1. Dehydroxylative Fluorination of Tertiary Alcohols
- Author
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Yu-Cheng Gu, Wei Zhang, Jin-Hong Lin, and Ji-Chang Xiao
- Subjects
Primary (chemistry) ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Combinatorial chemistry ,0104 chemical sciences ,chemistry.chemical_compound ,Reagent ,Physical and Theoretical Chemistry ,Selectfluor ,Tertiary alcohols ,Phosphine - Abstract
A large number of fluorination methods have been developed, but the construction of a tertiary C-F bond remains challenging. Herein, we describe an efficient dehydroxylative fluorination of tertiary alcohols with Selectfluor via the activation of a hydroxyl group by a Ph2PCH2CH2PPh2/ICH2CH2I system. Although the reagents appear to be not compatible (Selectfluor with the phosphine and I- generated in situ), the reactions occur rapidly to give the desired products in moderate to high yields. This work may present a new discovery in fluorination of alcohols since the reported methods are mainly limited to primary and secondary alcohols.
- Published
- 2020