1. Anergy and Suppression in B-Cell Responses.
- Author
-
Elliott, J. I.
- Subjects
HAPTENS ,ANTIGENS ,IMMUNOGLOBULINS ,B cells ,T cells ,IMMUNITY - Abstract
Two main ideas have been put forward lo explain the unexpectedly low anti-hapten antibody titres which can result from pre-priming a mouse with carrier before hapten-carrier immunization. The first involves the interaction of a network of idiotype-specific suppressor T cells, the second instead arguing for the role of intrinsie B-cell anergy. This paper proposes that the data available can equally be interpreted as reflecting the suboptimal interaction between T and B cells at differing stages of maturity, provided that memory B cells can be divided into two subsets. Further, it is suggested that these considerations must be taken into account in the analysis of B-cell anergy in receptor transgenic mice. [ABSTRACT FROM AUTHOR]
- Published
- 1992
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