Search

Researchers at the University of Sonora in Hermosillo, Mexico, have developed karaya gum-containing thermosensitive hydrogels for the controlled release of lidocaine, a local injectable anesthetic. The study found that the integration of karaya gum with a thermosensitive polymer network improved the compressive strength of the hydrogel and enhanced drug entrapment efficiency. The dual temperature- and pH-responsive hydrogels showed promise for biomedical applications, supporting both short- and long-term analgesic effects. This research was funded by Consejo Nacional de Humanidades Ciencias y Tecnologias (CONAHCYT) and Universidad de Sonora, and has been peer-reviewed. [Extracted from the article]

A study from the Technical University of Munich (TUM) explores the antimicrobial effects of lidocaine against Staphylococcus species, particularly in the context of arthritis management. The research investigates the concentration-dependent antimicrobial properties of lidocaine in combination with hyaluronan and triamcinolone, showing promising results in reducing bacterial levels. The study suggests that lidocaine, when combined with other injectables, may help mitigate the risk of septic arthritis, highlighting its potential clinical relevance. [Extracted from the article]

A recent study conducted by a researcher at the China Academy of Chinese Medical Sciences focused on the protective effects of liensinine against acetaminophen-induced liver injury. The study found that liensinine, an alkaloid with pharmaceutical activities, demonstrated potential in alleviating liver damage caused by acetaminophen through various pathways, including inflammation suppression, oxidative stress reduction, and inhibition of cell apoptosis. The research, which involved treating mice with liensinine and conducting biochemical assays and transcriptome analysis, concluded that liensinine could mitigate acetaminophen-induced hepatotoxicity through multifaceted mechanisms. [Extracted from the article]

Recent research from Autonomous University Madrid explores the photodegradation of acetaminophen using titania-based fibers prepared by electrospinning. The study highlights the potential of solar photocatalysis as an advanced oxidation technique to degrade pharmaceutical emerging pollutants in water without the addition of chemical compounds. The research demonstrates that fibers calcined at lower temperatures exhibit higher photocatalytic activity, making them suitable for continuous reaction systems. This study, supported by the Spanish Government, provides valuable insights into the application of nanotechnology in addressing environmental and health challenges related to pharmaceutical pollutants. [Extracted from the article]

Researchers from Isfahan University of Medical Sciences conducted a study on effective strategies to improve sexual satisfaction in women during pregnancy and postpartum. The study reviewed 40 articles and found that educational techniques, sexual counseling, and pelvic exercises were commonly used interventions. The research highlighted the importance of midwifery professionals in providing accessible and affordable services to enhance women's sexual experiences during these periods. The findings suggest that these approaches can help women better adjust to pregnancy and postpartum phases. [Extracted from the article]

Research from Cairo University in Giza, Egypt, has developed a novel electrochemical sensor for the simultaneous detection of lidocaine and epinephrine in human serum samples. The sensor, made with poly(L-serine), graphene oxide, and beta-cyclodextrin, showed improved performance in detecting the two drugs. The study concluded that the sensor effectively analyzed drugs in serum samples and pharmaceutical formulations with accepted recovery percentages. [Extracted from the article]

A study conducted at Mashhad University of Medical Sciences in Iran focused on developing a dual-targeted oral delivery system for mesalazine and acetaminophen to treat inflammatory bowel disease (IBD). The research aimed to enhance the effectiveness of mesalazine by delivering it to the large intestine and acetaminophen to the stomach simultaneously. The study concluded that the optimized formulation successfully achieved targeted delivery of both drugs in a single dosage form. For more information, readers can refer to the Journal of Mazandaran University of Medical Sciences. [Extracted from the article]

Researchers from Shahid Beheshti University in Tehran, Iran, conducted a study on the degradation of Acetaminophen tablets stored under unfavorable conditions such as high temperature and humidity. Using Raman spectroscopy analysis, they found that the quantity of the active pharmaceutical ingredient (API) decreased after exposure to specific temperature and humidity levels. The research concluded that the degradation pattern of the API follows a logarithmic trend under unfavorable storage conditions. This peer-reviewed study provides valuable insights into the impact of storage conditions on the quality of Acetaminophen tablets. [Extracted from the article]

A study conducted at the Heilongjiang Institute of Technology in Harbin, People's Republic of China, focused on constructing bimetallic nickel-cobalt selenide nanoparticles on carbon cloth for the electrochemical determination of acetaminophen. The research utilized a simple in situ synthesis strategy to convert MOF nanosheets into NiCoSe nanoparticles, resulting in an integrated electrode with enhanced electrocatalytic activity for acetaminophen sensing. The study achieved a low detection limit of 0.012 μM for acetaminophen and demonstrated practical detection in tablet samples and environmental water samples. This research provides new insights into the application of MOF-derived bimetallic selenides in flexible electrochemical sensing. [Extracted from the article]

A recent study conducted by researchers at the University of Cartagena focused on the potential impacts of acetaminophen (APAP) and benzo(a)pyrene (B[a]P) on human target proteins. The study utilized inverse molecular docking and molecular dynamics simulations to identify proteins affected by these substances. The results suggest that co-exposure to B[a]P can exacerbate the toxicity of APAP, providing insights into the toxic effects of combined exposure. For more information, the full article can be accessed for free at the link provided. [Extracted from the article]

Researchers at Capital Medical University have conducted a study on acetaminophen therapy, focusing on its role in acetaminophen-induced acute liver injury (AILI). The study found that depressed mitochondrial transcription factor A (TFAM) plays a crucial role in AILI pathogenesis, regulated by the DDX3X-PGC1a-NRF2 signaling pathway. This research sheds light on potential mechanisms underlying AILI and the therapeutic implications for treating acetaminophen overdose. [Extracted from the article]

A study conducted at Boston Children's Hospital explored the safety and tolerability of using intravenous lidocaine infusions as an adjunct to opioids in children hospitalized with sickle cell vaso-occlusive pain. The research found that lidocaine was administered in 64.6% of admissions without serious toxicities, and 82.2% of recipients chose to receive lidocaine during subsequent admissions. The study suggests that the efficacy of adjuvant lidocaine infusions should be further studied prospectively to better understand their impact on pain management for children with sickle cell disease. [Extracted from the article]

Researchers from Lincoln Memorial University conducted a study on the physicochemical properties and cytochromes P-450 kinetics of the trifluoroacetamido derivative of phenacetin, an analgesic antipyretic drug. The study found that the trifluoroacetamido derivative (TFA-phenacetin) of phenacetin is over seven times more lipophilic than phenacetin, potentially leading to better bioavailability. Additionally, both phenacetin and TFA-phenacetin showed the same apparent binding affinity for the SD rat liver microsome CYP proteome and underwent CYP catalyzed oxidation at the same rate. The research was funded by the University of Tennessee, Knoxville and the Appalachian College Association. [Extracted from the article]

A recent study conducted at the University of Sindh in Pakistan focused on the electrocatalytic detection of Acetaminophen (APN) using sodium ferrite nanoparticles. The research aimed to develop a method for the selective and sensitive detection of APN, which is known for its analgesic and antipyretic properties. The study successfully synthesized Na2Fe4O7-NPs and created an electrochemical sensor that showed selective sensing of APN in a wide dynamic range with a low detection limit. The researchers concluded that the developed method was stable, reproducible, and efficient for detecting APN in real samples. [Extracted from the article]

A recent study from the Faculty of Pharmacy explores species-specific differences in acetaminophen hepatotoxicity, focusing on the role of heat shock protein 70 (HSP70) expression levels. The research found that the EC50 for APAP-induced cell death varied among mouse, rat, and human hepatoma cell lines, with HSP70 expression positively correlating with cell death resistance. The study suggests that HSP70 may play a role in inhibiting APAP-induced cell death, highlighting potential differences in acetaminophen therapy outcomes across species. [Extracted from the article]

A recent study conducted at the University of Zaragoza in Spain focused on the thermophysical properties of eutectic mixtures of lidocaine with thymol or l-menthol, which are used in antifungal treatments. The research aimed to characterize these mixtures and determine various properties such as solid-liquid equilibrium, density, speed of sound, and viscosity. The findings suggested that the mixtures with l-menthol exhibited almost ideal behavior, while those with thymol showed more complex properties. The study concluded that a predictive model could be used to understand the thermodynamic behavior of these systems in different conditions. [Extracted from the article]

Researchers from the University of Yaounde 1 have conducted a study on the therapeutic potential of Khaya grandifoliola extract in protecting mice from acetaminophen-induced liver damage. The study found that delayed treatment with the extract inhibited liver damage, reduced enzyme levels, and restored liver function in mice. The extract was shown to prevent JNK activation and mitochondrial dysfunction, offering a potential antidote against acetaminophen-hepatotoxicity. The research was published in Pharmaceutical Science Advances and can be accessed for further information. [Extracted from the article]

Researchers at Jadavpur University have developed a method for UV spectrophotometric analysis of amoxicillin trihydrate in the presence of acetaminophen in different pH media. The study found that the Beer-Lambert law was obeyed in the concentration range of 2-10 g/ml for both substances. The research also highlighted the stability of amoxicillin trihydrate in different pH media in the presence of acetaminophen. The method developed was found to comply with validation parameters and was successfully applied to estimate the combination of these two drugs in pharmaceutical dosage forms. [Extracted from the article]

Researchers from Tongji University conducted a study on chronic kidney disease (CKD) in rats, focusing on the effects of epidural block with lidocaine. The research found that epidural block with lidocaine improved renal function and fibrosis in CKD rats, potentially mediated by decreasing sympathetic nerve activities. This study was supported by Shanghai Fourth People's Hospital and published in The American Journal of the Medical Sciences. For more information, readers can contact Tongji University in Shanghai, People's Republic of China. [Extracted from the article]

Researchers from Lebanese American University conducted a study on acetaminophen formulations to detect organic volatile impurities in both intravenous and oral forms of the drug. The study found that a significant percentage of samples analyzed contained impurities, some of which are highly toxic. The researchers emphasized the importance of pharmaceutical industries taking measures to control these impurities to ensure patient safety. The study was published in the Microchemical Journal and was supported by financial assistance from Lebanese American University. [Extracted from the article]

A recent study conducted at Wuhan University evaluated the effectiveness of chamomile tincture and lidocaine hydrochloride gel in treating periodontitis, a common oral disease characterized by inflammation and bone loss. The research, funded by the National Natural Science Foundation of China, found that the gel reduced inflammation and bone loss in rats with periodontitis by enhancing bone volume and thickness while inhibiting osteoclastogenesis. The study suggests that the gel may serve as an adjunctive therapy for periodontitis, offering potential benefits in mitigating the disease. [Extracted from the article]

Researchers at Panjab University in Chandigarh, India, have developed a novel electrochemical sensor based on graphene oxide functionalized with silatrane for the detection of acetaminophen in pharmaceutical tablets. The sensor showed a linear detection range from 2.5 to 100 mu M with a limit of detection of 84.8 nM, demonstrating its potential application in quality control and safety monitoring of pharmaceutical formulations. This study highlights the importance of precise monitoring of acetaminophen levels to ensure patient safety and prevent accidental overdoses that can lead to severe liver damage. [Extracted from the article]

A recent study conducted at Persian Gulf University in Bushehr, Iran, focused on the enhanced catalytic degradation of acetaminophen using magnesium oxide-infused clay activated by hydrogen peroxide and ultrasonic waves. The study found that the clay-MgO catalyst showed promise in efficiently removing acetaminophen from wastewater, with optimal conditions achieving 75% efficiency. The research highlighted the importance of hydroxyl radicals in the degradation process and demonstrated the catalyst's effectiveness in complex solutions, including seawater. The study concluded that the MgO-modified clay could be a valuable tool for degrading pharmaceutical pollutants through hydrogen peroxide activation, maintaining stability and reusability across multiple cycles. [Extracted from the article]

Researchers at Rangsit University in Thailand have developed a lidocaine-loaded thermoresponsive gel to accelerate wound healing in oral wounds, specifically targeting dry socket, a condition that causes severe pain and delayed healing after oral surgery. The gel transitions from a liquid to a gel at body temperature, ensuring sustained contact with the wound site and prolonged release of lidocaine. In vitro and in vivo studies showed that the gel significantly improved wound closure rates, reduced inflammation, and accelerated epithelialization, making it a promising therapeutic option for managing pain and enhancing oral wound healing. The study was funded by the Research Institute of Rangsit University and published in the journal Gels. [Extracted from the article]

Researchers from Deakin University in Australia have developed biocompatible MXene-reinforced molecularly imprinted membranes for the simultaneous filtration and capture of acetaminophen molecules. The incorporation of MXene into the membranes improved mechanical integrity and surface reactivity, allowing for efficient deposition of a molecularly imprinted polymer layer. This study offers insights into enhancing the functionality of polymer materials by incorporating MXene nanofillers into membrane production. The research was supported by Deakin University Institute for Frontier Materials and has been peer-reviewed. [Extracted from the article]

Researchers from the Council of Scientific and Industrial Research (CSIR) in Nagpur, India, conducted a study on the use of coconut shell biochar (CBC) for removing acetaminophen and ciprofloxacin from water. The study found that CBC was effective in adsorbing these pharmaceutical compounds at low concentrations, with optimal removal observed at specific dosages and pH levels. The research also discussed the potential reusability of CBC for water purification and highlighted the importance of proper disposal measures to prevent environmental pollution. [Extracted from the article]

A study conducted at the National Medical Research Center in Moscow, Russia, evaluated the effectiveness of multimodal opioid-saving anesthesia in pediatric oncosurgery. The study involved 40 children aged 12 to 18 years undergoing extended operations in the head and neck area. The research concluded that multimodal opioid-saving anesthesia is an effective and safe method for managing perioperative pain in children, reducing adverse reactions associated with opioids. The study was published in Regional Anesthesia and Acute Pain Management in 2024. [Extracted from the article]

The article discusses the impact of fatty acids on CYP2E1 activity in HepaRG cells and its association with acetaminophen cytotoxicity. It highlights that while certain fatty acids can induce CYP2E1 activity, not all of them lead to exacerbated acetaminophen-induced cytotoxicity. The study found that palmitic acid and stearic acid increased acetaminophen cytotoxicity, while linoleic acid did not, suggesting that fatty acid-mediated CYP2E1 activity does not always result in steatosis or heightened acetaminophen toxicity. [Extracted from the article]

Researchers at the University of California Berkeley have reported new findings on acetaminophen therapy, specifically focusing on the production of acetaminophen in the edible cyanobacterium Arthrospira platensis. This study highlights the development of genetic tools and transformation methods for engineering this bacterium to produce acetaminophen, showcasing its potential for pharmaceutical production in an edible host. The research, funded by organizations such as NASA and the NIH, aims to open up possibilities for enhancing nutrition, modifying taste, and delivering pharmaceuticals orally through engineered cyanobacteria. [Extracted from the article]

A recent study conducted at the College of Sciences and Humanities in Alkharj, Saudi Arabia, explored the use of beachwood sawdust as a low-cost and effective adsorbent for pharmaceutical acetaminophen drug effluent management. The research focused on creating a sustainable and green approach to pharmaceutical uptake in aqueous solutions by utilizing cellulose isolated from waste and magnetite nanoparticles. The study found that the M:SD (1:2) composite showed the highest removal rate of acetaminophen, with optimal conditions at pH 7.0 and an adsorbent dose of 2.0 g/L at room temperature. The research highlights the potential of utilizing agriculture-based waste for pharmaceutical waste management. [Extracted from the article]

A study conducted at Iran University of Science and Technology explored the use of rhamnolipid functionalized luffa fibers for removing pharmaceutical contaminants from water, specifically focusing on acetaminophen. The research found that the adsorbent had a high adsorption capacity for acetaminophen under optimized conditions. The study concluded that this method could be effective for water remediation, offering practical applications and optimization strategies. For more information, readers can refer to the Chemical Engineering Science journal. [Extracted from the article]

A study conducted at Universidade Federal Rural de Pernambuco (UFRPE) in Brazil explored the impact of different carbon sources on bacterial cellulose (BC) production and its properties. The research focused on how these carbon sources influenced BC yield, fiber morphology, network properties, and the release of lidocaine hydrochloride, a local anesthetic. The findings suggest that the selection of carbon sources plays a crucial role in shaping BC network architecture and drug release profiles, highlighting the potential of BC for wound healing and drug delivery applications. The study underscores the versatility and sustainability of BC as a material for enhancing wound management strategies. [Extracted from the article]

A study conducted at Guilan University of Medical Sciences compared the effectiveness of ketorolac intravenous versus acetaminophen intravenous in reducing headaches in patients following head trauma. The research found that ketorolac intravenous was more effective in pain control compared to acetaminophen intravenous. The study suggests that with more samples, the results could be expressed more decisively in the future. The findings were published in the Chinese Neurosurgical Journal. [Extracted from the article]

A study conducted by the Polish Academy of Sciences focused on the properties of local injectable anesthetics, specifically oleogels based on olive oil containing lidocaine. The research highlighted the potential of oleogels to stabilize active substances and emphasized the importance of surfactant type and amount in influencing their physicochemical properties. The study concluded that SPAN-stabilized oleogels showed better stability and mechanical properties, making them promising for medical applications, particularly in pain relief formulations. For more information, the full article can be accessed in the International Journal of Molecular Sciences. [Extracted from the article]

Researchers from the Affiliated Hospital of Guilin Medical University in China conducted a study on the effects of FAK inhibition on liver repair after acetaminophen-induced acute liver injury. The study utilized proteomics analysis and RNA-Seq to identify dysregulated proteins and genes in the livers of mice treated with acetaminophen. The findings suggest that inhibiting focal adhesion kinase (FAK) activation delays liver repair by suppressing hepatocyte proliferation and macrophage recruitment. This research provides valuable insights for potential clinical interventions in cases of acetaminophen overdose. [Extracted from the article]

A report from the College of Environmental and Chemical Engineering in Lianyungang, People's Republic of China, discusses a new method for detecting acetaminophen using a Cu2O@CF array electrode. The research highlights the electrode's broad linear range, low detection limit, and stability, making it promising for pharmaceutical applications. Funded by various organizations, the study emphasizes the electrode's potential in detecting acetaminophen in medicine samples. For more information, readers can contact Mingyan Wang at Jiangsu Ocean Univ. [Extracted from the article]

A study conducted in Busan, South Korea, focused on pediatric acetaminophen intoxication, the largest proportion of pediatric poisoning cases in the country. The research analyzed the characteristics and prognosis of pediatric patients who overdosed on acetaminophen, comparing intentional and accidental cases. The study found that patients who intentionally ingested acetaminophen had higher doses, were older, and were more likely to experience hepatotoxicity, highlighting the importance of monitoring for liver damage in these cases. The research concluded that tracking hepatotoxicity in patients who intentionally overdose on acetaminophen is crucial. [Extracted from the article]

Researchers from Islamic Azad University in Mashhad, Iran, have developed a method using magnetic dispersive micro solid-phase extraction to extract and clean up Caffeine, Lidocaine, and Chlorpromazine before determining them by HPLC-DAD. The method showed wide linearity and low LODs and LOQs for the three drugs. This research, published in the International Journal of Environmental & Analytical Chemistry, offers a straightforward and green procedure for analyzing these substances in biological and water samples. [Extracted from the article]

A study published in Industrial Chemistry & Materials explores a new biochar nanocomposite made from Elaeagnus angustifolia gum for detecting acetaminophen (APAP) in urine. The material, activated with ferric chloride and cobalt oxide doping, shows enhanced conductivity and specific recognition of APAP molecules. This research offers a faster, more sensitive, and automated method for APAP detection compared to traditional liquid chromatography, with potential for further improvements in sensor performance. The study was conducted by researchers from Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, and Dezhou University, funded by the Chinese Academy of Sciences. [Extracted from the article]

A recent study conducted at the University of Science & Technology Liaoning in Liaoning, People's Republic of China, focused on the synthesis of a Cd-MOF in MoS2 for the simultaneous detection of acetaminophen (AP) and dopamine (DA) using modified electrodes. The research resulted in a highly sensitive strategy with low detection limits for AP and DA, showcasing wide linear range, high sensitivity, selectivity, and stability. The study broadened the horizons for the development of MOF composites on electrochemical sensors, providing a new strategy for modified loading of MOF materials. The findings were published in the Chemical Engineering Journal and have been peer-reviewed. [Extracted from the article]

Researchers at Autonomous University Queretaro in Mexico have developed an electrochemical sensor for the quantification of ascorbic acid and acetaminophen in pharmaceutical samples. The sensor, which utilizes multi-walled carbon nanotubes and polyarginine, demonstrated excellent specificity, sensitivity, stability, and reproducibility. The study concluded that the sensor showed a fast response time, low limits of detection and quantification, and good correlation in measuring both substances in pharmaceuticals. This research has been peer-reviewed and offers valuable insights into the development of sensors for pharmaceutical analysis. [Extracted from the article]

Researchers at Shanghai Jiao Tong University have developed a lidocaine-loaded iontophoresis-driven fiber-based microneedle patch for transdermal local analgesia. This innovative system allows for controllable and long-lasting pain relief through a smartphone application that enables precise dosage control. The patch combines fiber-based dissolving microneedles with iontophoresis, offering different delivery modes for various pain conditions and ensuring efficient and prolonged pain management. This research has been peer-reviewed and offers a promising system for patient-controlled local analgesia treatment. [Extracted from the article]

A recent report discusses research on acetaminophen therapy and its role in drug-induced liver injury (DILI). The study found that neddylation, a post-translational modification involved in mitochondrial function, was upregulated in liver biopsies from patients with acetaminophen-induced liver injury (AILI) and in mice treated with an acetaminophen overdose. Inhibiting neddylation with MLN4924, an inhibitor of the NEDD8-activating enzyme, improved liver regeneration and reduced necrosis in AILI. The study suggests that understanding the crosstalk between neddylation and AILI could lead to the development of targeted inhibitors for DILI treatment. [Extracted from the article]

A study conducted by the Institute of Research and Development examined the potential use of non-fibrous Mg-clays as adsorbents for removing emerging contaminants (ECs) from water. The researchers characterized the materials and found that certain clays, such as Ad-8, exhibited high adsorption capacities for EC molecules like ciprofloxacin and lidocaine. The study suggests that these Mg-clays could be effectively used to remove pharmaceutical pollutants, expanding their commercial possibilities. The research was funded by the Autonomous University of Madrid and the National University of Comahue. [Extracted from the article]

A recent study conducted by researchers at the Medical School of Chinese People's Liberation Army (PLA) has found that pentagalloylglucose (PGG), a natural compound, has potential therapeutic effects for acetaminophen-induced acute liver injury (AILI). The study focused on the cGAS-STING pathway, an important component of the immune system, and its role in AILI. The researchers discovered that PGG blocked the activation of the cGAS-STING pathway, reduced inflammation, and improved liver function in both in vitro and in vivo experiments. These findings suggest that PGG could be a promising treatment strategy for AILI. [Extracted from the article]

A study conducted by researchers at Payame Noor University in Tehran, Iran, has focused on the use of carbon nanotubes to determine the presence of the cardiac drug isoproterenol in the presence of acetaminophen. Isoproterenol is commonly used to treat heart attacks, bronchitis, and allergic emergencies, but excessive use can lead to adverse effects such as decreased blood pressure and heart failure. The researchers developed a sensitive electrochemical sensor using a modified electrode with multiwall carbon nanotubes and ionic liquid, which showed promising results in detecting isoproterenol in serum and urine samples. The study was peer-reviewed and received financial support from Payame Noor University. [Extracted from the article]

Researchers from Shiraz University in Iran have developed a sustainable material called MACC-N, which is derived from Prunus scoparia shells and consists of Fe3O4 nanoparticles supported on chemically functionalized carbon. This material was found to be effective in removing toxic pharmaceuticals, specifically metronidazole and acetaminophen, from water. The MACC-N exhibited desirable surface properties and reactive functional groups, allowing for efficient adsorption of the pharmaceuticals. The research suggests that MACC-N could be a viable alternative to traditional wastewater treatment methods on a commercial scale. [Extracted from the article]

A report from Kazan National Research Technological University in Tatarstan, Russia, discusses a study on the grinding of lidocaine using the rapid expansion of supercritical solutions (RESS) method. The experiments were conducted at various pressures and temperatures, and the analysis focused on the morphology and size of particles. The research found that reducing the particle size increased the yield of the drug in a shorter period of time compared to the untreated drug. This study was supported by the Russian Science Foundation and has been peer-reviewed. [Extracted from the article]

Researchers at Wroclaw Medical University in Poland have conducted a study on a novel combination therapy using diphenhydramine and lidocaine for managing inflammatory and allergic skin conditions with coexisting itch. Diphenhydramine, an antihistamine, and lidocaine, a local anesthetic, were found to have synergistic effects in providing relief for symptoms such as erythema, edema, and pruritus. The study evaluated the efficacy and safety of the combination therapy and concluded that it represents an innovative approach in dermatology for addressing both inflammation and itch associated with these skin conditions. The research has been peer-reviewed and published in Acta Poloniae Pharmaceutica - Drug Research. [Extracted from the article]

A recent study conducted at Amsterdam University Medical Center explored the use of intravenous lidocaine as a potential treatment for refractory pain in patients with pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). The study included 30 patients and found that while lidocaine did not show an overall clinically relevant reduction in pain, it did have a positive effect in a third of patients, with the response lasting up to a month and only minor side effects reported. The researchers suggest that further studies with larger sample sizes and less heterogeneous patient groups are needed to determine the efficacy of intravenous lidocaine as a treatment option. [Extracted from the article]