1. Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology.
- Author
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Ketelhuth DFJ, Lutgens E, Bäck M, Binder CJ, Van den Bossche J, Daniel C, Dumitriu IE, Hoefer I, Libby P, O'Neill L, Weber C, and Evans PC
- Subjects
- Animals, Arteries metabolism, Arteries physiopathology, Atherosclerosis metabolism, Atherosclerosis physiopathology, Consensus, Humans, Immune System metabolism, Immune System physiopathology, Inflammation metabolism, Inflammation physiopathology, Inflammation Mediators immunology, Inflammation Mediators metabolism, Macrophages immunology, Macrophages metabolism, Monocytes immunology, Monocytes metabolism, Plaque, Atherosclerotic, Signal Transduction, T-Lymphocytes immunology, T-Lymphocytes metabolism, Arteries immunology, Atherosclerosis immunology, Energy Metabolism immunology, Immune System immunology, Immunomodulation, Inflammation immunology
- Abstract
Inflammation is an important driver of atherosclerosis, and the favourable outcomes of the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial revealed the large potential of anti-inflammatory drugs for the treatment of cardiovascular disease, especially in patients with a pro-inflammatory constitution. However, the complex immune reactions driving inflammation in the vascular wall in response to an atherosclerotic microenvironment are still being unravelled. Novel insights into the cellular processes driving immunity and inflammation revealed that alterations in intracellular metabolic pathways are strong drivers of survival, growth, and function of immune cells. Therefore, this position paper presents a brief overview of the recent developments in the immunometabolism field, focusing on its role in atherosclerosis. We will also highlight the potential impact of immunometabolic markers and targets in clinical cardiovascular medicine., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2019
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