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Objective To explore the vitamin D nutritional status and influencing factors of primary and middle school students in poverty areas of Guizhou Province, and to provide scientific basis for the development of targeted nutritional improvement measures. Methods A total of 2,519 students from 4 primary and4 middle schools in 9 key monitoring counties (districts) in Guizhou Province, where the Nutrition Improvement Program for Rural Compulsory Education Students was implemented in 2023, were selected for questionnaire surveys, physical examinations, and blood biochemistry tests using multistage cluster sampling methods. Multifactorial logistic regression was used to analyze the current status of vitamin D nutrition and its influencing factors. Results The average vitamin D level of primary and middle school students in poverty areas of Guizhou Province was (22. 59 ± 6. 66) ng/ml, and the rate of low vitamin D was 37. 51%. The prevalence of low vitamin D among female students (46. 17%) was higher than that of male students (29. 11%), and the difference was statistically significant 仗2 = 78. 213, P < 0. 001). There was a significant difference in the rate of low vitamin D among students in different regions 仗2 二 23. 454, P <0. 001), and the rate of low vitamin D tended to increase with age = 44. 905, P <0. 001). The results of multifactorial logistic regression analysis showed that, compared with the corresponding reference group, ethnic minorities (OR = 0. 706, 95% CI: 0. 590 - 0. 844), physical activity M60 min/d (OR = 0. 791, 95% CI: 0. 663 - 0. 943), and living in the countryside (OR - 0. 747, 95% CI: 0. 616 -0.906) were protective factors for low vitamin D levels; obesity (OR =2. 133, 95% C/: 1.390 - 3.272), female students (OR 二2. 238, 95% CI: 1.882 -2.662), the 11-13 years old group (OR =1. 849, 95% CI: 1. 521 - 2. 248) and the 14 - 17 years old group (OR = 2. 000, 95% CI: 1. 576 - 2. 539) were risk factors for low vitamin D levels. Conclusion High rates of low vitamin D among primary and middle school students in poverty areas of Guizhou Province require the development of personalized nutritional interventions to improve vitamin D nutritional status. [ABSTRACT FROM AUTHOR]

In order to achieve the safety of autonomous driving, it is crucial to accurately detect traffic signs. Addressing the issue of low accuracy in traditional methods for traffic sign detection, a modified YOLOv5 algorithm incorporating the RepVGG module for traffic sign recognition was proposed. Firstly, by replacing certain CBS modules in the original algorithm with the RepVGG module, the feature extraction capability was enhanced. Additionally, the channel block attention module(CBAM) attention mechanism was introduced in the feature fusion module to strengthen the detection model's resistance to interference. Finally, during network training, the efficient-IoU(EIoU) loss function was utilized to achieve more precise target positioning, thereby improving the algorithm's detection accuracy and iteration speed. Experimental results demonstrate that the improved YOLOv5 algorithm exhibits faster iteration speed. On the CCTSDB traffic sign dataset, it achieves improvements of 4. 99% in accuracy, 3. 62% in recall rate, and 1. 73% in average accuracy compared to the original YOLOv5 algorithm, making it more suitable for practical applications. [ABSTRACT FROM AUTHOR]

Objective: To explore the changes in levels of angiogenic T lymphocyte (Tang)in the peripheral blood of rats exposed to chronic intermittent hypoxia (CIH)during early atherosclerotic vascular changes. Methods: Healthy adult Sprague Dawley (SD)rats were randomly divided into two groups: the normal feeding group (RA group)and the chronic intermittent hypoxia group (IH group), with the IH exposed to intermittent hypoxia for 8 h per day for a total of 6 weeks. The intermittent hypoxia pattern was set to repeat every 2 min, with 40 s of nitrogen gas to reduce the oxygen concentration from 21% to 8% and stabilize for 20 s, followed by normal air to restore the oxygen concentration to 21% for 40 s and maintain for 20 s. After modeling, levels of Tang and endothelial progenitor cells (EPC)were measured by flow cytometry. Levels of high⁃density lipoprotein cholesterol (HDL⁃C), low⁃density lipoprotein cholesterol (LDL ⁃C), triglycerides (TG), total cholesterol (TC), and homocysteine (Hcy)were measured by ELISA. pathological changes were observed in HE stained pathological sections of the thoracic aorta. Results: Flow cytometry results showed that compared to the RA group, the levels of Tang in rats of the IH group were significantly elevated [ (22.975±1.866)% vs. (15.713±1.746)%, P < 0.001], and there was no statistical difference in EPC levels [ (0.040±0.028)% vs. (0.028±0.012)%, P > 0.05]；H E staining results showed that the IMT of rats thoracic aorta in the IH group was significantly increased compared to the RA group [ (121.275 ± 30.896)μm vs. (84.075±7.452)μm, P < 0.05]；ELISA results showed that the Hcy level in the IH group was significantly higher compared to the RA group [ (6.2±0.6)μmol/L vs (. 5.5±0.6)μmol/L, P < 0.05], but there were no statistical differences in HDL ⁃C, LDL ⁃C, TC, and TG levels. Conclusion: Early atherosclerosis occurs in the blood vessels of CIH rats and the levels of Tang elevated, suggesting that the level of Tang is related to the occurrence and development of early atherosclerosis. [ABSTRACT FROM AUTHOR]

Integrated Research on Disaster Risk (IRDR) Program is a 10-year international science program initiated by International Council of Scientific Unions (ICSU), International Social Sciences Council (ISSC), and United Nations Office International Strategy for Disaster Reduction (UNISDR). In 2009, International Programme Office (IPO) of IRDR Program successfully applied by China Association for Science and Technology in Beijing, became the first office of ICSU Interdisciplinary Body hosted in Asia. IRDR Program has been implemented for ten years, and it has become the flagship program for global integrated research on disaster risk, established an extensive global disaster risk comprehensive research network, and formed an effective international science program management mechanism. Four major achievements have been achieved through ten years: (1) successfully implemented the international science program of the ICSU for the first time; (2) operated for ten years to ensure the successful implementation of the program; (3) improved the level of technology governance on global disaster risk; (4) facilitated the establishment of the IRDR Phase II New Decade Plan. The platform has been utilized to learn advanced international concepts, to contribute Chinese wisdom and strength, to provide China's experience in organizing the international science program, and to make important contributions to global integrated disaster risk reduction. [ABSTRACT FROM AUTHOR]

Digital technology can promote the sustainable development of countries and regions along the route of Belt and Road Initiative and help enhance interconnectivity in technology, standards, rules, and digital infrastructure. Science and technology play a crucial role in the construction of the Digital Belt and Road. However, currently, some countries and regions along the route of Belt and Road Initiative lack sufficient digital infrastructure, and there is a shortage of critical core digital technology and challenges in its promotion. It is essential to build an innovative ecosystem for the Digital Belt and Road that includes facilities, technology, mechanisms, and capabilities to promote the sustainable development. This study analyzes the current status and major challenges of the construction of the Digital Belt and Road, proposes the development direction, and puts forward relevant policy suggestions to provide decision-making reference for the construction of the Belt and Road Initiative. [ABSTRACT FROM AUTHOR]

To promote economic development, social progress, and scientific and technological innovation, it is necessary to strengthen scientific cooperation and information sharing. Open data has emerged in response and become a seemingly inevitable development in the evolution of digital technology. Open data, however, must be supported by infrastructure composed of physical entities and virtual systems that meet the needs of data applications in many fields. Constructing and strengthening open data infrastructure should therefore be considered important objectives of information technology development. This study analyzes the elements of open data infrastructure and expounds its significant positive role in implementing open science. Based on an analysis of the current state and substantial development of China's open data infrastructure, this study puts forward relevant measures and suggestions in view of the shortcomings and challenges China has faced with its open data infrastructure. [ABSTRACT FROM AUTHOR]

The graphite felt was modified by electrochemical polymerization of pyrrole ・ The effects of polymerization pulse time, pulse number and pulse interval time on the morphology and electrochemical properties of polypyrrole-coated graphite felt were investigated・ The results show that the polypyrrole coating can be tuned by the polymerization pulse time, pulse number and pulse interval time. The coating of polypyrrole can also improve the hydrophilicity and 2-electron oxygen reduction activity of the carbon fiber. The optimal electrochemical polymerization conditions are the polymerization pulse time of 100 s, the interval of 120 s and 10 pulses・ The maximum specific electrochemical activitg surface area reachs 1.502 8 cm2/cm3 ・ In the sodium sulfate solution with pH = 3, a H2O2 production rate of 25. 775 mol/(m3 • h) was achieved, which is about 3・ 17 times of that of the unmodified graphite felt electrode. [ABSTRACT FROM AUTHOR]

The WC-12Co and WC-10Co-4Cr coatings were deposited on the surface of screw pump rotor substrate ( 45 steel) by high velocity oxygen fuel ( HVOF) technology. The micro-morphology, porosity, phase structure and Vickers hardness of the coatings were characterized by SEM, EDS, XRD and microhardness tester. The wear and corrosion mechanisms of the coating were discussed based on friction and wear test and electrochemical test. The results show that the microstructure of WC-12Co coating and WC-10Co-4Cr coating is compact, and the porosity values are 0. 58% and 0. 48%, respectively. The average Vickers hardness values are respective 1 385. 87 HV0. 3 and 1 268. 62 HV0. 3, and the wear mass loss are 19. 5% and 21. 8% of the substrate, respectively. The wear resistance of WC-12Co coating is better. The wear mechanisms of the two coatings are mild abrasive wear, while the substrate is dominated by abrasive wear and supplemented by adhesive wear. The corrosion current densities of WC-12Co coating and WC-10Co-4Cr coating are 21. 1 % and 12. 8% of that of the substrate, respectively. The passivation film formed by Cr oxide makes the WC-10Co-4Cr coating have good corrosion resistance. Microgalvanic corrosion occurs between WC and metal bonded phase in both coatings, leading to the dissolution of bonded phase and shedding of some WC particles, and the corrosion products can protect the coating. [ABSTRACT FROM AUTHOR]

Objective To evaluate the safety and efficacy of balloon-expandable vertebral body stenting(VBS)in treating elderly patients with osteoporotic vertebral compression fractures. Methods Thirty-eight elderly patients with osteoporotic vertebral compression fractures were randomly divided into two groups according to the parity of their hospital admission numbers to receive VBS and traditional percutaneous kyphoplasty(PKP), respectively. The two groups were compared regarding changes in the intensity of pain, functional score, imaging parameters related to vertebral compression, and sagittal Cobb angle as well as the incidence of bone cement leakage after treatment, to evaluate the safety and efficacy of VBS. Results All the patients underwent the operations smoothly, which were performed with the bilateral percutaneous puncture technique under local anesthesia by the same surgeon, and were followed up for more than half a year. Both VBS group and PKP group showed significant improvement in the visual analogue scale score, the Oswestry disability index, the height of the fractured vertebral body, and the Cobb angle at 3 days, 1 month, 3 months and 6 months after treatment(all P<0. 05). There were significant differences in those indicators between the two groups(all P<0. 05). Conclusion VBS is an effective treatment approach for elderly patients with osteoporotic vertebral compression fractures. It can effectively recover fractured vertebral body height, relieve patients' pain, and have fewer complications such as bone cement leakage. [ABSTRACT FROM AUTHOR]

Ｏｂｊｅｃｔｉｖｅ:Ｔｏｅｘｐｌｏｒｅｔｈｅｃｈａｎｇｅｏｆｔｉｍｅｐｅｒｃｅｐｔｉｏｎｏｆｄｅｐｒｅｓｓｉｏｎｐａｔｉｅｎｔｓｂｙａｔｉｍｅｂｉｓｅｃｔｉｏｎ ｔａｓｋＭｅｔｈｏｄｓ:ＴｈｉｒｔｙｐａｔｉｅｎｔｓｗｉｔｈｄｅｐｒｅｓｓｉｏｎｍｅｅｔｉｎｇＤＳＭ.ＩＶｄｉａｇｎｏｓｔｉｃｃｒｉｔｅｒｉａｆｏｒｄｅｐｒｅｓｓｉｏｎａｎｄ３０ｎｏｒｍａｌ ｃｏｎｔｒｏｌｓｗｅｒｅｓｅｌｅｃｔｅｄＴｈｅｓｙｍｐｔｏｍｓｏｆｄｅｐｒｅｓｓｉｏｎａｎｄａｎｘｉｅｔｙｗｅｒｅａｓｓｅｓｓｅｄｗｉｔｈｔｈｅＨａｍｉｌｔｏｎＤｅｐｒｅｓｓｉｏｎＳｃａｌｅ (ＨＡＭＤ)ａｎｄＨａｍｉｌｔｏｎＡｎｘｉｅｔｙＳｃａｌｅ(ＨＡＭＡ)Ａｃｃｏｒｄｉｎｇｔｏｔｈｅｒｅｓｕｌｔｓｏｆｔｈｅｔｉｍｅｂｉｓｅｃｔｉｏｎｔａｓｋ牞ｔｈｅｐｒｏｐｏｒｔｉｏｎ ｏｆｌｏｎｇｒｅｓｐｏｎｓｅｓ牞ｔｈｅｓｕｂｊｅｃｔｂｉｓｅｃｔｉｏｎｐｏｉｎｔ牞ｔｈｅｄｉｆｆｅｒｅｎｃｅｔｈｒｅｓｈｏｌｄ牞ａｎｄｔｈｅＷｅｂｅｒｒａｔｉｏｗｅｒｅｃａｌｃｕｌａｔｅｄＲｅｓｕｌｔｓ: Ｃｏｍｐａｒｅｄｗｉｔｈｔｈｅｃｏｎｔｒｏｌｇｒｏｕｐ牞ｔｈｅｐｒｏｐｏｒｔｉｏｎｓｏｆｌｏｎｇｒｅｓｐｏｎｓｅｓｗｅｒｅｈｉｇｈｅｒａｔ４００ｍｓ>６００ｍｓ牞８００ｍｓ ａｎｄ １０００ｍｓａｎｄｌｏｗｅｒａｔ１６００ｍｓｉｎｔｈｅｄｅｐｒｅｓｓｉｏｎｇｒｏｕｐ(Ｐ＜００５)Ｔｈｅｖａｌｕｅｏｆｔｈｅｓｕｂｊｅｃｔｉｖｅｂｉｓｅｃｔｉｏｎｐｏｉｎｔｏｆ ｔｈｅｄｅｐｒｅｓｓｉｏｎｇｒｏｕｐｗａｓｓｍａｌｌｅｒｔｈａｎｔｈｅｃｏｎｔｒｏｌｇｒｏｕｐ(Ｐ＜００５)ＴｈｅｖａｌｕｅｏｆｄｉｆｆｅｒｅｎｃｅｔｈｒｅｓｈｏｌｄａｎｄＷｅｂｅｒ ｒａｔｉｏｏｆｔｈｅｄｅｐｒｅｓｓｉｏｎｇｒｏｕｐｗｅｒｅｇｒｅａｔｅｒｔｈａｎｔｈｅｃｏｎｔｒｏｌｇｒｏｕｐ(Ｐｓ＜００５)Ｃｏｎｃｌｕｓｉｏｎ:Ｃｏｍｐａｒｅｄｗｉｔｈｔｈｅｎｏｒ. ｍａｌｐｅｏｐｌｅ ｐａｔｉｅｎｔｓｗｉｔｈｄｅｐｒｅｓｓｉｏｎａｒｅｍｏｒｅｌｉｋｅｌｙｔｏｊｕｄｇｅｔｈｅｓｈｏｒｔｔｉｍｅｉｎｔｅｒｖａｌｓａｓ＂ｌｏｎｇ＂牞ｉｎｄｉｃａｔｉｎｇｔｈａｔｔｈｅｙ ｍａｙｏｖｅｒｅｓｔｉｍａｔｅｔｈｅｓｈｏｒｔｔｉｍｅｉｎｔｅｒｖａｌｓＴｈｅｔｉｍｅｐｅｒｃｅｐｔｉｏｎｓｅｎｓｉｔｉｖｉｔｙｏｆｐａｔｉｅｎｔｓｗｉｔｈｄｅｐｒｅｓｓｉｏｎｍａｙｂｅｄｅ. ｃｒｅａｓｅｄ [ABSTRACT FROM AUTHOR]

The Synthetic Aperture Radar(SAR) technology and its application have developed rapidly since the birth of the first SAR in April of 1960.The deepening and comprehensive technological utilization of different electromagnetic wavebands,polarization,amplitude and phase information,is characterized by the bi-static/multi-static or constellation observation,polarimetric SAR interferometric measurement,high revisit and wide swath mapping with high resolution,3 D/4 D structure information retrieval,and ultra-high resolution observation.In application aspects,it is featured by efforts to realize the high precision,large scale and time continuous monitoring and evaluation of the Earth surface dynamic process,under the background of major global issues such as global change and global sustainable development.In this paper,we introduce the research background and significance of the new SAR technology for earth observation,and then analyze the progresses of four typical advanced SAR technologies for the past decade,including polarimetric SAR(PolSAR),polarimetric interferometric SAR(PolInSAR),tomographic SAR(TomoSAR),and ultra-high resolution SAR(UHR SAR).Finally,the future development trend of the SAR earth observation technology is analyzed,mainly focused on four aspects:multi-channel information acquisition,multi-angle observation,high temporal observation,high resolution and wide swath mapping. [ABSTRACT FROM AUTHOR]

In order to investigate the seismic behavior of a steel reinforced concrete (SRC) mega column from the mega frame structure in a high rise building, the 40000 kN loading device is utilized to conduct low cyclic loading test on 2 circular mega column specimens, where a H-shaped profiled steel or crisscross shaped profiled steel is encased. The cross-sectional geometric dimension, steel ratio, reinforcement ratio and concrete strength of the 2 specimens are the same. The main difference lies in the profiled steel type. The failure feature, hysteretic curve, bearing capacity, deformability, stiffness degradation and energy dissipating ability are analyzed and compared. The influence of profiled steel type on seismic behavior is obtained. Also the bearing capacity is calculated by fiber method. Research shows that:for both specimens, a major bending failure is observed; the hysteretic curves are full, and the bearing capacity declines smoothly; the ultimate drift ratio exceeds 5%; deformability and enery dissipating ability exhibit very well. The seismic behavior along the two engineering axis of the mega column encased crisscross shaped profiled steel is the same, but the seismic behavior along strong axis of the mega column encased H shaped profiled steel is better relativly. The calculated bearing capacity matches the test results well. [ABSTRACT FROM AUTHOR]

Food is highly related to the national security and people’s livelihood. The efficient supply of food depends on the efficient operation of the whole food system. At present, domestic research on food system is rare, therefore, systematically sorting out the research progress abroad can provide a good reference for China’s food system research. In order to better grasp the research context of the food system, this paper studies foreign food system research literature by document analysis. Relevant theories, methods and main research fields of food system research are summarized and analyzed. Food system is the organic integration of economic, social, and ecological sustainable development consisting of the interaction of subsystems such as production, processing, distribution, consumption, and waste disposal based on the elements of material, capital, technology, culture, and political system. Food Footprint, GIS Analysis, Food Domain Analysis, Stakeholder Analysis, Life Cycle Theory, Elasticity Theory, Food Landscape and Scenario Analysis are the most commonly used methods in food system study. Focusing on the research content, globalization and localization of food systems, food system planning, resources and environmental effects on the food system, food safety and policy research are systematically reviewed. Based on the study of food system research abroad and existing research foundations and social needs in China, the focuses of China’s food system research are proposed, including empirical studies on food systems at different scales, interdisciplinary and multidisciplinary research, the design of quantitative index systems for food systems, the impact of technological innovation on food systems, and research on stakeholders in food systems, etc. [ABSTRACT FROM AUTHOR]

Acid-modified natural magnetite shows excellent arsenic removal properties due to its change in specific surface area and internal structure. It is essential to study further its adsorption to arsenic in water， in order to provide data for practical engineering applications. The feature of arsenic adsorption by modified magnetite immersed in 0.5 mol/L hydrochloric acid and ignited for 10 minutes at 150°C, and the construction of its adsorption rate curve chart is described in this paper. Results of the experiment on adsorption influencing factors indicate that when initial pH value are 6 - 9, magnetite shows strong adsorption property. Ions such as Cl-, Ca2+, Mg2+, HCO3-, CO32- do not have competitive adsorption with As( III ) and As( V ) , but PO43- , NO3-, and SO42- have competitive adsorption with As ( III ), in the order of PO43- > SO42- > NO3-. PO43- and NO3- have competitive adsorption with As ( V ). In combination with XRD, SEM, and preliminarily studies show the arsenic removal mechanism of modified magnetite, and conclude that modified magnetite shows an obviously increased specific surface area and that Fe( II ) and Fe( III ) contained in its surface products are the main cause for improving arsenic adsorption ability. Experimental results natural magnetite is a de-arsenic material for water, which deserves further study and practical application. [ABSTRACT FROM AUTHOR]

[Objective] Conduct genetic analysis of the main nutritional quality traits of maize stems at the molecular level. to provide theoretical basis for genetic improvement of the main nutritional quality traits of maize stems. (Methods] The study used 381 different types of maize inbred lines as associated populations and planted randomly in the experimental field of the Hebi Academy of Agricultural Sciences in Henan Province in 2016 and 2017. The nutritional quality traits acid washing fiber (ADF), neutral washing fiber (NDF), and digestibility (IVDMD) were investigated during the heading, filling, and maturity stages. Using the Maize SNP50 gene chip. 461 053 high-quality SNPs were obtained for genome-wide association analysis. [Results] Using the generalized linear model (GLM) analysis, a total of 392 significantly correlated stem nutritional quality traits SNPs (P<1.08x10-7) were detected on 10 chromosomes of maize during different growth stages of the two years, with phenotypic variation interpretation rates of 9.69% -17.34%. 97 SNPs were found to be independently associated more than twice, resulting in a total of 77 candidate genes associated with stem nutritional quality traits. Using the mixed linear model (MLM) analysis, a total of 257 significantly correlated SNPs were detected over the two years (P<2.17x10-6), with phenotypic variation interpretation rates of 9.82% -20.20% 17 SNPs were found to be independently associated more than twice, resulting in a total of 82 candidate genes. Among them, 10 overlap with GLM model candidate genes. A total of 159 candidate association genes were identified by GLM and MLM, among which 43 candidate genes were detected twice or more. Zm00001/021261 was found to be associated with ADF, NDF, and IVDMD in different years 31 times at multiple loci. This gene encoded ATP binding protein and chloroplast sensor kinase, had the highest expression in leaves at maturity stage. Zm00001/021255 was found to be associated with stem nutritional quality traits 10 times at two loci. This gene encoded cysteine rich receptor like protein kinase 25, which was only expressed in developmental internodes and female panicles, can be further studied and validated. [Conclusion]Using GLM and MLM models could quickly and effectively associate significant loci related to maize stem nutrient quality. HC-SNP could be screened through repetitive significant loci, and then associated gene enrichment regions could be excavated. [ABSTRACT FROM AUTHOR]

Genetic transformation system is of great significance for the verification of plant gene function. In order to establish Agrobacterium rhizogenes mediated genetic transformation system in sweet potato(Ipomoea batatas L.), a three‑factor design of 3×3×5 was used to study the effects of infection time, explant type, and A. rhizogenes strains on the induction rate of hairy roots in sweet potato. The appropriate explant type and infection time were determined, and the 5×5 two‑factor design was used to study the effects of five A. rhizomei strains and sweet potato varieties(lines)on the induction rates of sweet potato. The detection of induced hairy roots by PCR confirmed that the rolB gene of the A. rhizogenes Ri plasmid was integrated into the genome of sweet potato cells. The results showed that the infection time, explant type, A. rhizogenes strain, and sweet potato variety all affected the induction rate of hairy roots, and there was an interaction between the factors. Stem segment was the most suitable explants for hair roots, and the optimal infection time was 20 min. MSU440 was the suitable strain for‘Xushu 22’. The suitable strain for‘Taizhong 6’‘YS’were K599. The suitable strain for‘1610’was C58C1. The suitable strain for‘Huishu’was C58C1. Using the A. rhizogenes strain MSU440, stem segments of‘Xushu 22’were used as explants and Agrobacterium infection for 20 min, and the highest induction rate of hairy root was 79.63%. The transgenic efficiency of the hairy root of sweet potato was found to be 38.1% by PCR amplification of the target gene. A genetic transformation system of sweet potato mediated by A. rhizogenes was established, which lays the foundation for further transgenic breeding of sweet potato. [ABSTRACT FROM AUTHOR]

Objective To evaluate the stability of U6 and let-7a as internal reference genes of miRNAs in RT-qPCR by using femoral head samples of cartilage tissue from inbred DA rats. Methods Total RNA was extracted from femoral head cartilage tissues of female DA rats at three different time points, i.e. at birth (D0), ablactation (D21) and maturation (D42). The expressions of different miRNAs (miR-1, -25, -26a, -140, -146a, -150, -181a, -195, -223 and -337) were detected by RT-qPCR using U6 or let-7a as the internal reference. The two sets of miR expression were compared with the results from Solexa sequencing in our pioneer work to evaluate the stability of the two internal references. Results The relative values of U6 (P=0.045) and let-7a (P=0.0215) revealed significant difference in the D42 sample. Both in U6 and let-7a systems, miR -26a, -140, -223, and -337 showed a similar tendency in expression and quantification but miR-1 and -146a did not have significant differences. miR -25, -150, -181a and -195 differed significantly (P<0.05). Comparison of absolute quantification results between the two generations' sequencing showed that let-7a is more stable than U6. Conclusion Let-7a is more suitable to be used as the internal reference gene in RT-qPCR for miRNAs in cartilage tissue. [ABSTRACT FROM AUTHOR]

Single-layer cylindrical reticulated shell structures with the advantages in providing powerful transfer loads capability, large span space, excellent economic index, good light transmission performance and beautiful architectural style, not only are widely used in civil engineering, but also get more and more use in greenhouse construction because they can meet the requirement of rapid development of facility agriculture. Considering the high frequency of disaster winds in many regions of China, and the characteristics of reticulated shell structure including low overall stiffness, numerous vibration modes and great sensitivity to wind loads, the dynamic collapse may occur for single-layer reticulated cylindrical shell structure with large span and light weight in the weather of severe disaster winds. To analyze the collapse mechanism and the influence factor of this type of structure under wind loads is very important for the engineering design and theoretical analysis. In this paper, the analysis model of global dynamic collapse for single-layer cylindrical reticulated shell structure of greenhouse under wind loads was established by considering geometric nonlinearity, material nonlinearity and contact nonlinearity. In the numerical analysis, the effective plastic strain was defined to simulate the failure of tension members. To illustrate the influence of dynamic buckling of compression members on the collapse of the structure, each member was equally divided into 6 beam elements. The finite element explicit analysis software ANSYS/LS-DYNA was employed, and the dynamic buckling of compression members was considered. The collapse process of reticulated shell was analyzed and then was showed with the maximum nodal displacement, the deformed configuration and the plastic member distribution of the structure at different time. Based on the numerical analysis results and performance of the structure, the collapse process of reticulated shell was divided into 3 stages, which were named mild damage stage, collapse formation stage and overall collapse stage respectively. During the first stage (from the beginning to 21.7 s), the reticulated shell was generally in a deformation recoverable state with only a few members entering the plastic state in the compression area of the center and both ends of the structure. Therefore no local collapse occurred and little damage was produced to the structure performance. In the second stage (from 21.7 to 22.6 s), a series of dynamic buckling of members in the wind pressure zone from the bottom to the top of shell occurred, and a band-like buckling region was formed. At the same time, a number of tensile members entered the plastic state and gradually formed a plastic area. This weakened the stiffness of the structure, caused the structural vibration equilibrium position to deviate from its initial position, and finally caused the local collapse in the compression area of the structure. In the third stage (after 22.6 s), the plastic deformation of members in the buckling area of the reticulated shell reached its failure strain at first, and then the fracture failure of the members occurred. Under continuous dynamic forces, the collapse area rapidly expanded with the time, and finally led the shell to lose structural integrity completely at 24.8 s. In addition, considering most of the reticulated shell structures were supported with substructure, this paper also investigated the influence of substructure on the dynamic collapse performance of the upper reticulated shell under wind loads. The same reticulated shell model used above but without substructure was analyzed. The results of calculation showed that the load factor of the collapse of reticulated shell with substructure was reduced by 25% compared with that of the reticulated shell without substructure. The substructure would weaken the stiffness of the whole structure, and therefore reduce the wind loads bearing capacity of reticulated shell structure. It was necessary to consider the influence of substructure in the dynamic collapse analysis of reticulated shell structure under wind loads. Otherwise, the wind loads of the collapse of reticulated shell would be over-estimated. Based on the analysis results, some conclusions are drawn, which provide the basis theoretical reference for engineering analysis and further studies of reticulated shell structure in modern greenhouse. [ABSTRACT FROM AUTHOR]

Iron oxides and their complex oxides such as siderite and ferrihydrite have high surface charge and specific surface area, which have strong binding capacity and affinity for arsenite and arsenate under specific conditions. Natural magnetite, mainly consisting of Fe3O4, has low activity itself, and is not efficient for direct treatment of high arsenic water. Reported in this paper, natural magnetite is modified by acidification, alkalization, and calcined at different temperatures for different periods, in order to enhance arsenic removal from water. Experimental results show that the modified magnetite acidified in 0.5 mol/L hydrochloric acid and calcined at 150℃ for 10 min, has high removal efficiencies for both As(Ⅲ) and As(Ⅴ). Removal efficiency was 98% for As(Ⅴ), whereas the removal efficiency was 75% for As(Ⅲ) with concentration decreases from 1000 μg/L to 250 μg/L (in Fig. 2). The modified natural magnetite has stronger adsorption capacity for As than natural magnetite, and is identical to other modified iron minerals. In addition, the modification method is simple and convenient. Therefore, the modified natural magnetite would be a potential adsorbent for controlling arsenic content in high arsenic water. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect and mechanism of Hedgehog signaling pathway on the invasion of breast cancer cells in vitro. Methods The SHH, SMO and Gli-1 expression levels of breast cancer cell line MDA-231 and normal mammary epithelial cell line MCF-10A were detected by Western blot at protein level and by Real-time RT-PCR at mRNA level. Next, shRNA vector was transfected into the MDA-231 cells with highly expressed SMO, and the stable transfected cells were selected by G418. Western blot and Real-time RT-PCR were performed to observe the inhibitory effect of RNAi on SMO expression. MTT assay was used to assess the influence of SMO siRNA on cell proliferation. Transwell assay was applied to observe cell invasion ability. The expressions of Gli-1, Snail, MMP-9, E-cadherin and Vimentin protein were determined by Western blot. Results Compared with those of normal mammary epithelial cell line MCF-10A, the expressions of SHH, SMO and Gli-1 were significantly increased. The invasion of MDA-231 cells was inhibited significantly after SMO silencing. Additionally, the protein expressions of Gli-1, Snail, MMP-9 and Vimentin were obviously inhibited, and E-cadherin was significantly increased. Conclusion Mutative activation of Hedgehog signaling pathway in breast cancer cells promotes cell invasion probably through induction of epithelial-mesenchymal transition of the tumor cells. [ABSTRACT FROM AUTHOR]

Using potato variety ‘Xuanshu 2' as materials，we studied the changes of relative conductivity，content of chlorophyll，POD activity ，SOD activity，contents of MDA ，free pro line，water soluble sugar and water soluble protein under different low temperature stress by artificial，at the seedling stage of potatoes. Based on these physiological and biochemical indexes correlation analysis，Some key indexes were screened out which could evaluate the cold tolerance of potato seedlings，the results indicated that with the lowering of stress temperature and the prolonging of stress time，the relative conductivity of potato seedlings was increased，content of chlorophyll was decreased，POD activity and SOD activity were firstly increased and then decreased，increased slowly at last，content of MDA，free proline and water soluble sugar were firstly increased and then decreased， content of water soluble protein was constantly increased. The relative conductivity， content of chlorophyll，POD activity，SOD activity，water soluble sugar and water soluble protein，were significant or extremely significant respectively， but a single index could not evaluate the cold tolerance of potato seedlings. It must be combined with other indexes to a comprehensive evaluation. Evaluation on cold tolerance of 14 potato varieties were made through fuzzy comprehensive evaluation method，the cold tolerance order was Zhuanxinwu > Hui-2 > Jizhangshu12 > Lishu6 > Zhongshu18 > Jinshu16 > Mira > Favorita > Diantongshu1 > Dianshu716 > Mangguoyangyu > Xuanshu2 > Hezuo88 > Weiyu3. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the efficacy of tandanone citrate combined with conventional antihypertensive therapy for hypertension complicated with anxiety. METHODS: Totally 126 patients with hypertension complicated with anxiety admitted into Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine from Feb. 2016 to Feb. 2018 were extracted to be divided into the observation group and the control group via the random number table, with 63 cases in each group. The control group was given conventional antihypertensive therapy, while the observation group received tandospirone citrate on the basis of the control group. The Hamilton’s anxiety scale (HAMA), Hamilton’s depression scale (HAMD), patient health questionnaire-9 (PHQ-9), and the World Health Organization quality of life brief scale (WHOQOL-BREF) score of two groups were observed before and after treatment, and the differences of serum norepinephrine (NA), neuropeptide Y (NPY), serotonin (5-HT), blood pressure, endothelin 1 (ET-1), endogenous nitric oxide synthetase (eNOS) and nitric oxide (NO) were compared. RESULTS: The total effective rate of the observation group was 96. 83% (61/63), significantly higher than that of the control group [79.37% (50/63)], the difference was statistically significant (P<0.05). After treatment, the PHQ-9, HAMA and HAMD scores in the observation group were significantly lower than those in the control group, and the WHOQOL-BREF score in the observation group was significantly higher than that in the control group, the serum levels of NA, NPY and 5-HT in the observation group were significantly lower than those in the control group, the serum levels of eNOS and NO in the observation group were significantly higher than those in the control group, and ET-1 was significantly lower than that in the control group,and the differences were statistically significant (P<0.05); there was no significant difference in diastolic blood pressure and systolic blood pressure between two groups (P>0.05). CONCLUSIONS: The efficacy of tandanone citrate combined with conventional antihypertensive therapy for hypertension complicated with anxiety is significant, can improve patients’ clinical anxiety. [ABSTRACT FROM AUTHOR]

Objective To observe the clinical effect of different methods of sputum suction in severe craniocerebral injury patients with tracheotomy. Methods A total of 80 severe craniocerebral injury patients with tracheotomy，who were all unconscious without mechanical ventilation，in Department of Neurosurgery in the hospital from May 2016 to May 2017 were selected and divided into the control group and the research group according to tracheotomy sequence，40 cases in each group. The control group took the sputum suction method according to the demand，while the research group took the sputum suction method with percussion on back，and the effect of sputum suction in the two group was compared. Results The proportion of saturation of pulse oximetry rising to 90% or more in 30 min after sputum suction and the sputum interval time in the research group[84.0%（42/50），（3.60±0.66）h ] were more than those in the control group[66.0%（33/50），（1.65±0.53）h]，and the degree of artificial airway patency in the research group was superior to that in the control group. The occurrence rate of hypostatic pneumonia and tracheal mucosa damage in the research group [22.5%（9/40），15.0%（6/40）] were remarkably lower than those in the control group [45.0%（18/40），35.0%（14/40）]，with statistically significant difference（P<0.05）. Conclusion For the severe craniocerebral injury patients with tracheotomy，sputum suction with percussion on back can restore saturation pulse oximetry quickly，decrease the occurrence of hypoxia，prolong sputum interval time，reduce the incidence of hypostatic pneumonia and tracheal mucosa damage. [ABSTRACT FROM AUTHOR]

In this study, the treatments with 2-pin shading net covering the potato, without shading net as the control were designed. The effect of different shading treatments on growing, yield and nutritional quality of ‘Qingshu9' was researched. It turned out that height, internode length, leaf area increased obviously compared with the control treatment after shaded, stem diameter decreased compared with the control treatment, main stem number, and pitch number had no significant difference compared with the control treatment. And the shading treatment had a serious effect on tuber yield. Under the 70. 22 % shading, the commodity rate, weight of individual plant, yield decreased remarkably compared with the control which could reduce 87. 08 % production,other shade treatments that the shading over the 80 % was never produced. Therefore the shading 70 % was used as the selection pressure for another 9 potato varieties of shade-tolerant evaluation. The results indicated that the reduction in yield were significant fearfully in all varieties of potato. The reduction rate of yield range between 62. 14 % and 90. 74 %. There were obvious differences between varieties of shade-tolerance. The variety of ‘Zhongshu20 'was the most shade-tolerant,the second shade-tolerance varieties were the ‘Woff', ‘Qingshu9', ‘Favorite', and the least shade-tolerant variety was the ‘Hezuo88'. From the point of tuber quality influence, dry matter and starch content all decreased, however, the vast majority of potato cultivars protein content increased after shading treatment. [ABSTRACT FROM AUTHOR]

Objective: To explore the entry points and working methods of clinical pharmacists in the delivery of pharmaceutical care in the gynecological oncology ward. Methods: A summary of the entry points for pharmaceutical care by clinical pharmacists was made in the gynecological oncology ward through analysis of typical eases. Results: The entry points for pharmaceutical care by clinical pharmacists in the gynecological oncology ward included the following: treatment of catheter-related infections, which could avoid abuse of senior grade antibiotics; education of patients as well as medical personnel, which could improve medication compliance: awareness of adverse drug reactions. Conclusion: By taking full advantage of the pharmaceutical knowledge, clinical pharmacists, in the delivery of pharmaceutical care in the gynecological oncology ward, could promote rational use of drugs, ensure safe, effective and economic medication in this particular population. improve medication compliance of the patients, and more importantly avoid serious adverse drug reactions. [ABSTRACT FROM AUTHOR]

OBJECTIVE:To investigate the incidence of adverse drug reactions (ADR) in obstetrical department, and probe into the function of clinical pharmacists in ADR disposal. METHODS:Clinical pharmacists participated in consultations and provided pharmaceutical service for 3 ADR patients which were respectively induced by indometacin suppositories, Nifedipine sustained release tablets and neostigmine. RESULTS:Clinical pharmacists analyzed ADR induced by indometacin suppositories, Nifedipine sustained release tablets and neostigmine, took pharmaceutical cares and assisted clinicians with formulating and optimizing therapeutic regimen. All patients turned better after treatment. CONCLUSIONS:Clinical pharmacists should give full play of professional advantages and take positive participation in clinical treatment, so as to enhance clinicians-pharmacists-patients cooperation and promote clinical rational drug application. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To investigate the incidence of adverse drug reactions (ADR) in obstetrical department, and probe into the function of clinical pharmacists in ADR disposal. METHODS: Clinical pharmacists participated in consultations and provided pharmaceutical service for 3 ADR patients which were respectively induced by indometacin suppositories, Nifedipine sustained release tablets and neostigmine. RESULTS: Clinical pharmacists analyzed ADR induced by indometacin suppositories, Nifedipine sustained release tablets and neostigmine, took pharmaceutical cares and assisted clinicians with lormulating and optimizing therapeutic regimen. All patients turned better alter treatment. CONCLUSIONS: Clinical pharmacists should give full play of professional advantages and take positive participation in clinical treatment, so as to enhance clinicians-pharmacists-patients cooperation and promote clinical rational drug application. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To investigate the application status of proton pump inhibitors (PPI) in gynecology department of the Third Affiliated Hospital of Zhengzhou University (hereinafter referred to as "our hospital "). METHODS: 1 424 medical records with PPI from gynecological department from Jul. 1st 2014 to Dec. 31th 2015 were randomly selected to conduct the retrospective analysis, and the rationality was evaluated. RESULTS: The rate of improper indication was 83. 08% (1 183 /1 424); patients with treatment more than 7 d accounted for 18. 40% (262 /1 424); and the rate of improper usage and dosage up to 17. 33% (239 /1 379). CONCLUSIONS: It is suggested to enhance the medication intervention measures and establish standard on rational use of PPI in hospital, so as to improve the situation of inappropriate application. [ABSTRACT FROM AUTHOR]

Objectives To investigate the effect of the expression of low-density lipoprotein receptor associated protein (LDLR) on the vascular abnormalities in hepatocellular carcinoma (HCC) and its mechanisms. Methods Based on the information of Oncomine Cancer GeneChip database, we analyzed the correlation between the expression level of LDLR and the expression level of carcinoembryonic antigen (CEA) and CD31 in hepatocellular carcinoma tissues. Lentiviral transfection of short hairpin RNA target genes was used to construct LDLR-knockdown MHCC-97H and HLE hepatocellular carcinoma cells. The differential genes and their expression level changes in LDLR-knockdown hepatocellular carcinoma cells were detected by transcriptome sequencing, real-time fluorescence quantitative polymerase chain reaction, and protein immunoblotting. The gene-related signaling pathways that involve LDLR were clarified by enrichment analysis. The effect of LDLR on CEA was assessed by the detection of CEA content in conditioned medium of hepatocellular carcinoma cells. Angiogenesis assay was used to detect the effect of LDLR on the angiogenic capacity of human umbilical vein endothelial cells, as well as the role of CEA in the regulation of angiogenesis by LDLR. Immunohistochemical staining was used to detect the expression levels of LDLR in 176 hepatocellular carcinoma tissues, and CEA and CD31 in 146 hepatocellular carcinoma tissues, and analyze the correlations between the expression levels of LDLR, CEA, and CD31 in the tissues, serum CEA, and alanine transaminase (ALT). Results Oncomine database analysis showed that the expressions of LDLR and CEA in the tissues of hepatocellular carcinoma patients with portal vein metastasis were negatively correlated (r=−0.64, P=0.001), whereas the expressions of CEA and CD31 in these tissues were positively correlated ( r= 0.46, P=0.010). The transcriptome sequencing results showed that there were a total of 1 032 differentially expressed genes in the LDLR-knockdown group and the control group of MHCC-97H cells, of which 517 genes were up-regulated and 515 genes were down-regulated. The transcript expression level of CEACAM5 was significantly up-regulated in the cells of the LDLR-knockdown group. The Gene Ontology (GO) function enrichment analysis showed that the differential genes were most obviously enriched in the angiogenesis function. The Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway enrichment analysis showed that the relevant pathways involved mainly included the cellular adhesion patch, the extracellular matrix receptor interactions, and the interactions with the extracellular matrix receptors. The CEA content in the conditioned medium of the LDLR-knockdown group was 43.75±8.43, which was higher than that of the control group (1.15±0.14, P＜0.001). The results of angiogenesis experiments showed that at 5 h, the number of main junctions, the number of main segments, and the total area of the lattice formed by HUVEC cells cultured with the conditioned medium of MHCC-97H cells in the LDLR-knockdown group were 295.3±26.4, 552.5±63.8, and 2 239 781.0±13 8211.9 square pixels, which were higher than those of the control group (113.3±23.5, 194.8±36.5, and 660 621.0±280 328.3 square pixels, respectively, all P＜0.01).The number of vascular major junctions, the number of major segments, and the total area of the lattice formed by HUVEC cells cultured in conditioned medium with HLE cells in the LDLR-knockdown group were 245.3±42.4, 257.5±20.4, and 2 535 754.5±249 094.2 square pixels, respectively, which were all higher than those of the control group (113.3±23.5, 114.3± 12.2, and 1 565 456.5±219 259.7 square pixels, respectively, all P＜0.01). In the conditioned medium for the control group of MHCC-97H cells, the number of main junctions, the number of main segments, and the total area of the lattice formed by the addition of CEA to cultured HUVEC cells were 178.9±12.0, 286.9±12.3, and 1 966 990.0±126 249.5 spixels, which were higher than those in the control group (119.7±22.1, 202.7±33.7, and 1 421 191.0±189 837.8 square pixels, respectively). The expression of LDLR in hepatocellular carcinoma tissues was not correlated with the expression of CEA, but was negatively correlated with the expression of CD31 (r=−0.167, P=0.044), the level of serum CEA (r=−0.061, P=0.032), and the level of serum ALT(r=−0.147,P=0.05). The expression of CEA in hepatocellular carcinoma tissues was positively correlated with the expression of CD31 (r= 0.192, P=0.020). The level of serum CEA was positively correlated with the level of serum ALT (r= 0.164, P=0.029). Conclusion Knocking down LDLR can promote vascular abnormalities in HCC by releasing CEA. [ABSTRACT FROM AUTHOR]

Aim To investigate the relationship between fibrinogen (FIB) and the progression of coronary plaque stenosis rate in patients with type 2 diabetes mellitus (T2DM). Methods Hospitalized T2DM patients who underwent two or more coronary CT angiography (CCTA) examinations in the First Affiliated Hospital of Xi􀆳an Jiaotong University from January 2015 to December 2020 were included. The subjects were divided into high FIB and low FIB groups according to the median of FIB. The differences in the progression of coronary plaque stenosis rate and other clinical characteristics were compared between the two groups, and the relationship between FIB level and the progression of coronary plaque stenosis rate was analyzed by Spearman􀆳s correlation analysis and Logistic regression. Results A total of 145 patients were included, 73 in the high FIB group and 72 in the low FIB group at baseline, with a median follow-up time of 25 (18, 40) months between CCTA. The age, proportion of women, and the progression of coronary plaque stenosis rate were higher in the high FIB group than those in the low FIB group, and the differences were statistically significant (P<0. 05). FIB level was positively correlated with the change in coronary plaque stenosis rate (r2 = 0. 308, P< 0. 001). Multivariate Logistic regression analysis showed that FIB level was a risk factor for the progression of coronary plaque stenosis rate in patients with T2DM (OR=5. 25, 95%CI: 1. 97 ~14. 02, P<0. 001), after adjusting for age, sex and other clinical risk factors. Conclusion High baseline FIB level is an independent risk factor for the progression of coronary plaque stenosis rate in patients with T2DM, and monitoring FIB level is beneficial to cardiovascular risk stratification in patients with T2DM. [ABSTRACT FROM AUTHOR]

目的总结脂质沉积性肌病(LSM)的临床特点。方法回顾性分析13例LSM的临床资料。结果临 床表现为双下肢近端无力及运动不耐受8例，全身肌肉酸胀痛2例，抬头困难伴咀嚼困难、双侧下肢肌肉萎缩、代 谢性脑病及精神发育迟滞各1例;神经电生理分析正常2例，肌原性损害9例，神经源性损害、神经源性损害合并肌 原性损害各1例;肌酸磷酸激酶升高13例，α-羟基丁酸脱氢酶升高12例，乳酸脱氢酶升高10例，肌酸激酶同工酶 升高6例。光镜下HE染色可见大量含有筛孔样空泡的肌纤维，轻度患者肌纤维大小基本一致，其中3例为中重度 患，可见大小不等、变性、坏死的肌纤维;油红〇染色显示I型纤维中脂质颗粒明显增多;高碘酸Schiff反应染色均 阴性。电镜下肌细胞的大小及形态基本一致，大部分肌细胞的肌膜下、核旁、肌原纤维间可见大量脂滴沉积，脂滴 呈“串珠”状排列或堆积;肌细胞间隙无明显增宽，肌细胞内线粒体、糖原无明显增多，未见炎症细胞浸润。结论 LSM临床表现为明显的肌无力或疼痛、肌电图正常或异常、血清肌酶谱升高等，结合肌肉活检光镜及电镜检查有利 于LSM的早期诊断及鉴别诊断。 [ABSTRACT FROM AUTHOR]

[Objective] The purpose of this experiment was to explore the effects of potato stem and leaf returning on the physiochemical properties of soil and the structure of the bacterial community. [Method] Differences in soil physiochemical properties and bacterial communities were compared between soil samples with (treatment group R) and without (treatment group NR) potato stem and leaf returning using soil physiochemical analysis and Illumina high-throughput sequencing techniques. [Result] Compared to CK treatment, potato stem and leaf returning significantly increased soil pH, organic matter, alkali-hydrolysable nitrogen, available phosphorus and available potassium content, particularly the available potassium content with an increases from 42. 36 to 141.53 mg/kg. Potato stem and leaf returning significantly affected the structure of the soil bacterial community, with a significant increase in the abundance of 12 bacterial taxa in the R treatment group (on the 45th and 90th day). In addition, the diversity of soil bacterial species was significantly higher in the R treatment group compared to the NR treatment group. Co-occurrence network analysis indicated that the inter-species interactions of bacteria occurred primarily in the Acidobacteria, Actinobacteria, and Proteobacteria phyla. The strength of the interaction was significantly higher in the potato stem and leaf returning treatment compared with the non-returning treatment. Correlation analysis revealed a highly significant negative correlation between Latescibacterota and Desulfobacterota with available phosphorus content and a significant positive correlation with alkali hydrolysable nitrogen and organic matter content. Furthermore, significant positive correlations were observed between Myxococcota, Bdelloyibrionota, Patescibacteria, Entotheonellaeota, Gemmatimonadota, Nitrospirota, Proteobacteria and available potassium content. [Conclusion] The findings indicated that the returning of the potato stem and leaf could significantly improve the soil nutrient content, the diversity of bacterial species and the strength of interspecies interactions in the soil bacterial community. There were significant correlations between the physiochemical properties of the soil and the composition of the bacterial community of the soil. [ABSTRACT FROM AUTHOR]

Objective To explore the spatio - temporal distribution characteristic's of mushroom poisoning outbreaks in Guizhou Province; from 2012 to 2021, and to provide a reference basis for organizing and implementing regional prevention and control strategies for mushroom poisoning in Guizhou Province. Methods Descriptive analysis and spatio - temporal clustering analysis were conducted on the; data of mushroom poisoning outbreaks in Guizhou Province; from 2012 to 2021 in the; Foodbornc; Disease; Outbreak Surveillance; System. Results A total of 1 509 mushroom poisoning outbreaks were; reporter! in Guizhou Province; from 2012 to 2021, with 5 221 c;asc;s and an average; annual reported incidence; rate; of 0. 14/100 000. Mushroom poisoning outbreaks in Guizhou Province; was clustering (Moran / = 0.286, P <0.05). There; were; 19 spatial clusters, including 6 "high - high" clusters, 1 "high-low" cluster, and 12"low-low" clusters. Further analysis revealed three; spatio - temporal clusters in mushroom poisoning outbreaks. Among them, there; were; 24 counties (districts) in type; 1 spatio - temporal clustering, 1 county (district) in type; 2 spatio - temporal clustering, and 6 counties? (districts) in type; 3 spatio - temporal clustering, and the; differences were; statistically significant (P < 0. 05). Conclusion There is spatio - temporal clustering in mushroom poisoning outbreaks in Guizhou Province; from 2012 to 2021, and precise; prevention and control should be; carried out in each spatio - temporal clustering arc;a. [ABSTRACT FROM AUTHOR]

Aiming at heat transfer enhancement of solar collector tubes, the flow field distribution based on the field synergy principle with circumferentially non-uniform heat flux boundary condition was investgated. The momentum equation with a special additional volume force was calculated with constructing Lagrange function using variational method through the numerical simulation. The relationship of longitudinal vortexes and heat transfer coefficient was established. The method of heat transfer enhancement with optimizing the flow field and improving the rate of usage for solar energy was put forward. The results show that under the condition of non-uniform heat flux the longitudinal vortexes in the heat exchange tube can enhance the heat transfer markedly and the flow resistance increase is similar to heat transfer enhancement.And the increase range of the flow resistance is less than the heat transfer enhancement. The effect of heat transfer of optimize flow field is much higher with greater longitudinal vortex intensity and larger Reynolds number. [ABSTRACT FROM AUTHOR]

[ Objective ] In order to obtain the high photosynthetie efficiency potatos varieties (lines) , we used five different potatoes varieties (lines) as an experiment object to determine tin; photosynthetie efficiency of the potatoes varieties (lines) under different ecological conditions. [Method] The photosynthetie parameters of five different potatoes varieties (lines) were determined through 1.1-6400 XT portable photosynthetie meter measurement system. [ResultjThe data suggested that the photosynthetie traits of five different stains were significantly different under same condition of life, and under different condition ol life, tin; photosynthetie traits of same strains were also different. ‘ Dian-shu 701 ’ had higher net photosynthetie rate than other varieties ( lines)under the weak light, ‘ Qingshu 9 ’ with high apparent quantum efficiency , maximum net photosynthetie efficiency, lower light compensation point and dark respiration rate was suitable for planting in Kunming city and Dali prefecture. Under the oligonucleotides sunshine conditions ,apparent quantum efficiency, maximum net photosynthetie rate, saturation light intensity of the five different potato varieties (or lines) all decreased, dark respiration rate and light compensation point had not obvious change. [Conclusion] ‘Qingshu 9’ ’and ‘ Dianshu 701 were high light efficiency varieties. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the effects of Paracetamol, caffeine, bovis calculus sativus and chlorphenamine maleate capsules ( Ankahuangmin capsules) on blood concentration of clozapine in patients with mental disorder during cold. METHODS: Medical records of 44 inpatients with mental disorders who underwent stable treatment with clozapine and took Paracetamol, caffeine, bovis calculus sativus and chlorphenamine maleate capsules (Ankahuangmin capsules) during cold from Jan. 2020 to Oct. 2021 in the hospital were retrospectively collected to obtain information on patients’ gender, age, dosing regimen, drug combination and blood concentration of clozapine, and statistical analysis was performed by using SPSS 25. 0. RESULTS: The blood concentration of clozapine increased to different degrees in 44 patients treated with Paracetamol, caffeine, bovis calculus sativus and chlorphenamine maleate capsules (Ankahuangmin capsules), the mean blood concentration was (444. 23±289. 24) ng / mL at baseline period and (621. 43±375. 23) ng / mL at intervention period; the white blood cell count (WBC) also increased to different degrees, the median value of WBC was 6. 67×109 / L at baseline period and 8. 06×109 / L at cold period; 12 patients experienced adverse drug reactions after blood concentration elevation of clozapine. CONCLUSIONS: The application of Paracetamol, caffeine, bovis calculus sativus and chlorphenamine maleate capsules (Ankahuangmin capsules) during the cold period has an effect on blood concentration elevation of clozapine, while the elevation of WBC could not significantly affect the blood concentration of clozapine. The monitoring on blood concentration of clozapine after drug combination of Paracetamol, caffeine, bovis calculus sativus and chlorphenamine maleate capsules ( Ankahuangmin capsules) and clozapine is crucial to avoid adverse drug reactions related to blood concentration of clozapine. [ABSTRACT FROM AUTHOR]

With the support of information technology and industrial transformation and upgrading the focus of global economic development has gradually shifted to knowledge intensive industries with high growth low pollution and high added value and cultural and creative industries have become the focus of a new round of competition around the world. The Yangtze River Delta urban agglomeration is one of the most representative and demonstrative regions in the development of cultural and creative industries in China. With the continuous expansion of the industrial scale problems of the cultural and creative industries in the Yangtze River Delta urban agglomeration have also gradually emerged in the process of development such as unreasonable spatial layout insufficient connectivity of resource elements and cutthroat competition of industrial homogeneity and non-differentiation. With the in-depth promotion of the national strategy of the integrated development of the Yangtze River Delta and the high-quality development strategy of the Yangtze River Delta urban agglomeration how to improve the spatial layout of the cultural and creative industries in the Yangtze River Delta urban agglomeration has become a practical issue to be solved urgently. Although the academia has studied the spatial problems of cultural and creative industries in the Yangtze River Delta urban agglomeration from the theoretical and empirical perspectives there are still few empirical studies on the spatial correlation and network structure characteristics of cultural and creative industries in the Yangtze River Delta urban agglomeration from the perspectives of space and geography. In order to promote the spatial layout of cultural and creative industries in the Yangtze River Delta urban agglomeration we from the perspective of coordinated development of the Yangtze River Delta urban agglomeration combining with relevant data from 2011 to 2019 use the revised spatial gravity model social network analysis method and Ucinet and ArcGIS software to conduct empirical analysis on the spatial correlation strength and spatial network structure characteristics of cultural and creative industries in the Yangtze River Delta urban agglomeration from the perspective of centrality and core edge and further explore the agglomeration sub-groups of cultural and creative industries spatial correlation plates and the correlation between plates of the Yangtze River Delta urban agglomeration. The spatial correlation and network structure characteristics of cultural and creative industries in the Yangtze River Delta urban agglomeration are clarified which provides decision-making reference for the construction of a new pattern of differentiated and misplaced development of regional cultural and creative industries the optimal allocation of industrial resources the efficient circulation of industrial factors and the high-quality development of industries. The results show that i the spatial correlation intensity of cultural and creative industries in the Yangtze River Delta urban agglomeration increases year by year ii the cultural and creative industry network structure of the Yangtze River Delta urban agglomeration is becoming increasingly stable and Shanghai Nanjing and Hangzhou are the central nodes and channel controllers of the entire network iii the cities in the east wing of the Yangtze River Delta are located in the core area of the whole network and the core area is closely connected with each other but the trickle-down effect on the marginal cities is limited iv the cultural and creative industries of the Yangtze River Delta urban agglomeration mainly focus on Shanghai Nanjing Hangzhou Hefei and other central cities and form a cohesive sub-cluster closely related internally. How to effectively build the coordinated development mechanism for cultural and creative industries along the Yangtze River Delta so as to facilitate the smooth flow of industrial resources how to form the network pattern of differentiated and dislocated development of regional cultural and creative industries so as to improve the efficiency of spatial allocation of industrial factors and how to form a well-proportioned regional industrial innovation ecosystem so as to promote the high- quality development of industries are the major issues that need further research. [ABSTRACT FROM AUTHOR]

Energy consumption is the key factor affecting the network lifecycle in wireless sensor networks, so low power consumption is expected for the industry. Several existing network clustering protocols, such as LEACH protocol, can solve and reduce network energy consumption to some extent. Although they can prolong the life cycle of the network to a certain extent, there are yet many incalculable factors in the network environment and actual environment. LEACH protocol ignores the residual energy of the current node and the node distribution situation. In this regard, we present a low power clustering protocol based on fuzzy control (LECPFC) to solve the aforementioned problems. In the process of selecting cluster heads, node energy, node degree, node center, distance and listen density etc. are focused. Network configuration and simulation results show that the proposed protocol can greatly improve the work efficiency of the network. [ABSTRACT FROM AUTHOR]

To explore the effects of group interpersonal psychotherapy (IPT) on cognitive and social function in patients with first-episode schizophrenia， and to provide references for appropriate psychological treatment for the patients. Methods A total of 62 patients with first-episode schizophrenia who met the diagnostic criteria of International Classification of Diseases， tenth edition (ICD-10) and were admitted to the Third People's Hospital of Foshan from January to December 2021 were selected as the study objects. And patients were divided into study group and control group according to random number table method， each with 31 cases. Both groups were treated with risperidone for 8 weeks， based on this， study group received group IPT. Before and after 8 weeks of treatment， Positive and Negative Syndrorne Scales (PANSS)， Wisconsin Card Sorting Tests (WCST) and Personal and Social Performance Sale (PSP) were adopted to assess the patients' psychiatric symptoms， cognitive function and social function. Results After 8 weeks of treatment， there was no significant difference in PANSS scores between the two groups (t=0. 296，P>0. 05). The WCST total number of responses in the study group was larger than that in the control group， the number of perseverative errors and non-perseverative errors were smaller than those in the control group， and PSP score of the study group was higher than that of the control group， with statistically significant differences (t=0. 398，2. 609，0. 523，0. 381，P<0. 05 or 0. 01). Conclusion Group IPT may have no significant efficacy on alleviating the symptoms of patients with first-episode schizophrenia， but it may help improve the cognitive and social function in patients. [ABSTRACT FROM AUTHOR]

Industrial policy plays an extremely important guiding role in industrial growth and development. Since the 1980s and 1990s, the rapid development of high technology has promoted the organic integration of culture and economy, giving birth to a new format of cultural and creative industry. Countries all over the world have formulated corresponding industrial policies to promote the development of cultural and creative industry. Cultural and creative industry policy with the important functions of remedying market defects, optimizing resource allocation and protecting industrial development has become the hotspot of related research in the theoretical circles. In view of few results of econometric analysis on cultural and creative industry policies, in order to strengthen the guiding role of cultural and creative industry policy on industrial development, it is necessary to summarize and analyze the results of existing cultural and creative industry policy research. Adopting the method of bibliometrics and taking 411 cultural and creative industry policy research documents retrieved from CNKI as samples, this paper conducts clustering and econometric analysis on the cultural and creative industry policy research documents from the dimensions of annual document distribution, core author distribution, research institution distribution and research frontier using CiteSpace and Excel software, and draws the corresponding knowledge map to explore the theme evolution, focus of attention and research trend of cultural and creative industry policy research. All the sample data in this paper come from CNKI, which is a relatively complete and authoritative journal database in nowadays China, so as to ensure the authority of the research samples and the high quality of the research conclusions. The econometric analysis of cultural and creative industry policy research literature can not only provide decision-making reference for the policy-making of cultural and creative industry, but also provide theoretical guidance for the differentiated development and the construction of new pattern of regional cultural and creative industry. It is found that the research on China’ s cultural and creative industry policy started at the beginning of the new century, reached a climax around 2013, and showed a downward trend after 2015; China’s cultural and creative industry policy research forces are unevenly distributed in a relatively scattered state, and no cooperation network among research institutions has been established; China’ s cultural and creative industry policy research has gradually shifted from focusing on industrial development in the initial stage to focusing on system reform and policy entity content. The current research pays increasing attention to the combination with the practice of socio-economic development. The existing cultural and creative industry policy research mainly focuses on theoretical discussion, and lacks quantitative analysis of different industrial categories and different local policies, which is not conducive to improving the accuracy and pertinence of policy formulation. In the future, we must strengthen the integration of research forces, establish a cooperative research network, promote the cooperation and exchange among research institutions, and strengthen the quantitative research on the cultural and creative industry policies. In view of the important role of cultural and creative industry in promoting regional economic development, cultural and creative industry policy research is still a major issue to be continued. The expansion and refinement of the content and scope of cultural and creative industry policies, the construction of cultural and creative industry policy coordination mechanism, the optimization and governance of cultural and creative industry policy network structure, the evaluation of cultural and creative industry policy effectiveness and policy effect analysis will be major topics worthy of in-depth study in the future. [ABSTRACT FROM AUTHOR]

Based on the particle spectrum of floating dust, with the analysis of the scattering efficiency factor and scattering coefficient of floating dust particle size by Mie scattering theory; Monte Carlo method was used to simulate and analyze the effect of floating dust particle size and concentration on UV communication in floating dust weather. Finally, an experimental device was built to test and analyze the effects of particle size and concentration on UV communication performance in different floating dust weather, the results of which were then contrasted with the simulation ones. The results show that: 1)the scattering efficiency factor and extinction efficiency factor of floating dust particles show an oscillatory attenuation trend, and the oscillation finally converges near 2.07 and 1.14 with the increase of scale parameters, respectively. 2)When the floating dust concentration is constant, the path loss of UV communication decreases first and then increases with the increase of particle size, and the radius of the minimum is 1.0～1.5 μm. 3)During short distance communication in dusty weather, the path loss decreases with the increase of dust concentration and increases with the increase of communication distance and transceiver elevation. [ABSTRACT FROM AUTHOR]

Objective: To investigate relationship between serum CXC subfamily chemokine receptor 3 (CXCR3),C-X-C chemokine ligand (CXCL) 5, CXCL12 levels and the severity of coronary artery disease and prognosis in patients with coronary heart disease (CHD). Methods: A total of 189 patients with CHD (CHD group) who were admitted to the department of cardiology of our hospital from February 2018 to February 2020 were selected. According to Gensini integral, the patients were divided into mild lesion group (≤ 20 scores, 62 cases), moderate lesion group (21～40 scores, 84 cases) and severe lesion group (> 40 scores, 43 cases). According to the occurrence of major adverse cardiovascular events (MACE) during the follow-up period, the patients were divided into MACE group (45 cases) and non MACE group (144 cases), another 102 volunteers who underwent physical examination in our hospital at the same time were selected as the control group. Serum CXCR3, CXCL5, CXCL12 levels were detected, and the relationship between they and the occurrence of MACE in patients with CHD during follow-up. Results: The serum CXCR3, CXCL5 and CXCL12 levels in CHD group were higher than those in control group (P<0.05), and the serum CXCR3, CXCL5 and CXCL12 levels in severe lesion group were higher than those in moderate lesion group and mild lesion group (P<0.05). The serum CXCR3, CXCL5 and CXCL12 levels in moderate lesion group were higher than those in mild lesion group (P<0.05). The results of single factor analysis showed that left ventricular ejection fraction(LVEF), hypertension, diabetes, hyperlipemia, blood sugar, number of coronary artery lesions, length of coronary artery lesions, Gensini integral, serum C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), CXCR3, CXCL5, CXCL12 levels were correlated with the occurrence of MACE in patients with CHD during follow-up (P<0.05). Multivariate Logistic regression analysis showed that the number of coronary artery lesions, hypertension, CXCR3, CXCL5 and CXCL12 were the influential factors for the occurrence of MACE in patients with CHD during follow-up (P<0.05). Conclusions: The serum CXCR3, CXCL5 and CXCL12 levels in patients with CHD are increased, and they are related to the exacerbation of coronary artery disease and the occurrence of MACE. The detection of serum CXCR3, CXCL5 and CXCL12 is helpful to evaluate the condition and prognosis of CHD patients. [ABSTRACT FROM AUTHOR]

Objective To investigate the mechanism of Danshensu (DSS, tanshinol) in improving energy metabolism of hypoxia/reoxygenation (H/R) cardiomyocytes・ Methods The cultured H9C2 cardiomyocytes were divided into five groups: control group, model group, Danshensu low-, medium-, and high-dose groups・ The control group was continuously cultured in complete medium for 7 hours under normal conditions・ The other groups were subjected to the oxy・glucose deprivation mode, after 4 hours of hypoxia and hypoglycemic stimulation, the culture was resumed under normal conditions for 3 hours・ In Danshensu low-, medium- and highgroups, the complete medium contained 1, 10 and 20 |jimol/L DSS respectively・ The activity of cells was detected by CCK-8 method and the content of lactic dehydrogenase (LDH) was determined by ELISA to select the best drug concentration. The optimal drug concentration was selected as Danshensu optimal dose group・ And then the mitochondrial membrane potential (MMP) was detected by JC-1 method, and the mitochondrial membrane permeability transition pore (mPTP) openness was monitored by fluorescence method. The protein expression level of ATP5G3 was evaluated by Western Blot (WB)・ The expression level of ATP5G3 was detected by RT-PCR・ Results Compared with that of the control group, the cell activity was decreased, while LDH release was increased in the model group・ After the intervention of DSS, the cell activity was increased, and LDH release was decreased in the Danshensu medium- and high-dose groups, but there was no significant difference between those two groups; so Danshensu medium-dose group was selected as the optimal dose group・ Compared w让h that of the control group, in the model group ADP/ATP was increased, MMP was decreased, mPTP over-opened, and expression levels of mRNA ATP5G3 and protein ATP5G3 were up-regulated, with remarkable difierence in statistics (P <0. 01); whereas all these were obviously reversed by treatment of DSS in Danshensu medium-dose group (P <0. 05, P < 0. 01)・ Conclusion DSS potentially plays an important role in improving energy metabolism of H/R cardiomyocytes and reducing cell damage, which may be related to the regulation of ATP5G3 expression. [ABSTRACT FROM AUTHOR]

探讨接受单孔胸腔镜肿瘤切除术治疗非小细胞肺癌患者术后出现持续性咳嗽(CAP)的危险因素.方法 收集258例接受单孔胸腔镜肿瘤切除术治疗的非小细胞肺癌患者的临床资料,根据术后是否发生CAP将其 分为发生CAP及未发生CAP者,采用单因素分析和二分类Logistic回归分析法分析患者术后出现CAP的危险因素.结果 258例患者术后CAP发生率39. 1%(101/258). 与术后未发生CAP者比较,术后发生CAP者性别,吸烟史,手 术侧,手术方式,麻醉方式,气管树周围淋巴结切除等因素具有差异.性别,麻醉方式,手术方式,气管树周围淋巴结 切除是术后出现CAP的独立危险因素(P均<0. 05).结论 接受单孔胸腔镜肿瘤切除术治疗的非小细胞肺癌患者 术后出现CAP的危险因素为女性,双腔管气管插管,非楔形切除术,气管树周围淋巴结清扫. [ABSTRACT FROM AUTHOR]

In order to improve the accuracy of short-range wireless ultraviolet distance measurement, based on the principle that the pulse response width of wireless ultraviolet communication system increases with the communication distance, the wireless ultraviolet communication pulse broadening ranging method was proposed. Based on Monte Carlo multiple scattering simulation model, the impulse response of wireless ultraviolet communication system after three scatterings in clear weather was studied, and the expression of impulse response was given. The relationship between the half peak and full width, 10% of the pulse width of the system’s impulse response and the communication distance under different elevations of transmitter and receiver are studied, then the formula of pulse broadening ranging was given and compared with the experimental results. The results show that the average ranging error of the half-peak full-width ranging formula is less than 2.8 m, and the average ranging error of the 10% pulse width ranging formula is less than 1.5 m when the transmitting and receiving elevation angle is less than or equal to 20° and the effective ranging is 0~50 m. [ABSTRACT FROM AUTHOR]

[Objective] The present paper was conducted to detect the main volatile aromatic compounds in steamed potatoes tuber. [Method] Head space solid phase micmextraction (HS-SPME) and gas chromatography-mass spectrometer (GC-MS) were used for determination. [Result] The results showed that 43 volatile aroma compounds were detected from 46 steamed potatoes tuber including 14 aldehydes, 5 esters, 5 alcohols, 5 alkanes, 2 furan, 3 ketones, 7 benzenes and 2 other compounds. [Conclusion] Aldehydes were the main volatile aroma components of steamed potatoes, while benzaldehyde, 3-(methylthio) pmpionaldehyde, decanal, nonanal, hexanal and 2-pentylfuranis were the main compounds of steamed potatoes. It means that the types and relative contents of aroma compounds for different potato varieties have great differences. [ABSTRACT FROM AUTHOR]

Currently the main difficulties in the coalfield seismic exploration are the image generation on the deep and complex geological structure. With the development of Reverse Time Migration(RTM), it is one of the urgent problem how to improve its efficiency at the same accuracy. From the point of view of imaging regional grid discretization, in the premise of ensuring the accuracy of migration imaging, to overcome the problem of over-sampling for high speed layer and under-sampling for low speed layer, this study puts forward the concept of multi-scale grid for RTM. The algorithm has a good flexibility which can image the geological model in the way of sparse and dense. Firstly, the multi-scale grid model is developed according to the velocity model, the small scale grid for the low speed area and large scale grid for high speed area are used. Secondly, the wave field value of each point is calculated based on the high order FDTD, especially the points in transition zone. Finally, the underground media is imaged based on the imaging condition. The experimental results show that under the condition of guaranteeing the accuracy of the same simulation order, the multi-scale RTM computational efficiency can be promoted by 25.05% average compared with the traditional method. [ABSTRACT FROM AUTHOR]

Aiming at the problems of slow speed and poor realtime performance of traditional file storage methods, a fast file storage method for collecting data is presented. The method adopts the dual consumption mode of producer and consumer, synchronizing data acquisition and data processing. Namely, we synchronize the storage, calculation, and display of files in data processing, making file storage processing sustainable, with TDMS file storage format further accelerating the speed of file storage. In order to test the validity of the method, a set of software and hardware testing platform is built with data acquisition, USB data transmission, waveform display and data storage function. The result shows that the sampling data takes less time than the traditional file storage method at the same time, and the longer the sampling time, the higher the efficiency. [ABSTRACT FROM AUTHOR]

Cement is a basic material, which plays an important role in ensuring national economic construction. Cement grinding roller press plays an important role in cement production and grinding process. The grinding roller is the key component on the grinding roller press and the abrasion loss is quite large. Therefore, increasing the wear resistance and reducing abrasion loss of the grinding roller press will bring huge economic benefits to cement production. Organisms have evolved a large number of non-smooth surface structures in the process of natural selection. Such as the scale structure on the surface of the pangolin, the fringe structure on the shell surface, the blocky protuberance structure on the surface of the lizard, etc. These non-smooth structures play an important role in improving wear resistance and reducing abrasion of biological surfaces. In order to improve the wear resistance and fragmentation of cement grinding roller press. Based on the excellent wear resistance and drag reduction characteristics of the non-surface structure. Guided by bionics non-smooth theory. According to the working principle and actual size of the grinding roller press. The bionic pit shape structure with different depth, different diameter, different axial spacing and different circumferential angle designed on the surface of grinding roll. Each factor selected at two levels. The factors of the pits arranged according to the orthogonal experimental design method. The grinding roller machined according to orthogonal experimental design. To do the wear test of the grinding roller after processing carried out. The composition and structure of the test bench are basic the same as the actual roller press. Two relatively rotating grinding rollers driven by an electric motor. The grinding rollers extruded the abrasive quartz sand in the middle of them. The wear condition judged by measuring the quality loss. The test results showed that the reasonable bionic pit structure could significantly improve the wear resistance of the grinding roller. The wear resistance of the grinding roller improved by 29.06% compared with the standard grinding roller. In order to explore the wear mechanism of bionic grinding roller, the force analysis of the grinding roller analyzed by finite element software. The reasonable bionic pit shape structure could effectively reduce the stress in the inner surface and the stress distribution of grinding roller surface. It can also reduce the stress gradient and optimize the force on the grinding roller surface, reduce abrasion and improve wear resistance. The crushing test of the grinding roller carried out according to the orthogonal experimental design. The fragmentation rate of quartz sand used as a criterion for evaluating crushability. The bionic pit structure can effectively improve the crushability of the grinding roller according to the test results. Its crushability increased by 18.7% compared with the standard grinding roll. Combined with the explicit dynamic finite element method to explore the crushing process of grinding roller. It found that the maximum extrusion pressure was an important factor affecting the crushability of grinding roller. It found that the maximum extrusion pressure was an important factor affecting the crushability of grinding roller. It was the best grinding roller with both wear resistance and breakage when the diameter of the pit is 8 mm, the depth of the pit is 2 mm, the distance of the axial pit is 16 mm and the number of circumferential pit is 12. The single particle crush test of the bionic grinding roller carried out and the whole process of quartz sand breakage recorded by high-speed camera. Compared with the standard grinding roll, the bionic pit shape grinding roller can seize quartz sand quickly, form transient stability structure, reduce the sliding probability of quartz sand on the grinding roller surface. Reduced the probability of scratch on the grinding roll surface by the quartz sand. The bionic pit shape structure makes the single point support become multi-point support in the process of extruding quartz sand by grinding roller. The extrusion force dispersed which was the important reason to improve the abrasion resistance and crushability of the grinding roller press. [ABSTRACT FROM AUTHOR]