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A recent study conducted by researchers at Muhimbili University of Health and Allied Sciences in Tanzania aimed to determine the stability of Schistosoma mansoni circulating cathodic antigens (CCA) in filter paper-based dried urine spot (FP-DUS) samples under different temperature conditions. The study found that despite a decrease in intensity, S. mansoni CCA remained stable and detectable in urine samples stored in FP-DUS. The findings suggest that FP-DUS samples can be used as a reliable method for detecting S. mansoni infection. Further information on the study can be found in the journal article "Longevity of Schistosoma mansoni circulating cathodic antigens in filter paper dried urine spots" published in Practical Laboratory Medicine. [Extracted from the article]

Jiangsu Bioperfectus Technologies Co. Ltd. has filed a patent application for an auxiliary test paper detection device that aims to improve pathogen detection. The device addresses the limitations of current methods by reducing waiting times, cross-infection risks, and costs associated with hospital treatment. It consists of a reagent cap and a test paper cassette, which form a closed space for sample absorption. The device simplifies the detection process, prevents environmental pollution, and allows for autonomous operation at home. The patent application provides further details and claims. [Extracted from the article]

Researchers at Shaanxi University of Science and Technology in Xi'an, China, have developed a new method for visual detection of Carcinoembryonic Antigen (CEA) using double-hybrid nanoflowers grown on paper. The study involved synthesizing nanoflowers on filter paper and achieving visual detection of CEA through a double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) system. This innovative immune-biosensing system offers advantages such as easy operation, low cost, rapid detection, and on-site testing compared to traditional ELISA methods. [Extracted from the article]

A recent systematic review and expert consensus paper from the American College of Allergy, Asthma, and Immunology addresses the use of vaccines in patients receiving dupilumab, a monoclonal antibody used to treat various conditions including asthma and atopic dermatitis. The review found that the available literature suggests that vaccines, including live vaccines, can be safely administered to patients receiving dupilumab. The expert panel agreed that the use of vaccines in these patients is likely safe and effective. This information is important for patients and clinicians who are faced with the clinical dilemma of vaccinating patients receiving dupilumab. [Extracted from the article]

A new position paper from the American College of Allergy, Asthma & Immunology (ACAAI) examines the safety of administering live vaccines to patients currently being treated with dupilumab, a biologic therapy for allergic conditions. The paper concludes that it is not necessary to stop treatment with dupilumab to give live vaccines, but the decision should be made in consultation between the physician and the patient/parent. The goal of the review was to ensure that patients receiving dupilumab can also receive the full protection of recommended vaccines. The panel recommends shared decision-making between doctors and patients/parents regarding the timing and administration of live vaccines while on dupilumab. [Extracted from the article]

A patent application has been submitted for a new technology called microfluidic enzyme-linked paper analytical device (mEL-PAD), which aims to improve the performance of lateral flow assays (LFAs) used for point-of-care testing. LFAs are commonly used for rapid diagnostic tests but have limitations in sensitivity and quantification. The mEL-PAD utilizes a vertical flow microfluidic device that incorporates enzyme-linked assays into paper-based devices. This technology has the potential to enhance the analytical performance of LFAs and enable easy-to-use point-of-care tests with high sensitivity and accuracy. The device can be used to detect various analytes, and a smartphone can be used to quantify the color change. [Extracted from the article]

A recent study conducted by researchers at the University of California in Merced has developed a highly sensitive electrochemical sensor for detecting SARS-CoV2 spike antibodies. The sensor, made from a composite of polypyrrole and reduced graphene oxide, demonstrated high selectivity and reproducibility in detecting the antibodies. The researchers believe that this sensor could be a promising tool for monitoring COVID-19 exposures and infections. The study was supported by UC CITRIS and has been peer-reviewed. [Extracted from the article]

A recent study conducted by Technical University Munich (TU Munich) in Germany has highlighted the importance of endoscopic nasal polyp scoring in the diagnosis and monitoring of chronic rhinosinusitis with nasal polyps (CRSwNP). Unlike patient-reported outcomes, endoscopic scoring provides an objective measurement that is not influenced by the placebo effect. The study emphasizes that endoscopic scoring is a safer and more cost-effective alternative to computed tomography imaging for assessing the extent of the disease. The research aims to establish a unified endoscopic nasal polyp scoring system that can serve as a reference standard for researchers and practitioners involved in managing CRSwNP. [Extracted from the article]

Researchers from COMSATS University in Lahore, Pakistan have developed a cellulose paper-based aptasensing protocol for the detection of the cancer biomarker mucin 1 (MUC1). The paper surface was modified using polydopamine modified carbon nanotubes (PDA@CNTS) to create a strong adhesion and binding interface. The researchers used dynamic laser speckle (DLS) analysis to analyze the speckle patterns generated from the cellulose-based paper surface, providing sensitive and accurate analysis of the target biomarker. The paper-based aptasensor demonstrated sensitive and selective detection of MUC1, making it a promising tool for low-cost and portable biological applications. [Extracted from the article]

We collected sera and FPSs from 23 wild turkeys (Meleagris gallopavo) and 20 northern bobwhites (Colinus virginianus) experimentally infected with West Nile virus (WNV) to compare FPS storage methods with WNV plaque reduction neutralization test (PRNT) sensitivity." FPS eluates and sera were co-titrated to determine endpoint antibody titers, which were compared between FPS sera eluted immediately and sera, and among FPS eluates that underwent different storage conditions. Antibody titers were similar to 4-fold less in FPS sera eluted immediately versus sera, and dropped more frequently below PRNT detection threshold in northern bobwhites, which had similar to 10-fold lower serum antibody titers than wild turkeys. [Extracted from the article]

The University of California has been issued a patent for a device that can detect and quantify analytes in a sample. The device utilizes a lateral-flow assay or a flow-through assay, along with an aqueous two-phase system (ATPS), to capture and immobilize the analyte. The ATPS separates into a leading phase and a lagging phase, with a probe binding to the analyte in the leading phase and a development reagent providing a detectable signal in the lagging phase. This device offers a point-of-care diagnostic solution that is portable and stand-alone, addressing the limitations of current assays. [Extracted from the article]

A recent study conducted at Pontifical Catholic University in Campinas, Brazil, has developed an electrochemical biosensor to detect anti-asparaginase antibodies in patients undergoing treatment for acute lymphoblastic leukemia (ALL). The biosensor, which uses carbon-printed electrodes and a nanocomposite Fe3O4/chitosan, showed promising results in quantifying antibodies in ALL patients. The researchers concluded that this biosensor has the potential to be a valuable tool for monitoring treatment efficacy in ALL patients. This research was funded by Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) and Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP). [Extracted from the article]

Keywords for this news article include: Vienna, Austria, Europe, Allergies, Cancer, Health and Medicine, Immune System Diseases and Conditions, Immunology, Oncology, Risk and Prevention, University of Vienna. Keywords: Vienna; Austria; Europe; Allergies; Cancer; Health and Medicine; Immune System Diseases and Conditions; Immunology; Oncology; Risk and Prevention EN Vienna Austria Europe Allergies Cancer Health and Medicine Immune System Diseases and Conditions Immunology Oncology Risk and Prevention 981 981 1 10/30/23 20231031 NES 231031 2023 OCT 31 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Research findings on Immune System Diseases and Conditions - Allergies are discussed in a new report. [Extracted from the article]

Keywords: Paris; France; Europe; Antibodies; Blood Proteins; Breast Cancer; Cancer; Diagnostics and Screening; Drug Conjugates; Drug Development; Drugs and Therapies; Health and Medicine; Immunoglobulins; Immunology; Interstitial Lung Disease; Lung Diseases and Conditions; Oncology; Proteins; Respiratory Tract Diseases and Conditions; Risk and Prevention; Women's Health EN Paris France Europe Antibodies Blood Proteins Breast Cancer Cancer Diagnostics and Screening Drug Conjugates Drug Development Drugs and Therapies Health and Medicine Immunoglobulins Immunology Interstitial Lung Disease Lung Diseases and Conditions Oncology Proteins Respiratory Tract Diseases and Conditions Risk and Prevention Women's Health 434 434 1 09/25/23 20230926 NES 230926 2023 SEP 26 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Fresh data on Respiratory Tract Diseases and Conditions - Lung Diseases and Conditions are presented in a new report. The mechanisms of ILD induced by many chemotherapy drugs, other drug classes and ADCs used in cancer, including breast cancer, are not clearly elucidated.". [Extracted from the article]

Keywords: Guangzhou; People's Republic of China; Asia; Autoimmunity; Cell Differentiation; Immunology; Peptides and Proteins; Proteins; Ubiquitins EN Guangzhou People's Republic of China Asia Autoimmunity Cell Differentiation Immunology Peptides and Proteins Proteins Ubiquitins 1318 1318 1 08/21/23 20230825 NES 230825 2023 AUG 25 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- A new study on Immunology - Autoimmunity is now available. Guangzhou, People's Republic of China, Asia, Autoimmunity, Cell Differentiation, Immunology, Peptides and Proteins, Proteins, Ubiquitins. [Extracted from the article]

Keywords for this news article include: Suwon, South Korea, Asia, Biochip Technology, Biotechnology, Anions, Chemicals, Connective Tissue Cells, Electrolytes, Elements, Gases, Health and Medicine, Hydrogen, Hydrogen Peroxide, Immunology, Inorganic Chemicals, Ions, Macrophages, Mononuclear Phagocyte System, Myeloid Cells, Organic Chemicals, Oxides, Peroxides, Phagocytes, Reactive Oxygen Species, Ajou University. Keywords: Suwon; South Korea; Asia; Biochip Technology; Biotechnology; Anions; Chemicals; Connective Tissue Cells; Electrolytes; Elements; Gases; Health and Medicine; Hydrogen; Hydrogen Peroxide; Immunology; Inorganic Chemicals; Ions; Macrophages; Mononuclear Phagocyte System; Myeloid Cells; Organic Chemicals; Oxides; Peroxides; Phagocytes; Reactive Oxygen Species EN Suwon South Korea Asia Biochip Technology Biotechnology Anions Chemicals Connective Tissue Cells Electrolytes Elements Gases Health and Medicine Hydrogen Hydrogen Peroxide Immunology Inorganic Chemicals Ions Macrophages Mononuclear Phagocyte System Myeloid Cells Organic Chemicals Oxides Peroxides Phagocytes Reactive Oxygen Species 3014 3014 1 08/14/23 20230818 NES 230818 2023 AUG 18 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Researchers detail new data in Biotechnology - Biochip Technology. [Extracted from the article]

Keywords: Karnataka; India; Asia; Biological Factors; Biological Tumor Markers; Biomarkers; Cancer; Cancer Biomarkers; Carcinoembryonic Antigen; Carcinoma Biomarkers; Cell Adhesion Molecules; Cell Research; Diagnostics and Screening; Emerging Technologies; Enolase; Enzymes and Coenzymes; Glycoproteins; Health and Medicine; Immunology; Lung Cancer; Lung Diseases and Conditions; Lung Neoplasms; Membrane Proteins; Nanotechnology; Neoplasm Antigens; Oncology; Physics; Quantum Dots; Quantum Physics; Tumor Markers EN Karnataka India Asia Biological Factors Biological Tumor Markers Biomarkers Cancer Cancer Biomarkers Carcinoembryonic Antigen Carcinoma Biomarkers Cell Adhesion Molecules Cell Research Diagnostics and Screening Emerging Technologies Enolase Enzymes and Coenzymes Glycoproteins Health and Medicine Immunology Lung Cancer Lung Diseases and Conditions Lung Neoplasms Membrane Proteins Nanotechnology Neoplasm Antigens Oncology Physics Quantum Dots Quantum Physics Tumor Markers 532 532 1 05/15/23 20230516 NES 230516 2023 MAY 16 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Diagnostics and Screening - Cancer Biomarkers have been published. According to the news editors, the research concluded: "This can become a promising diagnostic tool if extended for detection of other proteins or biomarkers involved in environmental and food safety research.". [Extracted from the article]

Keywords: Guelph; Canada; North and Central America; Antibodies; Blood Proteins; Health and Medicine; Immunoassay; Immunoglobulins; Immunology; Proteins EN Guelph Canada North and Central America Antibodies Blood Proteins Health and Medicine Immunoassay Immunoglobulins Immunology Proteins 2095 2095 1 04/03/23 20230407 NES 230407 2023 APR 7 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Immunology - Immunoglobulins. Keywords for this news article include: Guelph, Canada, North and Central America, Antibodies, Blood Proteins, Health and Medicine, Immunoassay, Immunoglobulins, Immunology, Proteins, University of Guelph. [Extracted from the article]

The method of claim 18, wherein the conjugating is of a protein, peptide, or polysaccharide and the protein, peptide, or polysaccharide is an antibody. For example, the protein, peptide, or polysaccharide can be an antibody, such as an antibody for a cytokine or a chemokine. [Extracted from the article]

Keywords: Madrid; Spain; Europe; Biological Products; Diagnostics and Screening; Epidemiology; Health and Medicine; Immunization; Immunology; Mortality; Pediatrics; Public Health; Risk and Prevention; Vaccination; Vaccines EN Madrid Spain Europe Biological Products Diagnostics and Screening Epidemiology Health and Medicine Immunization Immunology Mortality Pediatrics Public Health Risk and Prevention Vaccination Vaccines 2023 FEB 26 (NewsRx) -- By a News Reporter-Staff News Editor at Vaccine Weekly -- Researchers detail new data in Immunization - Vaccines. Madrid, Spain, Europe, Biological Products, Diagnostics and Screening, Epidemiology, Health and Medicine, Immunization, Immunology, Mortality, Pediatrics, Public Health, Risk and Prevention, Vaccination, Vaccines. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the development of a novel diagnostic test for West Nile virus (WNV) infections in crocodiles. The researchers created a lateral flow assay (LFA) using chimeric viral antigens derived from the Binjari virus (BinJV) and modified to display the outer proteins of WNV. The LFA demonstrated 100% sensitivity and specificity in detecting WNV seroconversion in crocodiles, with results obtained in less than 15 minutes. The researchers suggest that this method could be adapted for detecting vector-borne virus infections in humans and other animals. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]

Keywords: Antibodies; Biological Structures; Blood Proteins; Cyborgs; Emerging Technologies; Engineering; Immunoglobulins; Immunology; Indiana University; Machine Learning; Proteins; Software EN Antibodies Biological Structures Blood Proteins Cyborgs Emerging Technologies Engineering Immunoglobulins Immunology Indiana University Machine Learning Proteins Software 118 118 1 08/07/23 20230812 NES 230812 2023 AUG 12 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Imaging Week -- Katy Borner's team from the Luddy School of Informatics, Computing, and Engineering's Cyberinfrastructure for Network Science Center has made significant contributions to constructing a Human Reference Atlas and has led or co-authored six research articles in a just-released HuBMAP package in Nature. Antibodies, Biological Structures, Blood Proteins, Cyborgs, Emerging Technologies, Engineering, Immunoglobulins, Immunology, Indiana University, Machine Learning, Proteins, Software. [Extracted from the article]

Keywords for this news article include: Philadelphia, Pennsylvania, United States, North and Central America, Antibodies, Antineoplastics, Blood Proteins, Dermatomyositis, Health and Medicine, Immunoglobulin G, Immunoglobulins, Immunology, Immunoproteins, Intravenous Immunoglobulin, Intravenous Immunoglobulins, Muscular Diseases and Conditions, Musculoskeletal Diseases and Conditions, Nervous System Diseases and Conditions, Neuromuscular Diseases and Conditions, Polymyositis, Proteins, Rheumatology, Serum Globulins, Skin Diseases and Conditions, Skin and Connective Tissue Diseases and Conditions, Therapy, Corporal Michael J. Crescenz Veterans Affairs Medical Center. Philadelphia, State:Pennsylvania, United States, North and Central America, Antibodies, Antineoplastics, Blood Proteins, Dermatomyositis, Health and Medicine, Immunoglobulin G, Immunoglobulins, Immunology, Immunoproteins, Intravenous Immunoglobulin, Muscular Diseases and Conditions, Musculoskeletal Diseases and Conditions, Nervous System Diseases and Conditions, Neuromuscular Diseases and Conditions, Polymyositis, Proteins, Rheumatology, Serum Globulins, Skin Diseases and Conditions, Skin and Connective Tissue Diseases and Conditions, Therapy, Intravenous Immunoglobulins. [Extracted from the article]

COVID-19, Communicable Disease Control, Coronavirus, Environment and Public Health, Health and Medicine, Heterotopic Ossification, Immunization, Immunology, Musculoskeletal Diseases and Conditions, Myositis Ossificans, Public Health, Public Health Practice, RNA Viruses, Risk and Prevention, SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus 2, Vaccination, Viral, Virology Keywords: COVID-19; Communicable Disease Control; Coronavirus; Environment and Public Health; Health and Medicine; Heterotopic Ossification; Immunization; Immunology; Musculoskeletal Diseases and Conditions; Myositis Ossificans; Public Health; Public Health Practice; RNA Viruses; Risk and Prevention; SARS-CoV-2; Severe Acute Respiratory Syndrome Coronavirus 2; Vaccination; Viral; Virology EN COVID-19 Communicable Disease Control Coronavirus Environment and Public Health Health and Medicine Heterotopic Ossification Immunization Immunology Musculoskeletal Diseases and Conditions Myositis Ossificans Public Health Public Health Practice RNA Viruses Risk and Prevention SARS-CoV-2 Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination Viral Virology 77 77 1 04/03/23 20230409 NES 230409 2023 APR 7 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx COVID-19 Weekly -- A new study on COVID-19 is now available. [Extracted from the article]

Reports the announcement by Xcyte Therapies, Inc. of the publication of a scientific paper describing the mechanism of action of its lead product, Xcellerated T Cells, in chronic lymphocyte leukemia. Implication of the research on the field of biotechnology; Basis for the conclusion; Periodical that published the research.

Reports that Xcyte Therapies, Inc. has announced the publication of a scientific paper describing the mechanism of action of its lead product, Xcellerated T Cells, in chronic lymphocytic leukemia. Demonstration of Xcyte's Xcellerate Process' capability in restoring the ability of T cells to interact with the malignant B cells.

Reports on the publication of a scientific paper from the Antigen Express immunomedicine subsidiary of Generex Biotechnology Corp. Progress in the development of a novel peptide vaccine for HIV; Presentation of T-helper cell-stimulating; Validation of the use of Ii-Ky hybrid peptides as T helper-cell vaccines for HIV.

A recent study conducted at Hyogo Prefectural Kobe Children's Hospital in Kobe, Japan, aimed to assess the current treatment of macrophage activation syndrome (MAS) worldwide. The researchers performed a systematic literature review using the Embase and PubMed databases and included 57 papers describing 1,148 patients with MAS. The study found that high-dose glucocorticoids (GCs) in combination with IL-1 and IFNg inhibitors have shown efficacy in MAS, particularly in MAS associated with systemic juvenile idiopathic arthritis (sJIA). However, the overall level of evidence for MAS treatment, especially in other conditions, is still poor and requires standardized studies for confirmation. [Extracted from the article]

Discusses research being done on retracting an antiviral factor source for AIDS defense. Reference to study by Dr. David Ho, published in the 2004 issue of the journal "Science"; Information on alpha defensins natural proteins; Interpretation of the source of compound neutrophils for HIV defense.

Reports on the development of a method for poliovirus sampling using sodium dodecyl sulfate/EDTA-pretreated chromatography paper strips, by U.S. researchers. Usability of SDS/EDTAtreated chromatography paper strips to collect and transport poliovirus-containing stool samples; Amplification of poliovirus RNA using real-time polymerase chain reaction; Dilutions of poliovirus containing feces and stored at different temperatures.

Announces the publication of Generex Biotechnology Corp.'s scientific paper from its Antigen Express immunomedicine subsidiary reporting progress in developing a novel peptide vaccine for HIV. Method use in the study of the potent immune responses; Findings on the clinical effects of the vaccine; Significance of the result of HIV peptide vaccine for the vaccines industry.

A study conducted by researchers at the University of Agricultural Sciences and Veterinary Medicine focused on the antigenic structure of Oestrus ovis larvae. The researchers used techniques such as electrophoresis, western blot, and immunoassay to identify and characterize the larval antigens. The study found that the western blot technique was more sensitive in detecting specific antigens compared to electrophoresis. The researchers concluded that the immunoassay test could be used to diagnose O. ovis infestation. For more information, readers can refer to the article "The Antigenic Structure Characterization of Oestrus Ovis Larvae" published in Scientific Papers Animal Science and Biotechnologies. [Extracted from the article]

A new report from Central South University in China presents fresh data on thyroid cancer, specifically focusing on lymph node metastasis in papillary thyroid carcinoma (PTC). The study conducted a comprehensive bibliometric analysis of approximately 3,292 publications from 2012 to 2022 to understand the research trends and impact of lymph node metastasis in PTC. The analysis revealed a pattern of growth in the number of publications per year, with China having the highest number of papers. The study concludes by outlining the current state of research on lymph node metastasis in PTC and highlighting significant contributions, trends, and future research directions. [Extracted from the article]

Cites a research published in the 2004 issue of the journal "Science," conducted by David Ho and colleagues on alpha defensin, a natural protein that fights AIDS.

A new report from researchers at Jamia Hamdard in New Delhi, India, discusses the development of a paper-based origami biosensor for the detection of dengue virus antigens. The researchers synthesized gold-decorated nanocomposites of zinc and graphene oxide and coupled them with an aptamer to create an origami-based aptasensor. The biosensor demonstrated good sensitivity and specificity in detecting polyvalent antigens of the dengue virus in human serum. The researchers believe that this affordable and efficient biosensor could be used for point-of-care testing in remote areas and underdeveloped countries, as well as during outbreaks. [Extracted from the article]

Researchers from Palacky University in Olomouc conducted a study on breast cancer patients to analyze ultrasound findings in axillary lymph nodes with morphological changes requiring biopsy. The study found that metastases in lymph nodes with minimal morphological changes can be challenging to recognize, with specific signs including non-homogeneities in the cortex, absence of fat hilum, and perinodal oedema. Biopsy of these lymph nodes is crucial to confirm or exclude metastases, especially for determining treatment. The research was published in Biomedical Papers and can be accessed for further information. [Extracted from the article]

A research paper published in Oncotarget's Volume 15 on October 1, 2024, titled "Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition," discusses the humanization of the monoclonal lupus-derived autoantibody 3E10 for tumor-specific targeting. Researchers from Yale University School of Medicine and Gennao Bio report that humanized variants of 3E10 show faster cell uptake and superior in vivo tumor targeting, with one variant retaining the ability to bind RAD51 and inhibit homology-directed repair. The study affirms the preservation of crucial biological properties essential for therapeutic efficacy in humanized 3E10. [Extracted from the article]

Researchers at the Affiliated Hospital of Qingdao University in China have conducted a bibliometric analysis to examine the research trends in the tumor microenvironment of hepatocellular carcinoma (HCC) over the past 20 years. They collected 2,157 English studies from the Web of Science database and found that China published the most papers on this topic, with the highest number of citations. The study identified four key areas of focus in the study of the tumor microenvironment in HCC: the main components and roles in the tumor microenvironment, immunotherapy, combination therapy, and the microenvironmental landscape. The researchers also noted that the effect of ferroptosis on the tumor microenvironment in HCC may become a future research trend. [Extracted from the article]

A research paper titled "Single-cell analysis of anti-BCMA CAR T cell therapy in patients with central nervous system autoimmunity" was published in the journal Science Immunology. The paper discusses the use of a fully human BCMA targeting autologous CAR-T cell injection called Equecabtagene Autoleucel in the treatment of patients with neuromyelitis optica spectrum disorder (NMOSD). The study analyzes the molecular characteristics of CAR-T cells in the central nervous system, reveals the mechanism of immune remodeling during CAR-T therapy, and compares the molecular differences of CAR-T cells between autoimmune diseases and cancers. The research provides insights into the potential of CAR-T cell therapy for autoimmune diseases. [Extracted from the article]

A recent study conducted by researchers at the Faculty of Veterinary Medicine examined the effects of potassium dichromate on the osmotic resistance of rat erythrocyte membranes. The experiment involved three generations of female rats exposed to the toxic substance. The results showed a significant decrease in hemoglobin levels and a decrease in osmotic resistance of the erythrocyte membrane, indicating a hemolytic effect. This research highlights the potential toxicity of potassium dichromate on blood cells and provides valuable insights into animal science. For more information, readers can refer to the original article published in Scientific Papers Animal Science and Biotechnologies. [Extracted from the article]

A study conducted by researchers at Banat University of Agricultural Sciences and Veterinary Medicine in Timisoara, Romania, investigated the influence of deuterium-depleted water on rats intoxicated with chromium. The study found that the administration of deuterium-depleted water improved the hematocrit and stimulated the non-specific defense of neutrophils in the rats. The research provides valuable insights into the potential benefits of deuterium-depleted water in the context of chromium intoxication. For more information, readers can refer to the original article published in Scientific Papers Animal Science and Biotechnologies. [Extracted from the article]

Researchers from the University of Medicine in Timisoara, Romania, conducted a study on the effects of Sempervivum tectorum and melatonin administration on erythrocyte catalase activity in rats exposed to aluminum sulfate. The study involved Wistar albino rats divided into different groups, including a control group and experimental groups that received various treatments. The researchers found that the administration of Sempervivum tectorum and melatonin led to an increase in catalase activity compared to rats exposed only to aluminum. The effect of melatonin was more pronounced than that of Sempervivum tectorum. For more information, readers can refer to the article published in Scientific Papers Animal Science and Biotechnologies. [Extracted from the article]

A study conducted by the Faculty of Veterinary Medicine aimed to investigate the impact of chromium hexavalent ions on the resistance of erythrocyte membrane in female rats. The study found that exposure to chromium resulted in a significant decrease in haemoglobin levels in all groups compared to the control group. The researchers concluded that increasing chromium intake levels induced a haemolytic effect. For more information, readers can refer to the article "ERYTHROCYTE MEMBRANE RESISTANCE IN ADULT FEMALE RATS EXPOSED TO POTASSIUM DICHROMATE (Cr VI) IN UTERO, DURING SUCKLING AND PRE-PUBERTY PERIOD" published in Scientific Papers Animal Science and Biotechnologies. [Extracted from the article]

The bifunctional fusion protein of claim 1, wherein the rcSso7d antigen-binding protein comprises a tuberculosis antigen-binding domain, a Flavivirus non-structural 1 (NS1) binding domain, an interleukin-6 (IL-6) binding domain, or a fluorophore binding domain. In some embodiments, the rcSso7d antigen-binding protein comprises a tuberculosis antigen-binding domain, a Flavivirus non-structural 1 (NS1) binding domain, an interleukin-6 (IL-6) binding domain, or a fluorophore binding domain. The bifunctional fusion protein of claim 1, wherein the bifunctional fusion protein comprises at least 2, 3, 4, 5, 6, 7, 8, 9 or 10 rcSso7d antigen-binding proteins. The bifunctional fusion protein of claim 1, wherein the engineered rcSso7d antigen-binding protein comprises a streptavidin-binding domain. [Extracted from the article]

A recent report from the Federal Institute for Materials Research and Testing in Berlin, Germany discusses the importance of determining the affinity constant of antibodies in antibody-antigen pairs. The report highlights the challenges in obtaining this information and the unreliability of existing methods. The researchers propose a simple approach using standard immunoassay technology that can be easily and quickly performed. They demonstrate the effectiveness of this approach using a well-known antibody as a model system. The researchers argue that determining the affinity constant should be a crucial parameter in quality control and should be mandatory in papers using immunochemical protocols. [Extracted from the article]

A recent study conducted by researchers at the Second Clinical Medical College of Jinan University in China has analyzed the existing literature on macrophage pyroptosis, a process that plays a significant role in various diseases such as acute lung injury, atherosclerosis, and sepsis. The study used bibliometric analysis to identify research trends and foci in this field. The analysis included 1,321 papers published between 2001 and 2022, with China and the United States being the top contributors. The study concluded that the field of macrophage pyroptosis is rapidly evolving and holds promise as a potential target for treating related diseases. [Extracted from the article]

CellOrigin Biotechnology has announced the treatment of the first patient in China with their CAR-macrophage therapy product (CAR-M) SY001. This marks the first investigator-initiated clinical study of CAR-M cell therapy in China. The treatment was well tolerated with no dose-limiting toxicity observed, and the company expects that this innovative product will prove its safety and effectiveness in clinical trials, offering new hope for the treatment of solid tumors. CellOrigin has also collaborated with Zhejiang University on research papers exploring the development of second-generation CAR-iMAC and targeted glycan degradation for solid tumors. They are conducting further pre-clinical and clinical studies to provide safe and effective treatment choices for patients. [Extracted from the article]

A research paper published by the Aneurin Bevan University Health Board discusses alternative techniques for sentinel lymph node biopsy (SLNB). The paper reviews fifteen articles that explore different methods and their outcomes compared to traditional techniques. The findings suggest that indocyanine green fluorescence (ICG) and magnetic tracers are non-inferior to blue dye and isotope in localizing sentinel lymph nodes. However, further studies are needed to investigate the use of these techniques in combination and to assess cost efficacy and long-term outcomes. [Extracted from the article]