptomyces hygroscopicus 15 isolation and structure elucidation.
- Author
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Ivanova V, Gesheva V, and Kolarova M
- Subjects
- Anti-Bacterial Agents metabolism, Chromatography, High Pressure Liquid, Heterocyclic Compounds, 2-Ring metabolism, Lactones metabolism, Macrolides, Magnetic Resonance Spectroscopy, Molecular Structure, Spectrum Analysis methods, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents isolation & purification, Heterocyclic Compounds, 2-Ring chemistry, Heterocyclic Compounds, 2-Ring isolation & purification, Lactones chemistry, Lactones isolation & purification, Streptomyces metabolism
- Published
- 2000
- Full Text
- View/download PDF
48. [Our procedure with patients with spontaneous pneumothorax].
- Author
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Kolarov I, Iarŭmov N, and Kolarova M
- Subjects
- Acute Disease, Adult, Aged, Diagnosis, Differential, Drainage, Female, Hemothorax diagnosis, Hemothorax surgery, Humans, Male, Middle Aged, Pneumothorax diagnosis, Thoracotomy, Time Factors, Pneumothorax surgery
- Abstract
Experience hitherto accumulated with the treatment of spontaneous hemopneumothorax (SHPT) is shared. The successful treatment of the condition is largely dependent on the promptly made diagnosis and hemorrhage control. Four patients are subjected to emergency thoracotomy, two are operated according to routinely planned surgery, and the remainder are treated by effecting closed pleural drainage following trocar thoracentesis. There are no postoperative complications, and postoperative lethality is nil.
- Published
- 1995
49. [PROBLEMS IN THE CHOICE OF A CAREER FOR STUDENTS IN SPECIAL SCHOOLS].
- Author
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KOLAROVA M and STIRSKA J
- Subjects
- Czechoslovakia, Humans, Choice Behavior, Education of Intellectually Disabled, Persons with Mental Disabilities, Schools, Students
- Published
- 1963
50. [Can chemotherapeutic drugs induce neo-antigens?].
- Author
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Kolar V and Kolarova M
- Subjects
- Animals, Antilymphocyte Serum administration & dosage, Histocompatibility, Injections, Intradermal, Leukemia, Experimental, Mice radiation effects, Radiation Effects, Skin Transplantation, Transplantation, Homologous, Antigens, Cyclophosphamide administration & dosage, Hydrazines administration & dosage, Methotrexate administration & dosage, Skin immunology
- Published
- 1969
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